The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Sustained Neuronal Activation Raises Oxidative Metabolism to a New Steady-State Level: Evidence from 1H NMR Spectroscopy in the Human Visual Cortex
Open accessAbstract
To date, functional 1 H NMR spectroscopy has been utilized to report the time courses of few metabolites, primarily lactate. Benefiting from the sensitivity offered by ultra-high magnetic field (7 T), the concentrations of 17 metabolites were measured in the human visual cortex during two paradigms of visual stimulation lasting 5.3 and 10.6 mins. Significant concentration changes of approximately 0.2 μmol/g were observed for several metabolites: lactate increased by 23% ± 5% ( P < 0.0005), glutamate increased by 3% ± 1% ( P < 0.01), whereas aspartate decreased by 15% ± 6% ( P < 0.05). Glucose concentration also manifested a tendency to decrease during activation periods. The lactate concentration reached the new steady-state level within the first minute of activation and came back to baseline only after the stimulus ended. The changes of the concentration of metabolites implied a rise in oxidative metabolism to a new steady-state level during activation and indicated that amino-acid homeostasis is affected by physiological stimulation, likely because of an increased flux through the malate—aspartate shuttle.
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Cites
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BackgroundResultWilliamson, D., Lund, P., & Krebs, H. (1967) · Biochemical Journal · doi:10.1042/bj1030514 · Cited by 1,871
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Self-citationLinear coupling between cerebral blood flow and oxygen consumption in activated human cortex
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Cited by
Walter, M., Henning, A., Grimm, S., Schulte, R. F., Beck, J., Dydak, U., Schnepf, B., Boeker, H., Boesiger, P., & Northoff, G. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.39 · Cited by 306
13 C MRS studies of neuroenergetics and neurotransmitter cycling in humans
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Glutamate and glutamine: a review of in vivo MRS in the human brain
Ramadan, S., Lin, A., & Stanwell, P. (2013) · NMR in Biomedicine · doi:10.1002/nbm.3045 · Cited by 282
Cerebral Blood Flow Response to Functional Activation
Paulson, O. B., Hasselbalch, S. G., Rostrup, E., Knudsen, G. M., & Pelligrino, D. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.188 · Cited by 264
Multifunctional role of astrocytes as gatekeepers of neuronal energy supply
Stobart, J. L., & Anderson, C. M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00038 · Cited by 264
Metadata
- Authors
- Mangia, S., Tkáč, I., Gruetter, R., Van de Moortele, P.-F., Maraviglia, B., & Uğurbil, K.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2007-05
- Volume
- 27
- Issue
- 5
- Pages
- 1055-1063
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2131211368
- Cited by
- 285
- References
- 39
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mangia, S., Tkáč, I., Gruetter, R., Van de Moortele, P.-F., Maraviglia, B., & Uğurbil, K. (2007). Sustained Neuronal Activation Raises Oxidative Metabolism to a New Steady-State Level: Evidence from 1H NMR Spectroscopy in the Human Visual Cortex. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/sj.jcbfm.9600401
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