The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Two internal ribosome entry sites mediate the translation of p53 isoforms
Open accessAbstract
The p53 tumour suppressor protein has a crucial role in cell‐cycle arrest and apoptosis. Previous reports show that the p53 messenger RNA is translated to produce an amino‐terminal‐deleted isoform (ΔN‐p53) from an internal initiation codon, which acts as a dominant‐negative inhibitor of full‐length p53. Here, we show that two internal ribosome entry sites (IRESs) mediate the translation of both full‐length and ΔN‐p53 isoforms. The IRES directing the translation of full‐length p53 is in the 5′‐untranslated region of the mRNA, whereas the IRES mediating the translation of ΔN‐p53 extends into the protein‐coding region. The two IRESs show distinct cell‐cycle phase‐dependent activity, with the IRES for full‐length p53 being active at the G2–M transition and the IRES for ΔN‐p53 showing highest activity at the G1–S transition. These results indicate a novel translational control of p53 gene expression and activity.
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Cites
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New frontiers in translational control of the cancer genome
Truitt, M. L., & Ruggero, D. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.27 · Cited by 378
Translational Control in Cancer Etiology
Ruggero, D. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012336 · Cited by 367
Shi, Z., & Barna, M. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125346 · Cited by 205
IRES Trans-Acting Factors, Key Actors of the Stress Response
Godet, A.-C., David, F., Hantelys, F., Tatin, F., Lacazette, E., Garmy-Susini, B., & Prats, A.-C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040924 · Cited by 202
RNA binding protein/RNA element interactions and the control of translation
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Metadata
- Authors
- Ray, P. S., Grover, R., & Das, S.
- Venue
- EMBO reports
- Published
- 2006-01-20
- Volume
- 7
- Issue
- 4
- Pages
- 404-410
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2120296922
- Cited by
- 208
- References
- 3
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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