MDMX regulation of p53 response to ribosomal stress

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p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

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Signaling to p53: ribosomal proteins find their way

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Coping with stress: multiple ways to activate p53

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The p53 orchestra: Mdm2 and Mdmx set the tone

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Nucleolus: the fascinating nuclear body

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Nucleolar Stress: hallmarks, sensing mechanism and diseases

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MDM2 and MDM4: p53 regulators as targets in anticancer therapy

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Mechanism of p53 stabilization by ATM after DNA damage

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Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

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Targeting tumour-supportive cellular machineries in anticancer drug development

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Ribosomal Proteins and Human Diseases: Pathogenesis, Molecular Mechanisms, and Therapeutic Implications

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Efficient p53 Activation and Apoptosis by Simultaneous Disruption of Binding to MDM2 and MDMX

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An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

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Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2

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Ribosomal protein S14 unties the MDM2–p53 loop upon ribosomal stress

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The Regulation of Multiple p53 Stress Responses is Mediated through MDM2

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Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

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Aberrant Expression of Nucleostemin Activates p53 and Induces Cell Cycle Arrest via Inhibition of MDM2

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Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX Network

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Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

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The role of ubiquitin modification in the regulation of p53

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Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis

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Protein degradation and the stress response

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MDM2 and MDMX: Alone and together in regulation of p53.

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Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3

LeBron, C., Chen, L., Gilkes, D. M., & Chen, J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601032 · Cited by 122

p53 -Dependent and -Independent Nucleolar Stress Responses

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Mdm2 and MdmX partner to regulate p53

Wang, X., & Jiang, X. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.02.049 · Cited by 117

Polyadenylation and degradation of incomplete RNA polymerase I transcripts in mammalian cells

Shcherbik, N., Wang, M., Lapik, Y. R., Srivastava, L., & Pestov, D. G. (2010) · EMBO Reports · doi:10.1038/embor.2009.271 · Cited by 109

Identification of ribosomal protein S25 (RPS25)–MDM2–p53 regulatory feedback loop

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AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity

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MdmX is a substrate for the deubiquitinating enzyme USP2a

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Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability

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The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells

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Loss of Tumor Suppressor RPL5/RPL11 Does Not Induce Cell Cycle Arrest but Impedes Proliferation Due to Reduced Ribosome Content and Translation Capacity

Teng, T., Mercer, C. A., Hexley, P., Thomas, G., & Fumagalli, S. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01174-13 · Cited by 98

Guarding the ‘translation apparatus’: defective ribosome biogenesis and the p53 signaling pathway

Chakraborty, A., Uechi, T., & Kenmochi, N. (2011) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.73 · Cited by 100

Antitumor effect of miR-197 targeting in p53 wild-type lung cancer

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Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activationPreprint

Zheng, J., Lang, Y., Zhang, Q., Cui, D., Sun, H., Jiang, L., Chen, Z., Zhang, R., Gao, Y., Tian, W., et al. (2015) · Genes & Development · doi:10.1101/gad.261792.115 · Cited by 94

The Regulation of the p53-mediated Stress Response by MDM2 and MDM4Preprint

Perry, M. E. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000968 · Cited by 100

Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cells

Li, H., Zhang, H., Huang, G., Bing, Z., Xu, D., Liu, J., Luo, H., & An, X. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02230-z · Cited by 88

Versatile functions of p53 protein in multicellular organisms

Chumakov, P. M. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907130019 · Cited by 85

MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and BeyondPreprint

Marine, J., & Jochemsen, A. G. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026237 · Cited by 82

Regulation of MDMX Expression by Mitogenic Signaling

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Perturbation of 60 S Ribosomal Biogenesis Results in Ribosomal Protein L5- and L11-dependent p53 Activation

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MDM4 (MDMX) localizes at the mitochondria and facilitates the p53‐mediated intrinsic‐apoptotic pathway

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Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress

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Scission of the p53-MDM2 Loop by Ribosomal Proteins

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The Evolution of the Ribosomal Protein–MDM2–p53 PathwayPreprint

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Nucleolus and Nucleolar Stress: From Cell Fate Decision to Disease Development

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Inhibition of p53 DNA Binding Function by the MDM2 Protein Acidic Domain

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The long and the short of it: the MDM4 tail so far

Haupt, S., Mejía-Hernández, J. O., Vijayakumaran, R., Keam, S. P., & Haupt, Y. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz007 · Cited by 70

Feedback Regulation of c-Myc by Ribosomal Protein L11

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Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths

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Putting a Finger on Growth Surveillance: Insight into MDM2 Zinc Finger-Ribosomal Protein Interactions

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p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors

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Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis

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The Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and Famine

Deisenroth, C., & Zhang, Y. (2011) · Genes & Cancer · doi:10.1177/1947601911409737 · Cited by 68

Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma

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MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

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HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of the HDMX Gene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity

Phillips, A., Teunisse, A., Lam, S., Lodder, K., Darley, M., Emaduddin, M., Wolf, A., Richter, J., de Lange, J., Verlaan-de Vries, M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.129726 · Cited by 55

Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1

Sun, X. (2014) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v5.i2.75 · Cited by 56

Susceptibility of p53 Unstructured N Terminus to 20 S Proteasomal Degradation Programs the Stress Response

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Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy

Vlatković, N., Boyd, M. T., & Rubbi, C. P. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1361-x · Cited by 54

Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding.

Wei, X., Wu, S., Song, T., Chen, L., Gao, M., Borcherds, W., Daughdrill, G. W., & Chen, J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603838113 · Cited by 50

A Critical Role for Noncoding 5S rRNA in Regulating Mdmx Stability

Li, M., & Gu, W. J. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.020 · Cited by 54

Nucleostemin

Lo, D., & Lu, H. (2010) · Cell Cycle · doi:10.4161/cc.9.16.12605 · Cited by 50

Autoinhibition of MDMX by intramolecular p53 mimicry

Chen, L., Borcherds, W. M., Wu, S., Becker, A., Schönbrunn, E., Daughdrill, G. W., & Chen, J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420833112 · Cited by 49

Casein Kinase 1α Regulates an MDMX Intramolecular Interaction To Stimulate p53 Binding

Wu, S., Chen, L., Becker, A., Schönbrunn, E., & Chen, J. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00851-12 · Cited by 48

Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX

Spinnler, C., Hedström, E., Li, H., de Lange, J., Nikulenkov, F., Teunisse, A. F. A. S., Vries, M. V., Grinkevich, V. V., Jochemsen, A. G., & Selivanova, G. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.45 · Cited by 42

Clinical approach to marrow failure

Shimamura, A. (2009) · Hematology · doi:10.1182/asheducation-2009.1.329 · Cited by 41

Anatomy of Mdm2 and Mdm4 in evolution

Tan, B. X., Liew, H. P., Chua, J. S., Ghadessy, F. J., Tan, Y. S., Lane, D. P., & Coffill, C. R. (2017) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjx002 · Cited by 40

The Pharmacodynamics of the p53-Mdm2 Targeting Drug Nutlin: The Role of Gene-Switching Noise

Puszyński, K., Gandolfi, A., & d’Onofrio, A. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003991 · Cited by 41

Full-length hdmX transcripts decrease following genotoxic stress

Markey, M., & Berberich, S. J. (2008) · Oncogene · doi:10.1038/onc.2008.266 · Cited by 38

Functions of MDMX in the Modulation of the p53‐Response

Lenos, K., & Jochemsen, A. G. (2011) · BioMed Research International · doi:10.1155/2011/876173 · Cited by 40

Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2‐mediated p53 ubiquitination

Bhatt, P., d’Avout, C., Kane, N. S., Borowiec, J. A., & Saxena, A. D. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08430.x · Cited by 37

Characterization of an HIV-Targeted Transcriptional Gene-Silencing RNA in Primary Cells

Turner, A. W., Ackley, A., Matrone, M. A., & Morris, K. V. (2011) · Human Gene Therapy · doi:10.1089/hum.2011.165 · Cited by 36

CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells

Štětková, M., Growková, K., Fojtík, P., Valčíková, B., Palušová, V., Verlande, A., Jorda, R., Kryštof, V., Hejret, V., Alexiou, P., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02971-3 · Cited by 34

The roles of MDM2 and MDMX phosphorylation in stress signaling to p53

Chen, J. (2012) · Genes & Cancer · doi:10.1177/1947601912454733 · Cited by 33

Hydrophilic Residues Are Crucial for Ribosomal Protein L11 (RPL11) Interaction with Zinc Finger Domain of MDM2 and p53 Protein Activation

Zhang, Q., Xiao, H., Chai, S. C., Hoang, Q. Q., & Lu, H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277012 · Cited by 34

Abnormal MDMX degradation in tumor cells due to ARF deficiency

Li, X., Gilkes, D., Li, B., Cheng, Q., Pernazza, D., Lawrence, H., Lawrence, N., & Chen, J. (2012) · Oncogene · doi:10.1038/onc.2011.534 · Cited by 32

Analysis of U8 snoRNA Variants in Zebrafish Reveals How Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts

Badrock, A. P., Uggenti, C., Wacheul, L., Crilly, S., Jenkinson, E. M., Rice, G., Kasher, P. R., Lafontaine, D. L. J., Crow, Y. J., & O’Keefe, R. T. (2020) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2020.04.003 · Cited by 31

Inactivation of p53 Rescues the Maintenance of High Risk HPV DNA Genomes Deficient in Expression of E6

Lorenz, L. D., Cardona, J. R., & Lambert, P. F. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003717 · Cited by 28

Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks

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Ubiquitin and Ubiquitin-Like Proteins in the Nucleolus: Multitasking Tools for a Ribosome Factory

Shcherbik, N., & Pestov, D. G. (2010) · Genes & Cancer · doi:10.1177/1947601910381382 · Cited by 26

Spi-1 and Fli-1 Directly Activate Common Target Genes Involved in Ribosome Biogenesis in Friend Erythroleukemic Cells

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Comparative Proteomics of Dying and Surviving Cancer Cells Improves the Identification of Drug Targets and Sheds Light on Cell Life/Death Decisions

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Loss-of-function genetic screening identifies a cluster of ribosomal proteins regulating p53 function

Castro, M. E., Martínez-Leal, J. F., LLeonart, M. E., y Cajal, S. R., & Carnero, A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgm302 · Cited by 25

14-3-3γ Inhibition of MDMX-mediated p21 Turnover Independent of p53

Lee, J., & Lu, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.190470 · Cited by 22

The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword

Hölzel, M., Burger, K., Mühl, B., Orban, M., Kellner, M., & Eick, D. (2010) · Oncotarget · doi:10.18632/oncotarget.107 · Cited by 24

Heavy ion radiation-induced DNA damage mediates apoptosis via the Rpl27a-Rpl5-MDM2-p53/E2F1 signaling pathway in mouse spermatogonia

Li, H., Zhang, H., Huang, G., Dou, Z., Xie, Y., Si, J., & Di, C. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110831 · Cited by 24

Regulation of MDM4

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p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability

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