Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

Cao, X., & Südhof, T. C. (2001) · Science · doi:10.1126/science.1058783 · Cited by 1,202

Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

Kamal, A., Almenar-Queralt, A., LeBlanc, J. F., Roberts, E. A., & Goldstein, L. S. B. (2001) · Nature · doi:10.1038/414643a · Cited by 583

Amyloid Precursor Protein Processing and Alzheimer's Disease

O'Brien, R. J., & Wong, P. C. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113613 · Cited by 2,061

Amyloid Precursor Protein Trafficking, Processing, and Function

Thinakaran, G., & Koo, E. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800019200 · Cited by 1,141

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009505 · Cited by 1,060

APP processing in Alzheimer’s disease.

Zhang, Y.-W., Thompson, R., Zhang, H., & Xu, H. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-3 · Cited by 983

Demystifying Heparan Sulfate–Protein Interactions

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Not just amyloid: physiological functions of the amyloid precursor protein family

Müller, U. C., Deller, T., & Korte, M. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.29 · Cited by 634

The Alzheimer's disease Beta-secretase enzyme, BACE1

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Synaptic degeneration in Alzheimer's disease

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The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice

Ring, S., Weyer, S. W., Kilian, S. B., Waldron, E., Pietrzik, C. U., Filippov, M. A., Herms, J., Buchholz, C., Eckman, C. B., Korte, M., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1026-07.2007 · Cited by 390

Alzheimer disease models and human neuropathology: similarities and differences

Duyckaerts, C., Potier, M.-C., & Delatour, B. (2008) · Acta Neuropathologica · doi:10.1007/s00401-007-0312-8 · Cited by 375

A Critical Function for β-Amyloid Precursor Protein in Neuronal Migration Revealed by In Utero RNA Interference

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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

Liu, Q., Zerbinatti, C. V., Zhang, J., Hoe, H.-S., Wang, B., Cole, S. L., Herz, J., Muglia, L., & Bu, G. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.008 · Cited by 364

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

Vassar, R., Kuhn, P., Haass, C., Kennedy, M. E., Rajendran, L., Wong, P. C., & Lichtenthaler, S. F. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12715 · Cited by 311

Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseases

Alexander, A. G., Marfil, V., & Li, C. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00279 · Cited by 310

Energy Inhibition Elevates β-Secretase Levels and Activity and Is Potentially Amyloidogenic in APP Transgenic Mice: Possible Early Events in Alzheimer's Disease Pathogenesis

Velliquette, R. A., O'Connor, T., & Vassar, R. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2350-05.2005 · Cited by 254

Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth

Hoe, H.-S., Lee, K. J., Carney, R. S. E., Lee, J., Markova, A., Lee, J.-Y., Howell, B. W., Hyman, B. T., Pak, D. T. S., Bu, G., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4872-08.2009 · Cited by 219

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

Hick, M., Herrmann, U., Weyer, S. W., Mallm, J.-P., Tschäpe, J.-A., Borgers, M., Mercken, M., Roth, F. C., Draguhn, A., Slomianka, L., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-014-1368-x · Cited by 191

Molecular Dissection of the Interaction between Amyloid Precursor Protein and Its Neuronal Trafficking Receptor SorLA/LR11

Andersen, O. M., Schmidt, V., Spoelgen, R., Gliemann, J., Behlke, J., Galatis, D., McKinstry, W. J., Parker, M. W., Masters, C. L., Hyman, B. T., et al. (2006) · Biochemistry · doi:10.1021/bi052120v · Cited by 178

DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing

Hoe, H.-S., Tran, T. S., Matsuoka, Y., Howell, B. W., & Rebeck, G. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602162200 · Cited by 174

Perinatal iron deficiency results in altered developmental expression of genes mediating energy metabolism and neuronal morphogenesis in hippocampus

Carlson, E. S., Stead, J. D. H., Neal, C. R., Petryk, A., & Georgieff, M. K. (2007) · Hippocampus · doi:10.1002/hipo.20307 · Cited by 141

Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family

Cam (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-8 · Cited by 106

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

Li, H., Wang, B., Wang, Z., Guo, Q., Tabuchi, K., Hammer, R. E., Südhof, T. C., & Zheng, H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012568107 · Cited by 100

Small things matter: implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer’s disease.

Bukhari, H., Glotzbach, A., Kolbe, K., Leonhardt, G., Loosse, C., & Müller, T. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.005 · Cited by 88

Amyloid precursor protein (APP) May act as a substrate and a recognition unit for CRL4CRBN and Stub1 E3 ligases facilitating ubiquitination of proteins involved in presynaptic functions and neurodegeneration

Del Prete, D., Rice, R. C., Rajadhyaksha, A. M., & D'Adamio, L. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.733626 · Cited by 86

The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimers Disease

Vassar, R., & Cole, S. (2007) · Current Genomics · doi:10.2174/138920207783769512 · Cited by 84

The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior

Klevanski, M., Herrmann, U., Weyer, S. W., Fol, R., Cartier, N., Wolfer, D. P., Caldwell, J. H., Korte, M., & Müller, U. C. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2009-15.2015 · Cited by 83

Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis

Tamboli, I. Y., Prager, K., Thal, D. R., Thelen, K. M., Dewachter, I., Pietrzik, C. U., St. George-Hyslop, P., Sisodia, S. S., De Strooper, B., Heneka, M. T., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2635-08.2008 · Cited by 68

Beyond pathology: APP, brain development and Alzheimer's disease

Soldano, A., & Hassan, B. A. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.02.003 · Cited by 54

Amyloid Precursor Protein Is an Autonomous Growth Cone Adhesion Molecule Engaged in Contact Guidance

Sosa, L. J., Bergman, J., Estrada-Bernal, A., Glorioso, T. J., Kittelson, J. M., & Pfenninger, K. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064521 · Cited by 53

Shedding of APP limits its synaptogenic activity and cell adhesion properties

Stahl, R., Schilling, S., Soba, P., Rupp, C., Hartmann, T., Wagner, K., Merdes, G., Eggert, S., & Kins, S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00410 · Cited by 53

A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching

Ikin, A. F., Sabo, S. L., Lanier, L. M., & Buxbaum, J. D. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.02.003 · Cited by 38

Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer’s disease

Lemmens, M. A. M., Sierksma, A. S. R., Rutten, B. P. F., Dennissen, F., Steinbusch, H. W. M., Lucassen, P. J., & Schmitz, C. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0305-1 · Cited by 37