Human infrapatellar fat pad mesenchymal stem cells show immunomodulatory exosomal signatures

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“Remodeling the intestinal immune microenvironment”: immune regulation and tissue regeneration by mesenchymal stem/stromal cells in the repair microenvironment of inflammatory bowel disease

Li, H., Zhang, Y., Du, S., Shen, J., Liu, X., & Jing, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1543702 · Cited by 13 · see citing works

The roles of regulatory-compliant media and inflammatory/oxytocin priming selection in enhancing human mesenchymal stem/stromal cell immunomodulatory properties

Gardashli, M., Baron, M., Drohat, P. C., Quintero, D., Kaplan, L. D., Szeto, A., Mendez, A. J., Best, T. M., & Kouroupis, D. (2024) · Scientific Reports · doi:10.1038/s41598-024-80050-9 · Cited by 12 · see citing works

The Use of Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles in the Treatment of Osteoarthritis: Insights from Preclinical Studies

Jones, M., Jones, E., & Kouroupis, D. (2024) · Bioengineering · doi:10.3390/bioengineering11100961 · Cited by 10 · see citing works

Characterization of Extracellular Vesicles from Infrapatellar Fat Pad Mesenchymal Stem/Stromal Cells Expanded Using Regulatory-Compliant Media and Inflammatory/Hormonal Priming

Philippon, M. J., Labib, R., Ley, M. B. R. G., Kaplan, L. D., Mendez, A. J., Best, T. M., & Kouroupis, D. (2025) · Cells · doi:10.3390/cells14100706 · Cited by 10 · see citing works

Engineered Extracellular Vesicles in Arthritic Diseases: Therapeutic Applications & Challenges

Ehab, S., Gaser, O. A., Oyouni, A. A. A., Kameli, N., Alzahrani, F. A., & Dayem, A. A. (2025) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.70031 · Cited by 10 · see citing works

The Role of Exosomes in the Pathogenesis, Diagnosis, and Treatment of Parkinson's and Alzheimer's Diseases

Moradi, H. R., Abdollahinezhad, S., & Heydarian, S. (2024) · The Neuroscience Journal of Shefaye Khatam · doi:10.61186/shefa.12.2.87 · Cited by 8 · see citing works

Human mesenchymal stem/stromal cell‐derived extracellular vesicle transport in meniscus fibrocartilage

Schwartz, G., Rana, S., Jackson, A. R., Leñero, C., Best, T. M., Kouroupis, D., & Travascio, F. (2024) · Journal of Orthopaedic Research® · doi:10.1002/jor.25993 · Cited by 8 · see citing works

Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

Li, X.-H., Xiao, H.-X., Wang, Z.-X., Tang, X.-R., Yu, X., & Pan, Y.-P. (2024) · Cell Transplantation · doi:10.1177/09636897241235460 · Cited by 6 · see citing works

Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles (MSC-sEVs): A Promising Treatment Modality for Diabetic Foot Ulcer

Kouroupis, D., Kaplan, L. D., Ricordi, C., & Best, T. M. (2023) · Bioengineering · doi:10.3390/bioengineering10101140 · Cited by 6 · see citing works

Extracellular vesicles from primed Hoffa’s fat pad mesenchymal stem/stromal cells in osteoarthritis therapy: effects on cells critical to osteoarthritis progression

Gulová, S., Otahal, A., Kramer, K., Rothammer, M., Lacza, Z., Harvanová, D., Nehrer, S., & Luna, A. D. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04679-7 · Cited by 5 · see citing works

NMN-primed exosomes derived from infrapatellar fat pad mesenchymal stem cells exert synergistic anti-inflammatory and cartilage-protective effects via MERTK pathway activation in knee osteoarthritis

Chen, K.-T., Huang, C., Yadav, V. K., Pikatan, N. W., Fong, I.-H., Kuo, K.-T., & Chiu, Y.-S. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126367 · Cited by 5 · see citing works

The Infrapatellar Fat Pad in Osteoarthritis: From Pathophysiology to a Novel Therapeutic Target

Wang, Q., Liu, D., Hu, F., Wang, L., Zhang, Z., Yan, Y., & Zhang, X. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052369 · Cited by 5 · see citing works

Capture and release methods of extracellular vesicles based on functional magnetic beads

Liu, Z., Lu, Z., Li, Y., Fan, Y., He, W., & Cui, Y. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.170780 · Cited by 4 · see citing works

Cross-regulation of inflammation and metabolic mechanisms in osteoarthritis: recent advances bridging the gap to novel treatments

Abu‐Amer, Y. (2025) · Connective Tissue Research · doi:10.1080/03008207.2025.2500530 · Cited by 3 · see citing works

Isolation and Characterization of Marrow-Isolated Adult Multilineage Inducible (MIAMI) Cell-Derived Extracellular Vesicles Demonstrate Multifunctional Therapeutic Potential in Tissue Regeneration and Anti-Inflammatory Immunomodulation

Ley, M. B. R. G., Temple, H. T., Jackson, A. R., Best, T. M., Kouroupis, D., & D’Ippolito, G. (2026) · Cells · doi:10.3390/cells15050396 · Cited by 3 · see citing works

Preclinical Evidence of MSC-Derived Exosomes

Vonk, L. A., & Frank, R. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-84693-9_11 · Cited by 2 · see citing works

Tyrosine–Peptide Analog Modulates Extracellular Vesicles miRNAs Cargo from Mesenchymal Stem/Stromal and Cancer Cells to Drive Immunoregeneration and Tumor Suppression

Ley, M. B. R. G., Galoian, K. A., Martinez, D. A., Patel, A., Thomas, R., Parker, T. R., Friedman, L. R., Andryski, A. L., Hornicek, F. J., Best, T. M., et al. (2026) · Biomolecules · doi:10.3390/biom16020243 · Cited by 2 · see citing works

Infrapatellar Fat Pad-Derived Non-Cellular Products in Therapy for Musculoskeletal Diseases: A Scoping Review

Triangga, A. F. R., Asmara, W., Magetsari, R., Bachtiar, I., Fazatamma, D. A., Saraswati, P. A., Huwaidi, A. F., & Wirohadidjojo, Y. W. (2024) · Orthopedic Reviews · doi:10.52965/001c.125841 · Cited by 2 · see citing works

The Role of Viral Infections in Acute Kidney Injury and Mesenchymal Stem Cell-Based Therapy

Allela, O. Q. B., Ali, N. A. M., Sanghvi, G. V., Roopashree, R., Kashyap, A., Krithiga, T., Panigrahi, R., Kubaev, A., Kareem, R. A., Sameer, H. N., et al. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10873-0 · Cited by 2 · see citing works

Conditioned Medium of Infrapatellar Fat Stem Cells Alleviates Degradation of Chondrocyte Extracellular Matrix and Delays Development of Osteoarthritis

He, S., Wang, S., Liu, R., Chen, H., Wang, Q., Jia, D., Chen, L., Dai, J., & Li, X. (2024) · Gerontology · doi:10.1159/000540505 · Cited by 1 · see citing works

A review of the immunomodulatory properties of mesenchymal stem cells and their derived extracellular vesicles in small-cell and non-small-cell lung cancer cells

Kareem, R. A., Sameer, H. N., Yaseen, A., Athab, Z. H., Adil, M., & Ahmed, H. H. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113848 · Cited by 2 · see citing works

Infrapatellar fat pad resection: A potential approach for slowing knee osteoarthritis progression

Chiang, C.-Y., Wu, C., Lin, F., & Yang, K. (2025) · Medical Hypotheses · doi:10.1016/j.mehy.2025.111689 · Cited by 1 · see citing works

Comparison of the therapeutic potential of exosomes derived from different cells for the treatment of prostate cancer

Mehr, F. K., Emtiazi, N., Zolfi, E., & Moradi, Y. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.105055

The autophagy-exosome axis in chronic prostatitis/chronic pelvic pain syndrome: a hypothesis-driven narrative review

Nyame, D. K., Goku, F., Fiagbey, E. D. K., Asim, A., Ogony, B. R., Amoah, F., & Zhou, X. (2026) · Exploration of Immunology · doi:10.37349/ei.2026.1003247

Uncovering the Secret of Mesenchymal Stromal Cells Secretome: From Extracellular Vesicle Cargo to Neuroprotection

Joseph, M., Gabrielli, M., Tonoli, E., Cave, G. W. V., & Verderio, E. A. M. (2026) · Cells · doi:10.3390/cells15100889

Research progress on targeting macrophages for the prevention and treatment of osteoarthritis

Yi-Fan, D. A. N. G., & ZHANG, X.-L. (2026) · Shengming kexue · doi:10.3724/cbls.2026069

Articular Cartilage Tissue Engineering: Cells, Bioinstructive Scaffolds, Immunological Microenvironment, and Emerging Technologies

Mosaid, S. M., Jihad, Y., Jihad, M., Marudanayagam, A., & Lee, P. Y. (2026) · Bioengineering · doi:10.3390/bioengineering13070795

Application of stem cell-derived exosomes in skin wound healing: mechanisms, prospects, and challenges

Li, Y., Zheng, F., Bai, Y., Yu, Y., Zhang, R., Feng, Q., Yu, Y., Zhu, L., Wang, D., & Liu, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1846916

Matrix Protective and Anti-Inflammatory In Vitro Potential of Adipose Mesenchymal Stromal Cell-Derived EVs Coupled With Platelet-Derived Fibrin Gel

Ragni, E., Taiana, M. M., Landoni, S., Valli, F., Nebuloni, A. M., Luca, P. D., Lazzari, L., de Girolamo, L., & Peretti, G. M. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl54998

Mechanical Loading Reshapes Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicle microRNA Cargo Toward Predicted Immunomodulatory and EV Cargo-Trafficking Pathways: An In Vitro Mechanobiology Study

Gardashli, M., Bella, E. D., Herzog, M., Best, T. M., Stoddart, M. J., & Kouroupis, D. (2026) · Biomolecules · doi:10.3390/biom16101393

Extracellular Vesicles from Buccal Fat Pad-Derived Dedifferentiated Fat Cells Modulate Inflammatory Macrophage Responses and Attenuate Temporomandibular Joint Osteoarthritis

Oku, H., Nishiguchi, Y., Yamamoto, T., Jo, J., Hashimoto, Y., Kubo, H., & Takenobu, T. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209389

The cotyloid fossa fat pad as a hip-specific orthobiologic niche: lessons from the infrapatellar fat pad for mesenchymal stem/stromal cell and extracellular vesicle therapy in osteoarthritis

Rossow, R. P., Polavarapu, K., Naik, M., Kaplan, L. D., Best, T. M., Rizzo, M. G., & Kouroupis, D. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1930127

Mesenchymal Stem Cell-Derived Exosomes: Immunomodulatory Evaluation in an Antigen-Induced Synovitis Porcine Model

Casado, J. G., Blázquez, R., Vela, F. J., Álvarez, V., Tarazona, R., & Sanchez-Margallo, F. M. (2017) · Frontiers in Veterinary Science · doi:10.3389/fvets.2017.00039 · Cited by 65 · see citing works

Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation

Kouroupis, D., Bowles, A. C., Willman, M. A., Orfei, C. P., Colombini, A., Best, T. M., Kaplan, L. D., & Correa, D. (2019) · Scientific Reports · doi:10.1038/s41598-019-47391-2 · Cited by 68 · see citing works

The Effect of Osteoarthritic Synovial Fluid on Immunomodulatory Properties of Adipose Mesenchymal Stem Cells

Cifù, A., Domenis, R., Moretti, M., Vicario, A., Pistis, C., Pozzi, M., Bassini, F., Benedetto, P. D., Causero, A., Fabris, M., et al. (2018) · The FASEB Journal · doi:10.1096/fasebj.2018.32.1_supplement.817.11

CD10-Bound Human Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles Possess Immunomodulatory Cargo and Maintain Cartilage Homeostasis under Inflammatory Conditions

Kouroupis, D., Kaplan, L. D., Huard, J., & Best, T. M. (2023) · Cells · doi:10.3390/cells12141824 · Cited by 36 · see citing works

Immunomodulatory Potential of Human Adipose Mesenchymal Stem Cells Derived Exosomes on in vitro Stimulated T Cells

Blázquez, R., Sanchez-Margallo, F. M., de la Rosa, O., Dalemans, W., Álvarez, V., Tarazona, R., & Casado, J. G. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00556 · Cited by 377 · see citing works