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Cited by 112Stress Responses and CortisolNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

Neurobiology of the stress response early in life: evolution of a concept and the role of corticotropin releasing hormone

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Brunson, K L, Avishai-Eliner, S, Hatalski, C G, Baram, T Z·2001·Molecular Psychiatry
DOI 10.1038/sj.mp.4000942PMC PMC3100722
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Abstract

Over the last few decades, concepts regarding the presence of hormonal and molecular responses to stress during the first postnatal weeks in the rat and the role of the neuropeptide corticotropin releasing hormone (CRH) in these processes, have been evolving. CRH has been shown to contribute critically to molecular and neuroendocrine responses to stress during development. In turn the expression of this neuropeptide in both hypothalamus and amygdala is differentially modulated by single and recurrent stress, and is determined also by the type of stress (eg, psychological or physiological). A likely transcriptional regulatory factor for modulating CRH gene expression, the cAMP responsive element binding protein CREB, is phosphorylated (activated) in the developing hypothalamus within seconds of stress onset, preceding the transcription of the CRH gene and initiating the activation of stress-induced cellular and neuroendocrine cascades. Finally, early life stress may permanently modify the hypothalamic pituitary adrenal axis and the response to further stressful stimuli, and recent data suggest that CRH may play an integral role in the mechanisms of these long-term changes.

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  • The traumatic stress response in children is embedded within three major circuits: the HPA axis, the limbic system, and the prefrontal cortex.

    “most agree that it is embedded within three major circuits: the HPA axis, the limbic system, and the prefrontal cortex.”

    From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [35]

    The neuronal-circuitry section identifies the HPA axis and limbic pathways as major stress-response circuits. Its Summary identifies the three interrelated circuits as neuroendocrine, limbic, and brainstem—not prefrontal cortex. No page number is available in our copy. (LLM, conf=0.88)

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Cited by

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Authors
Brunson, K. L., Avishai-Eliner, S., Hatalski, C. G., & Baram, T. Z.
Affiliations
University of California, Irvine (US)
Corresponding author
Baram, T Z
ORCID
Baram, T Z
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2001-10-23
Volume
6
Issue
6
Pages
647-656
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
DOI
10.1038/sj.mp.4000942
PMC
PMC3100722
OpenAlex
W2022605561
Cited by
112
References
9
Citations by year
2026: 1 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2017: 9 · 2016: 7 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 7
FWCI
0.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (NS 28912, R01NS028912, NS 39307, R01NS039307)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
early life stress, corticotropin-releasing factor, stress response, hypothalamus, amygdala, hypothalamic-pituitary-adrenal axis, CREB, CRH gene expression, neuroendocrine development, postnatal development, psychological stress, physiological stress, transcriptional regulation
MeSH terms
Animals, Brain, Corticotropin-Releasing Hormone, Stress, Physiological, Rats

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