The Selective Serotonin-2A Receptor Antagonist M100907 Reverses Behavioral Deficits in Dopamine Transporter Knockout Mice
Abstract
A hyperdopaminergic state in humans has been hypothesized to contribute to the pathology of a number of psychiatric illnesses, including schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder. Mice that display elevated synaptic levels of dopamine due to a genetically engineered deletion of the dopamine transporter (DAT) model behavioral deficits that simulate the above conditions. As novel treatment strategies for these disorders have focused on the serotonin (5-HT) 2A receptor, we determined the capacity of the highly selective 5-HT(2A) receptor antagonist M100907 to reverse behavioral deficits in DAT knockout (KO) mice. Prior to drug treatment, DAT KO mice exhibited increased levels of locomotor activity and highly linearized movement in a novel environment, as well as reduced prepulse inhibition (PPI) of acoustic startle, compared to wild-type littermates. Treatment with M100907 (0.3-1.0 mg/kg, but not 0.1 mg/kg) reversed locomotor deficits in DAT KO mice. Similarly, treatment with 1.0 mg/kg M100907 reversed the PPI deficits in DAT KO mice. These data indicate that selective 5-HT(2A) receptor antagonists, such as M100907, may represent a class of drugs that can be used to treat conditions in which a chronic, elevated dopaminergic tone is present and contributes to abnormal behavior and sensorimotor gating deficits.
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Mice lacking the DAT gene display markedly increased levels of DA in the mesolimbic system and striatum, resulting in hyperlocomoter behaviors and deficits in PPI.
“Mice lacking the DAT gene display markedly increased levels of DA in the mesolimbic system and striatum [373], that results in hyperlocomoter behaviors [373,374] and also deficits in PPI [375,376].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [375]
Cites
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476 · see citing works
Self-citationMolecular, pharmacological and functional diversity of 5-HT receptors
Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,869 · see citing works
BRAFF, D. L., Geyer, M. A., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100810 · Cited by 1,701 · see citing works
Self-citationGeyer, M. A., Krebs-Thomson, K., Braff, D. L., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100811 · Cited by 1,484 · see citing works
Self-citationHoffman, H. S., & Ison, J. R. (1980) · Psychological Review · doi:10.1037/0033-295x.87.2.175 · Cited by 780 · see citing works
The Role of Serotonin in Antipsychotic Drug Action
Meltzer, H. M. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00046-9 · Cited by 664 · see citing works
Swerdlow, N. R., & Geyer, M. A. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033326 · Cited by 616 · see citing works
Self-citationJakab, R. L., & Goldman-Rakic, P. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.735 · Cited by 536 · see citing works
Serotonin model of schizophrenia: emerging role of glutamate mechanisms
Aghajanian, G. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00046-6 · Cited by 529 · see citing works
Aghajanian, G. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00135-3 · Cited by 371 · see citing works
Kehne, J. H., Baron, B. M., Carr, A. A., Chaney, S., Elands, J., Feldman, D. J., Frank, R. A., van Giersbergen, P. L. M., McCloskey, T. C., Johnson, M., et al. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12956-x · Cited by 359 · see citing works
Laruelle, M. (2000) · Brain research. Brain research reviews · doi:10.1016/s0165-0173(99)00054-5 · Cited by 347 · see citing works
Burnet, P. W. J. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00053-x · Cited by 286 · see citing works
Ralph, R. J., Paulus, M. P., Fumagalli, F., Caron, M. G., & Geyer, M. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00305.2001 · Cited by 271 · see citing works
Self-citationSensorimotor gating deficits in bipolar disorder patients with acute psychotic mania
Perry, W., Minassian, A., Feifel, D., & Braff, D. L. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01184-2 · Cited by 260 · see citing works
Sorensen, S. M., Kehne, J. H., Fadayel, G. M., Humphreys, T. M., Ketteler, H., Sullivan, C. K., Taylor, V. L., & Schmidt, C. J. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38366-7 · Cited by 258 · see citing works
Williams, J. H., Spurlock, G., McGuffin, P., Owen, M., Mallet, J. J., Nöthen, M. M., Gill, M., Aschauer, H. N., Nylander, P.-O., & Macciardi, F. M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90939-3 · Cited by 245 · see citing works
Functional hyperdopaminergia in dopamine transporter knock-out mice
Gainetdinov, R. R., Jones, S. R., & Caron, M. G. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00122-5 · Cited by 231 · see citing works
Self-citationBehavioural disturbances associated with hyperdopaminergia in dopamine-transporter knockout mice
Spielewoy, C., Roubert, C., Hamon, M., Nosten‐Bertrand, M., Betancur, C., & Bruno Giros, A. (2000) · Behavioural Pharmacology · doi:10.1097/00008877-200006000-00011 · Cited by 228 · see citing works
Porras, G. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00333-5 · Cited by 222 · see citing works
霊長類大脳皮質の5‐ヒドロキシトリプタミン2Aセロトニン受容体 錐体細胞先端樹状突起での幻覚剤及び抗精神病剤の作用部位
Jakab, R. L., & Goldman‐Rakic, P. S. (1998) · Cited by 182 · see citing works
Alterations in the cortical serotonergic system in schizophrenia: A postmortem study
Gurevich, E. V., & Joyce, J. N. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00321-1 · Cited by 176 · see citing works
Ralph, R. J., Varty, G. B., Kelly, M. A., Wang, Y.-M., Caron, M. G., Rubinstein, M., Grandy, D. K., Low, M. J., & Geyer, M. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04627.1999 · Cited by 174 · see citing works
Self-citationLucas, G., & Spampinato, U. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740693.x · Cited by 170 · see citing works
Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter
Gainetdinov, R. R., Mohn, A. R., Bohn, L., & Caron, M. G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191353298 · Cited by 168 · see citing works
Self-citationAtypical antipsychotics: are some more atypical than others?
Remington, G. J., & Kapur, S. (2000) · Psychopharmacology · doi:10.1007/s002130050017 · Cited by 156 · see citing works
Classification and nomenclature of 5-HT receptors: a comment on current issues
Hoyer, D., & Martin, G. R. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00109-x · Cited by 149 · see citing works
Varty, G. B., Bakshi, V. P., & Geyer, M. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00072-4 · Cited by 137 · see citing works
Liégeois, J.-F., Ichikawa, J., & Meltzer, H. Y. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02620-3 · Cited by 134 · see citing works
O‘Neill, M. F., Heron-Maxwell, C., & Shaw, G. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00240-8 · Cited by 134 · see citing works
A temporal and spatial scaling hypothesis for the behavioral effects of psychostimulants
Paulus, M. P., & Geyer, M. A. (1991) · Psychopharmacology · doi:10.1007/bf02244547 · Cited by 134 · see citing works
Self-citationAntagonism of 5-Hydroxytryptamine2A Receptors Attenuates the Behavioral Effects of Cocaine in Rats
McMahon, L. R., & Cunningham, K. A. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29546-x · Cited by 133 · see citing works
Pehek, E. A., McFarlane, H. G., Maguschak, K. A., Price, B., & Pluto, C. P. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03004-3 · Cited by 131 · see citing works
Monoamine transporter pharmacology and mutant mice
Gainetdinov, R. R., Sotnikova, T. D., & Caron, M. G. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02044-8 · Cited by 126 · see citing works
Self-citationPalfreyman, M. G., Schmidt, C. J., Sorensen, S. M., Dudley, M. W., Kehne, J. H., Moser, P. C., Gittos, M. W., & Carr, A. A. (1993) · Psychopharmacology · doi:10.1007/bf02245008 · Cited by 125 · see citing works
A systematic review of the use of atypical antipsychotics in autism
Barnard, L., Young, A. H., Pearson, J., Geddes, J. R., & O'Brien, G. (2002) · Journal of Psychopharmacology · doi:10.1177/026988110201600113 · Cited by 124 · see citing works
Dulawa, S. C., Hen, R., Scearce-Levie, K. A., & Geyer, M. A. (1997) · Psychopharmacology · doi:10.1007/s002130050328 · Cited by 122 · see citing works
Self-citationPadich, R. A., McCloskey, T. C., & Kehne, J. H. (1996) · Psychopharmacology · doi:10.1007/bf02245610 · Cited by 119 · see citing works
DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum
Sipes, T. E., & Geyer, M. A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00316-8 · Cited by 118 · see citing works
Self-citationReversal of amphetamine-induced behaviours by MDL 100,907, a selective 5-HT2A antagonist
Moser, P. C., Moran, P. M., Frank, R. A., & Kehne, J. H. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00090-3 · Cited by 111 · see citing works
Ngan, E. T. C., Yatham, L. N., Ruth, T. J., & Liddle, P. F. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.6.1016 · Cited by 104 · see citing works
Frechilla, D., Cobreros, A., Saldise, L., Moratalla, R., Insausti, R., Luquín, M. R., & R�o, J. D. (2001) · Synapse · doi:10.1002/1098-2396(20010315)39:4 · Cited by 103 · see citing works
Carlsson, M. L. (1995) · Journal of Neural Transmission · doi:10.1007/bf01276460 · Cited by 86 · see citing works
Behavioral Studies of Hallucinogenic Drugs in Animals: Implications for Schizophrenia Research
Geyer, M. A. (1998) · Pharmacopsychiatry · doi:10.1055/s-2007-979350 · Cited by 80 · see citing works
Self-citationCarlsson, M. L., Martin, P., Nilsson, M., Sorensen, S. M., Carlsson, A., Waters, N., & Waters, N. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050144 · Cited by 78 · see citing works
de Paulis, T. (2001) · PubMed · Cited by 71 · see citing works
High 5HT 2A receptor occupancy in M100907-treated schizophrenic patients
Talvik, M., Nyberg, S., Nordström, A., Ito, H., Halldin, C., Brunner, F., & Farde, L. (2000) · Psychopharmacology · doi:10.1007/s002130050069 · Cited by 61 · see citing works
Levitan, R., Masellis, M., Basile, V., Lam, R. W., Jain, U., Kaplan, A. S., Kennedy, S. H., Siegel, G., Walker, M., Vaccarino, F., et al. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00372-x · Cited by 57 · see citing works
Wadenberg, M.-L. G., Browning, J. L., Young, K. A., & Hicks, P. B. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00483-4 · Cited by 48 · see citing works
Andrée, B., Nyberg, S., Ito, H., Ginovart, N., Brunner, F., Jaquet, F., Halldin, C., & Farde, L. (1998) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199808000-00012 · Cited by 45 · see citing works
Marcus, M., Nomikos, G., & Svensson, T. (2000) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(00)00077-8 · Cited by 42 · see citing works
5-HT2A antagonists in psychiatric disorders.
Angelis, L. D. (2002) · PubMed · Cited by 41 · see citing works
Wadenberg, M.-L. G., Hicks, P. B., Richter, J. T., & Young, K. A. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00424-1 · Cited by 39 · see citing works
Pharmacological and molecular targets in the search for novel antipsychotics
Scatton, B., & Sanger, D. J. (2000) · Behavioural Pharmacology · doi:10.1097/00008877-200006000-00008 · Cited by 39 · see citing works
Ogilvie, C. M., Moore, J., Daker, M. G., Palferman, S., Docherty, Z., & IMGSAC (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(20000207)96:1 · Cited by 33 · see citing works
Offord, S. J., Wong, D. F., & Nyberg, S. (1999) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1999.tb05933.x · Cited by 27 · see citing works
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Alex, K. D., & Pehek, E. A. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.08.004 · Cited by 658 · see citing works
Realistic expectations of prepulse inhibition in translational models for schizophrenia research
Swerdlow, N. R., Weber, M., Qu, Y., Light, G. A., & Braff, D. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1072-4 · Cited by 529 · see citing works
Schizophrenia-Relevant Behavioral Testing in Rodent Models: A Uniquely Human Disorder?
Powell, C. M., & Miyakawa, T. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.008 · Cited by 368 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
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Russell, V. A., Sagvolden, T., & Johansen, E. B. (2005) · Behavioral and Brain Functions · doi:10.1186/1744-9081-1-9 · Cited by 234 · see citing works
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Powell, S. B., Zhou, X., & Geyer, M. A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.021 · Cited by 218 · see citing works
Self-citationPehek, E. A., Nocjar, C., Roth, B., Byrd, T. A., & Mabrouk, O. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300819 · Cited by 212 · see citing works
Trace amine-associated receptor 1—Family archetype or iconoclast?
Grandy, D. K. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.007 · Cited by 196 · see citing works
Overview of Animal Models of Attention Deficit Hyperactivity Disorder (ADHD)
Russell, V. A. (2011) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0935s54 · Cited by 176 · see citing works
Marta Ribasés, A., Ramos‐Quiroga, J. A., Amaia Hervas, G., Bosch, R., Bielsa, A., Gastaminza, X., Artigas-Pallarés, J., Rodriguez-Ben, S., Estivill, X., Casas, M., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002100 · Cited by 154 · see citing works
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Lohr, K. M., Masoud, S. T., Salahpour, A., & Miller, G. W. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13357 · Cited by 124 · see citing works
Young, J. W., Minassian, A., Paulus, M. P., Geyer, M. A., & Perry, W. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.05.009 · Cited by 122 · see citing works
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Psychostimulant withdrawal as an inducing condition in animal models of depression
Barr, A. M., & Markou, A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.012 · Cited by 107 · see citing works
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Tanaka, K., Shintani, N., Hashimoto, H., Kawagishi, N., Ago, Y., Matsuda, T., Hashimoto, R., Kunugi, H., Yamamoto, A., Kawaguchi, C., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4376-05.2006 · Cited by 85 · see citing works
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Efimova, E. V., Gainetdinov, R. R., Budygin, E. A., & Sotnikova, T. D. (2016) · Journal of Neurogenetics · doi:10.3109/01677063.2016.1144751 · Cited by 83 · see citing works
Self-citationTransgenic mouse models for ADHD
Leo, D., & Gainetdinov, R. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1639-1 · Cited by 74 · see citing works
Self-citationHomberg, J. R., Kyzar, E. J., Nguyen, M., Norton, W., Pittman, J. T., Poudel, M. K., Gaikwad, S., Nakamura, S., Koshiba, M., Yamanouchi, H., et al. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.013 · Cited by 83 · see citing works
Self-citationAlterations of dopamine and serotonin transmission in schizophrenia
Remington, G. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00906-0 · Cited by 81 · see citing works
Yamashita, M., Fukushima, S., Shen, H.-W., Hall, F. S., Uhl, G. R., Numachi, Y., Kobayashi, H., & Sora, I. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301009 · Cited by 77 · see citing works
Meck, W. H., Cheng, R., MacDonald, C. J., Gainetdinov, R. R., Caron, M. G., & Çevik, M. Ö. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.042 · Cited by 76 · see citing works
Self-citationAttention-deficit/hyperactive disorder updates
Kessi, M., Duan, H., Xiong, J., Chen, B., He, F., Yang, L., Ma, Y., Bamgbade, O. A., Peng, J., & Yin, F. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.925049 · Cited by 82 · see citing works
Dopamine transporter mutant mice in experimental neuropharmacology
Gainetdinov, R. R. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0216-0 · Cited by 75 · see citing works
Self-citationDopamine transporter‐dependent and ‐independent actions of trace amine β‐phenylethylamine
Sotnikova, T. D., Budygin, E. A., Jones, S. R., Dykstra, L., Caron, M. G., & Gainetdinov, R. R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02721.x · Cited by 74 · see citing works
Self-citationThe dopamine transporter role in psychiatric phenotypes
Salatino‐Oliveira, A., Rohde, L. A., & Hutz, M. H. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32578 · Cited by 72 · see citing works
Hall, F. S., Drgonová, J., Jain, S., & Uhl, G. R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.006 · Cited by 71 · see citing works
Herin, D. V., Liu, S., Ullrich, T., Rice, K. C., & Cunningham, K. A. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2030-4 · Cited by 69 · see citing works
Cross-species assessments of motor and exploratory behavior related to bipolar disorder
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Self-citationHeterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins
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Self-citationPowell, S. B., Young, J. W., Ong, J. C., Caron, M. G., & Geyer, M. A. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32830dc110 · Cited by 57 · see citing works
Self-citationWeiss, S., Nosten‐Bertrand, M., McIntosh, J. M., Bruno Giros, A., & Martres, M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301385 · Cited by 54 · see citing works
Animal models of tic disorders: A translational perspective
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Barr, A. M., Powell, S. B., Markou, A., & Geyer, M. A. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.04.004 · Cited by 49 · see citing works
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Fox, M. A., Panessiti, M., Hall, F. S., Uhl, G. R., & Murphy, D. L. (2013) · Psychopharmacology · doi:10.1007/s00213-013-2988-x · Cited by 48 · see citing works
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Weiss, S., Tzavara, E. T., Davis, R. J., Nomikos, G. G., McIntosh, J. M., Giros, B., & Martres, M. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.02.002 · Cited by 42 · see citing works
Fan, X., Bruno, K. J., & Hess, E. J. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_121 · Cited by 42 · see citing works
NAKAI, T., Nagai, T., Wang, R., Yamada, S., Kuroda, K., Kaibuchi, K., & Yamada, K. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.06.009 · Cited by 41 · see citing works
Heilbronner, S. R., & Meck, W. H. (2013) · Behavioural Processes · doi:10.1016/j.beproc.2013.09.013 · Cited by 38 · see citing works
Transgenic mice in the study of drug addiction and the effects of psychostimulant drugs
Sora, I., Li, B., Igari, M., Hall, F. S., & Ikeda, K. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05276.x · Cited by 38 · see citing works
Behavioral Animal Models of Antipsychotic Drug Actions
Peleg‐Raibstein, D., Feldon, J., & Meyer, U. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25761-2_14 · Cited by 37 · see citing works
Bari, A., & Robbins, T. W. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_102 · Cited by 35 · see citing works
Comet, M. ‐., Bernard, J., Hamon, M., Laguzzi, R. F., & Sévoz‐Couche, C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05673.x · Cited by 34 · see citing works
Gaisler‐Salomon, I., Diamant, L., Rubin, C., & Weiner, I. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0960-3 · Cited by 34 · see citing works
Annual Research Review: Transgenic mouse models of childhood‐onset psychiatric disorders
Robertson, H. R., & Feng, G. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02380.x · Cited by 33 · see citing works
Cerebellar 5HT-2A receptor mediates stress-induced onset of dystonia
Kim, J. E., Chae, S., Kim, S., Jung, Y., Kang, M., Heo, W. D., & Kim, D. (2021) · Science Advances · doi:10.1126/sciadv.abb5735 · Cited by 36 · see citing works
Barr, A. M., Young, C. E., Phillips, A. G., & Honer, W. G. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705006000 · Cited by 31 · see citing works
Self-citationReprint of “Neurobiology of animal models of attention-deficit hyperactivity disorder”
Russell, V. A. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2006.12.020 · Cited by 29 · see citing works
Choi, C. S., Hong, M., Kim, K. C., Kim, J., Yang, S. M., Seung, H., Ko, M. J., Choi, D., You, J. S., Shin, C. Y., et al. (2014) · Biomolecules & Therapeutics · doi:10.4062/biomolther.10.4062/biomolther.2014.027 · Cited by 27 · see citing works
From neurons to brain networks, pharmacodynamics of stimulant medication for ADHD
Parlatini, V., Bellato, A., Murphy, D., & Cortese, S. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105841 · Cited by 26 · see citing works
Dopamine Transporter Deficient Rodents: Perspectives and Limitations for Neuroscience
Savchenko, A. A., Targa, G., Fesenko, Z. S., Leo, D., Gainetdinov, R. R., & Sukhanov, I. (2023) · Biomolecules · doi:10.3390/biom13050806 · Cited by 29 · see citing works
Self-citationThe reelin receptors VLDLR and ApoER2 regulate sensorimotor gating in mice
Barr, A. M., Fish, K. N., & Markou, A. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.11.011 · Cited by 25 · see citing works
Self-citationStrengths and limitations of genetic models of ADHD
Gainetdinov, R. R. (2010) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-010-0021-3 · Cited by 24 · see citing works
Self-citationYoung, J. W., Winstanley, C. A., Brady, A. M., & Hall, F. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.029 · Cited by 24 · see citing works
Using affect‐modulated startle to study phenotypes of pediatric bipolar disorder
Rich, B. A., Bhangoo, R. K., Vinton, D. T., Berghorst, L. H., Dickstein, D. P., Grillon, C., Davidson, R. J., & Leibenluft, E. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00265.x · Cited by 24 · see citing works
Honer, W. G., Procyshyn, R. M., Chen, E. Y. H., MacEwan, G. W., & Barr, A. M. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0954 · Cited by 23 · see citing works
Self-citationLin, F., Li, F., Wang, C., Wang, J., Yang, Y., Yang, L., & Li, Y. (2017) · Molecules · doi:10.3390/molecules22071064 · Cited by 23 · see citing works
Semenova, S., & Markou, A. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.05.003 · Cited by 22 · see citing works
Bellesi, M., & Conti, F. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.225 · Cited by 22 · see citing works
Queiroz, A. I. G., de Araújo, M. M., Araújo, T. D. S., de Souza, G. C., Cavalcante, L. M., Machado, M. D. J. S., de Lucena, D. F., Quevedo, J., & Macêdo, D. S. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9697-6 · Cited by 22 · see citing works
If waking and dreaming consciousness became de-differentiated, would schizophrenia result?
Llewellyn, S. (2011) · Consciousness and Cognition · doi:10.1016/j.concog.2011.03.022 · Cited by 21 · see citing works
Altered performance of reelin-receptor ApoER2 deficient mice on spatial tasks using the Barnes maze.
Barr, A. M., MacLaurin, S. A., Semenova, S., Fish, K. N., & Markou, A. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.5.1101 · Cited by 18 · see citing works
Self-citationKaram, C. S., Williams, B. L., Jones, S. K., & Javitch, J. A. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03275-4 · Cited by 17 · see citing works
Ptukha, M. A., Fesenko, Z. S., Belskaya, A. D., Gromova, A. A., Pelevin, A., Kurzina, N. P., Gainetdinov, R. R., & Volnova, A. B. (2022) · Biomolecules · doi:10.3390/biom12101484 · Cited by 15 · see citing works
Self-citationSantini, M. A., Klein, A. B., El-Sayed, M., Ratner, C., Knudsen, G. M., Mikkelsen, J. D., & Aznar, S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.048 · Cited by 15 · see citing works
Queiroz, A. I. G., Filho, A. J. M. C., Araújo, T. D. S., Lima, C. N. D. C., Machado, M. D. J. S., Carvalho, A. F., Vasconcelos, S. M. M., de Lucena, D. F., Quevedo, J., & Macêdo, D. S. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.053 · Cited by 15 · see citing works
New therapeutic potential for psychoactive natural products
Prevatt‐Smith, K. M., & Prisinzano, T. E. (2009) · Natural Product Reports · doi:10.1039/b912196j · Cited by 14 · see citing works
Umezu, T., Kita, T., & Morita, M. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.10.005 · Cited by 13 · see citing works
Tadros, M. G., Mohamed, M. R., Youssef, A. M., Sabry, G. M., Sabry, N. A., & Khalifa, A. E. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.015 · Cited by 13 · see citing works
Methylphenidate and Guanfacine Ameliorate ADHD-Like Phenotypes in Fez1-Deficient Mice
Sumitomo, A., Saka, A., Ueta, K., Horike, K., Hirai, K., Gamo, N. J., Hikida, T., Nakayama, K. I., Sawa, A., Sakurai, T., et al. (2017) · Complex Psychiatry · doi:10.1159/000488081 · Cited by 12 · see citing works
Wolf, R. J., Dobrowolny, H., Matzke, K., Paelchen, K., Bogerts, B., & Schwegler, H. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.07.027 · Cited by 12 · see citing works
Marques, A. M., Macena, M. V., Cardoso, A. R., Hammes, C. S. O., Pinheiro, F. M. L., Castro, N. G., & Neves, G. A. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05485-0 · Cited by 10 · see citing works
Onogi, H., Nakagawasai, O., Sato, A., Mitazaki, S., Nakaya, K., Watanabe, K., Yaoita, F., Tan–No, K., Arai, Y., Kikuchi, T., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.06.002 · Cited by 9 · see citing works
Mutant Mouse Models in Evaluating Novel Approaches to Antipsychotic Treatment
O’Tuathaigh, C. M. P., Desbonnet, L., & Waddington, J. L. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25758-2_5 · Cited by 8 · see citing works
Solomon, M. B., Yegla, B., Newcorn, J. H., Maletic, V., Rubin, J. S., & Robbins, T. W. (2025) · Clinical Drug Investigation · doi:10.1007/s40261-025-01473-4 · Cited by 8 · see citing works
Faraone, S. V., Ward, C. L., Boucher, M., Elbekai, R. H., & Brunner, E. (2025) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2025.2552324 · Cited by 8 · see citing works
Ramadan, E., Chang, L., Chen, M., Ma, K., Hall, F. S., Uhl, G. R., Rapoport, S. I., & Basselin, M. (2012) · International Journal of Neuroscience · doi:10.3109/00207454.2012.665972 · Cited by 5 · see citing works
Attention-deficit hyperactivity disorder
Sotnikova, T. D., & Gainetdinov, R. R. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.015 · Cited by 8 · see citing works
Self-citationThe Ins and Outs of Dopamine Transporter Gene Manipulation: In Vivo Models of DAT Dysfunction
Stewart, A., & Blakely, R. (2025) · Advances in neurobiology · doi:10.1007/978-3-031-96364-3_10 · Cited by 3 · see citing works
Larrauri, J. A., & Levin, E. D. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.03.010 · Cited by 3 · see citing works
Olasupo, S. B., Uzairu, A., Shallangwa, G. A., & Uba, S. (2020) · The Journal of Engineering and Exact Sciences · doi:10.18540/jcecvl6iss2pp0107-0128 · Cited by 2 · see citing works
The metabolism of indoleamines
Tricklebank, M. D., & Martins, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813323-1.00001-3 · Cited by 1 · see citing works
Sirotin, B. Z., & Жмеренецкий, К. В. (2003) · PubMed · Cited by 1 · see citing works
Mathur, N. (2012) · Nottingham ePrints (University of Nottingham) · Cited by 1 · see citing works
Psychopathology of psychosis: Towards integration from an idealist perspective
Behrendt, R., & Young, C. C. (2004) · Behavioral and Brain Sciences · doi:10.1017/s0140525x04440187
Social dysfunction and mental retardation
Pietropaolo, S., Sluyter, F., & Crusio, W. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.010
Monoaminergic Approaches for Treatment of Schizophrenia
Rotella, D. P. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849734943-00035
Hall, F. S., & Sora, I. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.028
Substance dependence and abuse
Pietropaolo, S., Sluyter, F., & Crusio, W. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.024
DuPre, A. (2007) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.62107-5
Crawley, J. N. (2006) · Wiley eBooks · doi:10.1002/9780470119051.refs
Animal models of attention-deficit/hyperactivity disorder: Diversity and validity
Nehme, S. B. S., Sánchez‐Sarasúa, S., Medrano, M., Bouchatta, O., Bitar, T., Alameddine, A., Galineau, L., Brunault, P., Kerekes, N., Sánchez‐Pérez, A. M., et al. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100108
- Authors
- Barr, A. M., Lehmann-Masten, V., Paulus, M., Gainetdinov, R. R., Caron, M. G., & Geyer, M. A.
- Affiliations
- Scripps Research Institute (US)
- University of California San Diego (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Geyer, Mark A
- Venue
- Neuropsychopharmacology
- Published
- 2003-11-05
- Volume
- 29
- Issue
- 2
- Pages
- 221-228
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2123933616
- Cited by
- 103
- References
- 56
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 7
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institute of Mental Health (MH60451, MH61326, R01MH061326, P50MH060451)
- National Institute on Drug Abuse (DA 02925, R01DA002925)
- NIH Clinical Center
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- M100907, 5-HT2A receptor antagonist, dopamine transporter knockout mice, hyperdopaminergic state, prepulse inhibition, sensorimotor gating, locomotor activity, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder
- MeSH terms
- Acoustic Stimulation, Analysis of Variance, Animals, Mental Disorders, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Fluorobenzenes, Inhibition, Psychological, Locomotion, Membrane Glycoproteins, Nerve Tissue Proteins, Piperidines, Reflex, Acoustic, Reversal Learning, Spatial Behavior, Mice, Knockout, Gait Disorders, Neurologic, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Mice, Serotonin 5-HT2 Receptor Antagonists
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