The DOI matches its Crossref record; 249 of the 250 references it cites were found in a registry or an index.
Autophagy in healthy aging and disease
Open accessAbstract
Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In addition, we discuss current preclinical evidence arguing for the use of autophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases. Finally, we highlight key questions and propose novel research avenues that will likely reveal new links between autophagy and the hallmarks of aging. Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Autophagy, a highly conserved metabolic degradation process, maintains cellular homeostasis by delivering intracellular protein aggregates and damaged organelles to lysosomes for degradation and recycling.220,221”
From Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies. (2024) · cites this paper as [221]
In the citing paper
“CCF formation is also associated with autophagy, a collection of cellular homeostatic processes for trafficking and degradation of macromolecules and cellular components (Aman et al., 2021), and specifically autophagic degradation of Lamin B1 in senescent cells.”
From Cytoplasmic DNA: sources, sensing, and role in aging and disease (2021) · cites this paper as Aman et al., 2021
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED ARTICLE: Parkin and PINK1 mitigate STING-induced inflammation
Sliter, D. A., Martinez, J., Hao, L., Chen, X., Sun, N., Fischer, T. D., Burman, J. L., Li, Y., Zhang, Z., Narendra, D. P., et al. (2018) · Nature · doi:10.1038/s41586-018-0448-9 · Cited by 1,287
RetractedRepertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Self-citationDNA methylation age of human tissues and cell types
Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075
Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Swanson, K. V., Deng, M., & Ting, J. P.-Y. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0165-0 · Cited by 4,884
Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578
Self-citationAutophagy and Viruses: Adversaries or Allies?
Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,444
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Cited by
Sorted by citations
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Guo, J., Huang, X., Dou, L., Yan, M., Shen, T., Tang, W., & Li, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01251-0 · Cited by 1,976
Zhang, J., Zhang, Y., Wang, J., Xia, Y., Zhang, J., & Chen, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01911-3 · Cited by 1,138
“220,221 It primarily occurs via three types: micro-autophagy, chaperone-mediated autophagy, and macroauto-phagy (commonly referred to as autophagy).”
BackgroundThe mechanisms and roles of selective autophagy in mammals
Vargas, J. N. S., Hamasaki, M., Kawabata, T., Youle, R. J., & Yoshimori, T. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00542-2 · Cited by 1,088
The mitophagy pathway and its implications in human diseases
Wang, S., Long, H., Hou, L., Feng, B., Ma, Z., Wu, Y., Zeng, Y., Cai, J., Zhang, D., & Zhao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01503-7 · Cited by 991
Chronic inflammation and the hallmarks of aging
Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471
Cai, Y., Song, W., Li, J., Jing, Y., Liang, C., Zhang, L., Zhang, X., Zhang, W., Liu, B., An, Y., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2161-3 · Cited by 450
From geroscience to precision geromedicine: Understanding and managing aging
Kroemer, G., Maier, A. B., Cuervo, A. M., Gladyshev, V. N., Ferrucci, L., Gorbunova, V., Kennedy, B. K., Rando, T. A., Seluanov, A., Sierra, F., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.011 · Cited by 395
Self-citationFlavonoids and their role in oxidative stress, inflammation, and human diseases
Jomová, K., Alomar, S. Y., Valko, R., Líška, J., Nepovimová, E., Kuča, K., & Valko, M. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111489 · Cited by 449
Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging
Jiménez‐Loygorri, J. I., Villarejo‐Zori, B., Viedma-Poyatos, Á., Zapata‐Muñoz, J., Benítez‐Fernández, R., Frutos-Lisón, M. D., Tomás-Barberán, F. A., Espı́n, J. C., Área-Gómez, E., Gómez-Durán, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45044-1 · Cited by 394
Xie, C., Zhuang, X., Niu, Z., Ai, R., Lautrup, S., Zheng, S., Jiang, Y., Han, R., Gupta, T. S., Cao, S., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00819-5 · Cited by 350
Self-citationRedox regulation: mechanisms, biology and therapeutic targets in diseases
Li, B., Ming, H., Qin, S., Nice, E. C., Dong, J., Du, Z., & Huang, C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02095-6 · Cited by 389
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary
Schmauck-Medina, T., Molière, A., Lautrup, S., Zhang, J., Chlopicki, S., Madsen, H. B., Cao, S., Soendenbroe, C., Mansell, E., Vestergaard, M. B., et al. (2022) · Aging · doi:10.18632/aging.204248 · Cited by 319
Self-citationMolecular mechanisms of aging and anti-aging strategies
Li, Y., Tian, X., Luo, J., Bao, T., Wang, S., & Wu, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01663-1 · Cited by 380
Cytoplasmic DNA: sources, sensing, and role in aging and disease
Miller, K. N., Victorelli, S. G., Salmonowicz, H., Dasgupta, N., Liu, T., Passos, J. F., & Adams, P. D. (2021) · Cell · doi:10.1016/j.cell.2021.09.034 · Cited by 288
Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement
Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276
Human trials exploring anti-aging medicines
Guarente, L., Sinclair, D. A., & Kroemer, G. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.007 · Cited by 266
Self-citationAutophagy, aging, and age-related neurodegeneration
Palmer, J. E., Wilson, N., Son, S. M., Obrocki, P., Wróbel, L., Rob, M., Takla, M., Korolchuk, V. I., & Rubinsztein, D. C. (2024) · Neuron · doi:10.1016/j.neuron.2024.09.015 · Cited by 277
Self-citationMuhammad, P., Hanif, S., Li, J., Guller, A., Rehman, F. U., Ismail, M., Zhang, D., Yan, X., Fan, K., & Shi, B. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101530 · Cited by 209
Zhang, W., Xu, C., Sun, J., Shen, H., Wang, J., & Yang, C. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.01.008 · Cited by 221
Chaudhary, M. R., Chaudhary, S., Sharma, Y., Singh, T. A., Mishra, A. K., Sharma, S. G., & Mehdi, M. M. (2023) · Biogerontology · doi:10.1007/s10522-023-10050-1 · Cited by 218
Mechanisms of spermidine-induced autophagy and geroprotection
Hofer, S. J., Simon, A. K., Bergmann, M., Eisenberg, T., Kroemer, G., & Madeo, F. (2022) · Nature Aging · doi:10.1038/s43587-022-00322-9 · Cited by 218
Self-citationAutophagy enables microglia to engage amyloid plaques and prevents microglial senescence
Choi, I., Wang, M., Yoo, S., Xu, P., Seegobin, S. P., Li, X., Han, X., Wang, Q., Peng, J., Zhang, B., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01158-0 · Cited by 202
The role of lysosomes in metabolic and autoimmune diseases
Gros, F., & Muller, S. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00692-2 · Cited by 205
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
Woo, M. S., Mayer, C., Binkle-Ladisch, L., Sonner, J. K., Rosenkranz, S. C., Shaposhnykov, A., Rothammer, N., Tsvilovskyy, V., Lorenz, S., Raich, L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.031 · Cited by 197
Montégut, L., López-Otín, C., & Kroemer, G. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02020-z · Cited by 222
Self-citationCancer chemotherapy resistance: Mechanisms and recent breakthrough in targeted drug delivery
Davodabadi, F., Sajjadi, S. F., Sarhadi, M., Mirghasemi, S., Hazaveh, M. N., Khosravi, S., Andani, M. K., Cordani, M., Basiri, M., & Ghavami, S. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176013 · Cited by 202
Spermidine is essential for fasting-mediated autophagy and longevity
Hofer, S. J., Daskalaki, I., Bergmann, M., Friščić, J., Zimmermann, A., Mueller, M. I., Abdellatif, M., Nicastro, R., Masser, S., Durand, S., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01468-x · Cited by 186
Self-citationNeuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing
Tari, A. R., Walker, T. L., Huuha, A. M., Sando, S. B., & Wisløff, U. (2025) · The Lancet · doi:10.1016/s0140-6736(25)00184-9 · Cited by 189
Mechanisms of ovarian aging in women: a review
Wang, X., Wang, L., & Xiang, W. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01151-z · Cited by 179
Lysosomes in senescence and aging
Tan, J. X., & Finkel, T. (2023) · EMBO Reports · doi:10.15252/embr.202357265 · Cited by 178
Xu, C., Wu, J. S., Wu, Y., Ren, Z., Yao, Y., Chen, G., Fang, E. F., Noh, J. H., Liu, Y., Wei, L., et al. (2021) · Theranostics · doi:10.7150/thno.62376 · Cited by 151
Self-citationImmunosenescence: signaling pathways, diseases and therapeutic targets
Fu, Y., Wang, B., Alu, A., Hong, W., Hong, L., He, X., Shi, H., Cheng, P., & Yang, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02371-z · Cited by 168
Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
Hou, Y., Chu, X., Park, J., Zhu, Q., Hussain, M., Li, Z., Madsen, H. B., Yang, B., Wei, Y., Wang, Y., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13847 · Cited by 145
Self-citationThe Impact of Immune System Aging on Infectious Diseases
Quiros-Roldan, E., Sottini, A., Natali, P. G., & Imberti, L. (2024) · Microorganisms · doi:10.3390/microorganisms12040775 · Cited by 133
Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing
Reiten, O. K., Wilvang, M. A., Mitchell, S. J., Hu, Z., & Fang, E. F. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111567 · Cited by 136
Self-citationRecent advances in targeting autophagy in cancer
Jain, V., Singh, M. P., & Amaravadi, R. K. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.02.003 · Cited by 142
Autophagy in health and disease: From molecular mechanisms to therapeutic target
Lu, G. X., Wang, Y., Shi, Y. P., Zhang, Z., Huang, C., He, W., Wang, C., & Shen, H. (2022) · MedComm · doi:10.1002/mco2.150 · Cited by 135
New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death
Bu, L.-L., Yuan, H., Xie, L., Guo, M.-H., Liao, D., & Zheng, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015160 · Cited by 133
Ammonia-induced lysosomal and mitochondrial damage causes cell death of effector CD8+ T cells
Zhang, H., Liu, J., Yuan, W., Zhang, Q., Luo, X. L., Li, Y., Peng, Y., Feng, J., Liu, X., Chen, J., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01503-x · Cited by 127
Granic, A., Suetterlin, K., Shavlakadze, T., Grounds, M. D., & Sayer, A. A. (2023) · Clinical Science · doi:10.1042/cs20230319 · Cited by 124
Hou, Y., Chen, M., Bian, Y., Hu, Y., Chuan, J., Zhong, L., Zhu, Y., & Tong, R. (2024) · npj Vaccines · doi:10.1038/s41541-024-00874-4 · Cited by 132
Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases
Jiang, Z., Yin, X., Wang, M., Chen, T., Wang, Y., Gao, Z., & Wang, Z. (2022) · Aging and Disease · doi:10.14336/ad.2021.1217 · Cited by 116
Genomic Instability and Epigenetic Changes during Aging
López-Gil, L., Pascual‐Ahuir, A., & Proft, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814279 · Cited by 130
Role of autophagy in aging: The good, the bad, and the ugly
TABIBZADEH, S. S. (2022) · Aging Cell · doi:10.1111/acel.13753 · Cited by 107
Systemic Aging Fuels Heart Failure: Molecular Mechanisms and Therapeutic Avenues
Fang, Z., Raza, U., Song, J., Lu, J., Yao, S., Liu, X., Zhang, W., & Li, S. (2024) · ESC Heart Failure · doi:10.1002/ehf2.14947 · Cited by 117
Immune aging – A mechanism in autoimmune disease
Zheng, Y., Liu, Q., Goronzy, J. J., & Weyand, C. M. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101814 · Cited by 109
Autophagy in Parkinson’s Disease
Nechushtai, L., Frenkel, D., & Pinkas‐Kramarski, R. (2023) · Biomolecules · doi:10.3390/biom13101435 · Cited by 109
Mesenchymal Stem Cells in the Pathogenesis and Therapy of Autoimmune and Autoinflammatory Diseases
Zaripova, L. N., Midgley, A., Christmas, S. E., Beresford, M. W., Pain, C. E., Baildam, E. M., & Oldershaw, R. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216040 · Cited by 107
Kuzu, O. F., Granerud, L. J. T., & Saatcioglu, F. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02439-w · Cited by 128
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
Alizadeh, J., Rosa, S. C. D. S., Weng, X., Jacobs, J., Lorzadeh, S., Ravandi, A., Vitorino, R. M. P., Pecic, S., Živković, A., Stark, H., et al. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151337 · Cited by 99
Effects of Air Pollution on Cellular Senescence and Skin Aging
Martic, I., Jansen-Dürr, P., & Cavinato, M. (2022) · Cells · doi:10.3390/cells11142220 · Cited by 95
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease
Chou, C.-C., Vest, R., Prado, M. A., Wilson-Grady, J., Paulo, J. A., Shibuya, Y., Moran-Losada, P., Lee, T.-T., Luo, J., Gygi, S. P., et al. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01623-y · Cited by 94
Sharma, V., & Mehdi, M. M. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105490 · Cited by 100
Valorization and food applications of okara (soybean residue): A concurrent review
Asghar, A., Afzaal, M., Saeed, F., Ahmed, A., Ateeq, H., Shah, Y. A., Islam, F., Hussain, M., Akram, N., & Shah, M. A. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3363 · Cited by 89
Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics
Peng, M., Li, N., Wang, H., Li, Y., Liu, H., Luo, Y., Lang, B., Zhang, W., Li, S., Tian, L., et al. (2025) · MedComm · doi:10.1002/mco2.70304 · Cited by 98
Oxidative Stress and Age-Related Tumors
Carlo, E. D., & Sorrentino, C. (2024) · Antioxidants · doi:10.3390/antiox13091109 · Cited by 101
Pathological mechanisms of kidney disease in ageing
Yamamoto, T., & Isaka, Y. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00868-4 · Cited by 96
Song, Y., Liang, H., Li, G., Ma, L., Zhu, D., Zhang, W., Tong, B., Li, S., Gao, Y., Wu, X., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2274205 · Cited by 88
Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lens
Jiménez‐Loygorri, J. I., Benítez‐Fernández, R., Viedma-Poyatos, Á., Zapata‐Muñoz, J., Villarejo‐Zori, B., Gómez‐Sintes, R., & Boya, P. (2023) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2023.101205 · Cited by 84
Inflammasome assembly in neurodegenerative diseases
Singh, J., Habean, M. L., & Panicker, N. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.07.009 · Cited by 83
Engineered nanoparticles in aquatic systems: Toxicity and mechanism of toxicity in fish
Dube, E., & Okuthe, G. E. (2023) · Emerging contaminants · doi:10.1016/j.emcon.2023.100212 · Cited by 84
Jurcău, M. C., Jurcău, A., Cristian, A., Hogea, V. O., Diaconu, R. G., & Nunkoo, V. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910535 · Cited by 100
RNA damage compartmentalization by DHX9 stress granules
Zhou, Y., Panhale, A., Shvedunova, M., Balan, M., Gomez-Auli, A., Holz, H., Seyfferth, J., Helmstädter, M., Kayser, S., Zhao, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.028 · Cited by 83
Advances in Plant Polysaccharides as Antiaging Agents: Effects and Signaling Mechanisms
Deng, R., Wang, F., Wang, L., Xiong, L., Shen, X., & Song, H. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c00493 · Cited by 79
Regan, J. C., Lu, Y., Ureña, E., Meilenbrock, R. L., Catterson, J. H., Kißler, D., Fröhlich, J., Funk, E., & Partridge, L. (2022) · Nature Aging · doi:10.1038/s43587-022-00308-7 · Cited by 90
Self-citationInhibitors of the ATPase p97/VCP: From basic research to clinical applications
Kilgas, S., & Ramadan, K. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2022.12.007 · Cited by 82
Caenorhabditis elegans as a Model System to Study Human Neurodegenerative Disorders
Roussos, A., Kitopoulou, K., Borbolis, F., & Palikaras, K. (2023) · Biomolecules · doi:10.3390/biom13030478 · Cited by 82
Self-citationSamare‐Najaf, M., Neisy, A., Samareh, A. N., Moghadam, D., Jamali, N., Zarei, R., & Zal, F. (2023) · Autophagy · doi:10.1080/15548627.2023.2238577 · Cited by 78
The Endo-Lysosomal Damage Response
Meyer, H. H., & Kravić, B. (2024) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-030222-102505 · Cited by 79
Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity
Navakkode, S., & Kennedy, B. K. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1428244 · Cited by 75
TDP-43 pathology: From noxious assembly to therapeutic removal
Keating, S. S., Gil, R. S., Swanson, M. E. V., Scotter, E. L., & Walker, A. K. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102229 · Cited by 81
Microbiota-immune-brain interactions: A lifespan perspective
Ratsika, A., Cruz-Pereira, J. S., Lynch, C. M. K., Clarke, G. A., & Cryan, J. F. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102652 · Cited by 83
Magnesium and the Hallmarks of Aging
Dominguez, L. J., Veronese, N., & Barbagallo, M. (2024) · Nutrients · doi:10.3390/nu16040496 · Cited by 78
The application of nanoparticles-based ferroptosis, pyroptosis and autophagy in cancer immunotherapy
Deng, W., Shang, H., Tong, Y., Liu, X., Huang, Q., He, Y. T., Wu, J., Ba, X., Chen, Z., Chen, Y., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02297-8 · Cited by 80
Mitochondrial DNA signals driving immune responses: Why, How, Where?
Giordano, L., Ware, S. A., Lagranha, C. J., & Kaufman, B. A. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02042-0 · Cited by 82
Cellular Dormancy in Cancer: Mechanisms and Potential Targeting Strategies
Min, H.-Y., & Lee, H. (2023) · Cancer Research and Treatment · doi:10.4143/crt.2023.468 · Cited by 78
Rui, W., Xiao, H., Fan, Y., Ma, Z., Xiao, M., Li, S., & Shi, J. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02329-2 · Cited by 79
Autophagy in asthma and chronic obstructive pulmonary disease
Barnes, P. J., Baker, J. R., & Donnelly, L. (2022) · Clinical Science · doi:10.1042/cs20210900 · Cited by 73
Chen, W., Chen, C.-H., Hsu, M., Chang, R.-W., Wang, C., & Lee, T. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116192 · Cited by 70
Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies
Wei, Y., Giunta, S., & Xia, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158165 · Cited by 73
Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity
Ortmann, B. M. (2024) · BMJ Oncology · doi:10.1136/bmjonc-2023-000154 · Cited by 67
Subramanian, A., Tamilanban, T., Alsayari, A., Ramachawolran, G., Wong, L. S., Sekar, M., Gan, S. H., Subramaniyan, V., Chinni, S. V., Rani, N. N. I. M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1094351 · Cited by 70
Kakuda, K., Ikenaka, K., Kuma, A., Doi, J., Aguirre, C., Wang, N., Ajiki, T., Choong, C., Kimura, Y., Badawy, S. M. M., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2312306120 · Cited by 64
The mTOR–lysosome axis at the centre of ageing
Carosi, J. M., Fourrier, C., Bensalem, J., & Sargeant, T. J. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13347 · Cited by 70
mTOR signaling as a molecular target for the alleviation of Alzheimer's disease pathogenesis
Rapaka, D., Bitra, V. R., Challa, S. R., & Adiukwu, P. C. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105311 · Cited by 65
Geroscience and pathology: a new frontier in understanding age-related diseases
Fekete, M., Major, D., Fehér, Á., Fazekas‐Pongor, V., & Lehoczki, A. (2024) · Pathology & Oncology Research · doi:10.3389/pore.2024.1611623 · Cited by 67
The dual role of autophagy in acute myeloid leukemia
Seo, W., Silwal, P., Song, I., & Jo, E. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01262-y · Cited by 67
Kidney Aging and Chronic Kidney Disease
Zhang, Y., Chen, Y., & Li, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126585 · Cited by 72
Lipids associated with autophagy: mechanisms and therapeutic targets
Jarocki, M., Turek, K., Saczko, J., Tarek, M., & Kulbacka, J. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02224-8 · Cited by 68
TFEB is a central regulator of the aging process and age-related diseases
Abokyi, S., Ghartey‐Kwansah, G., & Tse, D. Y. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101985 · Cited by 61
Balancing lysosome abundance in health and disease
Mutvei, A. P., Nagiec, M. J., & Blenis, J. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01197-7 · Cited by 62
Rôżanowska, M. (2023) · Antioxidants · doi:10.3390/antiox12122111 · Cited by 61
The Promise of Piperine in Cancer Chemoprevention
Benayad, S., Wahnou, H., Kebbaj, R. E., Liagre, B., Sol, V., Oudghiri, M., Saad, E., Duval, R. E., & Limami, Y. (2023) · Cancers · doi:10.3390/cancers15225488 · Cited by 62
Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging
Wang, H., Yuan, T., Wang, Y., Liu, C., Li, D., Li, Z., & Sun, S. (2024) · Aging Cell · doi:10.1111/acel.14092 · Cited by 64
Liao, J., He, W., Li, L., Wang, J., Gong, L., Zhang, Q., & Lin, Z. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100016 · Cited by 63
Opportunities for Therapeutic Modulation of O-GlcNAc
Cheng, S. S., Mody, A. C., & Woo, C. M. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00417 · Cited by 64
Anti-aging effects and mechanisms of anthocyanins and their intestinal microflora metabolites
Wang, B., Tang, X., Mao, B., Zhang, Q., Tian, F., Zhao, J., Cui, S., & Chen, W. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2123444 · Cited by 55
Ballesteros‐Álvarez, J., Nguyen, W., Sivapatham, R., Rane, A., & Andersen, J. K. (2022) · GeroScience · doi:10.1007/s11357-022-00708-y · Cited by 60
Lifestyle effects on aging and CVD: A spotlight on the nutrient-sensing network
Yang, K., Hou, R., Zhao, J., Wang, X., Wei, J., Pan, X., & Zhu, X. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102121 · Cited by 59
Adapting health, economic and social policies to address population aging in China
Fang, E. F., Fang, Y., Chen, G., Wang, H., Zhang, J., Wu, C., Liao, J., Xie, C., Liu, X., Wang, K., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00999-8 · Cited by 64
Self-citation
Metadata
- Authors
- Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., Rubinsztein, D. C., Partridge, L., Kroemer, G., Labbadia, J., & Fang, E. F.
- Affiliations
- University of Oslo (NO)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Northwestern University (US)
- University of Oxford (GB)
- University College London (GB)
- National and Kapodistrian University of Athens (GR)
- Oslo University Hospital (NO)
- UiT The Arctic University of Norway (NO)
- University of Crete (GR)
- University of Cambridge (GB)
- Max Planck Institute for Biology of Ageing (DE)
- Karolinska University Hospital (SE)
- Corresponding author
- Labbadia, John
- ORCID
- Venue
- Nature Aging
- Published
- 2021-08-12
- Volume
- 1
- Issue
- 8
- Pages
- 634-650
- ISSN
- 2662-8465 (ISSN-L)
- PMC
- PMC8659158
- OpenAlex
- W3190631166
- Cited by
- 1,313
- References
- 250
- Citations by year
- 2026: 210 · 2025: 312 · 2024: 364 · 2023: 253 · 2022: 151 · 2021: 21
- FWCI
- 30.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Aging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- American Federation for Aging Research (GM117466)
- Larry L. Hillblom Foundation
- Kreftforeningen (190214, 207819, 249884, 171318)
- Kenneth Rainin Foundation (KRA000116)
- Wellcome Trust (FP7/2007–2013, ISSF3, 103830/Z/14/Z, 098565/Z/12/Z, 220784/Z/20/Z)
- Kennedy Trust for Rheumatology Research (KENN161708)
- Alzheimer's Society
- International Seafood Sustainability Foundation
- Cancer Research UK (FP7/2007-2013, A28990, C7893/ A28990, 28990)
- Academy of Medical Sciences (SBF004\1051)
- European Commission (262652, 2007–2013, FP7 2007-2013, FP7/2007, 233655)
- Agence Nationale de la Recherche (ANR-21-ESRE-0028, ANR-17-CE14-0030, ANR-18-IDEX-0001)
- National Natural Science Foundation of China (#81971327, FP7/2007-2013, 2021-021, FP7/2007)
- Ligue Contre le Cancer
- Max-Planck-Gesellschaft
- Centre National de la Recherche Scientifique (UMS3655)
- Norges Forskningsråd (#262652, #262175, 277813, 221831, 249884)
- Akershus Universitetssykehus (#269901, 261973)
- UK Dementia Research Institute (UKDRI-2002)
- National Institutes of Health (FP7/2007-2013, AG054407)
- Tau Consortium
- Medical Research Council (MR/M02492X/1)
- Biotechnology and Biological Sciences Research Council (BB/P005535/1, BB/T013273/1, ISSF3)
- Helse Sør-Øst RHF (2020001)
- National Institute on Aging (RF1AG057296, R37AG026647, P01AG054407, P01AG049665, R01AG038664)
- National Institute of General Medical Sciences (R01GM117466)
- H2020 European Research Council (695190, 842174)
- FP7 Ideas: European Research Council (268739)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, healthy aging, age-related diseases, lysosomal degradation, cellular homeostasis, autophagy modulators, neurodegenerative diseases, hallmarks of aging
- MeSH terms
- Healthy Aging, Aging, Autophagy, Humans, Lysosomes, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
