The central corticotropin releasing factor system during development and adulthood

Korosi, Aniko; Baram, Tallie Z.

doi:10.1016/j.ejphar.2007.11.066

Cited by 102Stress Responses and CortisolNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

The central corticotropin releasing factor system during development and adulthood

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Korosi, Aniko, Baram, Tallie Z.·2008·European Journal of Pharmacology

DOI 10.1016/j.ejphar.2007.11.066PMC PMC2329668

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Abstract

Corticotropin releasing factor (CRH) has been shown to contribute critically to molecular and neuroendocrine responses to stress during both adulthood and development. This peptide and its receptors are expressed in the hypothalamus, as well as in limbic brain areas including amygdala and hippocampus. This is consistent with roles for CRH in mediating the influence of stress on emotional behavior and cognitive function. The expression of CRH and of its receptors in hypothalamus, amygdala and hippocampus is age-dependent, and is modulated by stress throughout life (including the first postnatal weeks). Uniquely during development, the cardinal influence of maternal care on the central stress response governs the levels of central CRH expression, and may alter the 'set-point' of CRH-gene sensitivity to stress in a lasting manner.

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The central amygdala nucleus (CEA) is rich in stress hormones and their receptors and contributes to processing of stress signals.
“The CEA is rich in stress hormones and their receptors,98, 99, 100, 101 and contributes to processing of stress signals.102, 103, 104”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [100]

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A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828 · see citing works
The HPA axis in major depression: classical theories and new developments
Pariante, C. M., & Lightman, S. L. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.006 · Cited by 2,009 · see citing works
Psychobiological mechanisms underlying the social buffering of the hypothalamic-pituitary-adrenocortical axis: a review of animal models and human studies across development
Hostinar, C. E., Sullivan, R. M., & Gunnar, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0032671 · Cited by 739 · see citing works
A Novel Mouse Model for Acute and Long-Lasting Consequences of Early Life Stress
Rice, C. J., Sandman, C. A., Lenjavi, M. R., & Baram, T. Z. (2008) · Endocrinology · doi:10.1210/en.2008-0633 · Cited by 521 · see citing works
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Stress hormones mediate environment-genotype interactions during amphibian development
Denver, R. J. (2009) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2009.04.016 · Cited by 276 · see citing works
Consequences of post-weaning social isolation on anxiety behavior and related neural circuits in rodents
Lukkes, J. L. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.018.2009 · Cited by 235 · see citing works
Early-life stress disrupts attachment learning: the role of amygdala corticosterone, locus ceruleus corticotropin releasing hormone, and olfactory bulb norepinephrine
Moriceau, S., Shionoya, K., Jakubs, K., & Sullivan, R. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4106-09.2009 · Cited by 214 · see citing works
Stress physiology and developmental psychopathology: Past, present, and future
Doom, J. R., & Gunnar, M. R. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000667 · Cited by 204 · see citing works
Adaptation to potential threat: the evolution, neurobiology, and psychopathology of the security motivation system
Woody, E. Z., & Szechtman, H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.08.003 · Cited by 195 · see citing works
Social influences on neurobiology and behavior: Epigenetic effects during development
Curley, J. P., Jensen, C. L., Rahia Mashoodh, A., & Champagne, F. A. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.06.005 · Cited by 195 · see citing works
Developing a neurobehavioral animal model of infant attachment to an abusive caregiver
Raineki, C., Moriceau, S., & Sullivan, R. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.019 · Cited by 190 · see citing works
Sculpting the hippocampus from within: stress, spines, and CRH
Maras, P. M., & Baram, T. Z. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.01.005 · Cited by 174 · see citing works
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The Corticotropin-Releasing Hormone Network and the Hypothalamic-Pituitary-Adrenal Axis: Molecular and Cellular Mechanisms Involved
Bonfiglio, J. J., Inda, C., Refojo, D., Holsboer, F., ARZT, E. S., & Silberstein, S. (2011) · Neuroendocrinology · doi:10.1159/000328226 · Cited by 144 · see citing works
Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation
Banerjee, A., Shen, P., Ma, S., Bathgate, R. A. D., & Gundlach, A. L. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.019 · Cited by 132 · see citing works
Developmental influences on stress response systems: Implications for psychopathology vulnerability in adolescence
Roberts, A. G., & Lopez‐Duran, N. L. (2018) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2018.10.008 · Cited by 131 · see citing works
Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress
Maras, P. M., Molet, J., Chen, Y., Rice, C., Ji, S. G., Solodkin, A., & Baram, T. Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.12 · Cited by 118 · see citing works
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The hypothalamic-pituitary-adrenal axis as a substrate for stress resilience: Interactions with the circadian clock
Kinlein, S. A., & Karatsoreos, I. N. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100819 · Cited by 98 · see citing works
The pathways from mother's love to baby's future
Kőrösi, A. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.027.2009 · Cited by 92 · see citing works
Diversity of Reporter Expression Patterns in Transgenic Mouse Lines Targeting Corticotropin-Releasing Hormone-Expressing Neurons
Chen, Y., Molet, J., Gunn, B. G., Ressler, K. J., & Baram, T. Z. (2015) · Endocrinology · doi:10.1210/en.2015-1673 · Cited by 86 · see citing works
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Corticosteroid effects on cellular physiology of limbic cells
Joëls, M., Krugers, H. J., Lucassen, P. J., & Karst, H. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.036 · Cited by 75 · see citing works
Endocrinology and the brain: corticotropin-releasing hormone signaling
Inda, C., Armando, N. G., Claro, P. A. D. S., & Silberstein, S. (2017) · Endocrine Connections · doi:10.1530/ec-17-0111 · Cited by 77 · see citing works
Plasticity of the stress response early in life: Mechanisms and significance
Kőrösi, A., & Baram, T. Z. (2010) · Developmental Psychobiology · doi:10.1002/dev.20490 · Cited by 75 · see citing works
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Stress and Anxiety in Schizophrenia and Depression: Glucocorticoids, Corticotropin-Releasing Hormone and Synapse Regression
Ao, M. R. B. (2008) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670802512073 · Cited by 73 · see citing works
Interaction of Stress, Corticotropin-Releasing Factor, Arginine Vasopressin and Behaviour
Beurel, E., & Nemeroff, C. B. (2014) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2014_306 · Cited by 64 · see citing works
Volumetric MRI studies of the hippocampus in major depressive disorder: Meanings of inconsistency and directions for future research
Eker, M. C., & Gönül, A. S. (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970902737998 · Cited by 76 · see citing works
CRH Signaling
Refojo, D., & Holsboer, F. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04983.x · Cited by 64 · see citing works
Volumetric MRI studies of the hippocampus in major depressive disorder: Meanings of inconsistency and directions for future research
Eker, M. C., & Gönül, A. S. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970902737998 · Cited by 59 · see citing works
Enduring Neurobehavioral Effects of Early Life Trauma Mediated Through Learning and Corticosterone Suppression
Moriceau, S. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.022.2009 · Cited by 57 · see citing works
Stable reprogramming of brain transcription profiles by the early social environment in a cooperatively breeding fish
Barbara Taborsky, A., Tschirren, L., Meunier, C., & Aubin‐Horth, N. (2012) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2012.2605 · Cited by 53 · see citing works
Divergent evolution of two corticotropin-releasing hormone (CRH) genes in teleost fishes
Grone, B. P., & Maruska, K. P. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00365 · Cited by 53 · see citing works
Paternal Deprivation Affects the Development of Corticotrophin‐Releasing Factor‐Expressing Neurones in Prefrontal Cortex, Amygdala and Hippocampus of the BiparentalOctodon degus
Seidel, K., Poeggel, G., Holetschka, R., Helmeke, C., & Braun, K. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02208.x · Cited by 51 · see citing works
Relaxin: New Pathophysiological Aspects and Pharmacological Perspectives for an Old Protein
Cernaro, V., Lacquaniti, A., Lupica, R., Buemi, A., Trimboli, D., Giorgianni, G. M., Bolignano, D., & Buemi, M. (2013) · Medicinal Research Reviews · doi:10.1002/med.21277 · Cited by 50 · see citing works
A unifying framework for depression: Bridging the major biological and psychosocial theories through stress
Roy, A., & Campbell, M. K. (2013) · Clinical and investigative medicine · doi:10.25011/cim.v36i4.19951 · Cited by 50 · see citing works
Biological perspectives on the effects of early psychosocial experience
Marshall, P. J., & Kenney, J. W. (2009) · Developmental Review · doi:10.1016/j.dr.2009.05.001 · Cited by 47 · see citing works
A second corticotropin‐releasing hormone gene ( CRH 2) is conserved across vertebrate classes and expressed in the hindbrain of a basal N eopterygian fish, the spotted gar ( L episosteus oculatus)
Grone, B. P., & Maruska, K. P. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23729 · Cited by 42 · see citing works
Estrogen receptors α and β in the central amygdala and the ventromedial nucleus of the hypothalamus: Sociosexual behaviors, fear and arousal in female rats during emotionally challenging events
Moëne, O. L., Stavarache, M. A., Ogawa, S., Musatov, S. A., & Ågmo, A. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.03.045 · Cited by 42 · see citing works
Negative consequences of early-life adversity on substance use as mediated by corticotropin-releasing factor modulation of serotonin activity
Forster, G. L., Anderson, E. M., Scholl, J. L., Lukkes, J. L., & Watt, M. J. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.08.001 · Cited by 40 · see citing works
Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion channels
Kratzer, S., Mattusch, C., Metzger, M. W., Dedic, N., Noll‐Hussong, M., Kafitz, K. W., Eder, M., Deussing, J. M., Holsboer, F., Kochs, E. F., et al. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00091 · Cited by 40 · see citing works
Abnormal dendritic maturation of developing cortical neurons exposed to corticotropin releasing hormone (CRH): Insights into effects of prenatal adversity?
Curran, M. M., Sandman, C. A., Davis, E. P., Glynn, L. M., & Baram, T. Z. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180311 · Cited by 38 · see citing works
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Relaxin‐3/insulin‐like peptide 7, a neuropeptide involved in the stress response and food intake
Tanaka, M. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07931.x · Cited by 39 · see citing works
Sex-Dependent Pathology in the HPA Axis at a Sub-acute Period After Experimental Traumatic Brain Injury
Bromberg, C. E., Condon, A. M., Ridgway, S. W., Krishna, G., Garcia-Filion, P. C., Adelson, P. D., Rowe, R. K., & Thomas, T. C. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00946 · Cited by 38 · see citing works
Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation
Malta, M. B., Martins, J., Novaes, L. S., dos Santos, N. B., Sita, L. V., Camarini, R., Scavone, C., Bittencourt, J. C., & Munhoz, C. D. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02470-2 · Cited by 35 · see citing works
Chronic anabolic androgenic steroid exposure alters corticotropin releasing factor expression and anxiety-like behaviors in the female mouse
Costine, B. A., Oberlander, J. G., Davis, M. C., Penatti, C. A. A., Porter, D. M., Leaton, R. N., & Henderson, L. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.04.015 · Cited by 37 · see citing works
Involvement of CRFR 1 in the Basolateral Amygdala in the Immediate Fear Extinction Deficit
Hollis, F., Sevelinges, Y., Grosse, J., Zanoletti, O., & Sandi, C. (2016) · eNeuro · doi:10.1523/eneuro.0084-16.2016 · Cited by 36 · see citing works
Corticotropin-Releasing Hormone As the Homeostatic Rheostat of Feto-Maternal Symbiosis and Developmental Programming In Utero and Neonatal Life
Alcántara‐Alonso, V., Panetta, P., de Gortari, P., & Grammatopoulos, D. K. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00161 · Cited by 35 · see citing works
The HPA Axis in the Pathogenesis and Treatment of Depressive Disorders: Integrating Clinical and Molecular Findings
Baumeister, D., Lightman, S. L., & Pariante, C. M. (2016) · Psychopathology Review · doi:10.5127/pr.034413 · Cited by 32 · see citing works
Effect of early life social adversity on drug abuse vulnerability: Focus on corticotropin-releasing factor and oxytocin
Bardo, M. T., Hammerslag, L. R., & Malone, S. G. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108567 · Cited by 32 · see citing works
Resource scarcity but not maternal separation provokes unpredictable maternal care sequences in mice and both upregulate Crh-associated gene expression in the amygdala
Demaestri, C., Gallo, M. E., Mazenod, E., Hong, A. T., Arora, H., Short, A. K., Stern, H. S., Baram, T. Z., & Bath, K. G. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100484 · Cited by 33 · see citing works
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Modeling epileptic spasms during infancy: Are we heading for the treatment yet?
Velı́šek, L., & Velı́šková, J. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107578 · Cited by 31 · see citing works
Long-term losses of amygdala corticotropin-releasing factor neurons are associated with behavioural outcomes following neonatal hypoxia-ischemia
Carty, M. L., Wixey, J. A., Kesby, J. P., Reinebrant, H. E., Colditz, P. B., Gobe, G. C., & Buller, K. M. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.01.007 · Cited by 31 · see citing works
Corticotropin-Releasing Factor Modulation of Forebrain GABAergic Transmission has a Pivotal Role in the Expression of Anabolic Steroid-Induced Anxiety in the Female Mouse
Oberlander, J. G., & Henderson, L. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.334 · Cited by 30 · see citing works
Sex differences in the ontogeny of CRF receptors during adolescent development in the dorsal raphe nucleus and ventral tegmental area
Lukkes, J. L., Norman, K. J., Meda, S., & Andersen, S. L. (2015) · Synapse · doi:10.1002/syn.21882 · Cited by 29 · see citing works
The effect of CRF and α-helical CRF(9–41) on rat fear responses and amino acids release in the central nucleus of the amygdala
Skórzewska, A., Bidziński, A., Hamed, A., Lehner, M., Turzyńska, D., Sobolewska, A., Szyndler, J., Maciejak, P., Wisłowska-Stanek, A., & Płaźnik, A. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.04.016 · Cited by 29 · see citing works
Distribution of corticotropin-releasing factor receptor 1 in the developing mouse forebrain: A novel sex difference revealed in the rostral periventricular hypothalamus
Rosinger, Z. J., Jacobskind, J. S., Park, S. G., Justice, N. J., & Zuloaga, D. G. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.016 · Cited by 29 · see citing works
The Nutrient and Energy Sensor Sirt1 Regulates the Hypothalamic-Pituitary-Adrenal (HPA) Axis by Altering the Production of the Prohormone Convertase 2 (PC2) Essential in the Maturation of Corticotropin-releasing Hormone (CRH) from Its Prohormone in Male Rats
Toorie, A. M., Cyr, N. E., Steger, J. S., Beckman, R. M., Farah, G. M., & Nillni, E. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.675264 · Cited by 27 · see citing works
Long term effects of early life stress on HPA circuit in rodent models
Babicola, L., Ventura, R., D’Addario, S. L., Ielpo, D., Andolina, D., & Segni, M. D. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111125 · Cited by 27 · see citing works
This can't be stressed enough: The contribution of select environmental toxicants to disruption of the stress circuitry and response
Caudle, W. M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.09.021 · Cited by 26 · see citing works
Social interaction reward in rats has anti‐stress effects
Lemos, C., Salti, A., Amaral, I. M., Fontebasso, V., Singewald, N., Dechant, G., Hofer, A., & Rawas, R. E. (2020) · Addiction Biology · doi:10.1111/adb.12878 · Cited by 26 · see citing works
What was learned from studying the effects of early institutional deprivation
Gunnar, M. R., & Bowen, M. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173272 · Cited by 26 · see citing works
Long term effects of stress on hippocampal function: Emphasis on early life stress paradigms and potential involvement of neuropeptide Y
Alviña, K., Farshbaf, M. J., & Mondal, A. K. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24614 · Cited by 23 · see citing works
Development of the Stress Axis: Maternal and Environmental Influences
Walker, C., & McCormick, C. M. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00061-9 · Cited by 22 · see citing works
The metabolic sensor Sirt1 and the hypothalamus: Interplay between peptide hormones and pro-hormone convertases
Nillni, E. A. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.09.002 · Cited by 21 · see citing works
The Developmental Psychobiology of Stress and Emotion in Childhood
Hostinar, C. E., & Gunnar, M. R. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop206005 · Cited by 20 · see citing works
Biological intersection of sex, age, and environment in the corticotropin releasing factor (CRF) system and alcohol
Agoglia, A. E., Crofton, E. J., & Herman, M. A. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108045 · Cited by 19 · see citing works
Methylome profiling of young adults with depression supports a link with immune response and psoriasis
Lapsley, C. R., Irwin, R. E., McLafferty, M., Thursby, S. J., O’Neill, S. M., Bjourson, A. J., Walsh, C. P., & Murray, E. K. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00877-7 · Cited by 18 · see citing works
The Effects of Stress on Early Brain and Behavioral Development
Gunnar, M. R., & Davis, E. P. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397267-5.00063-7 · Cited by 13 · see citing works
Effortful control and context interact in shaping neuroendocrine stress responses during childhood
Mayer, S. E., Abelson, J. L., & Lopez‐Duran, N. L. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.06.019 · Cited by 12 · see citing works
Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions
Silberstein, S., Vogl, A. M., Refojo, D., Senin, S. A., Wurst, W., Holsboer, F., Deussing, J. M., & ARZT, E. S. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.014 · Cited by 12 · see citing works
Stress and the Reproductive System
Li, X.-F., & O’Byrne, K. T. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00036-3 · Cited by 13 · see citing works
17q21.31 Microdeletion associated with infantile spasms
Wray, C. D. (2012) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2012.10.011 · Cited by 12 · see citing works
Immunology, Signal Transduction, and Behavior in Hypothalamic–Pituitary–Adrenal Axis‐related Genetic Mouse Models
Silberstein, S., Vogl, A. M., Bonfiglio, J. J., Wurst, W., Holsboer, F., ARZT, E. S., Deussing, J. M., & Refojo, D. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03967.x · Cited by 12 · see citing works
Postnatal developmental profile of urocortin 1 and cocaine- and amphetamine-regulated transcript in the perioculomotor region of C57BL/6J mice
Cservenka, A., Spangler, E., Cote, D. M., & Ryabinin, A. E. (2010) · Brain Research · doi:10.1016/j.brainres.2010.01.003 · Cited by 12 · see citing works
Adrenocortical deviations and adverse clinical outcomes in children and adolescents exposed to interparental intimate partner violence: A systematic review
Specht, L., Freiberg, A., Mojahed, A., Garthus‐Niegel, S., & Schellong, J. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105866 · Cited by 13 · see citing works
Differential contribution of CBP:CREB binding to corticotropin-releasing hormone expression in the infant and adult hypothalamus
Cope, J. L., Regev, L., Chen, Y., Kőrösi, A., Rice, C. J., Ji, S., Rogge, G. A., Wood, M. A., & Baram, T. Z. (2013) · Stress · doi:10.3109/10253890.2013.806907 · Cited by 10 · see citing works
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Denial or receipt of expected reward through maternal contact during the neonatal period differentially affect the development of the rat amygdala and program its function in adulthood in a sex-dimorphic way
Diamantopoulou, A., Raftogianni, A., Stamatakis, A., Tzanoulinou, S., Oitzl, M. S., & Stylianopoulou, F. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.012 · Cited by 10 · see citing works
The Role of Vasopressin in Anxiety and Depression
Morales‐Medina, J. C., Witchey, S. K., & Caldwell, H. K. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_40 · Cited by 9 · see citing works
Long-range inputome of cortical neurons containing corticotropin-releasing hormone
Zhao, P., Zhao, M., Wang, H., Jiang, T., Jia, X., Tian, J., Li, A., Gong, H., & Li, X. (2020) · Scientific Reports · doi:10.1038/s41598-020-68115-x · Cited by 9 · see citing works
Early-life adversity is associated with poor iron status in infancy
Reid, B. M., East, P. L., Blanco, E., Doom, J. R., Burrows, R. A., Correa‐Burrows, P., Lozoff, B., & Gahagan, S. (2022) · Development and Psychopathology · doi:10.1017/s0954579422000517 · Cited by 9 · see citing works
Alpha‐melanocyte‐stimulating hormone attenuates behavioral effects of corticotropin‐releasing factor in isolated guinea pig pups
Schiml‐Webb, P. A., Miller, E., Terrence Deak, B., & Hennessy, M. B. (2009) · Developmental Psychobiology · doi:10.1002/dev.20379 · Cited by 8 · see citing works
The effects of stress on early brain and behavioral development
Noroña, A. N., Doom, J. R., Davis, E. P., & Gunnar, M. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814411-4.00026-3 · Cited by 7 · see citing works
Association between stress pathway gene (CRHR1⧹CRHBP) polymorphisms and heroin dependence
Su, H., Wang, Z., & Zhao, M. (2018) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2018.05.009 · Cited by 5 · see citing works
Targeting corticotropin-releasing hormone receptor type 1 (Crhr1) neurons: validating the specificity of a novel transgenic Crhr1-FlpO mouse
Hardy, M., Chen, Y., Baram, T. Z., & Justice, N. J. (2024) · Brain Structure and Function · doi:10.1007/s00429-024-02879-0 · Cited by 2 · see citing works
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Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments
Vieira, K., Schonwald, A., Chern, C., Shah, K., Velı́šková, J., & Velı́šek, L. (2025) · Epilepsia Open · doi:10.1002/epi4.70140 · Cited by 2 · see citing works
Neuropeptides Controlling Our Behavior
Nillni, E. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_2 · Cited by 2 · see citing works
Mechanisms by which early-life experiences promote enduring stress resilience or vulnerability
Short, A. K., Bolton, J. L., & Baram, T. Z. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813983-7.00012-4 · Cited by 2 · see citing works
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P7, a novel antagonist of corticotropin releasing factor receptor type 1 (CRFR1) screened from phage display library
Yu, J., Zhuo, R., Peng, P., Liu, X., Yan, H., Zhang, S., Zheng, J., Wei, X., & Ma, X. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.05.021 · Cited by 1 · see citing works
The Cell Biology Neuropeptide Hormones
Nillni, E. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_5 · Cited by 1 · see citing works
Nutrient Sensors Regulating Peptides
Çakır, I., & Nillni, E. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_6 · Cited by 1 · see citing works
CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling
Claro, P. A. D. S., Silbermins, M., Inda, C., & Silberstein, S. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.07.015 · Cited by 1 · see citing works
The Role of Genetic and Environmental Risk Factors in Aetiology of Suicidal Behaviour
Zainullina, A., Valiullina, A., & Хуснутдинова, Э. К. (2016) · Palgrave Macmillan UK eBooks · doi:10.1057/9781137437327_11 · Cited by 1 · see citing works
Dissection of Forebrain Corticotropin-Releasing Hormone Receptor 1 Signaling in Stress-Induced Cognitive Deficits –– The Role of Synaptic Cell Adhesion Molecules
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Authors: Korosi, A., & Baram, T. Z.
Affiliations: University of California, Irvine (US)
Corresponding author: Baram, Tallie Z.
ORCID: Baram, Tallie Z.
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 2008-04
Volume: 583
Issue: 2-3
Pages: 204-214
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/j.ejphar.2007.11.066
PMC: PMC2329668
OpenAlex: W2031394080
Cited by: 102
References: 172
Citations by year: 2026: 5 · 2025: 1 · 2024: 2 · 2022: 4 · 2021: 3 · 2020: 9 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 7
FWCI: 0.80
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders: National Institutes of Health
National Institute of Mental Health (MH73136, R01MH073136)
National Institute of Neurological Disorders and Stroke (NS 28912, R01NS028912, R01NS039307)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: corticotropin-releasing factor, CRH receptors, hypothalamus, amygdala, hippocampus, stress response, neuroendocrine stress response, developmental programming, maternal care, age-related gene expression, emotional behavior, cognitive function
MeSH terms: Adult, Age Factors, Animals, Brain, Corticotropin-Releasing Hormone, Humans, Rodentia, Stress, Physiological, Gene Expression, Receptors, Corticotropin-Releasing Hormone

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