The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
Roles of PFKFB3 in cancer
Open accessAbstract
The understanding of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFK-2/FBPase 3, PFKFB3) has advanced considerably since its initial identification in human macrophages in the mid-1990s. As a vital regulator of glycolysis, accumulating studies have suggested that PFKFB3 is associated with many aspects of cancer, including carcinogenesis, cancer cell proliferation, vessel aggressiveness, drug resistance and tumor microenvironment. In this review, we summarize current knowledge of PFKFB3 regulation by several signal pathways and its function in cancer development in different cell types in cancer tissues. Ubiquitous PFKFB3 has emerged as a potential target for anti-neoplastic therapy.
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Daskalaki, I., Gkikas, I., & Tavernarakis, N. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00104 · Cited by 188
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Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies
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Metadata
- Authors
- Shi, L., Pan, H., Liu, Z., Xie, J., & Han, W.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2017-11-24
- Volume
- 2
- Issue
- 1
- Pages
- 17044-17044
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W2768908212
- Cited by
- 292
- References
- 129
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
