Fronto-limbic disconnection in depressed patients with suicidal ideation: A resting-state functional connectivity study
Abstract
Background Suicidal ideation (SI) is highly prevalent and a known symptom of Major Depressive Disorder (MDD), but its underlying biological mechanisms are relatively unknown. Several studies linked suicidal ideation to dysfunctional brain circuits, specifically fronto-limbic connections. The purpose of this work was to investigate fronto-limbic disconnection in MDD patients with or without SI.Methods MDD patients with SI (SI, n=28) or without SI (NSI, n=20), identified by the Scale for Suicide Ideation and healthy controls (HCs, n=30) underwent resting-state functional MRI scanning. The functional properties of correlations in neural activity (intrinsic functional connectivity, iFC) of the rostral anterior cingulate cortex (rACC) were analyzed among the three groups. Furthermore, correlation analyses between iFC, SI severity and depression severity were performed.Results We found that the SI group exhibited decreased iFC between the rACC, the orbitomedial prefrontal cortex and the right middle temporal pole compared to HCs and NSI groups. The NSI group showed decreased iFC between the rACC and the orbitomedial prefrontal cortex compared to HCs. In the SI group, iFC strength between the right rACC and the middle temporal pole positively correlated with SI severity.Conclusion Transdiagnostic and diagnosis-specific alterations of fronto-limbic iFC were found in MDD patients with or without SI. Disrupted fronto-limbic circuits may impact decision-making and emotional processing in SI. These results provide useful information about the pathophysiological mechanisms of MDD patients with SI.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Resting-state fMRI indicates lower functional connectivity in adolescent and adult suicide attempters, predominantly in the default mode network.
“Resting-state functional MRI (rs-fMRI) indicates lower functional connectivity in adolescent and adult suicide attempters, predominantly in the default mode network, which is implicated in self-referential processing and social cognition (85-87).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [86]
Other studies have reported lower rs-fMRI activity and functional connectivity, probably due to different outcome measures and heterogeneity of suicidal ideation.
“However, other studies have reported lower rs-fMRI activity and functional connectivity (85, 86, 92, 93), probably due to use of different outcome measures of rs-fMRI activity, for example, regional homogeneity, fractional amplitude of low-frequency fluctuations among studies, and heterogeneity of suicidal ideation.”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [86]
Cites
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553 · see citing works
Development of a Rating Scale for Primary Depressive Illness
Hamilton, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410 · see citing works
Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.018 · Cited by 7,429 · see citing works
The brain's default mode network
Raichle, M. E. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014030 · Cited by 3,904 · see citing works
Movement‐Related effects in fMRI time‐series
Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S. J., & Turner, R. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350312 · Cited by 3,774 · see citing works
Assessment of suicidal intention: The Scale for Suicide Ideation.
Beck, A. T., Kovacs, M., & Weissman, A. (1979) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.47.2.343 · Cited by 3,419 · see citing works
Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059 · cited 1× · see citing works
“The rACC was chosen due to its relationship to suicide (van Heeringen and Mann, 2014) as well its role in affective/emotional regulation in MDD (Etkin et al., 2011; Rihmer, 2007).”
MethodPrinciples of Behavioral and Cognitive Neurology
(2000) · doi:10.1093/oso/9780195134759.001.0001 · Cited by 1,448 · see citing works
Depression sum-scores don’t add up: why analyzing specific depression symptoms is essential
Fried, E. I., & Nesse, R. M. (2015) · BMC Medicine · doi:10.1186/s12916-015-0325-4 · Cited by 981 · see citing works
Borges, G., Nock, M. K., Haro Abad, J. M., Hwang, I., Sampson, N. A., Alonso, J., Andrade, L. H., Angermeyer, M. C., Beautrais, A., Bromet, E., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04967blu · Cited by 796 · see citing works
Klonsky, E. D., & May, A. M. (2014) · Suicide and Life-Threatening Behavior · doi:10.1111/sltb.12068 · Cited by 740 · see citing works
Towards a neural basis of music-evoked emotions
Koelsch, S. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.01.002 · Cited by 651 · see citing works
van Heeringen, K., & Mann, J. J. (2014) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)70220-2 · Cited by 550 · cited 4× · see citing works
“The rACC was chosen due to its relationship to suicide (van Heeringen and Mann, 2014) as well its role in affective/emotional regulation in MDD (Etkin et al., 2011; Rihmer, 2007).”
BackgroundMethodInfluentialAltered Functional Connectivity and Small-World in Mesial Temporal Lobe Epilepsy
Liao, W., Zhang, Z., Pan, Z., Mantini, D., Ding, J., Duan, X., Luo, C., Lu, G., & Chen, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008525 · Cited by 517 · see citing works
Psychopathology and the Human Connectome: Toward a Transdiagnostic Model of Risk For Mental Illness
Buckholtz, J. W., & Meyer‐Lindenberg, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.002 · Cited by 433 · see citing works
Suicide risk in mood disorders
Rihmer, Z. (2007) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3280106868 · Cited by 382 · see citing works
Monkul, E. S., Hatch, J. P., Nicoletti, M. A., Spence, S., Brambilla, P., Lacerda, A. L. T., Sassi, R. B., Mallinger, A. G., Keshavan, M. S., & Soares, J. C. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001919 · Cited by 321 · see citing works
Jollant, F., Lawrence, N. S., Olie, E., O'Daly, O., Malafosse, A., Courtet, P., & Phillips, M. L. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.03.027 · Cited by 312 · see citing works
Selective aberrant functional connectivity of resting state networks in social anxiety disorder
Liao, W., Chen, H., Feng, Y., Mantini, D., Gentili, C., Pan, Z., Ding, J., Duan, X., Qiu, C., Lui, S., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.05.010 · Cited by 304 · see citing works
Ballard, E. D., Ionescu, D. F., Vande Voort, J. L., Niciu, M. J., Richards, E. M., Luckenbaugh, D. A., Brutsché, N. E., Ameli, R., Furey, M. L., & Zarate, C. A. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.07.027 · Cited by 286 · see citing works
Dysfunction in the neural circuitry of emotional self-regulation in major depressive disorder
Beauregard, M., Paquette, V., & Le´vesque, J. (2006) · Neuroreport · doi:10.1097/01.wnr.0000220132.32091.9f · Cited by 254 · see citing works
Executive functioning in depressed patients with suicidal ideation
Marzuk, P. M., Hartwell, N., Leon, A. C., & Portera, L. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00585.x · Cited by 249 · see citing works
Peng, J., Liu, J., Nie, B., Li, Y., Shan, B., Wang, G., & Li, K. (2010) · European Journal of Radiology · doi:10.1016/j.ejrad.2010.04.006 · Cited by 245 · see citing works
Self-citationWagner, G., Koch, K., Schachtzabel, C., Schultz, C. C., Sauer, H., & Schlösser, R. G. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.082 · Cited by 230 · see citing works
Heeringen, C. V., Bijttebier, S., & Godfrin, K. A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.08.007 · Cited by 167 · see citing works
van Heeringen, K., Bijttebier, S., Desmyter, S., Vervaet, M., & Baeken, C. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00824 · Cited by 141 · see citing works
Cao, J., Chen, X., Chen, J., Ai, M., Gan, Y., Wang, W., Lv, Z., Zhang, S., Zhang, S., Wang, S., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.07.002 · Cited by 140 · see citing works
Identifying Suicidal Ideation in General Medical Patients
Cooper, L. A. (1994) · JAMA · doi:10.1001/jama.1994.03520220051030 · Cited by 134 · see citing works
Jia, Z., Wang, Y., Huang, X., Kuang, W., Wu, Q., Lui, S., Sweeney, J., & Gong, Q. (2014) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.130023 · Cited by 132 · see citing works
van Eijndhoven, P., van Wingen, G. A., Katzenbauer, M., Groen, W. B., Tepest, R., Fernández, G., Buitelaar, J. K., & Tendolkar, I. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12121504 · Cited by 126 · see citing works
Fan, T., Wu, X., Li, Y., & Dong, J. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.11.032 · Cited by 117 · see citing works
Self-citationPu, S., Nakagome, K., Yamada, T., Yokoyama, K., Matsumura, H., Yamada, S., Sugie, T., Miura, A., Mitani, H., Iwata, M., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.04.010 · Cited by 114 · see citing works
Willeumier, K., Taylor, D. V., & Amen, D. G. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.28 · Cited by 107 · see citing works
Myung, W., Han, C. E., Fava, M., Mischoulon, D., Papakostas, G. I., Heo, J.-Y., Kim, K. W., Kim, S. T., Kim, D. J. H., Kim, D. K., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.110 · Cited by 101 · see citing works
The prefrontal–limbic network in depression: Modulation by hypothalamus, basal ganglia and midbrain
Bennett, M. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.006 · Cited by 97 · see citing works
A diffusion tensor imaging study of suicide attempters
Olvet, D. M., Peruzzo, D., Thapa-Chhetry, B., Sublette, M. E., Sullivan, G. M., Oquendo, M. A., Mann, J. J., & Parsey, R. V. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.01.002 · Cited by 97 · see citing works
Peng, H., Wu, K., Li, J., Qi, H., Guo, S., Chi, M., Wu, X.-M., Guo, Y., Yang, Y., & Ning, Y. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.046 · Cited by 89 · see citing works
Sublette, M. E., Milak, M. S., Galfalvy, H., Oquendo, M. A., Malone, K. M., & Mann, J. J. (2013) · Archives of Suicide Research · doi:10.1080/13811118.2013.801813 · Cited by 86 · see citing works
Neurobiological Risk Factors for Suicide
Lippard, E., Johnston, J. A. Y., & Blumberg, H. P. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2014.06.009 · Cited by 83 · see citing works
Neural Correlates of Suicidal Ideation and Its Reduction in Depression
Ballard, E. D., Lally, N., Nugent, A. C., Furey, M. L., Luckenbaugh, D. A., & Zarate, C. A. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu069 · Cited by 73 · see citing works
Zhang, H., Chen, Z., Jia, Z., & Gong, Q. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.03.002 · Cited by 72 · see citing works
Gong, Q., Hu, X., Pettersson‐Yeo, W., Xu, X., Lui, S., Crossley, N. A., Wu, M. C., Zhu, H., & Mechelli, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.247 · Cited by 58 · see citing works
Identifying Corticothalamic Network Epicenters in Patients with Idiopathic Generalized Epilepsy
Ji, G., Zhang, Z., Xu, Q., Wang, Z., Wang, J., Jiao, Q., Yang, F., Tan, Q., Chen, G., Zang, Y., et al. (2015) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4308 · Cited by 51 · see citing works
Li, R., Liao, W., Li, Y., Yu, Y., Zhang, Z., Lu, G., & Chen, H. (2016) · Human Brain Mapping · doi:10.1002/hbm.23323 · Cited by 47 · see citing works
Self-citationIdentifying suicidal ideation among older adults in a general practice setting
Pfaff, J. J., & Almeida, O. P. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.03.006 · Cited by 37 · see citing works
Liao, W., Yu, Y., Miao, H., Feng, Y.-X., Ji, G., & Feng, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9863-9 · Cited by 31 · see citing works
Understanding Suicidal Behavior: The Contribution of Recent Resting-State fMRI Techniques
Serafini, G., Pardini, M., Pompili, M., Girardi, P., & Amore, M. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00069 · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies
Schmaal, L., van Harmelen, A.-L., Chatzi, V., Lippard, E. T. C., Toenders, Y. J., Averill, L. A., Mazure, C. M., & Blumberg, H. P. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0587-x · Cited by 373 · see citing works
Adolescent Suicide as a Failure of Acute Stress-Response Systems.
Miller, A. B., & Prinstein, M. J. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095625 · Cited by 235 · see citing works
“In adult samples, similar findings have emerged, suggesting decreased frontolimbic functional connectivity in individuals with suicidal ideation (Du et al. 2017, Kim et al. 2017, Minzenberg et al. 2015).”
BackgroundA brain-centric model of suicidal behavior
Mann, J. J., & Rizk, M. M. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20081224 · Cited by 214 · see citing works
Li, J., Duan, X., Cui, Q., Chen, H., & Liao, W. (2019) · Psychological Medicine · doi:10.1017/s0033291718001502 · Cited by 208 · see citing works
Chen, L., Wang, Y., Niu, C., Zhong, S., Hu, H., Chen, P., Zhang, S., Chen, G., Deng, F., Lai, S., et al. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.07.002 · Cited by 182 · see citing works
Liao, W., Li, J., Duan, X., Cui, Q., Chen, H., & Chen, H. (2018) · Human Brain Mapping · doi:10.1002/hbm.24235 · Cited by 132 · see citing works
Bani-Fatemi, A., Tasmim, S., Graff-Guerrero, A., Gerretsen, P., Strauss, J., Kolla, N., Spalletta, G., & De Luca, V. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.05.008 · Cited by 112 · see citing works
Network basis of suicidal ideation in depressed adolescents
Ordaz, S. J., Goyer, M. S., Ho, T. C., Singh, M. K., & Gotlib, I. H. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.09.021 · Cited by 111 · see citing works
Kang, S.-G., Na, K.-S., Choi, J.-W., Kim, J.-H., Son, Y.-D., & Lee, Y. J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.029 · Cited by 110 · see citing works
Kim, K., Kim, S.-W., Myung, W., Han, C. E., Fava, M., Mischoulon, D., Papakostas, G. I., Seo, S. W., Cho, H., Seong, J.-K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15926-0 · Cited by 107 · see citing works
Neural Correlates of Emotion Regulation and Adolescent Suicidal Ideation
Miller, A. B., McLaughlin, K. A., Busso, D. S., Brueck, S., Peverill, M., & Sheridan, M. A. (2018) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.08.008 · Cited by 96 · see citing works
Chen, M.-H., Lin, W.-C., Tu, P.-C., Li, C.-T., Bai, Y.-M., Tsai, S.-J., & Su, T.-P. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.022 · Cited by 78 · see citing works
Default mode dysfunction underpins suicidal activity in mood disorders
Malhi, G. S., Das, P., Outhred, T., Bryant, R. A., Calhoun, V., & Mann, J. J. (2020) · Psychological Medicine · doi:10.1017/s0033291719001132 · Cited by 73 · see citing works
Fan, S., Lippard, E. T. C., Sankar, A., Wallace, A., Johnston, J. A. Y., Wang, F., Pittman, B., Spencer, L., Oquendo, M. A., & Blumberg, H. P. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.095 · Cited by 72 · see citing works
Schreiner, M. W., Klimes‐Dougan, B., & Cullen, K. R. (2019) · Suicide and Life-Threatening Behavior · doi:10.1111/sltb.12471 · Cited by 69 · see citing works
Wagner, G., Li, M., Sacchet, M. D., Richard‐Devantoy, S., Turecki, G., Bär, K., Gotlib, I. H., Walter, M., & Jollant, F. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01232-x · Cited by 58 · see citing works
Shi, Y., Zhang, L., Wang, Z., Lu, X., Wang, T., Zhou, D., & Zhang, Z. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00256 · Cited by 61 · see citing works
Yang, Z., Jian, L., Qiu, H., Zhang, C., Cheng, S., Ji, J., Li, T., Wang, Y., Li, J., & Li, K. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01646-7 · Cited by 57 · see citing works
Neural substrates of suicide and suicidal behaviour: From a neuroimaging perspective
Balcioglu, Y. H., & Kose, S. (2018) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2017.1420378 · Cited by 50 · see citing works
Zhou, Z., Gao, Y., Bao, W., Liang, K., Cao, L., Tang, M., Li, H., Hu, X., Zhang, L., Sun, H., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105583 · Cited by 53 · see citing works
Zhang, R., Wei, S., Chang, M., Jiang, X., Tang, Y., & Wang, F. (2019) · Acta Neuropsychiatrica · doi:10.1017/neu.2019.45 · Cited by 50 · see citing works
Cao, J., Ai, M., Chen, X., Chen, J., Wang, W., & Kuang, L. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2019.112713 · Cited by 48 · see citing works
Schwartz, J., Ordaz, S. J., Ho, T. C., & Gotlib, I. H. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.009 · Cited by 46 · see citing works
Resting-state amplitude of low-frequency fluctuation is associated with suicidal ideation
Lan, M. J., Rizk, M. M., Pantazatos, S. P., Rubin‐Falcone, H., Miller, J. M., Sublette, M. E., Oquendo, M. A., Keilp, J. G., & Mann, J. J. (2019) · Depression and Anxiety · doi:10.1002/da.22888 · Cited by 48 · see citing works
Using resting-state intrinsic network connectivity to identify suicide risk in mood disorders
Stange, J. P., Jenkins, L. M., Pocius, S. L., Kreutzer, K. A., Bessette, K. L., DelDonno, S. R., Kling, L. R., Bhaumik, R., Welsh, R. C., Keilp, J. G., et al. (2019) · Psychological Medicine · doi:10.1017/s0033291719002356 · Cited by 42 · see citing works
Liu, X., He, C., Fan, D., Zang, F., Zhu, Y., Zhang, H., Zhang, Z., Zhang, H., & Xie, C. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01353-3 · Cited by 40 · see citing works
Zhang, R., Zhang, L., Wei, S., Wang, P., Jiang, X., Tang, Y., & Wang, F. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.585664 · Cited by 40 · see citing works
Fatigue and Suicidal Ideation in People With Multiple Sclerosis: The Role of Social Support
Mikula, P., Timková, V., Linkova, M., Vitková, M., Szilasiová, J., & Nagyová, I. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00504 · Cited by 39 · see citing works
Chen, Z., Xia, M., Zhao, Y., Kuang, W., Jia, Z., & Gong, Q. (2021) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27784 · Cited by 38 · see citing works
Nugent, A. C., Ballard, E. D., Gilbert, J. R., Tewarie, P. K., Brookes, M. J., & Zarate, C. A. (2020) · NeuroImage: Clinical · doi:10.1016/j.nicl.2020.102378 · Cited by 34 · see citing works
Chen, C.-F., Chen, W.-N., & Zhang, B. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-021-00503-x · Cited by 35 · see citing works
Vieira, R., Faria, A. R., Ribeiro, D., Picó‐Pérez, M., & Bessa, J. M. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110799 · Cited by 34 · see citing works
Chen, V. C., Chou, Y.-S., Tsai, Y., Huang, Y.-C., McIntyre, R. S., & Weng, J. (2021) · Brain Topography · doi:10.1007/s10548-020-00817-x · Cited by 32 · see citing works
Qiu, H., Cao, B., Cao, J., Li, X., Chen, J., Wang, W., Lv, Z., Zhang, S., Fang, W., Ai, M., et al. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112544 · Cited by 31 · see citing works
Slower perception of time in depressed and suicidal patients
Cáceda, R., Carbajal, J. M., Salomon, R. M., Moore, J., Perlman, G., Padala, P. R., Hasan, A., & Delgado, P. L. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.09.004 · Cited by 31 · see citing works
Dobbertin, M. D., Blair, K. S., Carollo, E., Blair, J., Dominguez, A. J., & Bajaj, S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1083244 · Cited by 31 · see citing works
Zhu, R., Tian, S., Wang, H., Jiang, H., Wang, X., Shao, J., Wang, Q., Yan, R., Tao, S., Liu, H., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.597770 · Cited by 30 · see citing works
Self-citationYang, J., Palaniyappan, L. K., Xi, C., Cheng, Y., Fan, Z., Chen, C., Zhang, M., Pan, Y., Tao, H., Ouyang, X., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.02.003 · Cited by 30 · see citing works
Cao, J., Chen, X., Chen, J., Ai, M., Gan, Y., He, J., & Kuang, L. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.567976 · Cited by 29 · see citing works
Modes of Resting Functional Brain Organization Differentiate Suicidal Thoughts and Actions
Cáceda, R., Bush, K., James, G. A., Stowe, Z. N., & Kilts, C. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.17m11901 · Cited by 30 · see citing works
Parsaei, M., Taghavizanjani, F., Cattarinussi, G., Moghaddam, H. S., Camillo, F. D., Akhondzadeh, S., Sambataro, F., Brambilla, P., & Delvecchio, G. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.08.034 · Cited by 27 · see citing works
Aberrant functional connectivity and graph properties in bipolar II disorder with suicide attempts
Wang, H., Zhu, R., Dai, Z., Tian, S., Shao, J., Wang, X., Sun, Y., Chen, Z., Li, X., Yao, Z., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.016 · Cited by 27 · see citing works
Zheng, M., Da, H., Pan, X., Bian, Y., Li, X., Xiao, Q., Qiu, M., Xiang, N., Dongmei, Z., Wei, Q., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.01.115 · Cited by 27 · see citing works
Wáng, Q., He, C., Wang, Z., Fan, D., Zhang, Z., Xie, C., Yan, C., Chen, X., Li, L., Castellanos, F. X., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02655-4 · Cited by 26 · see citing works
Self-citationMohan, A., Davidson, C., Ridder, D. D., & Vanneste, S. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9989-7 · Cited by 25 · see citing works
Lancaster, K., Venkatesan, U. M., Lengenfelder, J., & Genova, H. M. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00825 · Cited by 23 · see citing works
Li, W., Wang, C., Lan, X., Fu, L., Zhang, F., Ye, Y., Liu, H., Zhou, Y., & Ning, Y. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.07.001 · Cited by 23 · see citing works
Self-citationCheng, X., Chen, J., Zhang, X., Wang, T., Sun, J., Zhou, Y., Yang, R., Xiao, Y., Chen, A., Song, Z., et al. (2023) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-023-02242-4 · Cited by 22 · see citing works
Potvin, S., Tikàsz, A., Richard‐Devantoy, S., Lungu, O., & Dumais, A. (2018) · Schizophrenia Research and Treatment · doi:10.1155/2018/9898654 · Cited by 22 · see citing works
Suicide in Parkinson’s Disease: A Systematic Review
Berardelli, I., Belvisi, D., Nardella, A., Falcone, G., Lamis, D. A., Fabbrini, G., Berardelli, A., Girardi, P., & Pompili, M. (2019) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527318666190703093345 · Cited by 22 · see citing works
The neural connectome of suicidality in adults with mood and anxiety disorders
Bryant, R. A., Breukelaar, I. A., Williamson, T., Felmingham, K. L., Williams, L. M., & Korgaonkar, M. S. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00325-y · Cited by 21 · see citing works
Wang, W., Kang, L., Zhang, N., Guo, X., Wang, P., Zong, X., Yao, L., Bai, H., Cheng, J., Tu, N., et al. (2021) · Neural Plasticity · doi:10.1155/2021/7088856 · Cited by 21 · see citing works
Lucido, M. J., & Dunlop, B. W. (2025) · Brain Sciences · doi:10.3390/brainsci15020161 · Cited by 19 · see citing works
Sun, F., Yan, J., Pang, J., Song, M., Wang, M., Huang, T., & Zhao, Z. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.213 · Cited by 18 · see citing works
Hyung, W. S. W., Kang, J. C., Kim, J., Lee, S., Youn, H., Ham, B., Han, C., Suh, S., Han, C. E., & Jeong, H. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.049 · Cited by 17 · see citing works
Guo, M., Zhang, H., Huang, Y., Diao, Y., Wang, W., Li, Z., Feng, S., Zhou, J., Ning, Y., Wu, F., et al. (2025) · Research · doi:10.34133/research.0659 · Cited by 17 · see citing works
Altered Cortical Morphology in Major Depression Disorder Patients with Suicidality
Li, H., Zhang, H., Yin, L., Zhang, F., Chen, Z., Chen, T., Jia, Z., & Gong, Q. (2020) · Psychoradiology · doi:10.1093/psyrad/kkaa002 · Cited by 17 · see citing works
Dai, Z., Zhang, S., Wang, H., Chen, Z., Zhang, W., Hu, X., Yao, Z., & Lü, Q. (2022) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13487 · Cited by 17 · see citing works
Examination of structural brain changes in recent suicidal behavior
Kim, D. J., Bartlett, E. A., DeLorenzo, C., Parsey, R. V., Kilts, C. D., & Cáceda, R. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111216 · Cited by 16 · see citing works
Ouyang, X., Long, Y., Wu, Z., Liu, D., Liu, Z., & Huang, X. (2022) · Brain Sciences · doi:10.3390/brainsci12091263 · Cited by 18 · see citing works
Liu, X., Chen, J., Shen, B., Wang, G., Li, J., Hou, H., Chen, X., Guo, Z., & Mao, C. (2018) · Neural Plasticity · doi:10.1155/2018/1672708 · Cited by 17 · see citing works
Reis, J. V., Vieira, R., Portugal‐Nunes, C., Coelho, A., Magalhães, R. J. D. S., Moreira, P. S., Ferreira, S., Picó‐Pérez, M., Sousa, N., Dias, N. S., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.838111 · Cited by 15 · see citing works
Chen, S., Zhang, X., Lin, S., Zhang, Y., Xu, Z., Li, Y., Xu, M., Hou, G., & Qiu, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.11.022 · Cited by 15 · see citing works
Self-citationSu, Y., Ye, C., Qin, X., & Si, T. (2024) · General Psychiatry · doi:10.1136/gpsych-2024-101649 · Cited by 15 · see citing works
Wang, H., Zhu, R., Tian, S., Zhang, S., Dai, Z., Shao, J., Li, X., Yao, Z., & Lü, Q. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.03.010 · Cited by 15 · see citing works
He, M., Ping, L., Chu, Z., Zeng, C., Shen, Z., & Xu, X. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.856366 · Cited by 14 · see citing works
Detecting Suicide Ideation in the Era of Social Media: The Population Neuroscience Perspective
Morese, R., Gruebner, O., Sykora, M. D., Elayan, S., Fadda, M., & Albanese, E. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.652167 · Cited by 16 · see citing works
Chen, Y., Zhao, P., Pan, C., Chang, M., Zhang, X., Duan, J., Wei, Y., Tang, Y., & Wang, F. (2024) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.230069 · Cited by 12 · see citing works
Wu, Y., Zhang, H., Shen, Q., Jiang, X., Yuan, X., Li, M., Chen, M., Zhou, J., & Cui, J. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.07.009 · Cited by 12 · see citing works
Miller, A. B., & Eisenlohr-Moul, T. A. (2019) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-019-00185-2 · Cited by 12 · see citing works
Lin, C., Huang, C., Chang, W., Chang, Y., Liu, H., Ng, S., Lin, H., Lee, T. M. C., Lee, S., & Wu, S. (2024) · Brain and Behavior · doi:10.1002/brb3.3348 · Cited by 11 · see citing works
Self-citationDetecting Major Depressive Disorder by Graph Neural Network Exploiting Resting-State Functional MRI
Zhao, T., & Zhang, G. (2023) · Communications in computer and information science · doi:10.1007/978-981-99-1642-9_22 · Cited by 11 · see citing works
Lin, G., Chen, B., Yang, M., Wu, Z., Qiu, K., Zhang, M., Wang, Q., Zhang, S., Lao, J., Zeng, Y., et al. (2023) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2023.05.006 · Cited by 11 · see citing works
Verovnik, B., & Vovk, A. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15363 · Cited by 11 · see citing works
Altered Brain Activity in Depression of Parkinson’s Disease: A Meta-Analysis and Validation Study
Su, D., Cui, Y., Liu, Z., Chen, H., Fang, J., Ma, H., Zhou, J., & Feng, T. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.806054 · Cited by 10 · see citing works
Timková, V., Nagyová, I., Reijneveld, S. A., Tkáčová, R., Stewart, R. E., van Dijk, J. P., & Bültmann, U. (2018) · Journal of Health Psychology · doi:10.1177/1359105318758859 · Cited by 10 · see citing works
Yang, C., Duan, Y., Lei, L., Liu, P., Zhang, A., Li, G., Sun, N., Wang, Y., Liu, Z., & Zhang, K. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.849158 · Cited by 9 · see citing works
Li, H., Zhang, H., Qin, K., Yin, L., Chen, Z., Zhang, F., Wu, B., Chen, T., Sweeney, J. A., Gong, Q., et al. (2024) · Brain Imaging and Behavior · doi:10.1007/s11682-024-00870-1 · Cited by 9 · see citing works
Trajectories of suicidal ideation during rTMS for treatment-resistant depression
Zhan, D., Gregory, E., Humaira, A., Wong, H., Klonsky, E. D., Levit, A., Ridgway, L., & Vila‐Rodriguez, F. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.05.109 · Cited by 9 · see citing works
Suicidal ideation, hopelessness, and affective temperament in patients with blepharospasm
Berardelli, I., Ferrazzano, G., Belvisi, D., Baione, V., Fabbrini, G., Innamorati, M., Berardelli, A., & Pompili, M. (2020) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2020.1790613 · Cited by 9 · see citing works
Diao, Y., Huang, Y., Guo, M., Li, W., Wang, W., Li, Z., Zhang, H., Zhou, J., Li, X., Wu, F., et al. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03965-z · Cited by 7 · see citing works
Chen, X., Zhang, B., Yuan, S., Luo, X., Wang, M., Hu, Y., Zhou, Y., & Ning, Y. (2023) · European Psychiatry · doi:10.1192/j.eurpsy.2023.19 · Cited by 6 · see citing works
Infusing Hope Into the Treatment of Suicidality: a Review of Ketamine’s Effects on Suicidality
Rengasamy, M. L., Hsiung, K. S., & Price, R. B. (2019) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-019-00184-3 · Cited by 5 · see citing works
McKenna, B. G., Knight, A. K., Smith, A. K., Corwin, E. J., Carter, S. E., Palmer, R. H. C., Dunlop, A. L., & Brennan, P. A. (2023) · Development and Psychopathology · doi:10.1017/s0954579423001232 · Cited by 4 · see citing works
Zhang, Y., Wu, G., Witte, S. D., & Baeken, C. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.02.010 · Cited by 4 · see citing works
An Overview of Machine Learning Applications in Mood Disorders
Topolski, N., Jeong, S. H., & Mwangi, B. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.017 · Cited by 4 · see citing works
Hao, Z., Li, H., & Lin, Y. (2022) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2022.111562 · Cited by 4 · see citing works
Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis
Huang, H., Guo, Z., Yang, X., & Qin, L. (2026) · Dialogues in Clinical Neuroscience · doi:10.1080/19585969.2026.2612918 · Cited by 3 · see citing works
Lin, Y., Zeng, Y., Wu, Z., Chen, B., Zhang, M., Lin, G., Lao, J., Wang, Q., Xu, D., Yao, K., et al. (2026) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn-25-0068 · Cited by 3 · see citing works
Vieira, R., Reis, J. S., Portugal‐Nunes, C., Coelho, A., Magalhães, R. J. D. S., Ferreira, S., Moreira, P. S., Sousa, N., Picó‐Pérez, M., & Bessa, J. M. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.165 · Cited by 3 · see citing works
(2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018 · Cited by 3 · see citing works
Fattahi, M., Rostami, R., & Hossein‐Zadeh, G. (2021) · National and International Iranian Conference on Biomedical Engineering (ICBME) · doi:10.1109/icbme54433.2021.9750309 · Cited by 3 · see citing works
Zhang, M., Liu, Z., Zhong, M., Wang, Y. Q., Wang, F., Yang, J., & Yang, J. (2025) · Psychological Medicine · doi:10.1017/s0033291725102791 · Cited by 3 · see citing works
Liu, C., Fang, S., Cheng, C., Lin, P., Dong, D., Yao, S., Situ, W., & Wang, X. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111622 · Cited by 2 · see citing works
Neuroimaging Studies of Effects of Psychotherapy in Depression
Bauer, I. E., & Meyer, T. D. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.021 · Cited by 2 · see citing works
Electrophysiological Biomarkers for Mood Disorders
Ramakrishnan, N., Murphy, N., Selvaraj, S., & Cho, R. Y. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.015 · Cited by 2 · see citing works
Neural biomarkers of suicidal behavior: from cognition and circuits to cells (and back)
Jollant, F., & Mechawar, N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821398-8.00007-2 · Cited by 2 · see citing works
Dynamics of cerebral blood flow following sertraline treatment in adolescent depression
Ren, W., Liu, X., Zhang, Z., Zhang, X., Wu, W., Wang, X., Yu, Z., Liu, C., & Yu, R. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1521565 · Cited by 1 · see citing works
Bloemhof‐Bris, E., Levi‐Belz, Y., Guterman, A. T., Wexler, G., Noam, S., Cohen, S., & Feffer, K. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120705 · Cited by 1 · see citing works
Burhunduli, P., Vandeloo, K. L., Fang, Z., Blier, P., & Phillips, J. L. (2026) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyag016 · Cited by 1 · see citing works
- Authors
- Du, L., Zeng, J., Liu, H., Tang, D., Meng, H., Li, Y., & Fu, Y.
- Affiliations
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Corresponding author
- Li, Yongmei
- Fu, Yixiao
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 215
- Pages
- 213-217
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2590906340
- Cited by
- 129
- References
- 47
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 15 · 2021: 35 · 2020: 13 · 2019: 12 · 2018: 14 · 2017: 4
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- suicidal ideation, major depressive disorder, intrinsic functional connectivity, rostral anterior cingulate cortex, resting-state functional connectivity, suicide risk, decision-making, emotional processing
- MeSH terms
- Adult, Depressive Disorder, Major, Major Depressive Disorder, Emotions, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Temporal Lobe, Suicidal Ideation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
