Multimodal data integration using machine learning improves risk stratification of high-grade serous ovarian cancer
Open accessAbstract
Patients with high-grade serous ovarian cancer suffer poor prognosis and variable response to treatment. Known prognostic factors for this disease include homologous recombination deficiency status, age, pathological stage and residual disease status after debulking surgery. Recent work has highlighted important prognostic information captured in computed tomography and histopathological specimens, which can be exploited through machine learning. However, little is known about the capacity of combining features from these disparate sources to improve prediction of treatment response. Here, we assembled a multimodal dataset of 444 patients with primarily late-stage high-grade serous ovarian cancer and discovered quantitative features, such as tumor nuclear size on staining with hematoxylin and eosin and omental texture on contrast-enhanced computed tomography, associated with prognosis. We found that these features contributed complementary prognostic information relative to one another and clinicogenomic features. By fusing histopathological, radiologic and clinicogenomic machine-learning models, we demonstrate a promising path toward improved risk stratification of patients with cancer through multimodal data integration.
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Boehm et al. characterized multimodal datasets of high-grade serous ovarian cancer and proposed that a combination of histopathological, radiologic, and genomic features can better predict prognosis and aid risk stratification.
“Boehm et al. comprehensively characterized the multimodal datasets of high-grade serous ovarian cancer and proposed that a combination of histopathological, radiologic, and genomic features can better predict the prognosis of patients and aid in risk stratification [103].”
From Challenges in AI-driven Biomedical Multimodal Data Fusion and Analysis (2025) · cites this paper as [103]
Boehm and colleagues used TCGA and an internal cohort to fuse genomic data, histopathology imaging, and radiology imaging to predict survival in high-grade serous ovarian cancer.
“Boehm and colleagues (170) used TCGA and an internal cohort to fuse genomic data, histopathology imaging, and radiology imaging to predict survival in high-grade serous ovarian cancer.”
From Artificial Intelligence in Oncology: Current Landscape, Challenges, and Future Directions (2024) · cites this paper as [170]
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Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Textural Features for Image Classification
Haralick, R. M., Shanmugam, K., & Dinstein, I. (1973) · IEEE Transactions on Systems, Man, and Cybernetics · doi:10.1109/tsmc.1973.4309314 · Cited by 22,886 · see citing works
Rudin, C. (2019) · Nature Machine Intelligence · doi:10.1038/s42256-019-0048-x · Cited by 10,561 · see citing works
QuPath: Open source software for digital pathology image analysis
Bankhead, P., Loughrey, M. B., Fernández, J. A., Dombrowski, Y., McArt, D. G., Dunne, P. D., McQuaid, S., Gray, R. T., Murray, L. J., Coleman, H. G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17204-5 · Cited by 8,908 · see citing works
Integrated genomic analyses of ovarian carcinoma
Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927 · see citing works
scikit-image: image processing in Python
(2014) · doi:10.7717/peerj.453 · Cited by 6,794 · see citing works
Computational Radiomics System to Decode the Radiographic Phenotype
(2017) · doi:10.1158/0008-5472.can-17-0339 · Cited by 6,593 · see citing works
Zwanenburg, A., Vallières, M., Abdalah, M. A., Aerts, H. J. W. L., Andrearczyk, V., Apte, A., Ashrafinia, S., Bakas, S., Beukinga, R. J., Boellaard, R., et al. (2020) · Radiology · doi:10.1148/radiol.2020191145 · Cited by 4,177 · see citing works
Liu, J., Lichtenberg, T., Hoadley, K. A., Poisson, L. M., Lazar, A. J., Cherniack, A. D., Kovatich, A. J., Benz, C. C., Levine, D. A., Lee, A. V., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.052 · Cited by 3,725 · see citing works
Self-citationThe repertoire of mutational signatures in human cancer
Alexandrov, L. B., Kim, J., Haradhvala, N. J., Huang, M. N., Tian Ng, A. W., Wu, Y., Boot, A., Covington, K. R., Gordenin, D. A., Bergstrom, E. N., et al. (2020) · Nature · doi:10.1038/s41586-020-1943-3 · Cited by 3,496 · see citing works
Zehir, A., Benayed, R., Shah, R. H., Syed, A., Middha, S., Kim, H. R., Srinivasan, P., Gao, J., Chakravarty, D., Devlin, S. M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4333 · Cited by 3,380 · see citing works
Self-citationMaintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer
Moore, K., Colombo, N., Scambia, G., Kim, B.-G., Oaknin, A., Friedlander, M., Lisyanskaya, A., Floquet, A., Leary, A., Sonke, G. S., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1810858 · Cited by 2,870 · see citing works
OncoKB: A Precision Oncology Knowledge Base
Chakravarty, D., Gao, J., Phillips, S. M., Kundra, R., Zhang, H., Wang, J., Rudolph, J. E., Yaeger, R. D., Soumerai, T. E., Nissan, M. H., et al. (2017) · JCO Precision Oncology · doi:10.1200/po.17.00011 · Cited by 2,735 · see citing works
Self-citationTexture analysis using gray level run lengths
Galloway, M. M. (1975) · Computer Graphics and Image Processing · doi:10.1016/s0146-664x(75)80008-6 · Cited by 2,168 · see citing works
Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT)
Cheng, D. T., Mitchell, T. N., Zehir, A., Shah, R. H., Benayed, R., Syed, A., Chandramohan, R., Liu, Z. Y., Won, H. H., Scott, S. N., et al. (2015) · The Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2014.12.006 · Cited by 2,119 · see citing works
Cell Detection with Star-Convex Polygons
Schmidt, U., Weigert, M., Broaddus, C., & Myers, G. (2018) · Lecture Notes in Computer Science · doi:10.1007/978-3-030-00934-2_30 · Cited by 1,826 · see citing works
Fast wavelet transforms and numerical algorithms I
Beylkin, G., Coifman, R. R., & Rokhlin, V. (1991) · Communications on Pure and Applied Mathematics · doi:10.1002/cpa.3160440202 · Cited by 1,754 · see citing works
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer
Bowtell, D. D. L., Böhm, S., Ahmed, A. A., Aspuria, P.-J. P., Bast, R. C., Beral, V., Berek, J. S., Birrer, M. J., Blagden, S. P., Bookman, M. A., et al. (2015) · Nature reviews. Cancer · doi:10.1038/nrc4019 · Cited by 1,365 · see citing works
Texture analysis of SAR sea ice imagery using gray level co-occurrence matrices
Soh, L.-K., & Tsatsoulis, C. (1999) · IEEE Transactions on Geoscience and Remote Sensing · doi:10.1109/36.752194 · Cited by 1,238 · see citing works
Textural features corresponding to textural properties
Amadasun, M., & King, R. A. (1989) · IEEE Transactions on Systems Man and Cybernetics · doi:10.1109/21.44046 · Cited by 1,163 · see citing works
lifelines: survival analysis in Python
Davidson-Pilon, C. (2019) · The Journal of Open Source Software · doi:10.21105/joss.01317 · Cited by 1,045 · see citing works
Chang, M. T., Asthana, S., Gao, S. P., Lee, B. H., Chapman, J. S., Kandoth, C., Gao, J., Socci, N. D., Solit, D. B., Olshen, A. B., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3391 · Cited by 808 · see citing works
Self-citationQuPath: Open source software for digital pathology image analysisPreprint
Bankhead, P., Loughrey, M. B., Fernández, J. A., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/099796 · Cited by 808 · see citing works
Popova, T. G., Manié, É., Rieunier, G., Caux‐Moncoutier, V., Tirapo, C., Dubois, T., Delattre, O., Sigal‐Zafrani, B., Bollet, M. A., Longy, M., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1470 · Cited by 666 · see citing works
Harnessing multimodal data integration to advance precision oncology
Boehm, K. M., Khosravi, P., Vanguri, R., Gao, J., & Shah, S. P. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00408-3 · Cited by 662 · see citing works
Self-citationMulti-omic machine learning predictor of breast cancer therapy response
Sammut, S.-J., Crispin-Ortuzar, M., Chin, S.-F., Provenzano, E., Bardwell, H. A., Ma, W., Cope, W., Dariush, A., Dawson, S.-J., Abraham, J. E., et al. (2022) · Nature · doi:10.1038/s41586-021-04278-5 · Cited by 654 · see citing works
Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis
Fu, Y., Jung, A. W., Viñas, R., González, S., Vöhringer, H. S., Shmatko, A., Yates, L. R., Jimenez‐Liñan, M., Moore, L., & Gerstung, M. (2020) · Nature Cancer · doi:10.1038/s43018-020-0085-8 · Cited by 636 · see citing works
What Makes Training Multi-modal Classification Networks Hard?
Wang, W., Tran, D., & Feiszli, M. (2020) · 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr42600.2020.01271 · Cited by 588 · see citing works
Deep learning-based classification of mesothelioma improves prediction of patient outcome
Courtiol, P., Maussion, C., Moarii, M., Pronier, E., Pilcer, S., Sefta, M., Manceron, P., Toldo, S., Zaslavskiy, M., Le Stang, N., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0583-3 · Cited by 544 · see citing works
The Repertoire of Mutational Signatures in Human CancerPreprint
Alexandrov, L. B., Kim, J., Haradhvala, N. J., Huang, M. N., Ng, A. W. T., Wu, Y., Boot, A., Covington, K. R., Gordenin, D. A., Bergstrom, E. N., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/322859 · Cited by 529 · see citing works
Prevalence of Homologous Recombination–Related Gene Mutations Across Multiple Cancer Types
Heeke, A. L., Pishvaian, M. J., Lynce, F. C., Xiu, J., Brody, J. R., Chen, W.-J., Baker, T. M., Marshall, J. L., & Isaacs, C. J. (2018) · JCO Precision Oncology · doi:10.1200/po.17.00286 · Cited by 472 · see citing works
Copy number signatures and mutational processes in ovarian carcinoma
Macintyre, G., Goranova, T., Silva, D. D., Ennis, D. P., Piskorz, A., Eldridge, M., Sie, D., Lewsley, L.-A., Hanif, A., Wilson, C. A., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0179-8 · Cited by 434 · see citing works
Neighboring gray level dependence matrix for texture classification
Sun, C., & Wee, W. G. (1983) · Computer Vision Graphics and Image Processing · doi:10.1016/0734-189x(83)90032-4 · Cited by 415 · see citing works
Accelerating Discovery of Functional Mutant Alleles in Cancer
Chang, M. T., Shrestha-Bhattarai, T., Schram, A. M., Bielski, C. M., Donoghue, M. T. A., Jonsson, P., Chakravarty, D., Phillips, S. M., Kandoth, C., Penson, A. V., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0321 · Cited by 402 · see citing works
Self-citationInterfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer
Zhang, A. W., McPherson, A., Milne, K., Kroeger, D. R., Hamilton, P. T., Miranda, A., Funnell, T., Gierc, N. S., de Souza, C. P. E., Laan, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.073 · Cited by 349 · see citing works
Self-citationOvarian cancer mutational processes drive site-specific immune evasion
Vázquez-Garćıa, I., Uhlitz, F., Ceglia, N., Lim, J. L., Wu, M. K. Y., Mohibullah, N., Niyazov, J., Ruiz, A. E. B., Boehm, K. M., Bojilova, V., et al. (2022) · Nature · doi:10.1038/s41586-022-05496-1 · Cited by 318 · see citing works
Self-citationDetecting the mutational signature of homologous recombination deficiency in clinical samples
Gulhan, D., Lee, J. J.-K., Melloni, G. E. M., Cortés‐Ciriano, I., & Park, P. J. (2019) · Nature Genetics · doi:10.1038/s41588-019-0390-2 · Cited by 316 · see citing works
Diao, J. A., Wang, J. K., Chui, W. F., Mountain, V., Gullapally, S. C., Srinivasan, R., Mitchell, R. N., Glass, B., Hoffman, S., Rao, S. K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21896-9 · Cited by 281 · see citing works
Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes
Riaz, N., Blecua, P., Lim, R. S., Shen, R., Higginson, D. S., Weinhold, N., Norton, L., Weigelt, B., Powell, S. N., & Reis-Filho, J. S. (2017) · Nature Communications · doi:10.1038/s41467-017-00921-w · Cited by 246 · see citing works
Self-citationWhole slide imaging equivalency and efficiency study: experience at a large academic center
Hanna, M. G., Reuter, V. E., Hameed, M., Tan, L. K., Chiang, S., Sigel, C., Hollmann, T. J., Giri, D. D., Samboy, J., Moradel, C., et al. (2019) · Modern Pathology · doi:10.1038/s41379-019-0205-0 · Cited by 215 · see citing works
Lu, H., Arshad, M., Thornton, A., Avesani, G., Cunnea, P., Curry, E. W., Kanavati, F., Liang, J., Nixon, K., Williams, S. T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08718-9 · Cited by 213 · see citing works
SHAPE AND TEXTURE INDEXES APPLICATION TO CELL NUCLEI CLASSIFICATION
THIBAULT, G., Fertil, B., Navarro, C. L., Pereira, S., Cau, P., Lévy, N., Séqueira, J., & MARI, J.-L. (2013) · International Journal of Pattern Recognition and Artificial Intelligence · doi:10.1142/s0218001413570024 · Cited by 195 · see citing works
Wang, S., Liu, Z., Rong, Y., Zhou, B., Bai, Y., Wei, W., Wei, W., Wang, M., Guo, Y., & Tian, J. (2018) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2018.10.019 · Cited by 173 · see citing works
Rizzo, S., Botta, F., Raimondi, S., Origgi, D., Buscarino, V., Colarieti, A., Tomao, F., Aletti, G. D., Zanagnolo, V. L., Grande, M. D., et al. (2018) · European Radiology · doi:10.1007/s00330-018-5389-z · Cited by 131 · see citing works
Integrated genomic analyses of ovarian carcinoma
The Cancer Genome Atlas Research Network (2011) · Nature · doi:10.1038/nature10166 · Cited by 129 · see citing works
Vargas, H. A., Veeraraghavan, H., Miccò, M., Nougaret, S., Lakhman, Y., Meier, A. A., Sosa, R. E., Soslow, R. A., Levine, D. A., Weigelt, B., et al. (2017) · European Radiology · doi:10.1007/s00330-017-4779-y · Cited by 121 · see citing works
Self-citationGallagher, D. J., Konner, J. A., Bell-McGuinn, K. M., Bhatia, J., Sabbatini, P. J., Aghajanian, C. A., Offit, K., Barakat, R. R., Spriggs, D. R., & Kauff, N. D. (2010) · Annals of Oncology · doi:10.1093/annonc/mdq577 · Cited by 115 · see citing works
TCIA: An information resource to enable open science
Prior, F., Clark, K., Commean, P. K., Freymann, J., Jaffe, C. C., Kirby, J., Moore, S., Smith, K., Tarbox, L., Vendt, B. A., et al. (2013) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2013.6609742 · Cited by 114 · see citing works
Gorodnova, T. V., Соколенко, А. П., Ivantsov, A. O., Iyevleva, A. G., Suspitsin, E. N., Алексахина, С. Н., Yanus, G. A., Togo, A. V., Maximov, S. Y., & Имянитов, Е. Н. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.08.028 · Cited by 103 · see citing works
Pan-cancer computational histopathology reveals mutations, tumor composition and prognosisPreprint
Fu, Y., Jung, A. W., Viñas, R., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/813543 · Cited by 95 · see citing works
Copy-number signatures and mutational processes in ovarian carcinomaPreprint
Macintyre, G., Goranova, T., Silva, D. D., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/174201 · Cited by 94 · see citing works
Meier, A., Veeraraghavan, H., Nougaret, S., Lakhman, Y., Sosa, R. E., Soslow, R. A., Sutton, E. J., Hricak, H., Sala, E., & Vargas, H. A. (2018) · Abdominal Radiology · doi:10.1007/s00261-018-1840-5 · Cited by 73 · see citing works
Self-citationFunnell, T., Zhang, A. W., Grewal, D. S., McKinney, S. E., Bashashati, A., Wang, Y. K., & Shah, S. P. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006799 · Cited by 63 · see citing works
Self-citationWei, W., Liu, Z., Rong, Y., Zhou, B., Bai, Y., Wei, W., Wang, S., Wang, M., Guo, Y., & Tian, J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00255 · Cited by 60 · see citing works
Zargari, A., Du, Y., Heidari, M., Thai, T., Gunderson, C. C., Moore, K. N., Mannel, R. S., Liu, H., Zheng, B., & Qiu, Y. (2018) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aad3ab · Cited by 45 · see citing works
Rizzo, S., Manganaro, L., Dolciami, M., Gasparri, M. L., Papadia, A., & Grande, F. D. (2021) · Cancers · doi:10.3390/cancers13030573 · Cited by 39 · see citing works
The Landscape of Somatic Genetic Alterations in Breast Cancers from CHEK2 Germline Mutation Carriers
Mandelker, D. L., Kumar, R., Pei, X., Selenica, P., Setton, J. S., Arunachalam, S., Ceyhan‐Birsoy, O., Brown, D. N., Norton, L., Robson, M. E., et al. (2019) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkz027 · Cited by 36 · see citing works
Self-citationCurrent status and future directions of ovarian cancer prognostic models
Kobayashi, Y., Banno, K., & Aoki, D. (2021) · Journal of Gynecologic Oncology · doi:10.3802/jgo.2021.32.e34 · Cited by 14 · see citing works
Vázquez-Garćıa, I., Uhlitz, F., Ceglia, N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.24.454519 · Cited by 7 · see citing works
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Foersch, S., Glasner, C., Woerl, A.-C., Eckstein, M., Wagner, D.-C., Schulz, S., Kellers, F., Fernandez, A., Tserea, K., Kloth, M., et al. (2023) · Nature Medicine · doi:10.1038/s41591-022-02134-1 · Cited by 251 · see citing works
A guide to artificial intelligence for cancer researchers
Pérez-López, R., Laleh, N. G., Mahmood, F., & Kather, J. N. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00694-7 · Cited by 220 · see citing works
Shaik, T., Tao, X., Li, L., Xie, H., & Velasquez, J. D. (2023) · Information Fusion · doi:10.1016/j.inffus.2023.102040 · Cited by 213 · see citing works
Artificial Intelligence in Oncology: Current Landscape, Challenges, and Future Directions
Lotter, W., Hassett, M. J., Schultz, N., Kehl, K. L., Van Allen, E. M., & Cerami, E. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-1199 · Cited by 196 · see citing works
Hoang, D.-T., Dinstag, G., Shulman, E. D., Hermida, L. C., Ben-Zvi, D. S., Elis, E., Caley, K., Sammut, S.-J., Sinha, S., Sinha, N., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00793-2 · Cited by 157 · see citing works
Medical digital twins: enabling precision medicine and medical artificial intelligence
Sadée, C., Testa, S., Barba, T., Hartmann, K., Schuessler, M., Thieme, A. H., Church, G. M., Okoye, I. J., Hernandez‐Boussard, T., Hood, L., et al. (2025) · The Lancet Digital Health · doi:10.1016/j.landig.2025.02.004 · Cited by 153 · see citing works
Integrating multi-omics data with EHR for precision medicine using advanced artificial intelligence
Tong, L., Shi, W., Isgut, M., Zhong, Y., Lais, P., Gloster, L., Sun, J., Swain, A., Giuste, F., & Wang, M. D. (2024) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2023.3324264 · Cited by 130 · see citing works
Kang, W., Qiu, X., Luo, Y., Luo, J., Liu, Y., Xi, J., Li, X., & Yang, Z. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04437-4 · Cited by 125 · see citing works
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Mohsen, F., Al-Absi, H. R. H., Yousri, N. A., El Hajj, N., & Shah, Z. (2023) · npj Digital Medicine · doi:10.1038/s41746-023-00933-5 · Cited by 125 · see citing works
Deep learning in cancer genomics and histopathology
Unger, M., & Kather, J. N. (2024) · Genome Medicine · doi:10.1186/s13073-024-01315-6 · Cited by 124 · see citing works
Chen, Z., Chen, Y., Sun, Y., Tang, L., Zhang, L., Hu, Y., He, M., Li, Z., Cheng, S., Yuan, J., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01932-y · Cited by 116 · see citing works
Khader, F., Müller-Franzes, G., Wang, T., Han, T., Tayebi Arasteh, S., Haarburger, C., Stegmaier, J., Bressem, K., Kuhl, C., Nebelung, S., et al. (2023) · Radiology · doi:10.1148/radiol.230806 · Cited by 107 · see citing works
Diagnosis of brain diseases in fusion of neuroimaging modalities using deep learning: A review
Shoeibi, A., Khodatars, M., Jafari, M., Ghassemi, N., Moridian, P., Alizadehsani, R., Ling, S. H., Khosravi, A., Alinejad‐Rokny, H., Lam, H., et al. (2022) · Information Fusion · doi:10.1016/j.inffus.2022.12.010 · Cited by 106 · see citing works
Jiang, Y., Ma, D., Jin, X., Xiao, Y., Yu, Y., Shi, J., Zhou, Y.-F., Fu, T., Lin, C., Dai, L.-J., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00725-0 · Cited by 100 · see citing works
Self-citationMarra, A., Morganti, S., Pareja, F. G., Campanella, G. S. V., Bibeau, F., Fuchs, T. J., Loda, M. F., Parwani, A. V., Scarpa, A., Reis-Filho, J. S., et al. (2025) · Annals of Oncology · doi:10.1016/j.annonc.2025.03.006 · Cited by 108 · see citing works
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A multimodal machine learning model for the stratification of breast cancer risk
Qian, X., Pei, J., Han, C., Liang, Z., Zhang, G., Chen, N., Zheng, W., Meng, F., Yu, D., Chen, Y., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01302-7 · Cited by 80 · see citing works
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Aggarwal, A., Bharadwaj, S., Corredor, G., Pathak, T. B., Badve, S., & Madabhushi, A. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-00991-6 · Cited by 78 · see citing works
Crispin‐Ortuzar, M., Woitek, R., Reinius, M., Moore, E. K., Beer, L., Bura, V., Rundo, L., McCague, C., Ursprung, S., Sánchez, L. E., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41820-7 · Cited by 73 · see citing works
Simon, B. D., Ozyoruk, K. B., Gelikman, D. G., Harmon, S. A., & Türkbey, B. (2024) · Diagnostic and Interventional Radiology · doi:10.4274/dir.2024.242631 · Cited by 73 · see citing works
Ahn, B., Moon, D., Kim, H.-S., Lee, C., Cho, N. H., Choi, H., Kim, D., Lee, J.-Y., Nam, E. J., Won, D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48667-6 · Cited by 73 · see citing works
Artificial Intelligence Advancements in Oncology: A Review of Current Trends and Future Directions
Huhulea, E. N., Huang, L., Eng, S., Sumawi, B., Huang, A., Aifuwa, E., Hirani, R., Tiwari, R. K., & Etienne, M. (2025) · Biomedicines · doi:10.3390/biomedicines13040951 · Cited by 74 · see citing works
Artificial intelligence in liver cancer — new tools for research and patient management
Caldéraro, J., Žigutytė, L., Truhn, D., Jaffe, A., & Kather, J. N. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00919-y · Cited by 72 · see citing works
Challenges in AI-driven Biomedical Multimodal Data Fusion and Analysis
Liu, J., Cen, X., Yi, C., Wang, F.-A., Ding, J., Cheng, J., Wu, Q., Gai, B., Zhou, Y., He, R., et al. (2025) · Genomics, Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzaf011 · Cited by 75 · see citing works
Slideflow: deep learning for digital histopathology with real-time whole-slide visualization
Dolezal, J. M., Kochanny, S. E., Dyer, E., Ramesh, S., Srisuwananukorn, A., Sacco, M., Howard, F. M., Li, A., Mohan, P., & Pearson, A. T. (2024) · BMC Bioinformatics · doi:10.1186/s12859-024-05758-x · Cited by 67 · see citing works
Current and Future Advances in Surgical Therapy for Pituitary Adenoma
Khan, D. Z., HANRAHAN, J. G., Baldeweg, S. E., Dorward, N., Stoyanov, D. V., & Marcus, H. J. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad014 · Cited by 65 · see citing works
Artificial Intelligence in Clinical Oncology: From Data to Digital Pathology and Treatment
Kumar, K. S., Miskovic, V., Blasiak, A., Sundar, R., Pedrocchi, A., Pearson, A. T., Prelaj, A., & Ho, D. (2023) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_390084 · Cited by 64 · see citing works
Artificial intelligence-based biomarkers for treatment decisions in oncology
Ligero, M., Nahhas, O. S. M. E., Aldea, M. D., & Kather, J. N. (2025) · Trends in cancer · doi:10.1016/j.trecan.2024.12.001 · Cited by 70 · see citing works
Huang, P., Li, C., He, P., Xiao, H., Ping, Y., Feng, P., Tian, S., Chen, H., Mercaldo, F., Santone, A., et al. (2024) · Information Fusion · doi:10.1016/j.inffus.2024.102333 · Cited by 57 · see citing works
Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer
Harkos, C., Hadjigeorgiou, A. G., Voutouri, C., Kumar, A. S., Stylianopoulos, T., & Jain, R. K. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00796-w · Cited by 60 · see citing works
Jiang, Y., Wang, C., & Zhou, S. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.09.005 · Cited by 62 · see citing works
Multimodality Fusion Aspects of Medical Diagnosis: A Comprehensive Review
Kumar, S., Rani, S., Sharma, S., & Min, H. (2024) · Bioengineering · doi:10.3390/bioengineering11121233 · Cited by 64 · see citing works
New horizons at the interface of artificial intelligence and translational cancer research
Yates, J., & Allen, E. M. V. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.03.018 · Cited by 55 · see citing works
Multimodal fusion for audio-image and video action recognition
Shaikh, M. B., Chai, D., Islam, S. M. S., & Akhtar, N. (2024) · Neural Computing and Applications · doi:10.1007/s00521-023-09186-5 · Cited by 54 · see citing works
Multimodal histopathologic models stratify hormone receptor-positive early breast cancer
Boehm, K. M., Nahhas, O. S. M. E., Marra, A., Waters, M., Jee, J., Braunstein, L. Z., Schultz, N. D., Selenica, P., Wen, H. Y., Weigelt, B., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57283-x · Cited by 52 · see citing works
Self-citationSong, B., Leroy, A., Yang, K., Dam, T., Wang, X., Maurya, H., Pathak, T. B., Lee, J. K., Stock, S. J., Li, X., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105663 · Cited by 56 · see citing works
CAMR: cross-aligned multimodal representation learning for cancer survival prediction
Wu, X., Shi, Y., Wang, M., & Li, A. (2023) · Bioinformatics · doi:10.1093/bioinformatics/btad025 · Cited by 49 · see citing works
Li, W., Ai, S., Zhu, H., & Lin, W. (2025) · Nature Communications · doi:10.1038/s41467-025-57673-1 · Cited by 49 · see citing works
Rajendran, S., Pan, W., Sabuncu, M. R., Chen, Y., Zhou, J., & Wang, F. (2024) · Patterns · doi:10.1016/j.patter.2023.100913 · Cited by 47 · see citing works
Advances in artificial intelligence for the diagnosis and treatment of ovarian cancer (Review)
Wang, Y., Lin, W., Zhuang, X., Wang, X., He, Y., Li, L., & Lyu, G. (2024) · Oncology Reports · doi:10.3892/or.2024.8705 · Cited by 45 · see citing works
Liu, F., Beck, S., Yang, L., Luo, H., & Zhang, K. C. (2026) · Nature reviews. Cancer · doi:10.1038/s41568-026-00922-2 · Cited by 52 · see citing works
Cheah, B. C. J., Vicente, C. R., & Chan, K. R. (2025) · Viruses · doi:10.3390/v17070882 · Cited by 43 · see citing works
Ovarian cancer beyond imaging: integration of AI and multiomics biomarkers
Hatamikia, S., Nougaret, S., Panico, C., Avesani, G., Nero, C., Boldrini, L., Sala, E., & Woitek, R. (2023) · European Radiology Experimental · doi:10.1186/s41747-023-00364-7 · Cited by 42 · see citing works
Cai, X., Zhang, H., Wang, Y., Zhang, J., & Li, T. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00287-y · Cited by 42 · see citing works
Cai, X., Li, L., Yu, F., Guo, R., Zhou, X., Zhang, F., Zhang, H., Zhang, J., & Li, T. (2023) · Laboratory Investigation · doi:10.1016/j.labinv.2023.100173 · Cited by 41 · see citing works
Towards equitable AI in oncology
Viswanathan, V. S., Parmar, V. V., & Madabhushi, A. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00909-8 · Cited by 44 · see citing works
Radiology and multi-scale data integration for precision oncology
Paverd, H., Zormpas-Petridis, K., Clayton, H., Burge, S., & Crispin-Ortuzar, M. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00656-0 · Cited by 41 · see citing works
Yin, M., Lin, J., Wang, Y., Liu, Y., Zhang, R., Duan, W., Zhou, Z., Zhu, S., Gao, J., Liu, L., et al. (2024) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2024.105341 · Cited by 40 · see citing works
Self-citationTang, M., Jiang, S., Huang, X., Ji, C., Gu, Y., Qi, Y., Xiang, Y., Yao, E. J., Zhang, N., Berman, E. L., et al. (2024) · Cell Discovery · doi:10.1038/s41421-024-00650-7 · Cited by 38 · see citing works
Clinical applications of graph neural networks in computational histopathology: A review
Meng, X., & Zou, T. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107201 · Cited by 38 · see citing works
Singh, S., Maurya, M. K., Singh, N., & Kumar, R. (2024) · Network Modeling Analysis in Health Informatics and Bioinformatics · doi:10.1007/s13721-024-00491-0 · Cited by 39 · see citing works
Huang, Y., Chen, X., Cui, Y., Yang, F., Huang, S. X., Li, Z., Ying, Y. J., Li, S. Y., Li, M. H., Gao, P. H., et al. (2025) · Annals of Oncology · doi:10.1016/j.annonc.2025.05.537 · Cited by 40 · see citing works
Wang, Z., Lin, R., Li, Y., Zeng, J., Chen, Y., Ouyang, W., Li, H., Jia, X., Lai, Z., Yu, Y., et al. (2024) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbae012 · Cited by 40 · see citing works
A multiplex single-cell RNA-Seq pharmacotranscriptomics pipeline for drug discovery
Dini, A., Barker, H. R., Piki, E., Sharma, S., Raivola, J., Murumägi, A., & Ungureanu, D. (2024) · Nature Chemical Biology · doi:10.1038/s41589-024-01761-8 · Cited by 35 · see citing works
Adam, M., Albaseer, A. M., Baroudi, U. A., & Abdallah, M. M. (2025) · IEEE Open Journal of the Communications Society · doi:10.1109/ojcoms.2025.3554537 · Cited by 36 · see citing works
Multimodal data integration using deep learning predicts overall survival of patients with glioma
Yuan, Y., Zhang, X., Wang, Y., Li, H., Qi, Z., Du, Z., Chu, Y., Feng, D., Hu, J., Xie, Q., et al. (2024) · Open Research (University of Surrey) · doi:10.1002/viw.20240001 · Cited by 32 · see citing works
Self-citationZeng, S., Wang, X., & Yang, H. (2024) · Military Medical Research · doi:10.1186/s40779-024-00580-1 · Cited by 36 · see citing works
Wang, J., Zhang, Z., & Wang, Y. (2025) · Biomolecules · doi:10.3390/biom15010081 · Cited by 32 · see citing works
Yu, Y., Ren, W., Mao, L., Ouyang, W., Hu, Q., Yao, Q., Tan, Y., He, Z., Ban, X., Hu, H., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107765 · Cited by 33 · see citing works
Huang, M.-L., Ren, J., Jin, Z., Liu, X., He, Y., Li, Y., & Xue, H. (2023) · Insights into Imaging · doi:10.1186/s13244-023-01464-z · Cited by 32 · see citing works
Li, Q., Liang, Z., Xie, J., Ye, G., Guan, P., Huang, Y., & Li, X. (2023) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-23-18 · Cited by 30 · see citing works
Bo, Z., Chen, B., Yang, Y., Yao, F., Mao, Y., Yao, J., Yang, J., He, Q., Zhao, Z., Shi, X., et al. (2023) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-023-06184-6 · Cited by 30 · see citing works
Radhakrishnan, M., Sampathila, N., Muralikrishna, H., & Swathi, K. S. (2024) · IEEE Access · doi:10.1109/access.2024.3448219 · Cited by 33 · see citing works
Zhang, H., Yang, F., Xu, Y., Zhao, S., Jiang, Y., Shao, Z.-M., & Xiao, Y. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101924 · Cited by 30 · see citing works
AI in Aesthetic/Cosmetic Dermatology: Current and Future
Thunga, S., Khan, M., Cho, S. I., Na, J., & Yoo, J. Y. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16640 · Cited by 30 · see citing works
Habets, P. C., Thomas, R. M., Milaneschi, Y., Jansen, R., Pool, R., Peyrot, W. J., Penninx, B. W. J. H., Meijer, O. C., van Wingen, G. A., & Vinkers, C. H. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.05.024 · Cited by 30 · see citing works
Deep Learning–Powered Whole Slide Image Analysis in Cancer Pathology
Dang, C., Qi, Z., Xu, T., Gu, M., Chen, J., Wu, J. J., Lin, Y., & Qi, X. (2025) · Laboratory Investigation · doi:10.1016/j.labinv.2025.104186 · Cited by 29 · see citing works
Zhi-hua, W., Yu, L., Ding, X., Liao, X., & Wang, L. (2023) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2023.3287256 · Cited by 27 · see citing works
Ligero, M., Gielen, B., Navarro, V., Morgado, P. C., Prior, O., Dienstmann, R., Nuciforo, P. G., Trebeschi, S., Beets‐Tan, R. G. H., Sala, E., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00534-9 · Cited by 30 · see citing works
You, C., Su, G.-H., Zhang, X., Xiao, Y., Zheng, R., Sun, S., Zhou, J.-Y., Lin, L., Wang, Z., Wang, H., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00666-y · Cited by 27 · see citing works
Wu, G., Gong, M., Wu, Y., Liu, L., Shi, B., & Zeng, Z. (2024) · Health care science · doi:10.1002/hcs2.118 · Cited by 27 · see citing works
Lin, H., Hua, J., Gong, Z., Chen, M., Qiu, B., Wu, Y., He, W., Wang, Y., Feng, Z., Liang, Y., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217557 · Cited by 27 · see citing works
Sheehy, J. J., Rutledge, H., Acharya, U. R., Loh, H. W., Gururajan, R., Tao, X., Zhou, X., Li, Y., Gurney, T., & Kondalsamy‐Chennakesavan, S. (2023) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2023.102536 · Cited by 28 · see citing works
Multimodal analysis methods in predictive biomedicine
Qoku, A., Katsaouni, N., Flinner, N., Buettner, F., & Schulz, M. H. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.11.011 · Cited by 29 · see citing works
HONeYBEE: enabling scalable multimodal AI in oncology through foundation model-driven embeddings
Tripathi, A. G., Waqas, A., Schabath, M. B., Yılmaz, Y., & Rasool, G. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-02003-4 · Cited by 37 · see citing works
Guo, S., Pan, D., Su, N., Huang, M.-Q., Zhou, Z.-Z., Huang, W., & Tian, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1266721 · Cited by 25 · see citing works
Continuous multimodal data supply chain and expandable clinical decision support for oncology
Chang, J. S., Kim, H., Baek, E. S., Choi, J. E., Lim, J. S., Kim, J. S., & Shin, S. J. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-01508-2 · Cited by 26 · see citing works
Multi-Modal Federated Learning for Cancer Staging Over Non-IID Datasets With Unbalanced Modalities
Borazjani, K., Khosravan, N., Ying, L. L., & Hosseinalipour, S. (2024) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2024.3450855 · Cited by 24 · see citing works
Momoli, C., Costa, B., Lenti, L., Tubertini, M., Parenti, M., Martella, E., Varchi, G., & Ferroni, C. (2025) · Cancers · doi:10.3390/cancers17040700 · Cited by 24 · see citing works
Amer, H., Flanagan, K. L., Kampan, N. C., Itsiopoulos, C., Scott, C. L., Kartikasari, A. E. R., & Plebanski, M. (2025) · Cancers · doi:10.3390/cancers17101691 · Cited by 27 · see citing works
Wu, M., Zhu, C., Yang, J., Cheng, S., Yang, X., Gu, S., Xu, S., Wu, Y., Shen, W., Huang, S., et al. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.1069673 · Cited by 24 · see citing works
Pathogenomics for accurate diagnosis, treatment, prognosis of oncology: a cutting edge overview
Feng, X., Shu, W., Li, M., Li, J., Xu, J., & He, M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04915-3 · Cited by 27 · see citing works
Zhou, C., Zhang, Y., Guo, S. J., Huang, Y., Qiao, X.-N., Wang, R., Zhao, L., Chang, D., Zhao, L.-M., Da, M., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1287995 · Cited by 22 · see citing works
Tian, R., Hou, F., Zhang, H., Yu, G., Yang, P., Li, J., Yuan, T., Chen, X., Chen, Y.-Z., Hao, Y., et al. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-01712-0 · Cited by 22 · see citing works
Lin, P., Lin, Y.-Q., Gao, R.-Z., Wan, W., He, Y., & Yang, H. (2023) · European Radiology · doi:10.1007/s00330-023-09503-5 · Cited by 23 · see citing works
Digital pathology and multimodal learning on oncology data
Waqas, A., Naveed, J., Shahnawaz, W., Asghar, S., Bui, M. M., & Rasool, G. (2024) · BJR|Artificial Intelligence · doi:10.1093/bjrai/ubae014 · Cited by 21 · see citing works
Lin, H., Hua, J., Wang, Y., Chen, M., Liang, Y., Yan, L., Zhao, W., Luo, S., Hong, D., Chen, X., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010723 · Cited by 20 · see citing works
Towards interpretable imaging genomics analysis: Methodological developments and applications
Cen, X., Dong, W., Lv, W., Zhao, Y. C., Dubee, F., Mentis, A. A., Jovic, D., Yang, H., & Li, Y. (2023) · Information Fusion · doi:10.1016/j.inffus.2023.102032 · Cited by 21 · see citing works
Yan, R., Zhang, X., Jiang, Z., Wang, B., Bian, X., Ren, F., & Zhou, S. K. (2025) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.2025.3611531 · Cited by 20 · see citing works
Lu, Y., Liu, F., Yu, Y., Chen, B., Yu, W., Zou, Z., Li, K., Man, M., Ou, C., Wang, C., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102216 · Cited by 18 · see citing works
Muneer, A., Waqas, M. M., Saad, M. B., Showkatian, E., Bandyopadhyay, R., Xu, H. M., Li, W., Chang, J., Liao, Z., Haymaker, C., et al. (2026) · Artificial Intelligence Review · doi:10.1007/s10462-026-11522-9 · Cited by 21 · see citing works
Liu, W., Wang, W., Guo, R., Zhang, H., & Guo, M. (2024) · BMC Cancer · doi:10.1186/s12885-024-12394-4 · Cited by 18 · see citing works
A novel prognostic signature related to programmed cell death in osteosarcoma
Jiang, Y., Xu, Q., Wang, H., Ren, S., & Zhang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1427661 · Cited by 18 · see citing works
Shojaei, S., Mousavi, A., Kazemian, S., Armani, S., Maleki, S., Fallahtafti, P., Arashlow, F. T., Daryabari, Y., Naderian, M., Alkhouli, M. A., et al. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15070302 · Cited by 17 · see citing works
Deep learning for pancreatic diseases based on endoscopic ultrasound: A systematic review
Yin, M., Liu, L., Gao, J., Lin, J., Qu, S., Xu, W., Liu, X., Xu, C., & Zhu, J. (2023) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2023.105044 · Cited by 17 · see citing works
Self-citationA multimodal deep learning model for predicting severe hemorrhage in placenta previa
Akazawa, M., & Hashimoto, K. (2023) · Scientific Reports · doi:10.1038/s41598-023-44634-1 · Cited by 17 · see citing works
Aggarwal, A., Khalighi, S., Babu, D., Li, H., Azarianpour, S., Corredor, G., Fu, P., Mokhtari, M., Pathak, T. B., Thayer, E. G., et al. (2024) · Communications Medicine · doi:10.1038/s43856-023-00428-0 · Cited by 16 · see citing works
- Authors
- Boehm, K. M., Aherne, E. A., Ellenson, L., Nikolovski, I., Alghamdi, M., Vázquez-García, I., Zamarin, D., Long Roche, K., Liu, Y., Patel, D., Aukerman, A., Pasha, A., Rose, D., Selenica, P., Causa Andrieu, P. I., Fong, C., Capanu, M., Reis-Filho, J. S., Vanguri, R., Veeraraghavan, H., Gangai, N., Sosa, R., Leung, S., McPherson, A., Gao, J., MSK MIND Consortium, Lakhman, Y., & Shah, S. P.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Lakhman, Yulia
- Shah, Sohrab P.
- ORCID
- Boehm, Kevin M.
- Aherne, Emily A.
- Ellenson, Lora
- Nikolovski, Ines
- Alghamdi, Mohammed
- Vázquez-García, Ignacio
- Zamarin, Dmitriy
- Long Roche, Kara
- Liu, Ying
- Patel, Druv
- Aukerman, Andrew
- Rose, Doori
- Selenica, Pier
- Fong, Chris
- Capanu, Marinela
- Reis-Filho, Jorge S.
- Vanguri, Rami
- Veeraraghavan, Harini
- Gangai, Natalie
- McPherson, Andrew
- Gao, JianJiong
- Lakhman, Yulia
- Shah, Sohrab P.
- Venue
- Nature Cancer
- Published
- 2022-06-28
- Volume
- 3
- Issue
- 6
- Pages
- 723-733
- ISSN
- 2662-1347 (ISSN-L)
- PMC
- PMC9239907
- OpenAlex
- W4283645969
- Cited by
- 357
- References
- 54
- Citations by year
- 2026: 76 · 2025: 118 · 2024: 94 · 2023: 59 · 2022: 9 · 2020: 1
- FWCI
- 59.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Nature Cancer (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (T32GM007739)
- U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (P30CA008748)
- Grayer Fellowship (MSKCC) Cycle for Survival
- Susan G. Komen Scholars Program Cycle for Survival
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Keywords
- high-grade serous ovarian cancer, multimodal data integration, risk stratification, prognostic factors, treatment response prediction, homologous recombination deficiency, H&E staining, contrast-enhanced CT, histopathology
- MeSH terms
- Machine Learning, Female, Humans, Ovarian Neoplasms, Cystadenocarcinoma, Serous, Risk Assessment
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