The DOI matches its Crossref record; 249 of the 250 references it cites were found in a registry or an index.
Autophagy in healthy aging and disease
Open accessAbstract
Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In addition, we discuss current preclinical evidence arguing for the use of autophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases. Finally, we highlight key questions and propose novel research avenues that will likely reveal new links between autophagy and the hallmarks of aging. Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health.
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“Autophagy, a highly conserved metabolic degradation process, maintains cellular homeostasis by delivering intracellular protein aggregates and damaged organelles to lysosomes for degradation and recycling.220,221”
From Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies. (2024) · cites this paper as [221]
In the citing paper
“CCF formation is also associated with autophagy, a collection of cellular homeostatic processes for trafficking and degradation of macromolecules and cellular components (Aman et al., 2021), and specifically autophagic degradation of Lamin B1 in senescent cells.”
From Cytoplasmic DNA: sources, sensing, and role in aging and disease (2021) · cites this paper as Aman et al., 2021
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Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
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“220,221 It primarily occurs via three types: micro-autophagy, chaperone-mediated autophagy, and macroauto-phagy (commonly referred to as autophagy).”
BackgroundThe mechanisms and roles of selective autophagy in mammals
Vargas, J. N. S., Hamasaki, M., Kawabata, T., Youle, R. J., & Yoshimori, T. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00542-2 · Cited by 1,088
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Chronic inflammation and the hallmarks of aging
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Metadata
- Authors
- Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., Rubinsztein, D. C., Partridge, L., Kroemer, G., Labbadia, J., & Fang, E. F.
- Affiliations
- University of Oslo (NO)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Northwestern University (US)
- University of Oxford (GB)
- University College London (GB)
- National and Kapodistrian University of Athens (GR)
- Oslo University Hospital (NO)
- UiT The Arctic University of Norway (NO)
- University of Crete (GR)
- University of Cambridge (GB)
- Max Planck Institute for Biology of Ageing (DE)
- Karolinska University Hospital (SE)
- Corresponding author
- Labbadia, John
- ORCID
- Venue
- Nature Aging
- Published
- 2021-08-12
- Volume
- 1
- Issue
- 8
- Pages
- 634-650
- ISSN
- 2662-8465 (ISSN-L)
- PMC
- PMC8659158
- OpenAlex
- W3190631166
- Cited by
- 1,313
- References
- 250
- Citations by year
- 2026: 210 · 2025: 312 · 2024: 364 · 2023: 253 · 2022: 151 · 2021: 21
- FWCI
- 30.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Aging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- American Federation for Aging Research (GM117466)
- Larry L. Hillblom Foundation
- Kreftforeningen (190214, 207819, 249884, 171318)
- Kenneth Rainin Foundation (KRA000116)
- Wellcome Trust (FP7/2007–2013, ISSF3, 103830/Z/14/Z, 098565/Z/12/Z, 220784/Z/20/Z)
- Kennedy Trust for Rheumatology Research (KENN161708)
- Alzheimer's Society
- International Seafood Sustainability Foundation
- Cancer Research UK (FP7/2007-2013, A28990, C7893/ A28990, 28990)
- Academy of Medical Sciences (SBF004\1051)
- European Commission (262652, 2007–2013, FP7 2007-2013, FP7/2007, 233655)
- Agence Nationale de la Recherche (ANR-21-ESRE-0028, ANR-17-CE14-0030, ANR-18-IDEX-0001)
- National Natural Science Foundation of China (#81971327, FP7/2007-2013, 2021-021, FP7/2007)
- Ligue Contre le Cancer
- Max-Planck-Gesellschaft
- Centre National de la Recherche Scientifique (UMS3655)
- Norges Forskningsråd (#262652, #262175, 277813, 221831, 249884)
- Akershus Universitetssykehus (#269901, 261973)
- UK Dementia Research Institute (UKDRI-2002)
- National Institutes of Health (FP7/2007-2013, AG054407)
- Tau Consortium
- Medical Research Council (MR/M02492X/1)
- Biotechnology and Biological Sciences Research Council (BB/P005535/1, BB/T013273/1, ISSF3)
- Helse Sør-Øst RHF (2020001)
- National Institute on Aging (RF1AG057296, R37AG026647, P01AG054407, P01AG049665, R01AG038664)
- National Institute of General Medical Sciences (R01GM117466)
- H2020 European Research Council (695190, 842174)
- FP7 Ideas: European Research Council (268739)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, healthy aging, age-related diseases, lysosomal degradation, cellular homeostasis, autophagy modulators, neurodegenerative diseases, hallmarks of aging
- MeSH terms
- Healthy Aging, Aging, Autophagy, Humans, Lysosomes, Neurodegenerative Diseases
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