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Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy
Open accessAbstract
Increased proteolytic activity has been widely associated with skeletal muscle atrophy. However, elevated proteolysis is also critical for the maintenance of cellular homeostasis by disposing cytotoxic proteins and non-functioning organelles. We recently demonstrated that exercise activates autophagy and re-establishes proteostasis in cardiac diseases. Here, we characterized the impact of exercise on skeletal muscle autophagy and proteostasis in a model of neurogenic myopathy induced by sciatic nerve constriction in rats. Neurogenic myopathy, characterized by progressive atrophy and impaired contractility, was paralleled by accumulation of autophagy-related markers and loss of acute responsiveness to both colchicine and chloroquine. These changes were correlated with elevated levels of damaged proteins, chaperones and pro-apoptotic markers compared to control animals. Sustained autophagy inhibition using chloroquine in rats (50 mg.kg −1 .day −1 ) or muscle-specific deletion of Atg7 in mice was sufficient to impair muscle contractility in control but not in neurogenic myopathy, suggesting that dysfunctional autophagy is critical in skeletal muscle pathophysiology. Finally, 4 weeks of aerobic exercise training (moderate treadmill running, 5x/week, 1 h/day) prior to neurogenic myopathy improved skeletal muscle autophagic flux and proteostasis. These changes were followed by spared muscle mass and better contractility properties. Taken together, our findings suggest the potential value of exercise in maintaining skeletal muscle proteostasis and slowing down the progression of neurogenic myopathy.
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Exercise reactivates mitophagy, reduces accumulation of ROS, improves mitochondrial health, and delays the loss of muscle mass that accompanies various pathologies, including aging sarcopenia, heart failure, and neurogenic myopathy.
“Moreover, exercise is the best non-pharmacological strategy to reactivate mitophagy, which reduces the accumulation of ROS and thus, improves mitochondrial health and delays the loss of muscle mass that accompanies various pathologies, including aging sarcopenia, heart failure and neurogenic myopathy [224, 238–240].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [238]
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Metadata
- Authors
- Campos, J. C., Baehr, L. M., Gomes, K. M. S., Bechara, L. R. G., Voltarelli, V. A., Bozi, L. H. M., Ribeiro, M. A. C., Ferreira, N. D., Moreira, J. B. N., Brum, P. C., Bodine, S. C., & Ferreira, J. C. B.
- Affiliations
- Universidade de São Paulo (BR)
- University of Iowa (US)
- Corresponding author
- Ferreira, Julio C. B.
- ORCID
- Venue
- Scientific Reports
- Published
- 2018-08-07
- Volume
- 8
- Issue
- 1
- Pages
- 11818-11818
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6081439
- OpenAlex
- W2885919710
- Cited by
- 32
- References
- 83
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 1
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2012/14416-1, 2015/, 15/20783-5, 2015/228145, 2016/01633-5)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (2015/22814-5, 2015/20783-5)
- Universidade de São Paulo
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- neurogenic myopathy, autophagy, proteostasis, exercise training, skeletal muscle atrophy, sciatic nerve constriction, ATG7, chloroquine, muscle contractility, protein damage, molecular chaperones, apoptosis, aerobic exercise
- MeSH terms
- Proteostasis, Animals, Autophagy, Chloroquine, Male, Mice, Transgenic, Muscle Contraction, Muscular Atrophy, Neuromuscular Diseases, Physical Conditioning, Animal, Rats, Sprague-Dawley, Mice, Knockout, Muscle, Skeletal, Antirheumatic Agents, Proteolysis
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