Cognitive Remediation in Schizophrenia
Open accessAbstract
Cognitive deficits in schizophrenia are pervasive, severe, and largely independent of the positive and negative symptoms of the illness. These deficits are increasingly considered to be core features of schizophrenia with evidence that the extent of cognitive impairment is the most salient predictor of daily functioning. Unfortunately, current schizophrenia treatment has been limited in addressing the cognitive deficits of the illness. Alterations in neuroplasticity are hypothesized to underpin these cognitive deficits, though preserved neuroplasticity may offer an avenue towards cognitive remediation. Key neuroplastic principles to consider in designing remediation interventions include ensuring sufficient intensity and duration of remediation programs, "bottom-up" training that proceeds from simple to complex cognitive processes, and individual tailoring of remediation regimens. We discuss several cognitive remediation programs, including cognitive enhancement therapy, which embrace these principles to target neurocognitive and social cognitive improvements and which havebeen demonstrated to be effective in schizophrenia. Future directions in cognitive remediation research include potential synergy with pharmacologic treatment, non-invasive stimulation techniques, and psychosocial interventions, identification of patient characteristics that predict outcome with cognitive remediation, and increasing the access to these interventions in front-line settings.
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Prolonged developmental plasticity may provide a diagnostic opportunity for cognitive interventions targeting brain plasticity in the prodromal stage.
“Prolonged developmental plasticity may then provide a diagnostic opportunity for cognitive interventions targeting brain plasticity in the prodromal stage (62–64).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [63]
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Sorted by citations
Predictive processing, source monitoring, and psychosis
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Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons
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- Authors
- Kaneko, Y., & Keshavan, M.
- Affiliations
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Keshavan, Matcheri
- Venue
- Clinical Psychopharmacology and Neuroscience
- Published
- 2012-12-28
- Volume
- 10
- Issue
- 3
- Pages
- 125-135
- ISSN
- 1738-1088 (ISSN-L)
- 2093-4327
- PMC
- PMC3569160
- OpenAlex
- W2163919275
- Cited by
- 51
- References
- 107
- Citations by year
- 2026: 4 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 2 · 2013: 4
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Clinical Psychopharmacology and Neuroscience (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- cognitive remediation, schizophrenia, cognitive impairment, neuroplasticity, cognitive enhancement therapy, social cognition, personalized treatment, non-invasive brain stimulation, predictors of treatment outcome
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