Cited by 359Ovarian cancer diagnosis and treatmentRadiomics and Machine Learning in Medical ImagingAI in cancer detection

Multimodal data integration using machine learning improves risk stratification of high-grade serous ovarian cancer

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Boehm, Kevin M., Aherne, Emily A., Ellenson, Lora, Nikolovski, Ines, Alghamdi, Mohammed, Vázquez-García, Ignacio, Zamarin, Dmitriy, Long Roche, Kara +20 more·2022·Nature Cancer

Abstract

Patients with high-grade serous ovarian cancer suffer poor prognosis and variable response to treatment. Known prognostic factors for this disease include homologous recombination deficiency status, age, pathological stage and residual disease status after debulking surgery. Recent work has highlighted important prognostic information captured in computed tomography and histopathological specimens, which can be exploited through machine learning. However, little is known about the capacity of combining features from these disparate sources to improve prediction of treatment response. Here, we assembled a multimodal dataset of 444 patients with primarily late-stage high-grade serous ovarian cancer and discovered quantitative features, such as tumor nuclear size on staining with hematoxylin and eosin and omental texture on contrast-enhanced computed tomography, associated with prognosis. We found that these features contributed complementary prognostic information relative to one another and clinicogenomic features. By fusing histopathological, radiologic and clinicogenomic machine-learning models, we demonstrate a promising path toward improved risk stratification of patients with cancer through multimodal data integration.

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  • Boehm et al. characterized multimodal datasets of high-grade serous ovarian cancer and proposed that a combination of histopathological, radiologic, and genomic features can better predict prognosis and aid risk stratification.

    “Boehm et al. comprehensively characterized the multimodal datasets of high-grade serous ovarian cancer and proposed that a combination of histopathological, radiologic, and genomic features can better predict the prognosis of patients and aid in risk stratification [103].”
  • Boehm and colleagues used TCGA and an internal cohort to fuse genomic data, histopathology imaging, and radiology imaging to predict survival in high-grade serous ovarian cancer.

    “Boehm and colleagues (170) used TCGA and an internal cohort to fuse genomic data, histopathology imaging, and radiology imaging to predict survival in high-grade serous ovarian cancer.”

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Authors
Boehm, K. M., Aherne, E. A., Ellenson, L., Nikolovski, I., Alghamdi, M., Vázquez-García, I., Zamarin, D., Long Roche, K., Liu, Y., Patel, D., Aukerman, A., Pasha, A., Rose, D., Selenica, P., Causa Andrieu, P. I., Fong, C., Capanu, M., Reis-Filho, J. S., Vanguri, R., Veeraraghavan, H., Gangai, N., Sosa, R., Leung, S., McPherson, A., Gao, J., MSK MIND Consortium, Lakhman, Y., & Shah, S. P.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Corresponding author
  • Lakhman, Yulia
  • Shah, Sohrab P.
Venue
Nature Cancer
Published
2022-06-28
Volume
3
Issue
6
Pages
723-733
ISSN
2662-1347 (ISSN-L)
OpenAlex
W4283645969
Cited by
357
References
54
Citations by year
2026: 76 · 2025: 118 · 2024: 94 · 2023: 59 · 2022: 9 · 2020: 1
FWCI
59.41
Type
journal article
Language
en
Open access
Locations
  • Nature Cancer (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (T32GM007739)
  • U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (P30CA008748)
  • Grayer Fellowship (MSKCC) Cycle for Survival
  • Susan G. Komen Scholars Program Cycle for Survival
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
  • Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
Keywords
high-grade serous ovarian cancer, multimodal data integration, risk stratification, prognostic factors, treatment response prediction, homologous recombination deficiency, H&E staining, contrast-enhanced CT, histopathology
MeSH terms
Machine Learning, Female, Humans, Ovarian Neoplasms, Cystadenocarcinoma, Serous, Risk Assessment

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