Oxidative Stress Regulation of Stem and Progenitor Cells
Abstract
In recent years, it has become clear that balanced regulation of reactive oxygen species is of critical significance for cell-fate determination as well as for stem cell development, function, and survival. Although many questions regarding intracellular redox status regulation of stem cell fate remain, we review here what is known regarding the impact of cell-fate signaling as shown with a variety of human cancer cells and more recently on cancer-initiating cells and on the regenerative capacity of skeletal muscle and hematopoietic tissue and their stem cells. We also discuss the role of altered intracellular redox status as a potential primary pathogenic mechanism in muscular dystrophy and hematopoietic pathologies. Studies discussed here illustrate how understanding altered redox regulation of stem cell behavior may contribute to the development of novel stem cell therapies. Antioxid. Redox Signal. 11, 2777–2789.
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The free radical theory of aging points to elevated ROS as a principal cause of mtDNA mutation.
“The free radical theory of aging points to elevated ROS as a principal cause of mtDNA mutation, as mitochondria represent the primary sources of ROS in the cell5.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [5]
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- Authors
- Pervaiz, S., Taneja, R., & Ghaffari, S.
- Affiliations
- National University of Singapore (SG)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Ghaffari, Saghi
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2009-11
- Volume
- 11
- Issue
- 11
- Pages
- 2777-2789
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W1991891117
- Cited by
- 176
- References
- 131
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 11 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 6 · 2017: 16 · 2016: 12 · 2015: 16 · 2014: 20 · 2013: 14 · 2012: 15
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- oxidative stress, reactive oxygen species, redox regulation, stem cells, progenitor cells, cell fate determination, cancer stem cells, skeletal muscle regeneration, hematopoietic stem cells, muscular dystrophy, stem cell therapy
- MeSH terms
- Animals, Hematopoietic Stem Cells, Humans, Models, Biological, Oxidation-Reduction, Stem Cells, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal
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