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p63 is upstream of IKKα in epidermal development

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Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with ΔNp73

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Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure

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CD74 induces TAp63 expression leading to B-cell survival

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p63/p73 in the control of cell cycle and cell death

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The role of P63 in cancer, stem cells and cancer stem cells

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p63 regulates glutaminase 2 expression

Giacobbe, A., Bongiorno‐Borbone, L., Bernassola, F., Terrinoni, A., Markert, E. K., Levine, A. J., Fen, Z., Agostini, M., Zolla, L., Finazzi‐Agrò, A., et al. (2013) · Cell Cycle · doi:10.4161/cc.24478 · Cited by 79 · see citing works

MicroRNA-21: a ubiquitously expressed pro-survival factor in cancer and other diseases

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Identification of NCF2/p67phox as a novel p53 target gene

Italiano, D., Lena, A. M., Melino, G., & Candi, E. (2012) · Cell Cycle · doi:10.4161/cc.22853 · Cited by 74 · see citing works

A double dealing tale of p63: an oncogene or a tumor suppressor

Chen, Y., Peng, Y., Fan, S., Li, Y., Xiao, Z. J., & Li, C. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2666-y · Cited by 74 · see citing works

The role of MiRNA-21 in gliomas: Hope for a novel therapeutic intervention?

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Tumor suppressors: enhancers or suppressors of regeneration?

Pomerantz, J. H., & Blau, H. M. (2013) · Development · doi:10.1242/dev.084210 · Cited by 67 · see citing works

p63 at the Crossroads between Stemness and Metastasis in Breast Cancer

Gatti, V., Bongiorno‐Borbone, L., Fierro, C., Annicchiarico‐Petruzzelli, M., Melino, G., & Peschiaroli, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112683 · Cited by 68 · see citing works

The role of p63 in germ cell apoptosis in the developing testis

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Biological functions and clinical significance of the newly identified long non‑coding RNA RP1‑85F18.6 in colorectal cancer

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Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade

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p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis

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TAp63α induces AP-2γ as an early event in epidermal morphogenesis

Koster, M. I., Kim, S., Huang, J. J., Williams, T., & Roop, D. R. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.10.041 · Cited by 61 · see citing works

Activation of TGF‐β within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor

Gressner, O. A., Lahme, B., Siluschek, M., Rehbein, K., Herrmann, J., Weiskirchen, R., & Gressner, A. M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00260.x · Cited by 59 · see citing works

Cytotoxicity of berberine on human cervical carcinoma HeLa cells through mitochondria, death receptor and MAPK pathways, and in-silico drug-target prediction

Lu, B., Hu, M., Liu, K., & Peng, J. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.07.017 · Cited by 60 · see citing works

Pin1 modulates p63α protein stability in regulation of cell survival, proliferation and tumor formation

Li, C., Chang, D. L. F., Yang, Z., Qi, J., Liu, R., He, H., Li, D., & Xiao, Z. J. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.468 · Cited by 57 · see citing works

Different class IIa HDACs repressive complexes regulate specific epigenetic responses related to cell survival in leiomyosarcoma cells

Giorgio, E. D., Dalla, E., Franforte, E., Paluvai, H., Minisini, M., Trevisanut, M., Picco, R., & Brancolini, C. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1120 · Cited by 57 · see citing works

ΔNp63α Confers Tumor Cell Resistance to Cisplatin through the AKT1 Transcriptional Regulation

Sen, T., Sen, N., Brait, M., Begum, S., Chatterjee, A., Hoque, M. O., Ratovitski, E. A., & Sidransky, D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1481 · Cited by 56 · see citing works

MicroRNA-301b promotes cell invasiveness through targeting TP63 in pancreatic carcinoma cells

Funamizu, N., Lacy, C., Parpart, S., Takai, A., Hiyoshi, Y., & Yanaga, K. K. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2243 · Cited by 56 · see citing works

Regulation of skin aging and heart development by TAp63

Paris, M., Rouleau, M., Pucéat, M., & Aberdam, D. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.181 · Cited by 54 · see citing works

Tumor suppression in skin and other tissues via cross-talk between vitamin D- and p53-signaling

Reichrath, J., Reichrath, S., Heyne, K., VOGT, T. M., & Roemer, K. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00166 · Cited by 53 · see citing works

Mechanisms of transcriptional repression of cell-cycle G2/M promoters by p63

Testoni, B. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj477 · Cited by 54 · see citing works

Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense

D’Alessandro, A., Amelio, I., Berkers, C. R., Antonov, A., Vousden, K. H., Melino, G., & Zolla, L. (2014) · Oncotarget · doi:10.18632/oncotarget.2300 · Cited by 53 · see citing works

Therapeutic prospects for p73 and p63: Rising from the shadow of p53

Vilgelm, A. E., El-Rifai, W. M., & Zaika, A. I. (2008) · Drug Resistance Updates · doi:10.1016/j.drup.2008.08.001 · Cited by 53 · see citing works

Stxbp4 Regulates ΔNp63 Stability by Suppression of RACK1-Dependent Degradation

Li, Y., Peart, M. J., & Prives, C. L. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00449-09 · Cited by 52 · see citing works

Identification of vitamin D receptor as a target of p63

Kommagani, R., Caserta, T. M., & Kadakia, M. (2006) · Oncogene · doi:10.1038/sj.onc.1209412 · Cited by 52 · see citing works

Caspase-1 is a novel target of p63 in tumor suppression

Celardo, I., Grespi, F., Antonov, A. V., Bernassola, F., Garabadgiu, A. V., Melino, G., & Amelio, I. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.175 · Cited by 51 · see citing works

Poly (C)-Binding Protein 1 Regulates p63 Expression through mRNA Stability

Cho, S.-J., Jung, Y.-S., & Chen, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071724 · Cited by 50 · see citing works

Interaction of long noncoding RNA MEG3 with miRNAs: A reciprocal regulation

Moradi, M., Fallahi, H., & Rahimi, Z. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27604 · Cited by 50 · see citing works

Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells

Hsu, Y.-F., Sheu, J., Lin, C., Yang, D.-S., Hsiao, G., Ou, G., Chiu, P.-T., Huang, Y., Kuo, W.-H., & Hsu, M. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.11.011 · Cited by 49 · see citing works

Interferon-α Acts on the S/G2/M Phases to Induce Apoptosis in the G1 Phase of an IFNAR2-expressing Hepatocellular Carcinoma Cell Line

Maeda, S., Wada, H., Naito, Y., Nagano, H., Simmons, S., Kagawa, Y., Naito, A., Kikuta, J., Ishii, T., Tomimaru, Y., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.551879 · Cited by 49 · see citing works

ATM kinase is a master switch for the ΔNp63α phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage

Huang, Y., Sen, T., Nagpal, J. K., Upadhyay, S. K., Trink, B., Ratovitski, E. A., & Sidransky, D. (2008) · Cell Cycle · doi:10.4161/cc.7.18.6627 · Cited by 49 · see citing works

Overexpression of p63 is associated with radiation resistance and prognosis in oral squamous cell carcinoma

Moergel, M., Abt, E. C., Stockinger, M., & Kunkel, M. (2010) · Oral Oncology · doi:10.1016/j.oraloncology.2010.06.012 · Cited by 48 · see citing works

The interplay between Epstein-Bar virus (EBV) with the p53 and its homologs during EBV associated malignancies

Chatterjee, K., Das, P., Chattopadhyay, N. R., Mal, S., & Choudhuri, T. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02624 · Cited by 48 · see citing works

Repression of New p53 Targets Revealed by ChIP on Chip Experiments

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ERβ decreases the invasiveness of triple-negative breast cancer cells by regulating mutant p53 oncogenic function

Bado, I. L., Nikolos, F., Rajapaksa, G. K., Gustafsson, J.-Α., & Thomas, C. G. (2016) · Oncotarget · doi:10.18632/oncotarget.7300 · Cited by 47 · see citing works

Regulation of p63 Isoforms by Snail and Slug Transcription Factors in Human Squamous Cell Carcinoma

Herfs, M. F., Hubert, P., Suarez‐Carmona, M., Reschner, A., Saussez, S., Berx, G., Savagner, P., Boniver, J., & Delvenne, P. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090804 · Cited by 46 · see citing works

Differences in the transactivation domains of p53 family members: a computational study

Mavinahalli, J., Madhumalar, A., Beuerman, R. W., Lane, D. P., & Verma, C. S. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-s1-s5 · Cited by 46 · see citing works

Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene Therapy

Bressy, C., Hastie, E. L., & Grdzelishvili, V. Z. (2017) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2017.03.002 · Cited by 46 · see citing works

Epidemiology, Genetic Etiology, and Intervention of Premature Ovarian Insufficiency

Guo, T., Liu, H., Xu, B., Qi, Y., Xu, K., Wu, X., He, X., Qin, Y., & Chen, Z. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf011 · Cited by 44 · see citing works

Expression of GATA-3 in epidermis and hair follicle: Relationship to p63

Chikh, A., Sayan, E., Thibaut, S., Lena, A. M., Giorgi, S. D., Bernard, B. A., Melino, G., & Candi, E. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.069 · Cited by 44 · see citing works

Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family

Schilling, T., Schleithoff, E. S., Kairat, A., Melino, G., Stremmel, W., Oren, M., Krammer, P. H., & Müller, M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.063 · Cited by 43 · see citing works

TAp63 suppress metastasis via miR-133b in colon cancer cells

Lin, C., Li, X., Zhang, Y., Hu, G., Guo, Y., Zhou, J. Y., Du, J., Lv, L., Gao, K., Zhang, Y., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.118 · Cited by 42 · see citing works

Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis

Sayan, B. S., Sayan, E., Yang, A. L., Aqeilan, R. I., Candi, E., Cohen, G. M., Knight, R. A., Croce, C. M., & Melino, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700761104 · Cited by 42 · see citing works

The E3 ubiquitin ligase WWP1 regulates ΔNp63-dependent transcription through Lys63 linkages

Peschiaroli, A., Scialpi, F., Bernassola, F., Sherbini, E. S. E., & Melino, G. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.050 · Cited by 42 · see citing works

Role of p63 and the Notch pathway in cochlea development and sensorineural deafness

Terrinoni, A., Serra, V., Bruno, E., Strasser, A., Valente, L. J., Flores, E. R., van Bokhoven, H., Lü, X., Knight, R. A., & Melino, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214498110 · Cited by 42 · see citing works

p63 controls cell migration and invasion by transcriptional regulation of MTSS1

Giacobbe, A., Compagnone, M., Bongiorno‐Borbone, L., Antonov, A. V., Markert, E. K., Zhou, H., Annicchiarico‐Petruzzelli, M., Melino, G., & Peschiaroli, A. (2015) · Oncogene · doi:10.1038/onc.2015.230 · Cited by 41 · see citing works

TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis

Huang, C., Zhao, S., Yang, Y., Guo, T., Ke, H., Mi, X., Qin, Y., Chen, Z., & Zhao, S. (2023) · Journal of Clinical Investigation · doi:10.1172/jci162315 · Cited by 41 · see citing works

The role of the TRAF‐interacting protein in proliferation and differentiation

Chapard, C., Hohl, D., & Huber, M. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01477.x · Cited by 41 · see citing works

OTX1 expression in breast cancer is regulated by p53

Terrinoni, A., Pagani, I. S., Zucchi, I., Chiaravalli, A. M., Serra, V., Rovera, F. A., Sirchia, S. M., Dionigi, G., Miozzo, M. R., Frattini, A., et al. (2011) · Oncogene · doi:10.1038/onc.2011.31 · Cited by 41 · see citing works

Aberrant Expression of p63 in Adenocarcinoma of the Prostate

Giannico, G. A., Ross, H. M., Lotan, T., & Epstein, J. I. (2013) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e31828d5c32 · Cited by 41 · see citing works

Nitric oxide and cell death in liver cancer cells

Muntané, J., de la Rosa, Á. J., Gómez, L. M. M., & Ruiz, F. J. P. (2012) · Mitochondrion · doi:10.1016/j.mito.2012.09.004 · Cited by 40 · see citing works

Effective Integration of Targeted Tumor Imaging and Therapy Using Functionalized InP QDs with VEGFR2 Monoclonal Antibody and miR-92a Inhibitor

Wu, Y., Sun, J., Zhang, Y., Pu, M., Zhang, G., He, N., & Zeng, X. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b02641 · Cited by 40 · see citing works

Dysregulated ΔNp63α Inhibits Expression of Ink4a/arf, Blocks Senescence, and Promotes Malignant Conversion of Keratinocytes

Ha, L., Ponnamperuma, R. M., Jay, S., Ricci, M., & Weinberg, W. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021877 · Cited by 40 · see citing works

A robust high resolution reversed-phase HPLC strategy to investigate various metabolic species in different biological models

D’Alessandro, A., Gevi, F., & Zolla, L. (2011) · Molecular BioSystems · doi:10.1039/c0mb00274g · Cited by 39 · see citing works

Dominant negative (ΔN) p63α induces drug resistance in hepatocellular carcinoma by interference with apoptosis signaling pathways

Mundt, H. M., Stremmel, W., Melino, G., Krammer, P. H., Schilling, T., & Müller, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.04.093 · Cited by 39 · see citing works

Simvastatin induces G 1 arrest by up‐regulating GSK3β and down‐regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells

Chen, M., Cheng, A., Lee, M., & Hsu, Y. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26156 · Cited by 38 · see citing works

Eine neue Rolle für TAp63α in Apoptose und Chemosensitivität von Hepatomzellen

Gressner, O. A., Koch, A., Lorenz, K., Hill, P., Candi, E., Melino, G., Krammer, P., Stremmel, W., & Müller, M. (2005) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2005-920107

TAp63alpha is involved in toll‐like receptor 3 (TLR3) induced apoptosis via death receptors and mitochondria

Hu, J., Sun, R., Zhang, Y., Liu, B., Jin, M., Zhang, W., Deng, M., Liu, X., Li, G., Li, Y., et al. (2011) · The FASEB Journal · doi:10.1096/fasebj.25.1_supplement.952.1

p63 induziert Apoptose durch Aktivierung von Signalwegen via Todesrezeptoren und Mitochondrien

Gressner, O. A., Koch, A., Lorenz, K., Schleithoff, A. S., Hill, P., Willen, D., Melino, G., Krammer, P., Stremmel, W., & Mueller-Schilling, M. (2004) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2004-831669

TAp63 and ΔNp63 in Cancer and Epidermal Development

Candi, E., Dinsdale, D. D., Rufini, A., Salomoni, P., Knight, R. A., Mueller, M., Krammer, P. H., & Melino, G. (2007) · Cell Cycle · doi:10.4161/cc.6.3.3797 · Cited by 188 · see citing works

TAp73/ΔNp73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma

Schleithoff, E. S., Sayan, E., Koch, A., Pieper, C. C., Gressner, O. A., Melino, G., Krammer, P., Tannapfel, A., Stremmel, W., & Müller, M. (2005) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2005-920108