Vitamin C Deficiency Causes Muscle Atrophy and a Deterioration in Physical Performance
Open accessAbstract
L-Ascorbic acid (AsA) is a water-soluble antioxidant. We examined the effect of AsA deficiency on skeletal muscle using senescence marker protein-30 (SMP30)-knockout (KO) mice that are defective in AsA biosynthesis, which makes this mouse model similar to humans, to clarify the function of AsA in skeletal muscle. Eight-week-old female SMP30-KO mice were divided into the following two groups: an AsA-sufficient group [AsA(+)] that was administered 1.5 g/L AsA and an AsA-deficient group [AsA(-)] that was administered tap (AsA-free) water. At 4 weeks, the AsA content in the gastrocnemius muscle of AsA(-) mice was 0.7% compared to that in the gastrocnemius muscle of AsA(+) mice. Significantly lower weights of all muscles were observed in AsA(-) mice than those in AsA(+) mice at 12 and 16 weeks. The cross-sectional area of the soleus was significantly smaller in AsA(-) mice at 16 weeks than that in AsA(+) mice. The physical performance of AsA(-) mice was significantly less than that of AsA(+) mice at 12 weeks. Following AsA deficiency for 12 weeks, the expression of ubiquitin ligases, such as atrogin1/muscle atrophy F-box (MAFbx) and muscle RING-finger protein 1 (MuRF1), was upregulated. Furthermore, all detected effects of AsA deficiency on muscles of the AsA(-) group at 12 weeks were restored following AsA supplementation for 12 weeks. Thus, longer-term AsA deficiency is associated with muscle wasting, that this can be reversed by restoring AsA levels.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Vitamin C deficiency causes muscle atrophy in mice, associated with high expression of MAFbx and MuRF1 and overproduction of ROS.
“Vitamin C deficiency causes muscle atrophy in mice, which is associated with high expression of muscle atrophy gene of MAFbx and MuRF1 and overproduction of ROS.”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [56]
Muscle atrophy in vitamin C deficient mice was restored by 12 weeks of vitamin C supplementation.
“The muscle atrophy was restored by 12 weeks of vitamin C supplementation [56].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990 · see citing works
Fiber Types in Mammalian Skeletal Muscles
Schiaffino, S., & Reggiani, C. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2010 · Cited by 3,022 · see citing works
Reconciling the chemistry and biology of reactive oxygen species
Winterbourn, C. C. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.85 · Cited by 2,504 · see citing works
Chomczyński, P., & Sacchi, N. (2006) · Nature Protocols · doi:10.1038/nprot.2006.83 · Cited by 2,084 · see citing works
Cellular and molecular diversities of mammalian skeletal muscle fibers
Pette, D., & Staron, R. S. (1990) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/3540528806_3 · Cited by 798 · see citing works
Vitamin C. Biosynthesis, recycling and degradation in mammals
Linster, C. L., & Van Schaftingen, E. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05607.x · Cited by 757 · see citing works
Li, Y.-P., Chen, Y., John, J., Moylan, J. S., Jin, B., Mann, D. L., & Reid, M. B. (2005) · The FASEB Journal · doi:10.1096/fj.04-2364com · Cited by 601 · see citing works
Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition
Haizlip, K. M., Harrison, B. C., & Leinwand, L. A. (2015) · Physiology · doi:10.1152/physiol.00024.2014 · Cited by 521 · see citing works
Skeletal Muscle Fiber Type: Influence on Contractile and Metabolic Properties
Zierath, J. R., & Hawley, J. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020348 · Cited by 518 · see citing works
Oxidative Stress, Chronic Disease, and Muscle Wasting
Moylan, J. S., & Reid, M. B. (2007) · Muscle & Nerve · doi:10.1002/mus.20743 · Cited by 416 · see citing works
The Role of Antioxidant Vitamins and Enzymes in the Prevention of Exercise-Induced Muscle Damage
Dekkers, J., van Doornen, L., & Kemper, H. C. G. (1996) · Sports Medicine · doi:10.2165/00007256-199621030-00005 · Cited by 314 · see citing works
Li, Y.-P., Chen, Y., Li, A. S., & Reid, M. B. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00129.2003 · Cited by 313 · see citing works
Antioxidative Effects of Exercise Training in Patients With Chronic Heart Failure
Linke, A., Adams, V., Schulze, P. C., Erbs, S., Gielen, S., Fiehn, E., Möbius‐Winkler, S., Schubert, A., Schuler, G. C., & Hambrecht, R. (2005) · Circulation · doi:10.1161/01.cir.0000165503.08661.e5 · Cited by 309 · see citing works
Are indices of free radical damage related to exercise intensity
Lovlin, R., Cottle, W. H., Pyke, I., Kavanagh, M., & BELCASTRO, A. N. (1987) · European Journal of Applied Physiology · doi:10.1007/bf00690898 · Cited by 292 · see citing works
Doxorubicin-dependent lipid peroxidation at low partial pressures of O2
Winterbourn, C. C., Gutteridge, J. M. C., & Halliwell, B. B. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90028-5 · Cited by 272 · see citing works
Effect of denervation on mitochondrially mediated apoptosis in skeletal muscle.
Adhihetty, P. J., O'Leary, M. F. N., Chabi, B., Wicks, K. L., & Hood, D. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00768.2006 · Cited by 240 · see citing works
Kondo, Y., Inai, Y., Sato, Y., Handa, S., Kubo, S., Shimokado, K., Goto, S., Nishikimi, M., Maruyama, N., & Ishigami, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511225103 · Cited by 227 · see citing works
Self-citationHoward, C., Ferrucci, L., Sun, K., Fried, L. P., Walston, J., Varadhan, R., Guralnik, J. M., & Semba, R. D. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00133.2007 · Cited by 214 · see citing works
Skeletal muscle gene expression in space-flown rats
Nikawa, T., Ishidoh, K., Hirasaka, K., Ishihara, I., Ikemoto, M., Kano, M., Kominami, E., Nonaka, I., Ogawa, T., Adams, G. R., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-0419fje · Cited by 212 · see citing works
Molecular regulation of individual skeletal muscle fibre types
Spangenburg, E. E., & Booth, F. W. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01158.x · Cited by 208 · see citing works
Coenzyme Q deficiency triggers mitochondria degradation by mitophagy
Rodríguez-Hernández, Á., Cordero, M. D., Salviati, L., Artuch, R., Pineda, M., Briones, P., Izquierdo, L. G., Cotán, D., Navas, P., & Sánchez-Alcázar, J. A. (2009) · Autophagy · doi:10.4161/auto.5.1.7174 · Cited by 194 · see citing works
Ishigami, A., Fujita, T., Handa, S., Shirasawa, T., Koseki, H., Kitamura, T., Enomoto, N., Sato, N., Shimosawa, T., & Maruyama, N. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64404-5 · Cited by 166 · see citing works
Self-citationMechanism of oxidative stress in skeletal muscle atrophied by immobilization
Kondo, H., Nakagaki, I., Sasaki, S., Hori, S., & Itokawa, Y. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.6.e839 · Cited by 158 · see citing works
Antioxidants in Exercise Nutrition
Sen, C. K. (2001) · Sports Medicine · doi:10.2165/00007256-200131130-00001 · Cited by 141 · see citing works
Both oxidative and nitrosative stress are associated with muscle wasting in tumour‐bearing rats
Barreiro, E., de la Puente, B., Busquets, S., López-Soriano, F. J., Gea, J., & Argilés, J. M. A. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.02.017 · Cited by 128 · see citing works
Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading
Siu, P. M., Pistilli, E. E., & Alway, S. E. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90800.2008 · Cited by 106 · see citing works
Arbogast, S., & Reid, M. B. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00072.2004 · Cited by 81 · see citing works
Vitamin C: Effects of Exercise and Requirements with Training
Peake, J. (2003) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.13.2.125 · Cited by 78 · see citing works
Nishikawa, M., Ishimori, N., Takada, S., Saito, A., Kadoguchi, T., Furihata, T., Fukushima, A., Matsushima, S., Yokota, T., Kinugawa, S., et al. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv103 · Cited by 74 · see citing works
Martin, H., Sayer, A. A., Jameson, K., Syddall, H. E., Dennison, E. M., Cooper, C. C., & Robinson, S. M. (2011) · Age and Ageing · doi:10.1093/ageing/afq175 · Cited by 74 · see citing works
Nishikimi, M., Koshizaka, T., Ozawa, T., & Yagi, K. (1988) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(88)90093-8 · Cited by 71 · see citing works
Saito, K., Yokoyama, A., Yoshida, H., Kim, H., Shimada, H., Yoshida, Y., Iwasa, H., Shimizu, Y., Kondo, Y., Handa, S., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr174 · Cited by 58 · see citing works
Self-citationKojima, N., Borlikova, G. G., Sakamoto, T., Yamada, K., Ikeda, T., Itohara, S., Niki, H., & Endo, S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0412-08.2008 · Cited by 53 · see citing works
Pohanka, M., Pejchal, J., Snopková, S., Havlíčková, K., Karasová, J. Ž., Boštík, P., & Pikula, J. (2011) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955712798868986 · Cited by 52 · see citing works
Pathophysiological significance of senescence marker protein‐30
Maruyama, N., Ishigami, A., & Kondo, Y. (2010) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2010.00586.x · Cited by 47 · see citing works
Self-citationSepsis Increases Oxidatively Damaged Proteins in Skeletal Muscle
Fagan, J. M. (1996) · Archives of Surgery · doi:10.1001/archsurg.1996.01430240080011 · Cited by 38 · see citing works
Arias‐Díaz, J., Vara, E., Torres-Melero, J., García, C., Hernández, J., & Jl, B. (1997) · PubMed · Cited by 35 · see citing works
Iwama, M., Shimokado, K., Maruyama, N., & Ishigami, A. (2010) · Nutrition · doi:10.1016/j.nut.2010.04.010 · Cited by 32 · see citing works
Self-citationKondo, Y., Sakuma, R., Ichisawa, M., Ishihara, K., Kubo, M., Handa, S., Mugita, H., Maruyama, N., Koga, H., & Ishigami, A. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf502587j · Cited by 20 · see citing works
Self-citationAmano, A., Sato, Y., Kishimoto, Y., Takahashi, K., Handa, S., Aigaki, T., Maruyama, N., & Ishigami, A. (2013) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.59.489 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Oxidative stress: Roles in skeletal muscle atrophy
Zhang, H., Qi, G., Wang, K., Yang, J., Shen, Y., Yang, X., Chen, X., Yao, X., Gu, X., Qi, L., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115664 · Cited by 319 · see citing works
Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update
Jiménez-Gutiérrez, G. E., Martínez-Gómez, L. E., Martínez-Armenta, C., Pineda, C., Martínez‐Nava, G. A., & López-Reyes, A. G. (2022) · Cells · doi:10.3390/cells11152359 · Cited by 243 · see citing works
Chen, M., Wang, Y., Deng, S., Lian, Z., & Yu, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.964130 · Cited by 187 · see citing works
Lewis, L. N., Hayhoe, R. P., Mulligan, A. A., Luben, R. N., Khaw, K.-T., & Welch, A. A. (2020) · The Journal of Nutrition · doi:10.1093/jn/nxaa221 · Cited by 72 · see citing works
Vignaud, J., Loiseau, C., Hérault, J., Mayer, C., Côme, M., Martin, I., & Ulmann, L. (2023) · Antioxidants · doi:10.3390/antiox12051050 · Cited by 72 · see citing works
Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy
Wang, Y., Liu, Q., Quan, H., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13061914 · Cited by 61 · see citing works
Nutrients against Glucocorticoid-Induced Muscle Atrophy
Lee, M., Jeong, H. H., Kim, M., Ryu, H., Baek, J.-W., & Lee, B. (2022) · Foods · doi:10.3390/foods11050687 · Cited by 52 · see citing works
Fang, J., Li, M., Zhang, G., Du, G., Zhou, J., Guan, X., & Chen, J. (2022) · Food & Function · doi:10.1039/d1fo04340d · Cited by 40 · see citing works
Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms
Shen, Y., Zhang, C., Dai, C., Zhang, Y., Wang, K., Gao, Z., Chen, X., Yang, X., Sun, H., Yao, X., et al. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300347 · Cited by 37 · see citing works
Ascorbate Is a Primary Antioxidant in Mammals
Fujii, J., Osaki, T., & Bo, T. (2022) · Molecules · doi:10.3390/molecules27196187 · Cited by 41 · see citing works
Advances in research on cell models for skeletal muscle atrophy
Li, L., Huang, C., Pang, J., Huang, Y., Chen, X., & Chen, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115517 · Cited by 34 · see citing works
Xue, T., Zheng, H., Zhao, Y., Zhao, Z., Wang, J., Zhang, Y., Li, Y., Wang, S., Liu, Y., Xue, C., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-07400-1 · Cited by 34 · see citing works
Pathophysiological changes of muscle after ischemic stroke: a secondary consequence of stroke injury
Hu, Q., Tian, D., Luan, F., Yang, R., & Zeng, N. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382221 · Cited by 33 · see citing works
Vitamin C Promotes Muscle Development Mediated by the Interaction of CSRP3 with MyoD and MyoG
Li, P., Zhang, X., Tian, L., Zhao, Y., Yan, Y., Li, S., Li, S., & Tong, H. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c02432 · Cited by 29 · see citing works
Elnagar, M. A., Khalil, R. H., Talaat, T. S., & Sherif, A. H. (2024) · BMC Veterinary Research · doi:10.1186/s12917-024-04180-y · Cited by 27 · see citing works
The Role of Vitamin C in Two Distinct Physiological States: Physical Activity and Sleep
Otocka-Kmiecik, A., & Król, A. (2020) · Nutrients · doi:10.3390/nu12123908 · Cited by 27 · see citing works
Sharma, Y., Popescu, A., Horwood, C., Hakendorf, P. H., & Thompson, C. H. (2021) · Nutrients · doi:10.3390/nu13062117 · Cited by 21 · see citing works
Natural Compounds Attenuate Denervation-Induced Skeletal Muscle Atrophy
Shirakawa, T., Miyawaki, A., Kawamoto, T., & Kokabu, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158310 · Cited by 21 · see citing works
The evidence to date: implications of l-ascorbic acid in the pathophysiology of aging
Sato, A., Kondo, Y., & Ishigami, A. (2024) · The Journal of Physiological Sciences · doi:10.1186/s12576-024-00922-7 · Cited by 19 · see citing works
Self-citationJanjuha, R., Bunn, D. K., Hayhoe, R. P. G., Hooper, L., Abdelhamid, A. S., Mahmood, S., Hayden-Case, J., Appleyard, W. O., Morris, S., & Welch, A. A. (2020) · Nutrients · doi:10.3390/nu12051457 · Cited by 18 · see citing works
Vargas-Mendoza, N., Ángeles-Valencia, M., Madrigal‐Santillán, E., Morales-Martínez, M., Tirado-Lule, J. M., Solano-Urrusquieta, A., Madrigal-Bujaidar, E., Álvarez‐González, I., Fregoso-Aguilar, T. A., Morales‐González, Á., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207724 · Cited by 16 · see citing works
Zanella, B. T. T., Magiore, I. C., Duran, B. O. D. S., Pereira, G. G., Vicente, I. S. T., de Carvalho, P. L. P. F., Salomão, R. A. S., Mareco, E. A., Carvalho, R. F., de Paula, T. G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062995 · Cited by 15 · see citing works
Zhang, X., Tian, B., Yu, H., Li, S., Li, S., Su, J., & Tong, H. (2024) · Food & Function · doi:10.1039/d3fo03938b · Cited by 14 · see citing works
Vermisoglou, E. C., Jakubec, P., Malina, O., Kupka, V., Schneemann, A., Fischer, R. A., Zbořil, R., Jayaramulu, K., & Otyepka, M. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00544 · Cited by 14 · see citing works
Vitamin C Is Essential for the Maintenance of Skeletal Muscle Functions
Takisawa, S., Takino, Y., Lee, J., Machida, S., & Ishigami, A. (2022) · Biology · doi:10.3390/biology11070955 · Cited by 14 · see citing works
Self-citationLow dietary vitamin C intake is associated with low muscle strength among elderly Korean women
Park, C. Y., & Shin, S. (2024) · Nutrition Research · doi:10.1016/j.nutres.2024.05.006 · Cited by 13 · see citing works
Canfora, I., Tarantino, N., & Pierno, S. (2022) · Cells · doi:10.3390/cells11162566 · Cited by 15 · see citing works
Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy
Moresi, V., Renzini, A., Cavioli, G., Seelaender, M. C. L., Coletti, D., Gigli, G., & Cedola, A. (2022) · Metabolites · doi:10.3390/metabo12111149 · Cited by 9 · see citing works
Mahmoodi, M., Shateri, Z., Nouri, M., Vali, M., Nasimi, N., Sohrabi, Z., Dabbaghmanesh, M. H., & Makhtoomi, M. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-04790-z · Cited by 7 · see citing works
Epigenetic regulation of myogenesis by vitamin C
Takeuchi, S. Y., Dusadeemeelap, C., Kawamoto, T., Matsubara, T., Kokabu, S., & Addison, W. N. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31472 · Cited by 7 · see citing works
Liu, L., Ding, X., Zhang, Y., Li, T., Xu, P., Ma, Y., Xing, H., Niu, Q., & Keerman, M. (2024) · BMC Public Health · doi:10.1186/s12889-024-20897-9 · Cited by 7 · see citing works
Shi, H., Li, J. P., Li, F., Yu, H., Zhang, F., Wu, T., Yang, L., Li, Y., Hu, R., Chen, M., et al. (2025) · Advanced Science · doi:10.1002/advs.202408912 · Cited by 8 · see citing works
Rasaei, N., Ghaffarian-Ensaf, R., Gholami, F., Shiraseb, F., Khadem, A., Fatemi, S. F., & Mirzaei, K. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-023-01274-w · Cited by 6 · see citing works
Çi̇çek, S. (2023) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2023.109559 · Cited by 5 · see citing works
Takahashi, M., Homma, T., Yamada, K., Miyata, S., Nakajima, O., & Fujii, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117501 · Cited by 5 · see citing works
Elucidating the potential mechanism and therapeutic targets of chronic stress-induced muscle atrophy
Agarwal, V., Gupta, A., Chaudhary, R., & Kumar, A. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115118 · Cited by 4 · see citing works
Pharmacological effects of denervated muscle atrophy due to metabolic imbalance in different periods
Qiu, J., CHANG, Y., LIANG, W., LIN, M., Xu, H., XU, W., ZHU, Q., ZHANG, H., & ZHANG, Z. (2023) · Biocell · doi:10.32604/biocell.2023.031043 · Cited by 3 · see citing works
Pang, E., Zou, Y., Lu, K., Li, J., Chen, X., Zhu, Y. M., Wang, T., Shi, L., & Kang, H. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1783596 · Cited by 3 · see citing works
Yeo, C., Kim, H., Jeon, W., Lee, J., Hong, J. Y., Kim, H., Lee, Y. J., Baek, S. H., & Ha, I. (2023) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-023-09661-5 · Cited by 3 · see citing works
Singhania, G., Singhania, N., & Chawla, N. (2020) · Case Reports in Medicine · doi:10.1155/2020/4798941 · Cited by 3 · see citing works
Park, S. G., & Kim, H. (2025) · Nutrients · doi:10.3390/nu17182977 · Cited by 2 · see citing works
Vitamin C is essential for proper myogenic differentiation
Kondo, Y., Sato, A., Osakabe, N., Minowa, T., Hung, Y.-L., Machida, S., & Ishigami, A. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110704 · Cited by 2 · see citing works
Self-citationEffect of ascorbic acid on collagen and some inflammatory mediators in rats
IŞIN, S., Yazıhan, N., Kesikli, B., Biriken, D., Akdaş, S., Celikkan, F. T., Bakırarar, B., & ARIBAL-AYRAL, P. (2022) · Ankara Üniversitesi Veteriner Fakültesi Dergisi · doi:10.33988/auvfd.1019201 · Cited by 2 · see citing works
Sandoval, D., Mella, J., Ojeda, J., Bermedo‐García, F., Low, M., Marcellini, S., Castro, M. A., Casas, M., Jaimovich, E., & Henríquez, J. P. (2024) · Biological Research · doi:10.1186/s40659-024-00554-6 · Cited by 2 · see citing works
Vu, K. T., Kim, J., Cho, I., Park, N., Kim, J., Chun, Y., Koo, Y. T., Lee, S., Paik, D., & Shim, S. (2022) · Journal of Food Science · doi:10.1111/1750-3841.16169 · Cited by 1 · see citing works
Aghaei, F., Arabzadeh, E., Feizolahi, F., Bezdi, A. N., Abasi, M., & Zargani, M. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103290 · Cited by 1 · see citing works
Abadi, A. S. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.110892 · Cited by 1 · see citing works
Kwatra, B., & labs, I. (2020) · International Journal of Innovative Science and Research Technology (IJISRT) · doi:10.38124/ijisrt20aug527 · Cited by 1 · see citing works
Research Status of Glucocorticoid Inducing Steroid Myopathy
侯, 洪. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.1361379
Park, S. G., & Kim, H. (2024) · Research Square · doi:10.21203/rs.3.rs-3936042/v1
Rashed, H. A. E.-H., Albogami, B., Alkhaldi, A. A. M., Abuzinadah, N. Y., Abuzahrah, S. S., Al‐Salmi, F. A., Fayad, E., Fouad, R. M., Fikry, M. E., ElSaey, A.-A. A., et al. (2024) · PeerJ · doi:10.7717/peerj.18381
韦, 继. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.152481
Function of Food Components on Bone and Skeletal Muscle Metabolism
Takeuchi, S. Y., Shirakawa, T., Okamoto, H., Okumura, N., Matsubara, T., & Kokabu, S. (2025) · The Journal of the Kyushu Dental Society · doi:10.2504/kds.79.rv00009
Elnagar, M. A., Khalil, R. H., Talaat, T. S., & Sherif, A. H. (2024) · Figshare · doi:10.6084/m9.figshare.26752345
Nutritional Strategies for Neuroprotection: Vitamins, Minerals, and Beyond
Kumari, M. (2026) · Springer eBooks · doi:10.1007/978-981-95-4169-0_4
Vitamin C Supplementation Mitigates Diabetes-Associated Skeletal Muscle AtrophyPreprint
Rao, V. K., Bevinakoppamath, S., Kala, P., Adusumalli, S., Ramadas, V., Makam, A. A., Prashant, A., & Gandasi, N. R. (2026) · Research Square · doi:10.21203/rs.3.rs-8342512/v1
Nutrition significance in the population sarcopenia prevention
Makarova, O. B., Usoltseva, A. I., & Суплотова, Л. А. (2026) · Russian Journal of Preventive Medicine · doi:10.17116/profmed202629051113
Ascorbic acid attenuates obesity induced myogenic impairment in C2C12 cells
Pinto, J. R., Deepika Bhat., K., Bose, B., & Sudheer Shenoy, P. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124612
Liu, X., Chen, B., Feng, Q., Wang, S., Fu, Z., Wu, J., Chen, X., & Zhang, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1899148
Muscle Strength and Physical Performance in Relation to Dietary Intake Among Older Men and Women
Pigłowska, M., Sołtysik, B. K., Kostka, J., Kostka, T., & Guligowska, A. (2026) · Nutrients · doi:10.3390/nu18162684
Bodo, D., Jójárt, F., Jójárt, R., Csupor, D., & Tóth, B. (2026) · Nutrients · doi:10.3390/nu18162704
Li, X., Zhou, K., Wong, R. M. Y., Cheung, W., & Cui, C. (2026) · Antioxidants · doi:10.3390/antiox15091167
Scott, J., Cameron, D., Yates, M. M., & Welch, A. A. (2026) · Calcified Tissue International · doi:10.1007/s00223-026-01614-7
- Authors
- Takisawa, S., Funakoshi, T., Yatsu, T., Nagata, K., Aigaki, T., Machida, S., & Ishigami, A.
- Affiliations
- Toho University (JP)
- Tokyo Metropolitan Institute of Gerontology (JP)
- Tokyo Metropolitan University (JP)
- Juntendo University (JP)
- Corresponding author
- Ishigami, Akihito
- Venue
- Scientific Reports
- Published
- 2019-03-20
- Volume
- 9
- Issue
- 1
- Pages
- 4702-4702
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6426981
- OpenAlex
- W2923144925
- Cited by
- 63
- References
- 41
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 14 · 2023: 9 · 2022: 11 · 2021: 4 · 2020: 8
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Funders
- MEXT | Japan Society for the Promotion of Science (15H04505, 15K15104)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- scurvy, vitamin C, skeletal muscle atrophy, muscle atrophy, physical performance, ascorbic acid biosynthesis, ubiquitin ligase, atrogin-1, MuRF1, gastrocnemius, soleus muscle, muscle cross-sectional area, vitamin C supplementation
- MeSH terms
- Animals, Ascorbic Acid, Ascorbic Acid Deficiency, Female, Muscle Proteins, Muscular Atrophy, Up-Regulation, Mice, Knockout, Muscle, Skeletal, Ubiquitin, Ubiquitin-Protein Ligases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
