Cited by 219Cannabis and Cannabinoid ResearchCardiac Ischemia and ReperfusionOrgan Transplantation Techniques and Outcomes

The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.

Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning.

Open access

Pacher, P, Haskó, G·2008·British Journal of Pharmacology

DOI 10.1038/sj.bjp.0707582PMC PMC2219536

Open this paper in CoChat — free account Open PDF

Abstract

Ischaemia-reperfusion (I/R) is a pivotal mechanism of organ injury during stroke, myocardial infarction, organ transplantation and vascular surgeries. Ischaemic preconditioning (IPC) is a potent endogenous form of tissue protection against I/R injury. On the one hand, endocannabinoids have been implicated in the protective effects of IPC through cannabinoid CB1/CB2 receptor-dependent and -independent mechanisms. However, there is evidence suggesting that endocannabinoids are overproduced during various forms of I/R, such as myocardial infarction or whole body I/R associated with circulatory shock, and may contribute to the cardiovascular depressive state associated with these pathologies. Previous studies using synthetic CB1 receptor agonists or knockout mice demonstrated CB1 receptor-dependent protection against cerebral I/R injury in various animal models. In contrast, several follow-up reports have shown protection afforded by CB1 receptor antagonists, but not agonists. Excitedly, emerging studies using potent CB2 receptor agonists and/or knockout mice have provided compelling evidence that CB2 receptor activation is protective against myocardial, cerebral and hepatic I/R injuries by decreasing the endothelial cell activation/inflammatory response (for example, expression of adhesion molecules, secretion of chemokines, and so on), and by attenuating the leukocyte chemotaxis, rolling, adhesion to endothelium, activation and transendothelial migration, and interrelated oxidative/nitrosative damage. This review is aimed to discuss the role of endocannabinoids and CB receptors in various forms of I/R injury (myocardial, cerebral, hepatic and circulatory shock) and preconditioning, and to delineate the evidence supporting the therapeutic utility of selective CB2 receptor agonists, which are devoid of psychoactive effects, as a promising new approach to limit I/R-induced tissue damage.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/sj.bjp.0707582

Cites

132 of 132 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.
Murry, C. E., Jennings, R. B., & Reimer, K. A. (1986) · Circulation · doi:10.1161/01.cir.74.5.1124 · Cited by 7,813
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Self-citation
Molecular characterization of a peripheral receptor for cannabinoids
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
The Pathophysiology and Treatment of Sepsis
Hotchkiss, R. S., & Karl, I. E. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021333 · Cited by 4,134
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.161 · Cited by 2,819
Leukocyte-endothelial adhesion molecules
Carlos, T., & Harlan, J. (1994) · Blood · doi:10.1182/blood.v84.7.2068.bloodjournal8472068 · Cited by 2,687
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077
Self-citation
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957
Role of Endogenous Cannabinoids in Synaptic Signaling
Freund, T. F., Katona, I., & Piomelli, D. (2003) · Physiological Reviews · doi:10.1152/physrev.00004.2003 · Cited by 1,616
Identification and Functional Characterization of Brainstem Cannabinoid CB2Receptors
Van Sickle, M. D., Duncan, M., Kingsley, P. J., Mouihate, A., Urbani, P., Mackie, K., Stella, N., Makriyannis, A., Piomelli, D., Davison, J. S., et al. (2005) · Science · doi:10.1126/science.1115740 · Cited by 1,470
Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol
Pacher, P., Nivorozhkin, A., & Szabó, C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.6 · Cited by 1,218
Self-citation
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
Osei‐Hyiaman, D., DePetrillo, M. A., Pacher, P., Liu, J., Radaeva, S., Bátkai, S., Harvey-White, J. D., Mackie, K., Offertáler, L., Wang, L., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23057 · Cited by 1,131
Self-citation
The endocannabinoid system and its therapeutic exploitation
Marzo, V. D., Bifulco, M., & Petrocellis, L. D. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1495 · Cited by 1,090
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
Panikashvili, D., Simeonidou, C., Ben‐Shabat, S., Hanuš, L., Breuer, A., Mechoulam, R., & Shohami, E. (2001) · Nature · doi:10.1038/35097089 · Cited by 752
Cannabinoid-based drugs as anti-inflammatory therapeutics
Klein, T. W. (2005) · Nature Reviews Immunology · doi:10.1038/nri1602 · Cited by 728
Activation of the peripheral endocannabinoid system in human obesity
Engeli, S., Böhnke, J., Feldpausch, M., Gorzelniak, K., Janke, J., Bátkai, S., Pacher, P., Harvey-White, J., Luft, F. C., Sharma, A. M., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2838 · Cited by 686 · cited 2×
“, 2005d) and liver (Batkai et al., 2001; Engeli et al., 2005; Osei-Hyiaman et al., 2005; TeixeiraClerc et al., 2006).”
BackgroundSelf-citation
Pharmacological Actions of Cannabinoids
Pertwee, R. G. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_1 · Cited by 613
The pharmacology of cannabinoid receptors and their ligands: an overview
Pertwee, R. G. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803272 · Cited by 588
CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis
Teixeira-Clerc, F., Julien, B., Grenard, P., Nhieu, J. T. V., Deveaux, V., Li, L., Serrière-Lanneau, V., Ledent, C. A., Mallat, A., & Lotersztajn, S. (2006) · Nature Medicine · doi:10.1038/nm1421 · Cited by 527
CANNABINOID RECEPTORS AS THERAPEUTIC TARGETS
Mackie, K. (2005) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141254 · Cited by 518
Modulation of the cannabinoid CB 2 receptor in microglial cells in response to inflammatory stimuli
Maresz, K., Carrier, E. J., Ponomarev, E. D., Hillard, C. J., & Dittel, B. N. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03380.x · Cited by 490
A biosynthetic pathway for anandamide
Liu, J., Wang, L., Harvey-White, J. D., Osei‐Hyiaman, D., Razdan, R. J., Gong, Q., Chan, A. C., Zhou, Z., Huang, B. X., Kim, H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601832103 · Cited by 481
Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions
Jaeschke, H. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00568.2005 · Cited by 478
Antifibrogenic role of the cannabinoid receptor CB2 in the liver
Julien, B., Grenard, P., Teixeira-Clerc, F., Nhieu, J. T. V., Li, L., Karsak, M., Zimmer, A., Mallat, A., & Lotersztajn, S. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.12.050 · Cited by 470
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
Steffens, S., Veillard, N. R., Arnaud, C., Pelli, G., Burger, F., Staub, C., Zimmer, A. D., Frossard, J., & Mach, F. (2005) · Nature · doi:10.1038/nature03389 · Cited by 469
Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures
Nagayama, T., Sinor, A. D., Simon, R. P., Chen, J., Graham, S. H., Jin, K., & Greenberg, D. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-08-02987.1999 · Cited by 468
Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia‐reperfusion injury and preconditioning
Ferdinándy, P., & Schulz, R. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705080 · Cited by 439
Platelet‐ and macrophage‐derived endogenous cannabinoids are involved in endotoxin‐induced hypotension
Varga, K., Wagner, J. A., Bridgen, D. T., & Kunos, G. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.11.1035 · Cited by 411
Evidence for novel cannabinoid receptors
Begg, M., Pacher, P., Bátkai, S., Osei‐Hyiaman, D., Offertáler, L., Mo, F.-M., LIU, J., & Kunos, G. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.11.005 · Cited by 396
Self-citation
Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis
Bátkai, S., Járai, Z., Wagner, J. A., Goparaju, S. K., Varga, K., Liu, J., Wang, L., Mirshahi, F., Khanolkar, A. D., Makriyannis, A., et al. (2001) · Nature Medicine · doi:10.1038/89953 · Cited by 376
Mecanismos de lesión hepatocelular
Muntané, J., González, R., Ranchal, I., Collado, J. A., Lopez-Sanchez, L. M., Herencia, C., Rodríguez‐Ariza, A., Muñoz-Castañeda, J. R., & de la Mata, M. (2007) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082007000700007 · Cited by 350
Cannabinoids and neuroinflammation
Walter, L. M., & Stella, N. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705667 · Cited by 341
Functional CB1 cannabinoid receptors in human vascular endothelial cells
Liu, J., Gao, B., Mirshahi, F., Sanyal, A. J., Khanolkar, A. D., Makriyannis, A., & Kunos, G. (2000) · Biochemical Journal · doi:10.1042/bj3460835 · Cited by 339
Endocannabinoids Acting at Cannabinoid-1 Receptors Regulate Cardiovascular Function in Hypertension
Bátkai, S., Pacher, P., Osei‐Hyiaman, D., Radaeva, S., Liu, J., Harvey-White, J. D., Offertáler, L., Mackie, K., Rudd, M. A., Bukoski, R. D., et al. (2004) · Circulation · doi:10.1161/01.cir.0000143230.23252.d2 · Cited by 325
Self-citation
Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+channel current
Gebremedhin, D., Lange, A. R., Campbell, W. B., Hillard, C. J., & Harder, D. R. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.6.h2085 · Cited by 313
Inhibition of tumor angiogenesis by cannabinoids
Blázquez, C., Casanova, M., Planas, A. M., del Pulgar, T. G., Villanueva, C., Fernández‐Aceñero, M. J., Aragonés, J., Huffman, J. W., Jorcano, J. L., & Guzmán, M. (2003) · The FASEB Journal · doi:10.1096/fj.02-0795fje · Cited by 304
Cannabinoid Receptors and Endocannabinoids: Evidence for New Players
Mackie, K., & Stella, N. (2006) · The AAPS Journal · doi:10.1007/bf02854900 · Cited by 303
Endocannabinoids and the regulation of their levels in health and disease
Marzo, V. D., & Petrosino, S. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32803dbdec · Cited by 294
Preconditioning and postconditioning: United at reperfusion
Hausenloy, D. J., & Yellon, D. M. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.005 · Cited by 285
Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock
Wagner, J. A., Varga, K., Ellis, E. F., Rzigalinski, B. A., Martin, B. R., & Kunos, G. (1997) · Nature · doi:10.1038/37371 · Cited by 284
Potent Metalloporphyrin Peroxynitrite Decomposition Catalyst Protects Against the Development of Doxorubicin-Induced Cardiac Dysfunction
Pacher, P., Liaudet, L., Bai, P., Mabley, J. G., Kaminski, P. M., Virág, L., Deb, A., Szabó, É., Ungvari, Z. I., Wolin, M. S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000048192.52098.dd · Cited by 279
Self-citation
CB2-receptor stimulation attenuates TNF-α-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion
Rajesh, M., Mukhopadhyay, P., Bátkai, S., Haskó, G., Liaudet, L., Huffman, J. W., Csiszár, A., Ungvari, Z. I., Mackie, K., Chatterjee, S. B., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00688.2007 · Cited by 262
Self-citation
Sequential observation of micrometastasis formation by bacterial lacZ gene-tagged Lewis lung carcinoma cells
Kobayashi, K., Nakanishi, H., Masuda, A., Tezuka, N., Mutai, M., & Tatematsu, M. (1997) · Cancer Letters · doi:10.1016/s0304-3835(96)04569-7 · Cited by 257
Cannabinoid‐2 receptor mediates protection against hepatic ischemia/reperfusion injury
Bátkai, S., Osei‐Hyiaman, D., Pan, H., El-Assal, O. N., Rajesh, M., Mukhopadhyay, P., Hong, F., Harvey-White, J. D., Jafri, A., Haskó, G., et al. (2007) · The FASEB Journal · doi:10.1096/fj.06-7451com · Cited by 252
Self-citation
The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects
Johns, D. G., Behm, D. J., Walker, D. J., Zhang, A., Shapland, E. M., Daniels, D. A., Riddick, M., Dowell, S. J., Staton, P. C., Green, P., et al. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707419 · Cited by 251
Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors
Golech, S., McCarron, R. M., Chen, Y., Bembry, J., Lenz, F. A., Mechoulam, R., Shohami, E., & Spatz, M. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.08.025 · Cited by 248
Therapeutic Potential of Cannabinoids in CNS Disease
Croxford, J. L. (2003) · CNS Drugs · doi:10.2165/00023210-200317030-00004 · Cited by 241
Endogenous cannabinoids: A new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat
Ros, J., Clària, J., To‐Figueras, J., Planagumà, A., Cejudo–Martín, P., Fernández‐Varo, G., Martín‐Ruiz, R., Arroyo, V., Rivera, F., Rodés, J., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.30305 · Cited by 237
Nitrosative stress and pharmacological modulation of heart failure
Pacher, P., Schulz, R., Liaudet, L., & Szabó, C. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.04.003 · Cited by 237
Self-citation
Occurrence and postmortem generation of anandamide and other long‐chain N‐acylethanolamines in mammalian brain
Schmid, P. C., Krebsbach, R. J., Perry, S. R., Dettmer, T. M., Maasson, J. L., & Schmid, H. H. O. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01194-j · Cited by 235
Lipopolysaccharide Induces Anandamide Synthesis in Macrophages via CD14/MAPK/Phosphoinositide 3-Kinase/NF-κB Independently of Platelet-activating Factor
Liu, J., Bátkai, S., Pacher, P., Harvey-White, J. D., Wagner, J. A., Cravatt, B. F., Gao, B., & Kunos, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306062200 · Cited by 234
Self-citation
The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
Panikashvili, D., Shein, N. A., Mechoulam, R., Trembovler, V., Kohen, R., Alexandrovich, A. G., & Shohami, E. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.11.004 · Cited by 229
Cannabinoids and brain injury: therapeutic implications
Mechoulam, R. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02276-1 · Cited by 229
Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice
Parmentier‐Batteur, S., Jin, K., Mao, X. O., Xie, L., & Greenberg, D. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09771.2002 · Cited by 226
The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids
Pertwee, R. G. (2005) · The AAPS Journal · doi:10.1208/aapsj070364 · Cited by 218
Pharmacological Inhibition of CB1Cannabinoid Receptor Protects Against Doxorubicin-Induced Cardiotoxicity
Mukhopadhyay, P., Bátkai, S., Rajesh, M., Czifra, N., Harvey-White, J. D., Haskó, G., Zsengellér, Z. K., Gerard, N. P., Liaudet, L., Kunos, G., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.03.057 · Cited by 208
Self-citation
Role of Oxidative-Nitrosative Stress and Downstream Pathways in Various Forms of Cardiomyopathy and Heart Failure
Ungvari, Z. I., Gupte, S. A., Recchia, F. A., Bátkai, S., & Pacher, P. (2005) · Current Vascular Pharmacology · doi:10.2174/1570161054368607 · Cited by 205
Self-citation
Modulation of Leukocyte-Mediated Myocardial Reperfusion Injury
Lucchesi, B. R. (1990) · Annual Review of Physiology · doi:10.1146/annurev.ph.52.030190.003021 · Cited by 204
Neuroprotective Antioxidants from Marijuana a
Hampson, A. J., GRIMALDI, M., Miljkovic-Lolic, M., Wink, D. A., Rosenthal, R., & Axelrod, J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06193.x · Cited by 203
Preconditioning: a paradigm shift in the biology of myocardial ischemia
Bolli, R. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00712.2006 · Cited by 197
Mechanisms of Inflammatory Liver Injury: Adhesion Molecules and Cytotoxicity of Neutrophils
Jaeschke, H., Smith, C. W., Clemens, M. G., Ganey, P. E., & Roth, R. A. (1996) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.0160 · Cited by 189
CB 1 cannabinoid receptors are involved in neuroprotection via NF-κB inhibition
Panikashvili, D., Mechoulam, R., Beni, S. M., Alexandrovich, A. G., & Shohami, E. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600047 · Cited by 180
Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats
Sinor, A. D., Irvin, S. M., & Greenberg, D. A. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00922-2 · Cited by 175
Anandamide induces necrosis in primary hepatic stellate cells†‡
Siegmund, S., Uchinami, H., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2005) · Hepatology · doi:10.1002/hep.20667 · Cited by 171
Effects of Cannabinoid Receptor Agonist and Antagonist Ligands on Production of Inflammatory Cytokines and Anti-Inflammatory Interleukin-10 in Endotoxemic Mice
Smith, S. R., Terminelli, C., & Denhardt, G. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39213-4 · Cited by 170
Cardiovascular Pharmacology of Cannabinoids
Pacher, P., Bátkai, S., & Kunos, G. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_20 · Cited by 169
Self-citation
Cannabinoid CB 2 Receptor Activation Decreases Cerebral Infarction in a Mouse Focal Ischemia/Reperfusion Model
Zhang, M., Martin, B. R., Adler, M. W., Razdan, R. K., Jallo, J., & Tuma, R. F. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600447 · Cited by 165
Lipopolysaccharide Downregulates Fatty Acid Amide Hydrolase Expression and Increases Anandamide Levels in Human Peripheral Lymphocytes
Maccarrone, M., PETROCELLIS, L. D., Bari, M., Fezza, F., Salvati, S., Marzo, V. D., & Finazzi‐Agrò, A. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2500 · Cited by 162
Massive accumulation of N‐acylethanolamines after stroke. Cell signalling in acute cerebral ischemia?
Berger, C., Schmid, P. C., Schäbitz, W.-R., Wolf, M., Schwab, S., & Schmid, H. H. O. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02244.x · Cited by 154
Pivotal Advance: Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis
Rajesh, M., Pan, H., Mukhopadhyay, P., Bátkai, S., Osei‐Hyiaman, D., Haskó, G., Liaudet, L., Gao, B., & Pacher, P. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0307180 · Cited by 154
Self-citation
Cannabinoid Receptors and Endocannabinoids: Evidence for New Players
Mackie, K., & Stella, N. (2006) · The AAPS Journal · doi:10.1208/aapsj080234 · Cited by 149
Endogenous cannabinoids mediate hypotension after experimental myocardial infarction
Wagner, J. A., Hu, K., Bauersachs, J. K., Karcher, J. C., Wiesler, M., Goparaju, S. K., Kunos, G., & Ertl, G. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01671-0 · Cited by 148
Endocannabinoids and Neuroprotection
Mechoulam, R., Spatz, M., & Shohami, E. (2002) · Science s STKE · doi:10.1126/stke.2002.129.re5 · Cited by 147
Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia
Muthian, S., Rademacher, D. J., Roelke, C. T., Gross, G. J., & Hillard, C. J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.044 · Cited by 143
Involvement of the Endocannabinoid System in Retinal Damage after High Intraocular Pressure–Induced Ischemia in Rats
Nucci, C., Gasperi, V., Tartaglione, R., Cerulli, A., Terrinoni, A., Bari, M., Simone, C. D., Finazzi‐Agrò, A., Morrone, L. A., Corasaniti, M. T., et al. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1355 · Cited by 137
Cellular adhesion molecules: regulation and functional significance in the pathogenesis of liver diseases
Jaeschke, H. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.3.g602 · Cited by 136
Endocannabinoids protect the rat isolated heart against ischaemia
Lépicier, P., Bouchard, J., Lagneux, C., & Lamontagne, D. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705313 · Cited by 133
Cardiovascular effects of cannabinoids
Randall, M. D., Harris, D., Kendall, D. A., & Ralevic, V. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00258-9 · Cited by 132
Anandamide initiates Ca2+ signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells
Zoratti, C., Kipmen‐Korgun, D., Osibow, K., Malli, R., & Graier, W. F. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705529 · Cited by 131
Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain
Ashton, J. C., Rahman, R. M. A., Nair, S. M., Sutherland, B. A., Glass, M., & Appleton, I. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.10.053 · Cited by 131
Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN
Filippo, C. D., Rossi, F., Rossi, S., & D’Amico, M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703303 · Cited by 129
Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct‐ligated rats
Gaskari, S. A., Liu, H., Moezi, L., Li, Y., Baik, S. K., & Lee, S. S. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706331 · Cited by 128
Management of acute ischaemic stroke: new guidelines from the American Stroke Association and European Stroke Initiative
Klijn, C. J. M., & Hankey, G. J. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00558-1 · Cited by 127
Cannabinoids: Between Neuroprotection and Neurotoxicity
Sarne, Y., & Mechoulam, R. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/156800705774933005 · Cited by 120
Endocannabinoids acting at CB1receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats
Bátkai, S., Mukhopadhyay, P., Harvey-White, J. D., Kechrid, R., Pacher, P., & Kunos, G. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00538.2007 · Cited by 118
Self-citation
Drug-Induced Hypothermia Reduces Ischemic Damage
Leker, R. R., Gai, N., Mechoulam, R., & Ovadia, H. (2003) · Stroke · doi:10.1161/01.str.0000079817.68944.1e · Cited by 115
Release of Fatty Acid Amides in a Patient With Hemispheric Stroke
Schäbitz, W.-R., Giuffrida, A., Berger, C., Aschoff, A. A., Schwaninger, M., Schwab, S., & Piomelli, D. (2002) · Stroke · doi:10.1161/01.str.0000023491.63693.18 · Cited by 111
Realizing the clinical potential of ischemic preconditioning and postconditioning
Yellon, D. M., & Hausenloy, D. J. (2005) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0346 · Cited by 105
Cannabinoids as therapeutic agents in cardiovascular disease: a tale of passions and illusions
Mendizábal, V. E., & Adler‐Graschinsky, E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707261 · Cited by 101
Characterization of the Diarylether Sulfonylester (−)-(R)-3-(2-Hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271) as a Potent Cannabinoid Receptor Agonist with Neuroprotective Properties
Mauler, F., Mittendorf, J., Horváth, E., & Vry, J. D. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.302.1.359 · Cited by 98
Involvement of cannabinoids in the cardioprotection induced by lipopolysaccharide
Lagneux, C., & Lamontagne, D. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703902 · Cited by 97
Fatty Acid Amide Hydrolase Determines Anandamide-induced Cell Death in the Liver
Siegmund, S., Seki, E., Osawa, Y., Uchinami, H., Cravatt, B. F., & Schwabe, R. F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509706200 · Cited by 95
Blood pressure regulation by endocannabinoids and their receptors
Pacher, P., Bátkai, S., & Kunos, G. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.12.005 · Cited by 94
Self-citation
Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart
Bouchard, J., Lépicier, P., & Lamontagne, D. (2003) · Life Sciences · doi:10.1016/s0024-3205(02)02474-8 · Cited by 93
Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts
Joyeux‐Faure, M. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00268-7 · Cited by 92
The anti-inflammatory activities of cannabinoid receptor ligands in mouse peritonitis models
Smith, S. R., Denhardt, G., & Terminelli, C. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01477-7 · Cited by 91
Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB1 and VR1 receptors
Moezi, L., Gaskari, S. A., Liu, H., Baik, S. K., Dehpour, A. R., & Lee, S. S. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706928 · Cited by 82
Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase
Pacher, P., Bátkai, S., Osei‐Hyiaman, D., Offertáler, L., Liu, J., Harvey-White, J., Brassai, A., Járai, Z., Cravatt, B. F., & Kunos, G. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00107.2005 · Cited by 79
Self-citation
Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia–reperfusion by a novel cannabinoid mechanism
Underdown, N. J., Hiley, C. R., & Ford, W. R. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706391 · Cited by 71
Cannabinoid pharmacology in the cardiovascular system: potential protective mechanisms through lipid signalling
Hiley, C. R., & Ford, W. R. (2004) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793103006201 · Cited by 70
Delta-9-tetrahydrocannabinol protects cardiac cells from hypoxia via CB2 receptor activation and nitric oxide production
Shmist, Y. A., Goncharov, I., Eichler, M., Shneyvays, V., Isaac, A., Vogel, Z., & Shainberg, A. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-2346-y · Cited by 68
Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors
Bátkai, S., Pacher, P., Járai, Z., Wagner, J. A., & Kunos, G. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00184.2004 · Cited by 64
Self-citation
CB 1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction
Wagner, J. A., Hu, K., Karcher, J. C., Bauersachs, J. K., Schäfer, A., Laser, M., Han, H. J., & Ertl, G. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705156 · Cited by 63
Cannabinoid receptors as new targets of antifibrosing strategies during chronic liver diseases
Mallat, A., Teixeira-Clerc, F., Deveaux, V., & Lotersztajn, S. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.3.403 · Cited by 62
Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism
Hayakawa, K., Mishima, K., Abe, K., Hasebe, N., Takamatsu, F., Yasuda, H., Ikeda, T., Inui, K., Egashira, N., Iwasaki, K., et al. (2004) · Neuroreport · doi:10.1097/00001756-200410250-00016 · Cited by 56
The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection
Mestre, L., Correa, F., Docagne, F., Clemente, D., & Guaza, C. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.06.037 · Cited by 54
Resorcinol Derivatives: A Novel Template for the Development of Cannabinoid CB1/CB2 and CB2-Selective Agonists
Wiley, J. L., Beletskaya, I. D., Ng, E. W., Dai, Z., Crocker, P. J., Mahadevan, A., Razdan, R. K., & Martin, B. R. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.2.679 · Cited by 54
Additional Outcomes and Subgroup Analyses of NXY-059 for Acute Ischemic Stroke in the SAINT I Trial
Lees, K. R., Dávalos, A., Davis, S. M., Diener, H., Grotta, J. C., Lyden, P. D., Shuaib, A. M., Ashwood, T. J., Hårdemark, H., Wasiewski, W. W., et al. (2006) · Stroke · doi:10.1161/01.str.0000249410.91473.44 · Cited by 53
2-Arachidonylglycerol Acting on CB1 Cannabinoid Receptors Mediates Delayed Cardioprotection Induced by Nitric Oxide in Rat Isolated Hearts
Wagner, J. A., Abeßer, M., Harvey-White, J. D., & Ertl, G. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000211752.08949.eb · Cited by 52
Activation of Type II Cannabinoid Receptors Improves Myocardial Tolerance to Arrhythmogenic Effects of Coronary Occlusion and Reperfusion
Krylatov, A. V., Ugdyzhekova, D. S., Бернацкая, Н. А., Маслов, Л. Н., Mekhoulam, R., Pertwee, R. G., & Stephano, G. B. (2001) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1012381914518 · Cited by 51
The effect of δ-9-tetrahydrocannabinol on forebrain ischemia in rat
Louw, D. F., Yang, F. W., & Sutherland, G. R. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02422-1 · Cited by 51
The Cannabinoid 1 Receptor Antagonist, AM251, Prolongs the Survival of Rats with Severe Acute Pancreatitis
Matsuda, K., Mikami, Y., Takeda, K., Fukuyama, S., Egawa, S., Sunamura, M., Maruyama, I., & Matsuno, S. (2005) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.207.99 · Cited by 50
Neuroprotective cannabinoid receptor antagonist SR141716A prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra
Sommer, C., Schomacher, M., Berger, C., Kuhnert, K., Müller, H. D., Schwab, S., & Schäbitz, W. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0110-8 · Cited by 48
GPR55 and the vascular receptors for cannabinoids
Hiley, C. R., & Kaup, S. S. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707421 · Cited by 44
Effect of chronic CB1 cannabinoid receptor antagonism on livers of rats with biliary cirrhosis
Yang, Y., Lin, H., Huang, Y., Lee, T.-Y., Hou, M., Wang, Y., Lee, F., & Lee, S. (2007) · Clinical Science · doi:10.1042/cs20060260 · Cited by 39
Role of Nitrosative Stress and Activation of Poly(ADP-ribose) Polymerase-1 in Cardiovascular Failure Associated with Septic and Hemorrhagic Shock
Evgenov, O. V., & Liaudet, L. (2005) · Current Vascular Pharmacology · doi:10.2174/1570161054368580 · Cited by 38
The endogenous cardiac cannabinoid system: a new protective mechanism against myocardial ischemia.
Lamontagne, D., Lépicier, P., Lagneux, C., & Bouchard, J. (2006) · PubMed · Cited by 35
Differential cardiac gene expression during cardiopulmonary bypass: Ischemia-independent upregulation of proinflammatory genes
Podgoreanu, M. V., Michelotti, G. A., Sato, Y., Smith, M. P., Lin, S. M., Morris, R. W., Grocott, H. P., Mathew, J. P., & Schwinn, D. A. (2005) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2004.11.052 · Cited by 34
Signaling Pathways Involved in the Cardioprotective Effects of Cannabinoids
Lépicier, P., Bibeau-Poirier, A., Lagneux, C., Servant, M. J., & Lamontagne, D. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj06011x · Cited by 33
2-Arachidonoylglycerol Increases in Ischemia–Reperfusion Injury of the Rat Liver
Kurabayashi, M., Takeyoshi, I., Yoshinari, D., Matsumoto, K., Maruyama, I., & Morishita, Y. (2005) · Journal of Investigative Surgery · doi:10.1080/08941930590905189 · Cited by 32
Endogenous Cannabinoid Anandamide Increases Heart Resistance to Arrhythmogenic Effects of Epinephrine: Role of CB1 and CB2 Receptors
Ugdyzhekova, D. S., Бернацкая, Н. А., Stefano, J. B., Graier, V. F., Tam, S. W., & Mekhoulam, R. (2001) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1017651432193 · Cited by 29
Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats
Kadoi, Y., Hinohara, H., Kunimoto, F., Saito, S., & Goto, F. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000187010.14426.cc · Cited by 27
Activation of Cannabinoid Receptors Decreases the Area of Ischemic Myocardial Necrosis
Ugdyzhekova, D. S., Krylatov, A. V., Бернацкая, Н. А., Маслов, Л. Н., Mechoulam, R., & Pertwee, R. G. (2002) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1015526217332 · Cited by 18
Cirrhotic cardiomyopathy: an endocannabinoid connection?
Pacher, P., Bátkai, S., & Kunos, G. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706332 · Cited by 18
Self-citation
[Anandamide and R-(+)-methanandamide prevent development of ischemic and reperfusion arrhythmia in rats by stimulation of CB2-receptors].
Krylatov, A. V., Uzhachenko, R. V., Маслов, Л. Н., Ugdyzhekova, D. S., Бернацкая, Н. А., Pertwee, R. G., Stefano, G. B., & Makriyannis, A. (2002) · PubMed · Cited by 17
Effects of AM281, a cannabinoid antagonist, on circulatory deterioration and cytokine production in an endotoxin shock model: comparison with norepinephrine
Kadoi, Y., & Goto, F. (2006) · Journal of Anesthesia · doi:10.1007/s00540-006-0428-3 · Cited by 17
[Increase of the heart arrhythmogenic resistance and decrease of the myocardial necrosis zone during activation of cannabinoid receptors].
Krylatov, A. V., Бернацкая, Н. А., Маслов, Л. Н., Pertwee, R. G., Mechoulam, R., Stefano, G. B., Ma, S., & Om, S. (2002) · PubMed · Cited by 12
Kupffer’s cells modulate neutrophile activity by superoxide anion and tumor necrosis factor–∂ in reperfusion injury of liver transplantation-mechanisms of radical generation and reperfusion injury after cold ischemia
Ohkohchi, N., Shibuya, H., Tsukamoto, S., Sakurada, M., Oikawa, K., Terashima, T., & Satomi, S. (1999) · Transplantation Proceedings · doi:10.1016/s0041-1345(98)01902-2 · Cited by 10
Cannabinoid CB1 receptor blockade enhances the protective effect of melanocortins in hemorrhagic shock in the rat
Cainazzo, M. M., Ferrazza, G., Mioni, C., Bazzani, C., Bertolini, A., & Guarini, S. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01487-5 · Cited by 8

Flagged first, then by citations

Research works printed but not linked: 1

10.1172/JCI200523057 · DOI

Sorted by citations

Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly
Pacher, P., Steffens, S., Haskó, G., Schindler, T. H., & Kunos, G. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.130 · Cited by 453
Self-citation
Emerging strategies for exploiting cannabinoid receptor agonists as medicines
Pertwee, R. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00048.x · Cited by 436
Is lipid signaling through cannabinoid 2 receptors part of a protective system?
Pacher, P., & Mechoulam, R. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.01.001 · Cited by 435
Self-citation
Role of liver sinusoidal endothelial cells in liver diseases
Gracia‐Sancho, J., Caparrós, E., Fernández‐Iglesias, A., & Francés, R. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00411-3 · Cited by 436
Modulating the endocannabinoid system in human health and disease – successes and failures
Pacher, P., & Kunos, G. (2013) · FEBS Journal · doi:10.1111/febs.12260 · Cited by 418
Self-citation

See all 219

Authors: Pacher, P., & Haskó, G.
Affiliations: National Institutes of Health (US)
Rutgers New Jersey Medical School (US)
Corresponding author: Pacher, P
ORCID: Pacher, P
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2008-01
Volume: 153
Issue: 2
Pages: 252-262
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1038/sj.bjp.0707582
PMC: PMC2219536
OpenAlex: W2027688921
Cited by: 217
References: 132
Citations by year: 2026: 3 · 2025: 8 · 2024: 8 · 2023: 11 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 15 · 2014: 14 · 2013: 12 · 2012: 14
FWCI: 2.13
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 394 d)
Locations: British Journal of Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (Z99‐AA999999)
National Institute on Alcohol Abuse and Alcoholism (Z01AA000375)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords: endocannabinoids, cannabinoid receptors, CB1 receptor, CB2 receptor, ischemia-reperfusion injury, ischemic preconditioning, myocardial infarction, cerebral ischemia, hepatic ischemia, shock, CB2 receptor agonist, endothelial activation, inflammation, leukocyte transendothelial migration, oxidative stress, neuroprotection
MeSH terms: Animals, Humans, Liver Diseases, Shock, Reperfusion Injury, Myocardial Reperfusion Injury, Ischemic Preconditioning, Stroke, Receptors, Cannabinoid, Cannabinoid Receptor Modulators, Cannabinoid Receptor Agonists, Endocannabinoids

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks