Autophagy in healthy aging and disease

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

DNA methylation age of human tissues and cell types

Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075

Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Swanson, K. V., Deng, M., & Ting, J. P.-Y. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0165-0 · Cited by 4,884

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578

Autophagy and Viruses: Adversaries or Allies?

Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,444

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

The million-molecule challenge: a moonshot project to rapidly advance longevity intervention discovery

Lee, M. B., Blue, B. W., Muir, M., & Kaeberlein, M. R. (2023) · GeroScience · doi:10.1007/s11357-023-00867-6 · Cited by 16

Protein aggregation: A detrimental symptom or an adaptation mechanism?

Lippi, A., & Kriško, A. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15955 · Cited by 18

Dynamic Assembly of DNA Nanostructures in Cancer Cells Enables the Coupling of Autophagy Activating and Real-Time Tracking

Guo, Y., Tong, Z., Huang, Y. H., Tang, J., Xue, X., Yang, D., & Yao, C. (2024) · Nano Letters · doi:10.1021/acs.nanolett.4c00552 · Cited by 15

Rejuvenating aged stem cells: therapeutic strategies to extend health and lifespan

Matteini, F., Montserrat‐Vazquez, S., & Florian, M. C. (2024) · FEBS Letters · doi:10.1002/1873-3468.14865 · Cited by 16

Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions

Shafqat, A., Masters, M. C., Tripathi, U., Tchkonia, T., Kirkland, J. L., & Hashmi, S. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102400 · Cited by 15

Unraveling the Molecular Mechanisms of Osteoarthritis: The Potential of Polyphenols as Therapeutic Agents

Rahaman, S. N., Lishadevi, M., & Anandasadagopan, S. K. (2025) · Phytotherapy Research · doi:10.1002/ptr.8455 · Cited by 16

Cellular senescence as a key player in chronic heart failure pathogenesis: Unraveling mechanisms and therapeutic opportunities

Zhao, S., Zhang, Y., Zhao, Y. R., & Lu, X. (2025) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2025.02.002 · Cited by 15

Repair mechanisms of the central nervous system: From axon sprouting to remyelination

Gluck, L., Gerstein, B., & Kaunzner, U. W. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00583 · Cited by 16

The connection between autophagy and Alzheimer’s disease

Nechushtai, L., Chen, D., Dan, F., & Pinkas‐Kramarski, R. (2025) · Inflammation Research · doi:10.1007/s00011-025-02118-0 · Cited by 19

Degradative and Non-Degradative Roles of Autophagy Proteins in Metabolism and Metabolic Diseases

Kuramoto, K., & He, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.844481 · Cited by 16

Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels

Prtenjača, N., Rob, M., Alam, M. S., Markovinović, A., Stuani, C., Buratti, E., & Munitić, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126829 · Cited by 13

Vacuolar proteases and autophagy in phytopathogenic fungi: A review

Juárez‐Montiel, M., Clark-Flores, D., Tesillo-Moreno, P., la Vega-Camarillo, E. D., Andrade-Pavón, D., Hernández-García, J. A., Hernández, G., & Villa‐Tanaca, L. (2022) · Frontiers in Fungal Biology · doi:10.3389/ffunb.2022.948477 · Cited by 14

Leucine mediates cognitive dysfunction in early life stress-induced mental disorders by activating autophagy

Wang, X., Wang, X. B., Xie, F., Sun, Z., Guo, B., Li, F., Wang, S., Wang, Y., Tian, Y., Zhao, Y. S., et al. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1060712 · Cited by 14

Aging: Epigenetic modifications

Mishra, S., Raval, M., Kachhawaha, A. S., Tiwari, B. S., & Tiwari, A. K. (2023) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2023.02.002 · Cited by 14

Effects of Natural Product-Derived Compounds on Inflammatory Pain via Regulation of Microglial Activation

Park, J., Lee, C.-H., & Kim, Y. T. (2023) · Pharmaceuticals · doi:10.3390/ph16070941 · Cited by 17

Stub1 ameliorates ER stress-induced neural cell apoptosis and promotes locomotor recovery through restoring autophagy flux after spinal cord injury

Lu, E., Tang, Y., Chen, J., Mamun, A. A., Feng, Z., Cao, L., Zhang, X., Zhu, Y., Mo, T., Chun, C., et al. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114495 · Cited by 14

Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging

Nithianandam, V., Bukhari, H., Leventhal, M. J., Battaglia, R. A., Dong, X., Fraenkel, E., & Feany, M. Β. (2023) · Nature Communications · doi:10.1038/s41467-023-42822-1 · Cited by 16

N6-Methyladenosine Modification of lncCCKAR-5 Regulates Autophagy in Human Umbilical Cord Mesenchymal Stem Cells by Destabilizing LMNA and Inhibits Diabetic Wound Healing

Wang, J., Wang, X., Chen, F., Ning, Q., Liu, Y., Zhu, Y., Wei, W., Leng, M., Wang, Z., Jin, P., et al. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.11.023 · Cited by 14

Impact of α-Globin Gene Expression and α-Globin Modifiers on the Phenotype of β-Thalassemia and Other Hemoglobinopathies: Implications for Patient Management

Traeger‐Synodinos, J., Vrettou, C., Sofocleous, C., Zurlo, M., Finotti, A., & Gambari, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063400 · Cited by 16

Parkin, a Parkinson's disease-associated protein, mediates the mitophagy that plays a vital role in the pathophysiology of major depressive disorder

Zhang, Y. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105808 · Cited by 14

Functional and metabolic effects of omega-3 polyunsaturated fatty acid supplementation and the role of β-hydroxy-β-methylbutyrate addition in chronic obstructive pulmonary disease: A randomized clinical trial

ENGELEN, M. P. K. J., Simbo, S. Y., Ruebush, L. E., Thaden, J. J., Have, G. A. M. T., Harrykissoon, R., Zachria, A. J., Calder, P. C., Pereira, S. L., & Deutz, N. E. P. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.08.004 · Cited by 15

The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies

Nunkoo, V. S., Cristian, A., Jurcău, A., Diaconu, R. G., & Jurcău, M. C. (2024) · Biomedicines · doi:10.3390/biomedicines12112540 · Cited by 15

Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone?

Russo, L., Babboni, S., Andreassi, M. G., Daher, J., Canale, P., Turco, S. D., & Basta, G. (2025) · Antioxidants · doi:10.3390/antiox14010099 · Cited by 16

RNA‐Based Therapies for Neurodegenerative Diseases Targeting Pathogenic Proteins

Rabbani, S. A., El‐Tanani, M., Sharma, S., El‐Tanani, Y., Kumar, R., Saini, M., Yadav, M., Khan, M. A., & Parvez, S. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70110 · Cited by 15

Enhancing autophagy by redox regulation extends lifespan in Drosophila

Lennicke, C., Bjedov, I., Grönke, S., Menger, K. E., James, A. M., Castillo-Quan, J. I., van Leeuwen, L. A. G., Foley, A., Buricova, M., Adcott, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60603-w · Cited by 16

Human autophagy measurement: an underappreciated barrier to translation

Sargeant, T. J., & Bensalem, J. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.09.003 · Cited by 13

Design, Synthesis and Antiproliferative Evaluation of Bis-Indole Derivatives with a Phenyl Linker: Focus on Autophagy

Budovská, M., Michalková, R., Kello, M., Vašková, J., & Mojžíš, J. (2022) · Molecules · doi:10.3390/molecules28010251 · Cited by 14

Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brainPreprint

Fraia, D. D., Marino, A., Lee, J. H., Sacramento, E. K., Baumgart, M., Bagnoli, S., da Silva, P. T., Sahu, A. K., Siano, G., Tiessen, M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.20.549210 · Cited by 13

Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged Mice

Ktena, N., Spyridakos, D., Georgilis, A., Kalafatakis, I., Thomoglou, E., Kolaxi, A., Nikoletopoulou, V., Savvaki, M., & Karagogeos, D. (2025) · Glia · doi:10.1002/glia.70012 · Cited by 15

How Cells Die in Psoriasis?

Chen, C.-H., Wu, N., & Tsai, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083747 · Cited by 17

Targeting mitophagy in the heart: Exploring the therapeutic potential of MicroRNAs

Javadifar, A., Tahani, M., Khayat, S., Rakhshaninasab, S., Karav, S., Kesharwani, P., & Sahebkar, A. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112082 · Cited by 13

Oxidative Stress, Mitochondrial Quality Control, Autophagy, and Sirtuins in Heart Failure

Krekora, J., Derwich, M., Dróżdż, J., Pawłowska, E., & Błasiak, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199826 · Cited by 17

Autophagy-mediated immune system regulation in reproductive system and pregnancy-associated complications

Komijani, E., Parhizkar, F., Abdolmohammadi‐Vahid, S., Ahmadi, H., Nouri, N., Yousefi, M., & Maleki, L. A. (2023) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2023.103973 · Cited by 13

Emerging roles of p300/CBP in autophagy and autophagy-related human disorders

Xu, Y., & Wan, W. (2023) · Journal of Cell Science · doi:10.1242/jcs.261028 · Cited by 13

The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension

Sporbeck, K., Haas, M. L., Pastor‐Maldonado, C. J., Schüssele, D. S., Hunter, C., Takács, Z., Oliveira, A. V. D. S., Franz‐Wachtel, M., Charsou, C., Pfisterer, S. G., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05236-9 · Cited by 13

Investigation into Molecular Brain Aging in Senescence-Accelerated Mouse (SAM) Model Employing Whole Transcriptomic Analysis in Search of Potential Molecular Targets for Therapeutic Interventions

Fujiwara, M., Ferdousi, F., & Isoda, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813867 · Cited by 13

Bisphenol-A exposure alters liver, kidney, and pancreatic Klotho expression by HSP60-activated mTOR/autophagy pathway in male albino rats

Morsi, A. A., Mersal, E. A., Alsabih, A. O., Alakabawy, S., Elfawal, R. G., Sakr, E. M., Faruk, E. M., Abu-Rashed, M., Al-Haddad, F., Alkhawajah, Z., et al. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.7.18 · Cited by 13

Spermidine Suppresses Oral Carcinogenesis through Autophagy Induction, DNA Damage Repair, and Oxidative Stress Reduction

Coeli‐Lacchini, F. B., da Silva, G. F., Belentani, M., Alves, J. S. F., Ushida, T. R., Lunardelli, G. T., Garcia, C. B., Silva, T. A., Lopes, N. P., & Leopoldino, A. M. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.09.005 · Cited by 13

Multi-Omic, Histopathologic, and Clinicopathologic Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy: A Pilot Study

Rivas, V. N., Kaplan, J. L., Kennedy, S. A., Fitzgerald, S., Crofton, A. E., Farrell, A., Grubb, L., Jauregui, C. E., Grigorean, G., Choi, E. A., et al. (2023) · Animals · doi:10.3390/ani13203184 · Cited by 14

Autophagy-related mechanisms for treatment of multiple myeloma

Kozalak, G., & Koşar, A. (2023) · Cancer Drug Resistance · doi:10.20517/cdr.2023.108 · Cited by 14

Lysosomal Dysfunction: Connecting the Dots in the Landscape of Human Diseases

Uribe-Carretero, E., Rey, V., Fuentes, J. M., & Tamargo‐Gómez, I. (2024) · Biology · doi:10.3390/biology13010034 · Cited by 15

Insights into How Plant-Derived Extracts and Compounds Can Help in the Prevention and Treatment of Keloid Disease: Established and Emerging Therapeutic Targets

Boo, Y. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021235 · Cited by 14

Molecular Basis of Neuronal and Microglial States in the Aging Brain and Impact on Cerebral Blood Vessels

Maeda, C., & Tsuruta, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084443 · Cited by 13

Lactate Contributes to Remote Ischemic Preconditioning–Mediated Protection Against Myocardial Ischemia Reperfusion Injury by Facilitating Autophagy via the AMP-Activated Protein Kinase–Mammalian Target of Rapamycin–Transcription Factor EB–Connexin 43 Axis

Yang, Z., Zhang, W., Jin, Q.-Q., Wu, Z.-R., Du, Y.-Y., Shi, H., Qu, Z.-S., Han, X., & Jiang, L. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.07.005 · Cited by 13

Rationally designed catalytic nanoplatform for enhanced chemoimmunotherapy via deploying endogenous plus exogenous copper and remodeling tumor microenvironment

Sun, D., Yu, L., Wang, G., Xu, Y., Wang, P., Wang, N., Wu, Z., Zhang, G., Zhang, J., Zhang, Y., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02696-x · Cited by 13

Environmentally relevant concentrations of perfluorobutane sulfonate impair locomotion behaviors and healthspan by downregulating mitophagy in C. elegans

Shang, Y. H., Chen, K., Ni, H., Zhu, X., Yuan, X., Wang, Y., Liu, X., Cui, Z., Niu, Y., Shi, Y., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135938 · Cited by 14

Promoting proteostasis by cAMP/PKA and cGMP/PKG

Ahammed, M. S., & Wang, X. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.10.006 · Cited by 13

Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway

Chen, Y., Chen, B., Li, J., Li, H., Wang, G., Cai, X., Zhang, Q., Liu, X., Chen, K., Wang, Z., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01237-8 · Cited by 13

Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome

Pan, H., Tian, A.-L., Chen, H., Xia, Y., Sauvat, A., Moriceau, S., Lambertucci, F., Motiño, O., Zhao, L., Liu, P., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01170-0 · Cited by 13

Targeted protein degradation with bifunctional molecules as a novel therapeutic modality for Alzheimer's disease & beyond

Sandhof, C. A., Murray, H. F. B., Silva, M. C., & Haggarty, S. J. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00499 · Cited by 14

Caspase 3 and caspase 7 promote cytoprotective autophagy and the DNA damage response during non-lethal stress conditions in human breast cancer cells

Samarasekera, G., Go, N. E., Choutka, C., Xu, J., Takemon, Y., Chan, J. A.-W., Chan, M., Perera, S., Aparicio, S. A. J. R., Morin, G. B., et al. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003034 · Cited by 16

Environmental Health Is Overlooked in Longevity Research

Mesnage, R. (2025) · Antioxidants · doi:10.3390/antiox14040421 · Cited by 15

A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients

Nardone, C., Mintseris, J., He, D., Rutter, J. C., Ebert, B. L., Gygi, S. P., & Rapoport, T. A. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01610-9 · Cited by 15

Autophagy in acute myeloid leukemia: a paradoxical role in chemoresistance

Khan, A., Singh, V. K., Thakral, D., & Gupta, R. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-02804-z · Cited by 15

Relationship between heat shock proteins and cellular resistance to drugs and ageing

Peinado-Ruiz, I. C., Burgos-Molina, A. M., Sendra‐Portero, F., & Ruiz-Gomez, M. J. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111896 · Cited by 13

Parkin deficiency exacerbates fasting-induced skeletal muscle wasting in mice

Peker, N., Sharma, M., & Kambadur, R. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00419-3 · Cited by 13

Aging aggravates acetaminophen-induced acute liver injury and inflammation through inordinate C/EBPα-BMP9 crosstalk

Liu, R., Xu, W., Zhu, H., Dong, Z., Dong, H., & Yin, S. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01014-6 · Cited by 12

NIPSNAP1 directs dual mechanisms to restrain senescence in cancer cells

Gao, E., Sun, X., Thorne, R. F., Zhang, X. D., Li, J., Shao, F., Ma, J., & Wu, M. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04232-1 · Cited by 13

Temporal analysis of skeletal muscle remodeling post hindlimb ischemia reveals intricate autophagy regulation

Scalabrin, M., Engman, V., MacCannell, A. D. V., Critchlow, A. J., Roberts, L. D., Yuldasheva, N. Y., & Bowen, T. S. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00174.2022 · Cited by 12

Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging

SenGupta, T., Lefol, Y., Lirussi, L., Suaste, V., Lüders, T., Gupta, S., Aman, Y., Sharma, K., Fang, E. F., & Nilsen, H. L. (2022) · Aging · doi:10.18632/aging.204375 · Cited by 12

From Youthful Vigor to Aging Decline: Unravelling the Intrinsic and Extrinsic Determinants of Hippocampal Neural Stem Cell Aging

Peinado, P. J., & Urbach, A. (2023) · Cells · doi:10.3390/cells12162086 · Cited by 13

Hypertrophic cardiomyopathy in MYBPC3 carriers in aging

Ananthamohan, K., Stelzer, J. E., & Sadayappan, S. (2024) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.29 · Cited by 13

Mitochondria, Autophagy and Inflammation: Interconnected in Aging

Silva, R. C. M. C. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01231-x · Cited by 13

Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer’s Disease: A Systematic Review and Meta-analysis of Preclinical Studies

Cai, J., Xie, D., Kong, F., Zhai, Z., Zhu, Z., Zhao, Y., Xu, Y., & Sun, T. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231249 · Cited by 13

Research progress on the role and mechanism of Sirtuin family in doxorubicin cardiotoxicity

Zhang, X., Huang, C., Hou, Y., Jiang, S., Zhang, Y., Wang, S., Chen, J., Lai, J., Wu, L., Duan, H., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155673 · Cited by 12

Does the liver facilitate aging‐related cognitive impairment: Conversation between liver and brain during exercise?

Wei, C., Li, X., Yu, J. Z., Zhang, Y., & Yuan, Q. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31287 · Cited by 13

β-arrestin1 protects intestinal tight junction through promoting mitofusin 2 transcription to drive parkin-dependent mitophagy in colitis

Wu, S., Liu, H., Yi, J., Xu, M., Jiang, J., Tao, J., & Wu, B. (2023) · Gastroenterology report · doi:10.1093/gastro/goae084 · Cited by 12

Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease

Galkin, F., Pulous, F. E., Fu, Y., Zhang, M., Pun, F. W., Ren, F., & Zhavoronkov, A. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102551 · Cited by 14

Decoding the role of large heat shock proteins in the progression of neuroinflammation‐mediated neurodegenerative disorders

Saxena, S. K., Sharma, D. K., Kumar, S., Maurya, V. K., Ansari, S., Malhotra, H. S., & Singh, A. (2025) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.68 · Cited by 12

Excessive Alcohol Use as a Risk Factor for Alzheimer’s Disease: Epidemiological and Preclinical Evidence

Anton, P. E., Maphis, N. M., Linsenbardt, D. N., & Coleman, L. G. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-81908-7_10 · Cited by 12

Fungal Bioactive Compounds as Emerging Therapeutic Options for Age-Related Neurodegenerative Disorders

Bonetto, V., Ferraresi, A., Sampò, S., & Isidoro, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104800 · Cited by 13

Identification and Expression Analysis of the Solanum tuberosum StATG8 Family Associated with the WRKY Transcription Factor

Song, I., Hong, S., & Huh, S. U. (2022) · Plants · doi:10.3390/plants11212858 · Cited by 12

A potential role of autophagy-mediated vascular senescence in the pathophysiology of HFpEF

Sanhueza‐Olivares, F., Troncoso, M. F., la Fuente, F. P.-D., Martinez-Bilbao, J., Riquelme, J. A., Norambuena‐Soto, I., Villa, M., Lavandero, S., Castro, P., & Chiong, M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1057349 · Cited by 13

Biological properties, synthetic pathways and anti-aging mechanisms of nicotinamide mononucleotide (NMN): Research progress and challenges

Wang, E., Wang, Y., Zhang, Z., Jiang, Y., & Zhao, C. (2025) · Biogerontology · doi:10.1007/s10522-025-10270-7 · Cited by 11

Progress in antisenescence biomaterials for improved osteoarthritis therapy

Ge, Y.-S., Ding, J.-Y., Shen, J., Meng, T.-T., Huang, C.-M., Li, W.-Y., Zhao, M.-J., Yin, J.-L., Zhai, Y.-Q., Wang, X., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.08.044 · Cited by 13

Selective autophagy in type 2 diabetes-associated cognitive dysfunction: Insightful mechanisms and therapies

Luo, L., Que, M., Zeng, L., Wang, X., Sun, T., Zhou, Z., Zhao, Y., Li, S., & Luo, A. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107947 · Cited by 11

Roles of Autophagy and Oxidative Stress in Cardiovascular Disease

Yun, H. R., Singh, M. K., Han, S., Ranbhise, J. S., Ha, J., Kim, S. S., & Kang, I. (2025) · Antioxidants · doi:10.3390/antiox14101263 · Cited by 13

Strategies for blood–brain barrier rejuvenation and repair

Searson, P. C., & Banks, W. A. (2026) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01364-5 · Cited by 15

Blue light stimulates light stress and phototactic behavior when received in the brain of Diaphorina citri

Wang, F.-F., Wang, M., Zhang, M., Qin, P., Cuthbertson, A. G. S., Lei, C., Qiu, B., Yu, L., & Sang, W. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114519 · Cited by 11

Effects of oral β-caryophyllene (BCP) treatment on perioperative neurocognitive disorders: Attenuation of neuroinflammation associated with microglial activation and reinforcement of autophagy activity in aged mice

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Li, H., Cheng, S., Wang, Y., Sun, Y., Zhang, J., Sun, M., Man, C., Zhang, Y., & Jiang, Y. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250172 · Cited by 17

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Fila, M., Chojnacki, J., Pawłowska, E., Sobczuk, P., Chojnacki, C. J., & Błasiak, J. (2023) · Nutrients · doi:10.3390/nu15234998 · Cited by 11

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Gao, K., Xu, X., & Wang, C. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.11.017 · Cited by 11

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Barbuti, P. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126525 · Cited by 12

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Lo, C., Liu, Z., Chen, S., Lin, F., Berneshawi, A. R., Yu, C. Q., Koo, E. B., Kowal, T. J., Ning, K., Hu, Y., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci175560 · Cited by 12

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Norambuena, A., Sagar, V. K., Wang, Z., Raut, P., Feng, Z., Wallrabe, H., Pardo, E., Kim, T., Alam, S. R., Hu, S., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14144 · Cited by 10

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Li, J., Ma, W., Tang, Z., Li, Y., Zheng, R., Xie, Y., & Li, G. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13381 · Cited by 11

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Carosi, J. M., Martin, A., Hein, L. K., Hassiotis, S., Hattersley, K. J., Turner, B. J., Fourrier, C., Bensalem, J., & Sargeant, T. J. (2025) · PLoS ONE · doi:10.1371/journal.pone.0325505 · Cited by 11

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Johnson, M. S., & Cook, J. G. (2023) · Faculty Reviews · doi:10.12703/r/12-5 · Cited by 16

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Silva-García, C. G. (2023) · GeroScience · doi:10.1007/s11357-023-00809-2 · Cited by 14

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Botella, J., Shaw, C. S., & Bishop, D. J. (2023) · International Journal of Sports Medicine · doi:10.1055/a-2153-9258 · Cited by 12

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Usman, M., Li, Y., Ke, Y., Chhetri, G., Islam, M. A., Wang, Z., & Li, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094900 · Cited by 11

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Xuan, L., Kang, S.-K., Jo, Y., Nguyen, P. A. H., Kim, A., Kim, K., Kim, N.-S., & Koh, Y. H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.808295 · Cited by 11

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Luo, L., & Qin, Z. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-0602-4_24 · Cited by 33

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Leidal, A. M., Levine, B., & Debnath, J. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0235-8 · Cited by 424

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Stead, E. R., Castillo-Quan, J. I., Martinez-Miguel, V. E., Lujan, C., Ketteler, R., Kinghorn, K. J., & Bjedov, I. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00308 · Cited by 61

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Rajawat, Y. S., & Bossis, I. (2008) · HORMONES · doi:10.14310/horm.2002.1111037 · Cited by 66

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Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101468 · Cited by 285