Cited by 176Redox biology and oxidative stressAntioxidant Activity and Oxidative StressMuscle Physiology and Disorders

Oxidative Stress Regulation of Stem and Progenitor Cells

Pervaiz, Shazib, Taneja, Reshma, Ghaffari, Saghi·2009·Antioxidants & Redox Signaling

Abstract

In recent years, it has become clear that balanced regulation of reactive oxygen species is of critical significance for cell-fate determination as well as for stem cell development, function, and survival. Although many questions regarding intracellular redox status regulation of stem cell fate remain, we review here what is known regarding the impact of cell-fate signaling as shown with a variety of human cancer cells and more recently on cancer-initiating cells and on the regenerative capacity of skeletal muscle and hematopoietic tissue and their stem cells. We also discuss the role of altered intracellular redox status as a potential primary pathogenic mechanism in muscular dystrophy and hematopoietic pathologies. Studies discussed here illustrate how understanding altered redox regulation of stem cell behavior may contribute to the development of novel stem cell therapies. Antioxid. Redox Signal. 11, 2777–2789.

Integrity signals

Registry

Crossref · 10.1089/ars.2009.2804

Cites

131 of 131 references verified0 citation errors · 0 not checkable

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  • The free radical theory of aging points to elevated ROS as a principal cause of mtDNA mutation.

    “The free radical theory of aging points to elevated ROS as a principal cause of mtDNA mutation, as mitochondria represent the primary sources of ROS in the cell5.”

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Authors
Pervaiz, S., Taneja, R., & Ghaffari, S.
Affiliations
  • National University of Singapore (SG)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Ghaffari, Saghi
Venue
Antioxidants & Redox Signaling
Published
2009-11
Volume
11
Issue
11
Pages
2777-2789
ISSN
  • 1523-0864 (ISSN-L)
  • 1557-7716
OpenAlex
W1991891117
Cited by
176
References
131
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 11 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 6 · 2017: 16 · 2016: 12 · 2015: 16 · 2014: 20 · 2013: 14 · 2012: 15
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Locations
  • Antioxidants and Redox Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
oxidative stress, reactive oxygen species, redox regulation, stem cells, progenitor cells, cell fate determination, cancer stem cells, skeletal muscle regeneration, hematopoietic stem cells, muscular dystrophy, stem cell therapy
MeSH terms
Animals, Hematopoietic Stem Cells, Humans, Models, Biological, Oxidation-Reduction, Stem Cells, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal

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