Self-monitoring of blood glucose in association with glycemic control in newly diagnosed non-insulin-treated diabetes patients: a retrospective cohort study
Open accessAbstract
The benefits of self-monitoring of blood glucose (SMBG) on glycemic control among type 2 diabetes (T2DM) patients not receiving insulin remains controversial. This study aimed to examine the association between SMBG and glycemic control in these patients. This retrospective longitudinal study enrolled 4987 eligible patients from a medical center in Taiwan. Data were collected from electronic medical records at 0 (baseline), 3, 6, 9, and 12 (end-point) months after enrollment. Patients were assigned to the early SMBG group or to the non-user group depending on whether they performed SMBG at baseline. Differences in glycated hemoglobin (HbA1c) reduction between groups at each time-point were assessed using SMBG group-by-time interaction in generalized estimating equations models, which were established using backward elimination method for multivariate regression analysis. Subgroup analyses for patients using non-insulin and insulin secretagogues were performed additionally. The estimated maximal difference in HbA1c reduction between groups (early SMBG users vs. non-users) was 0.55% at 3 months. Subgroup analyses showed maximal differences of 0.61% and 0.52% at 3 months in the non-insulin and insulin secretagogues groups, respectively. SMBG group-by-time interaction was statistically significant at 3 months and lasted for 12 months. The finding suggests that performing SMBG at disease onset was positively associated with better glycemic control in newly diagnosed non-insulin-treated T2DM patients, regardless whether non-insulin secretagogues or insulin secretagogues were used.
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The reduction in glycated haemoglobin from blood glucose monitoring in non-insulin-treated type 2 diabetes is particularly seen if monitoring is started at diagnosis.
“particularly if it is started at diagnosis6”
From Blood glucose monitoring devices: current considerations (2023) · cites this paper as [6]
The Results (Association between SMBG and changes in HbA1c; page unavailable) report greater HbA1c reduction among newly diagnosed patients who monitored at baseline than among early non-users. But this retrospective study describes an association, not a proven reduction caused by monitoring, and does not establish that starting at diagnosis works better than starting later. (LLM, conf=0.86)
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Cites
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742 · see citing works
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667 · see citing works
International Diabetes Federation 2017
Carracher, A. M., Marathe, P. H., & Close, K. L. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12644 · Cited by 13,369 · see citing works
10-year follow-up of intensive glucose control in type 2 diabetes
Holman, R. R., Paul, S. K., Bethel, M. A., Matthews, D. R., & Neil, H. A. W. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0806470 · Cited by 7,751 · see citing works
Levey, A. S., Coresh, J., Balk, E., Kausz, A. T., Levin, A., Steffes, M. W., Hogg, R. J., Perrone, R. D., Lau, J., & Eknoyan, G. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-2-200307150-00013 · Cited by 4,615 · see citing works
2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2019
(2018) · Diabetes Care · doi:10.2337/dc19-s002 · Cited by 2,738 · see citing works
9. Pharmacologic Approaches to Glycemic Treatment: <i>Standards of Medical Care in Diabetes—2020</i>
American Diabetes Association (2020) · Diabetes Care · doi:10.2337/dc20-s009 · Cited by 914 · see citing works
Mackenbach, J. P., Kulhánová, I., Bopp, M., Deboosere, P., Eikemo, T. A., Hoffmann, R., Kulik, M. C., Leinsalu, M., Martikainen, P., Menvielle, G., et al. (2014) · Social Science & Medicine · doi:10.1016/j.socscimed.2014.05.021 · Cited by 576 · see citing works
Self-monitoring of blood glucose in patients with type 2 diabetes mellitus who are not using insulin
Malanda, U. L., Welschen, L. M., Riphagen, I. I., Dekker, J. M., Nijpels, G., & Bot, S. D. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005060.pub3 · Cited by 358 · see citing works
O’Kane, M. J., Bunting, B., Copeland, M., & Coates, V. E. (2008) · BMJ · doi:10.1136/bmj.39534.571644.be · Cited by 326 · see citing works
Chalmers, J., & Cooper, M. E. (2008) · New England Journal of Medicine · doi:10.1056/nejme0807625 · Cited by 263 · see citing works
Durán, A., MARTÍN, P., Rünkle, I., PÉREZ, N., Abad, R., Fernández, M. L. A., del Valle, L., Sanz, F., & Calle‐Pascual, A. L. (2010) · Journal of Diabetes · doi:10.1111/j.1753-0407.2010.00081.x · Cited by 156 · see citing works
Young, L. A., Buse, J. B., Weaver, M. A., Vu, M. B., Mitchell, C. M., Blakeney, T., Grimm, K., Rees, J., Niblock, F., Donahue, K. E., et al. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2017.1233 · Cited by 148 · see citing works
Longitudinal study of new and prevalent use of self-monitoring of blood glucose
Karter, A. J., Parker, M. M., Moffet, H. H., Spence, M. M., Chan, J., Ettner, S. L., & Selby, J. V. (2006) · Diabetes Care · doi:10.2337/dc06-2073 · Cited by 139 · see citing works
Bosi, E., Scavini, M., Ceriello, A., Cucinotta, D., Tiengo, A., Marino, R., Bonizzoni, E., Giorgino, F., & on behalf of the PRISMA Study Group (2013) · Diabetes Care · doi:10.2337/dc13-0092 · Cited by 105 · see citing works
Mannucci, E., Antenore, A., Giorgino, F., & Scavini, M. (2018) · Journal of Diabetes Science and Technology · doi:10.1177/1932296817719290 · Cited by 90 · see citing works
Zhu, H., Zhu, Y., & Leung, S.-W. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010524 · Cited by 84 · see citing works
Machry, R. V., Rados, D. V., Gregório, G. R. D., & Rodrigues, T. C. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.05.037 · Cited by 55 · see citing works
Bloomgarden, Z. T., & Handelsman, Y. (2017) · Journal of Diabetes · doi:10.1111/1753-0407.12624 · Cited by 34 · see citing works
Virdi, N. S., Daskiran, M., Nigam, S., Kozma, C. M., & Raja, P. (2012) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2012.0047 · Cited by 27 · see citing works
Xu, Y., Tan, D. H. Y., & Lee, J. Y. (2019) · International Journal of Clinical Practice · doi:10.1111/ijcp.13357 · Cited by 26 · see citing works
García de la Torre, N., Durán, A., del Valle, L., Fuentes, M., Barca, I., Martín, P., Montañez, C., Perez-Ferre, N., Abad, R., Sanz, F., et al. (2013) · Acta Diabetologica · doi:10.1007/s00592-013-0467-9 · Cited by 24 · see citing works
Tomah, S., Mahmoud, N., Mottalib, A., POBER, D. M., Tasabehji, M. W., Ashrafzadeh, S., & Hamdy, O. (2019) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000659 · Cited by 20 · see citing works
Dallosso, H. M., Bodicoat, D. H., Campbell, M. J., Carey, M., Davies, M. J., Eborall, H., Hadjiconstantinou, M., Khunti, K. K., Speight, J., & Heller, S. R. (2014) · Diabetic Medicine · doi:10.1111/dme.12598 · Cited by 17 · see citing works
Hou, Y., Li, W., Qiu, J., & Wang, X. (2014) · International Journal of Nursing Sciences · doi:10.1016/j.ijnss.2014.05.003 · Cited by 13 · see citing works
Effect of self-monitoring of blood glucose on glycaemic outcome among type 2 diabetic patients
Sodipo, O. O., Adedokun, A., & Olusola, A. A. (2017) · South African Family Practice · doi:10.1080/20786190.2017.1340250 · Cited by 8 · see citing works
Hospital-based integrated diabetes care management: An overview
Kuo, J.-F., Tu, S., Hsu, S.-R., Mao, I., Li, Y.-C., Lin, G.-Y., Tian, J.-Y., Syu, Y.-Y., Chen, W., Hsu, C.-C., et al. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(14)70737-5 · Cited by 3 · see citing works
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Abeltino, A., Riente, A., Bianchetti, G., Serantoni, C., Spirito, M. D., Capezzone, S., Esposito, R., & Maulucci, G. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae035 · Cited by 93 · see citing works
Sia, H., Kor, C., Tu, S., Liao, P.-Y., & Wang, J. (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2075559 · Cited by 29 · see citing works
Self-citationLi, T., Wang, Q., An, Y., Guo, L. J., Ren, L., Lei, L., & Chen, X. (2025) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2025.107750 · Cited by 17 · see citing works
Blood glucose monitoring devices: current considerations
Sly, B., & Taylor, J. (2023) · Australian Prescriber · doi:10.18773/austprescr.2023.013 · Cited by 11 · see citing works
Johari, S. M., Razalli, N. H., Chua, K. J., & Shahar, S. (2024) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-024-01379-9 · Cited by 11 · see citing works
Allamreddy, S. R., Arora, M., Ganugula, R., Friend, R., Basu, R., & Kumar, M. N. V. R. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.124.001074 · Cited by 10 · see citing works
AlRasheed, A., Hashim, H., & Alrofaie, H. (2024) · Cureus · doi:10.7759/cureus.65545 · Cited by 6 · see citing works
EDUKASI DIABETES MELLITUS DAN PEMERIKSAAN KADAR GLUKOSA DARAH
Eltrikanawati, T., & Nurhafifah, B. F. (2023) · Sambulu Gana Jurnal Pengabdian Masyarakat · doi:10.56338/sambulu_gana.v2i2.3542 · Cited by 6 · see citing works
Kimura, M., Toyoda, M., Saito, N., Takahashi, M., Isozumi, K., Kato, E., Kawanami, D., & Fukagawa, M. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s363762 · Cited by 5 · see citing works
What is holding back glucometer use? -A comparative study of rural and urban India
Mishra, V., Nguyen, L., Wickramasinghe, N. S., & Islam, S. M. S. (2022) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2022.102677 · Cited by 6 · see citing works
Problems of blood glucose self-monitoring in patients with diabetes mellitus
Kononova, Y. A., Bregovskiy, V. B., & Babenko, A. Y. (2022) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2021-21-1-140-148 · Cited by 3 · see citing works
Glucose biosensing with gold and silver nanoparticles for real-time applications
Balamurugan, R., Shalini, S., Harikrishnan, M. P., Velmathi, S., & Bose, A. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99454-5.00002-0 · Cited by 3 · see citing works
Sarraf, D. P., & Gupta, P. P. (2023) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_90_23 · Cited by 3 · see citing works
Sofia, R., & Nadira, C. S. (2022) · Jurnal Vokasi · doi:10.30811/vokasi.v6i1.2922 · Cited by 3 · see citing works
Priorities of self-monitoring of glycemia: an important component of successful diabetes management
Biryukova, E. V., & Викторович, Ш. М. (2024) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2024-202 · Cited by 2 · see citing works
Park, M., Hwang, S. Y., Jang, A., Jang, S. Y., Song, E., Park, S. Y., Lee, D. Y., Kim, J., Park, B. C., Yu, J. H., et al. (2024) · Lasers in Medical Science · doi:10.1007/s10103-024-04128-6 · Cited by 2 · see citing works
Zhang, H., Cheng, L., Li, M., Ye, X., & Wan, X. (2025) · Medicine · doi:10.1097/md.0000000000041330 · Cited by 2 · see citing works
Chu, J., Chang, Y.-T., Liaw, S., & Yang, F.-L. (2023) · Bioengineering · doi:10.3390/bioengineering10101207 · Cited by 2 · see citing works
Kobos, E., Kostrzewa-Zabłocka, E., Ławnik, A. J., & Hornik, B. (2026) · Scientific Reports · doi:10.1038/s41598-026-42065-2 · Cited by 1 · see citing works
Rahadini, A. A. D., Murtini, S., & Soehita, S. (2023) · Majalah Biomorfologi · doi:10.20473/mbiom.v33i1.2023.38-43 · Cited by 1 · see citing works
Abozaid, H. A. I., Alalyani, G. M., Alkhaldi, S. A., Alharthi, E. K., Alrumaym, A. H., Alharthi, K. A. S., & Alharthi, A. A. (2022) · Medical Science · doi:10.54905/disssi/v26i130/ms539e2605
Kardila, I. Y., & Malini, H. (2022) · Jurnal Endurance · doi:10.22216/jen.v7i3.1672
Guo, L., Zhu, D., Chen, K., Xue, Y., Zhou, C. Y., Liu, P., Hu, Z., Gu, P., Zhang, W., Dong, H., et al. (2023) · doi:10.2196/preprints.47363
Deniz, M. S. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1006990
Kanwar, J., Shah, U. N., & Dawar, S. (2023) · Seminars in Medical Writing and Education · doi:10.56294/mw2023135
Shah, S. A., Ahmad, S., Bilal, M., Khan, Y. N., Ullah, S., & Khan, M. T. (2025) · Pakistan Journal of Health Sciences · doi:10.54393/pjhs.v6i7.3219
Hnamte, L., & Saikia, L. (2025) · Journal of Ecophysiology and Occupational Health · doi:10.18311/jeoh/2025/48111
Giger, O.-F. (2025) · medRxiv · doi:10.64898/2025.12.06.25341746
Mohammadi, A., Shafiee, G., Olyaeemanesh, A., Daroudi, R., Aghakhani, A., Nasli‐Esfahani, E., Razi, F., Heshmat, R., & Takian, A. (2026) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_1484_24
Huang, Y., Nagesh, N., Subramanian, A., Wang, L., Liu, Z., Sun, Y.-C., Hou, W., Azimi, I., Rahmani, A. M., & Stafford, R. S. (2026) · doi:10.2196/preprints.95679
Park, J.-H., Sherman, L. D., Smith, M. L., Patterson, M. S., & Prochnow, T. M. (2026) · Ethnicity and Health · doi:10.1080/13557858.2026.2655624
Agrawal, P., Maheshwari, A., Tewari, A., Verma, N., Kumar, D., Srivastava, R. K., Chandra, K. P., Srivastava, A., Gulati, P., Jain, S., et al. (2026) · International journal of clinical metabolism and diabetes. · doi:10.1177/30502071261446099
Huang, Y., Nagesh, N., Subramanian, A., Wang, L., Liu, Z., Sun, Y.-C., Hou, W., Azimi, I., Rahmani, A. M., & Stafford, R. S. (2026) · JMIR Formative Research · doi:10.2196/95679
- Authors
- Sia, H.-K., Kor, C.-T., Tu, S.-T., Liao, P.-Y., & Wang, J.-Y.
- Affiliations
- Asia University (TW)
- Changhua Christian Hospital (TW)
- Corresponding author
- Wang, Jiun-Yi
- Venue
- Scientific Reports
- Published
- 2021-01-13
- Volume
- 11
- Issue
- 1
- Pages
- 1176-1176
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC7806592
- OpenAlex
- W3121099789
- Cited by
- 33
- References
- 27
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 7
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Changhua Christian Hospital Research Foundation (109-CCH-IRP-009)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- self-monitoring of blood glucose, glycemic control, type 2 diabetes, newly diagnosed diabetes, non-insulin-treated diabetes, HbA1c, HbA1c reduction, insulin secretagogues, disease onset
- MeSH terms
- Glycemic Control, Blood Glucose, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Insulin, Longitudinal Studies, Male, Retrospective Studies, Taiwan, Blood Glucose Self-Monitoring
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