The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cannabinoid pharmacology: the first 66 years
Open accessAbstract
Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a cannabinoid was first detected in cannabis, is concisely reviewed. Also described is how this pharmacological research led to the discovery of cannabinoid CB 1 and CB 2 receptors and of endogenous ligands for these receptors, to the development of CB 1‐ and CB 2‐selective agonists and antagonists and to the realization that the endogenous cannabinoid system has significant roles in both health and disease, and that drugs which mimic, augment or block the actions of endogenously released cannabinoids must have important therapeutic applications. Some goals for future research are identified. British Journal of Pharmacology (2006) 147, S163–S171. doi:10.1038/sj.bjp.0706406
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Agurell, S., Halldin, M., Lindgren, J. E., Ohlsson, A., Widman, M., Gillespie, H., & Hollister, L. (1986) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06861-9 · Cited by 406
Cited by
Johnson, J. R., Burnell-Nugent, M., Lossignol, D., Ganae-Motan, E. D., Potts, R., & Fallon, M. T. (2010) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2009.06.008 · Cited by 622
The Endocannabinoid System and Pain
Guindon, J., & Hohmann, A. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709789824660 · Cited by 476
Emerging strategies for exploiting cannabinoid receptor agonists as medicines
Pertwee, R. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00048.x · Cited by 436
Self-citationThe Pharmacologic and Clinical Effects of Medical Cannabis
Borgelt, L. M., Franson, K. L., Nussbaum, A. M., & Wang, G. S. (2013) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1187 · Cited by 423
Portenoy, R. K., Ganae-Motan, E. D., Allende, S., Yanagihara, R., Shaiova, L., Weinstein, S., McQuade, R., Wright, S., & Fallon, M. T. (2012) · The Journal of Pain · doi:10.1016/j.jpain.2012.01.003 · Cited by 420
Early phytocannabinoid chemistry to endocannabinoids and beyond
Mechoulam, R., Hanuš, L. O., Pertwee, R., & Howlett, A. C. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3811 · Cited by 393
Self-citationFischedick, J. T., Hazekamp, A., Erkelens, T., Choi, Y. H., & Verpoorte, R. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.10.001 · Cited by 325
Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
Oláh, A., Tóth, B. I., Borbíró, I., Sugawara, K., Szöllõsi, A. G., Czifra, G., Pál, B., Ambrus, L., Kloepper, J., Camera, E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci64628 · Cited by 268
Phytocannabinoids beyond the Cannabis plant – do they exist?
Gertsch, J., Pertwee, R. G., & Di Marzo, V. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00745.x · Cited by 188
Self-citationAnand, U., Otto, W. R., Sanchez-Herrera, D., Facer, P., Yiangou, Y., Korchev, Y., Birch, R., Benham, C., Bountra, C., Chessell, I. P., et al. (2008) · Pain · doi:10.1016/j.pain.2008.06.007 · Cited by 166
Lim, K., See, Y. M., & Lee, J. (2017) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2017.15.4.301 · Cited by 166
Identification of candidate genes affecting Δ9-tetrahydrocannabinol biosynthesis in Cannabis sativa
Marks, M. D., Tian, L., Wenger, J. P., Omburo, S. N., Soto-Fuentes, W., He, J., Gang, D. R., Weiblen, G. D., & Dixon, R. A. (2009) · Journal of Experimental Botany · doi:10.1093/jxb/erp210 · Cited by 125
Dellazizzo, L., Potvin, S., Giguère, S., & Dumais, A. (2022) · Addiction · doi:10.1111/add.15764 · Cited by 120
An Analysis of Applicants Presenting to a Medical Marijuana Specialty Practice in California
Nunberg, H., Kilmer, B., Pacula, R. L., & Burgdorf, J. R. (2011) · Journal of Drug Policy Analysis · doi:10.2202/1941-2851.1017 · Cited by 121
Kuepper, R., Morrison, P. D., van Os, J., Murray, R. M., Kenis, G., & Henquet, C. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.05.031 · Cited by 116
A Systematic Review and Meta-Analysis of the Haemodynamic Effects of Cannabidiol
Sultan, S. R., Millar, S. A., England, T. J., & O'Sullivan, S. E. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00081 · Cited by 95
“…system, haemodynamic, blood pressure, heart rate, blood flow INTRODUCTION Cannabidiol (CBD) is the second most abundant phytocannabinoid, after 19- tetrahydrocannabinol (THC) (Pertwee, 2006; Tambaro and Bortolato, 2012) and was first isolated from the cannabis extract in 1940 (Adams et al., 1940).”
BackgroundZirpel, B., Stehle, F., & Kayser, O. (2015) · Biotechnology Letters · doi:10.1007/s10529-015-1853-x · Cited by 83
Da Fonseca Pacheco, D., Klein, A., De Castro Perez, A., Da Fonseca Pacheco, C. M., De Francischi, J. N., & Duarte, I. D. G. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.175 · Cited by 81
Taura, F., Dono, E., Sirikantaramas, S., Yoshimura, K., Shoyama, Y., & Morimoto, S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.079 · Cited by 60
Analgesic Effect of a Mixed T-Type Channel Inhibitor/CB2 Receptor Agonist
Gadotti, V. M., You, H., Petrov, R. R., Berger, N. D., Diaz, P., & Zamponi, G. W. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-32 · Cited by 45
Current Perspectives on Biotechnological Cannabinoid Production in Plants
Schachtsiek, J., Warzecha, H., Kayser, O., & Stehle, F. (2018) · Planta Medica · doi:10.1055/s-0043-125087 · Cited by 35
Metadata
- Authors
- Pertwee, R. G.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2006-01
- Volume
- 147
- Issue
- S1
- Pages
- S163-71
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1940834207
- Cited by
- 782
- References
- 1
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
