Cited by 1,313Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model OrganismsCalcium signaling and nucleotide metabolism

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Autophagy in healthy aging and disease

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Aman, Yahyah, Schmauck-Medina, Tomas, Hansen, Malene, Morimoto, Richard I., Simon, Anna Katharina, Bjedov, Ivana, Palikaras, Konstantinos, Simonsen, Anne, Johansen, Terje, Tavernarakis, Nektarios, Rubinsztein, David C., Partridge, Linda, Kroemer, Guido, Labbadia, John, Fang, Evandro F.·2021·Nature Aging

DOI 10.1038/s43587-021-00098-4PMC PMC8659158

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Abstract

Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In addition, we discuss current preclinical evidence arguing for the use of autophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases. Finally, we highlight key questions and propose novel research avenues that will likely reveal new links between autophagy and the hallmarks of aging. Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health.

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Authors: Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., Rubinsztein, D. C., Partridge, L., Kroemer, G., Labbadia, J., & Fang, E. F.
Affiliations: University of Oslo (NO)
Sanford Burnham Prebys Medical Discovery Institute (US)
Northwestern University (US)
University of Oxford (GB)
University College London (GB)
National and Kapodistrian University of Athens (GR)
Oslo University Hospital (NO)
UiT The Arctic University of Norway (NO)
University of Crete (GR)
University of Cambridge (GB)
Max Planck Institute for Biology of Ageing (DE)
Karolinska University Hospital (SE)
Corresponding author: Labbadia, John
ORCID: Aman, Yahyah
Schmauck-Medina, Tomas
Hansen, Malene
Morimoto, Richard I.
Simon, Anna Katharina
Bjedov, Ivana
Palikaras, Konstantinos
Simonsen, Anne
Johansen, Terje
Tavernarakis, Nektarios
Rubinsztein, David C.
Partridge, Linda
Kroemer, Guido
Labbadia, John
Fang, Evandro F.
Venue: Nature Aging
Publisher: Springer Science and Business Media LLC
Published: 2021-08-12
Volume: 1
Issue: 8
Pages: 634-650
ISSN: 2662-8465 (ISSN-L)
DOI: 10.1038/s43587-021-00098-4
PMC: PMC8659158
OpenAlex: W3190631166
Cited by: 1,313
References: 250
Citations by year: 2026: 210 · 2025: 312 · 2024: 364 · 2023: 253 · 2022: 151 · 2021: 21
FWCI: 30.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Aging (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion, other-oa)
MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
Apollo (University of Cambridge) (submittedVersion)
Apollo
Funders: American Federation for Aging Research (GM117466)
Larry L. Hillblom Foundation
Kreftforeningen (190214, 207819, 249884, 171318)
Kenneth Rainin Foundation (KRA000116)
Wellcome Trust (FP7/2007–2013, ISSF3, 103830/Z/14/Z, 098565/Z/12/Z, 220784/Z/20/Z)
Kennedy Trust for Rheumatology Research (KENN161708)
Alzheimer's Society
International Seafood Sustainability Foundation
Cancer Research UK (FP7/2007-2013, A28990, C7893/ A28990, 28990)
Academy of Medical Sciences (SBF004\1051)
European Commission (262652, 2007–2013, FP7 2007-2013, FP7/2007, 233655)
Agence Nationale de la Recherche (ANR-21-ESRE-0028, ANR-17-CE14-0030, ANR-18-IDEX-0001)
National Natural Science Foundation of China (#81971327, FP7/2007-2013, 2021-021, FP7/2007)
Ligue Contre le Cancer
Max-Planck-Gesellschaft
Centre National de la Recherche Scientifique (UMS3655)
Norges Forskningsråd (#262652, #262175, 277813, 221831, 249884)
Akershus Universitetssykehus (#269901, 261973)
UK Dementia Research Institute (UKDRI-2002)
National Institutes of Health (FP7/2007-2013, AG054407)
Tau Consortium
Medical Research Council (MR/M02492X/1)
Biotechnology and Biological Sciences Research Council (BB/P005535/1, BB/T013273/1, ISSF3)
Helse Sør-Øst RHF (2020001)
National Institute on Aging (RF1AG057296, R37AG026647, P01AG054407, P01AG049665, R01AG038664)
National Institute of General Medical Sciences (R01GM117466)
H2020 European Research Council (695190, 842174)
FP7 Ideas: European Research Council (268739)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: autophagy, healthy aging, age-related diseases, lysosomal degradation, cellular homeostasis, autophagy modulators, neurodegenerative diseases, hallmarks of aging
MeSH terms: Healthy Aging, Aging, Autophagy, Humans, Lysosomes, Neurodegenerative Diseases

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