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Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling

Hanyaloglu, Aylin C, McCullagh, Emma, von Zastrow, Mark·2005·The EMBO Journal
DOI 10.1038/sj.emboj.7600688
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Abstract

Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is well known to terminate cell signaling by sorting activated receptors to the MVB/lysosomal pathway. Here we identify a distinct role of Hrs in promoting rapid recycling of endocytosed signaling receptors to the plasma membrane. This function of Hrs is specific for receptors that recycle in a sequence-directed manner, in contrast to default recycling by bulk membrane flow, and is distinguishable in several ways from previously identified membrane-trafficking functions of Hrs/Vps27p. In particular, Hrs function in sequence-directed recycling does not require other mammalian Class E gene products involved in MVB/lysosomal sorting, nor is receptor ubiquitination required. Mutational studies suggest that the VHS domain of Hrs plays an important role in sequence-directed recycling. Disrupting Hrs-dependent recycling prevented functional resensitization of the beta(2)-adrenergic receptor, converting the temporal profile of cell signaling by this prototypic G protein-coupled receptor from sustained to transient. These studies identify a novel function of Hrs in a cargo-specific recycling mechanism, which is critical to controlling functional activity of the largest known family of signaling receptors.

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  • The ESCRT-0 complex partitions cargo arriving at the sorting endosome between recycling and progression to the MVB.

    “The ESCRT-0 complex, consisting of adaptor proteins hepatocyte growth factor-regulated substrate (Hrs) and signal transducing adaptor molecule (STAM) (9), partitions cargo arriving at the sorting endosome between recycling and progression to the MVB (10 -13)”

    From Regulation of Epidermal Growth Factor Receptor Ubiquitination and Trafficking by the USP8·STAM Complex (2010) · cites this paper as [10]

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Metadata

Authors
Hanyaloglu, A. C., McCullagh, E., & von Zastrow, M.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2005-06-09
Volume
24
Issue
13
Pages
2265-2283
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.1038/sj.emboj.7600688
Cited by
119
References
1
Language
en
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