Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist
Open accessAbstract
Repeated withdrawals from chronic ethanol induce a persistent adaptive change. Further, stress substitutes for the initial two withdrawals of a multiple-withdrawal protocol to sensitize rats to withdrawal-induced anxiety-like behavior ('anxiety'). Therefore, it was tested whether the persistent adaptation induced by multiple-withdrawal exposures allows stress to elicit anxiety after a period of abstinence. Social interaction was used to assess the degree of anxiety induced by 45 min of restraint stress 3, 7, or 14 days after rats were exposed to multiple withdrawals from a chronic 4.5% ethanol diet. Restraint stress reduced social interaction (ie anxiety-like behavior) at 3, but not at 7 or 14 days, after the multiple withdrawals. No anxiety response was observed in animals that received multiple withdrawals without stress or in animals that received stress when exposed only to control liquid diet. Drugs (ie a CRF1-receptor antagonist, a benzodiazepine receptor antagonist, and a 5-HT1A-receptor agonist) previously demonstrated to block the cumulative adaptation, when administered during repeated withdrawals, prevented stress-induced anxiety-like behavior during abstinence. Additionally, these drugs applied prior to stress in the rats previously exposed to the repeated withdrawal protocol, likewise, minimized stress-induced anxiety. The anxiety following stress during abstinence from previous chronic ethanol exposure is indicative of an interaction of stress with the persistent adaptive change caused by repeated withdrawals. Stress eliciting anxiety-like behavior during abstinence from previous ethanol exposures in rats is consistent with stress inducing anxiety during recovery (sobriety) in the alcoholic, a circumstance that can facilitate craving and relapse.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Systemic CRF1 receptor antagonist administration blocked anxiety-like responses to alcohol withdrawal.
“Systemic CRF 1 receptor antagonist administration blocked anxiety-like responses to alcohol withdrawal (Knapp et al., 2004;Overstreet et al., 2004b;Breese et al., 2005).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Breese et al., 2005
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
How does stress increase risk of drug abuse and relapse?
Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505 · see citing works
File, S. E. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90012-6 · Cited by 820 · see citing works
CAN SOCIAL INTERACTION BE USED TO MEASURE ANXIETY?
File, S. E., & Hyde, J. R. G. (1978) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1978.tb07001.x · Cited by 808 · see citing works
A review of 25 years of the social interaction test
File, S. E., & Seth, P. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01273-1 · Cited by 744 · see citing works
Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.
Cooney, N. L., Litt, M. D., Morse, P. A., Bauer, L. O., & al, E. (1997) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.106.2.243 · Cited by 479 · see citing works
Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.
Cooney, N. L., Litt, M. D., Morse, P. A., Bauer, L. O., & Gaupp, L. (1997) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.106.2.243 · Cited by 479 · see citing works
Rassnick, S., Heinrichs, S. C., Britton, K. T., & Koob, G. F. (1993) · Brain Research · doi:10.1016/0006-8993(93)91352-s · Cited by 407 · see citing works
Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02448.x · Cited by 387 · see citing works
Stress, vulnerability and adult alcohol relapse.
Brown, S. A., Vik, P. W., Patterson, T. L., Grant, I., & Schuckit, M. A. (1995) · Journal of Studies on Alcohol · doi:10.15288/jsa.1995.56.538 · Cited by 380 · see citing works
Stress and Alcohol Interaction: An Update of Human Research
Pohorecky, L. A. (1991) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1991.tb00543.x · Cited by 341 · see citing works
Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats
Lê, A. D., Quan, B. H., Juzytsch, W., Fletcher, P. J., Joharchi, N., & Shaham, Y. (1998) · Psychopharmacology · doi:10.1007/s002130050498 · Cited by 319 · see citing works
Stress Enhancement of Craving During Sobriety: A Risk for Relapse
Breese, G. R., Chu, K., Dayas, C. V., Funk, D. R., Knapp, D. J., Koob, G. F., Lê, A. D., Dell, L. E. O., Overstreet, D. H., Roberts, A. J., et al. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000153544.83656.3c · Cited by 247 · see citing works
Self-citationNeurobiology of relapse to alcohol in rats
Lê, A. D., & Shaham, Y. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00200-0 · Cited by 227 · see citing works
Chronic Daily Ethanol and Withdrawal: 1. Long-Term Changes in the Hypothalamo-Pituitary-Adrenal Axis
Rasmussen, D. D., Boldt, B. M., Bryant, C. A., Mitton, D. R., Larsen, S. A., & Wilkinson, C. W. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb01988.x · Cited by 216 · see citing works
Valdez, G. R., Roberts, A., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · PubMed · doi:10.1097/01.alc.0000033120.51856.f0 · Cited by 187 · see citing works
Valdez, G. R., Zorrilla, E. P., Roberts, A. J., & Koob, G. F. (2003) · Alcohol · doi:10.1016/s0741-8329(03)00020-x · Cited by 186 · see citing works
Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors
Overstreet, D. H. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.11.010 · Cited by 169 · see citing works
Self-citationConceptual framework for the etiology of alcoholism: a “kindling”/stress hypothesis
Breese, G. R., Overstreet, D. H., & Knapp, D. J. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2016-2 · Cited by 167 · see citing works
Self-citationANXIETY AS A PREDICTOR OF RELAPSE IN DETOXIFIED ALCOHOL-DEPENDENT PATIENTS
Willinger, U. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.6.609 · Cited by 165 · see citing works
Accentuated Decrease in Social Interaction in Rats Subjected to Repeated Ethanol Withdrawals
Overstreet, D. H., Knapp, D. J., & Breese, G. R. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02665.x · Cited by 160 · see citing works
Self-citationSeverity of psychosocial stress and outcome of alcoholism treatment.
Brown, S. A., Vik, P. W., McQuaid, J. R., Patterson, T. L., Irwin, M. R., & Grant, I. (1990) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.99.4.344 · Cited by 135 · see citing works
Pharmacological Characterisation of a Modified Social Interaction Model of Anxiety in the Rat
Guy, A. P., & Gardner, C. R. (2008) · Neuropsychobiology · doi:10.1159/000118187 · Cited by 133 · see citing works
SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats
Knapp, D. J., Overstreet, D. H., Moy, S. S., & Breese, G. R. (2004) · Alcohol · doi:10.1016/j.alcohol.2003.08.007 · Cited by 130 · see citing works
Self-citationCraving for alcohol: findings from the clinic and the laboratory.
Sinha, R., & O’Malley, S. S. (1999) · Alcohol and Alcoholism · doi:10.1093/alcalc/34.2.223 · Cited by 119 · see citing works
Hyperventilation, anxiety, craving for alcohol: A subacute alcohol withdrawal syndrome
Roelofs, S. M. G. J. (1985) · Alcohol · doi:10.1016/0741-8329(85)90123-5 · Cited by 116 · see citing works
Breese, G. R., Knapp, D. J., & Overstreet, D. H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300282 · Cited by 115 · see citing works
Self-citationFrye, G. D., McCown, T. J., & Breese, G. R. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21792-x · Cited by 107 · see citing works
Self-citationChronic Daily Ethanol and Withdrawal: 2. Behavioral Changes During Prolonged Abstinence
Rasmussen, D. D., Mitton, D. R., Green, J., & Puchalski, S. S. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02308.x · Cited by 98 · see citing works
Persistence of a “subacute withdrawal syndrome” following chronic ethanol intake
Begleiter, H., & Porjesz, B. (1979) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(79)90019-x · Cited by 86 · see citing works
Neurobiological Correlates of the Disposition and Maintenance of Alcoholism
Heinz, A., Schäfer, M. K.-H., Higley, J. D., Krystal, J. H., & Goldman, D. A. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-45139 · Cited by 85 · see citing works
Overstreet, D. H., Knapp, D. J., Moy, S. S., & Breese, G. R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1425-y · Cited by 83 · see citing works
Self-citationMalcolm, R. J., Roberts, J. S., Wang, W., Myrick, H., & Anton, R. F. (2000) · Alcohol · doi:10.1016/s0741-8329(00)00114-2 · Cited by 82 · see citing works
Animal models of addiction: models for therapeutic strategies?
Wolffgramm, J., Galli, G., Heyne, A., & Thimm, F. (2000) · Journal of Neural Transmission · doi:10.1007/s007020070067 · Cited by 78 · see citing works
Irvine, E. E., Bagnalasta, M., Marcon, C., Motta, C., Tessari, M., File, S. E., & Chiamulera, C. (2000) · Psychopharmacology · doi:10.1007/s002130000586 · Cited by 73 · see citing works
Duka, T., Townshend, J. M., Collier, K., & Stephens, D. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02606.x · Cited by 70 · see citing works
Liu, X., & Weiss, F. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1267-z · Cited by 65 · see citing works
Persisting consequences of drug intake: towards a memory of addiction
Heyne, A., May, T., Goll, P., & Wolffgramm, J. (2000) · Journal of Neural Transmission · doi:10.1007/s007020070065 · Cited by 60 · see citing works
Herbal Remedies for Alcoholism: Promises and Possible Pitfalls
Overstreet, D. H., Keung, W., Rezvani, A. H., Massi, M., & Lee, D. Y. W. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000051022.26489.cf · Cited by 51 · see citing works
Self-citationKnapp, D. J., Overstreet, D. H., & Breese, G. R. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000158840.07475.97 · Cited by 43 · see citing works
Self-citationPharmacological Treatments for Alcoholism: Revisiting Lithium and Considering Buspirone
FAWCETT, J. A., Kravitz, H. M., McGuire, M., Easton, M., Ross, J. S., Pisani, V. D., Fogg, L., Clark, D. T., Whitney, M., Kravitz, G., et al. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb02038.x · Cited by 34 · see citing works
Alcohol Withdrawal and Limbic Kindling:A Hypothesis of Relapse
Adinoff, B. H., O’Neill, H. K., & Ballenger, J. C. (1995) · American Journal on Addictions · doi:10.1111/j.1521-0391.1995.tb00254.x · Cited by 31 · see citing works
THE ROLE OF ANXIETY IN PREDICTING DRINKING BEHAVIOUR
Sloan, T. (2003) · Alcohol and Alcoholism · doi:10.1093/alcalc/agg090 · Cited by 29 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [5]5. Breese GR, Overstreet DH, Knapp DJ (2005b). Conceptual frame- work for the etiology of alcoholismFa 'kindling'/stress hypo- thesis. Psychopharmacology, on line, 2004.
Cited by
Sorted by citations
A Role for Brain Stress Systems in Addiction
Koob, G. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.012 · Cited by 1,056 · see citing works
A key role for corticotropin-releasing factor in alcohol dependence
Heilig, M., & Koob, G. F. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.006 · Cited by 503 · see citing works
Addiction as a stress surfeit disorder
Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.024 · Cited by 483 · see citing works
Role of Corticotropin-Releasing Factor in Drug Addiction
Logrip, M. L., Koob, G. F., & Zorrilla, E. P. (2011) · CNS Drugs · doi:10.2165/11587790-000000000-00000 · Cited by 476 · see citing works
Neurobiological substrates for the dark side of compulsivity in addiction
Koob, G. F. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.043 · Cited by 458 · see citing works
REVIEW: Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?
Heilig, M., Egli, M., Crabbe, J. C., & Becker, H. C. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00194.x · Cited by 435 · see citing works
Koob, G. F. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_129 · Cited by 428 · see citing works
Addiction is a Reward Deficit and Stress Surfeit Disorder
Koob, G. F. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00072 · Cited by 397 · see citing works
Brain stress systems in the amygdala and addiction
Koob, G. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.038 · Cited by 388 · see citing works
Alcohol dependence as a chronic pain disorder
Egli, M., Koob, G. F., & Edwards, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.010 · Cited by 347 · see citing works
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works
Sommer, W. H., Rimondini, R., Hansson, A. C., Hipskind, P. A., Gehlert, D. R., Barr, C. S., & Heilig, M. A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.01.010 · Cited by 309 · see citing works
Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk
Seo, D., Lacadie, C., Tuit, K. L., Hong, K., Constable, R. T., & Sinha, R. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.762 · Cited by 302 · see citing works
The role of CRF and CRF-related peptides in the dark side of addiction
Koob, G. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.008 · Cited by 290 · see citing works
Breese, G. R., Sinha, R., & Heilig, M. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.09.007 · Cited by 262 · see citing works
Self-citationCorticotropin releasing factor: A key role in the neurobiology of addiction
Zorrilla, E. P., Logrip, M. L., & Koob, G. F. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.01.001 · Cited by 255 · see citing works
Pharmacogenetic approaches to the treatment of alcohol addiction
Heilig, M. A., Goldman, D. A., Berrettini, W. H., & O’Brien, C. P. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3110 · Cited by 249 · see citing works
Dynamics of Neuronal Circuits in Addiction: Reward, Antireward, and Emotional Memory
Koob, G. F. (2009) · Pharmacopsychiatry · doi:10.1055/s-0029-1216356 · Cited by 244 · see citing works
Effects of stress on alcohol drinking: a review of animal studies
Becker, H. C., Lopez, M. F., & Doremus‐Fitzwater, T. L. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2443-9 · Cited by 239 · see citing works
Gehlert, D. R., Cippitelli, A., Thorsell, A., Lê, A. D., Hipskind, P. A., Hamdouchi, C., Lu, J., Hembre, E. J., Cramer, J. W., Song, M., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4985-06.2007 · Cited by 239 · see citing works
Neurocircuitry of alcohol addiction
Koob, G. F. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00003-3 · Cited by 227 · see citing works
Influence of stress associated with chronic alcohol exposure on drinking
Becker, H. C. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.04.028 · Cited by 191 · see citing works
Marinelli, P. W., Funk, D. R., Juzytsch, W., Harding, S. E., Rice, K. C., Shaham, Y., & Lê, A. D. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0905-x · Cited by 191 · see citing works
Alcohol Dependence, Withdrawal, and Relapse
Becker, H. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405941-2.00019-5 · Cited by 184 · see citing works
Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption
Becker, H. C. (2012) · Alcohol research · doi:10.35946/arcr.v34.4.09 · Cited by 171 · see citing works
Progress in corticotropin-releasing factor-1 antagonist development
Zorrilla, E. P., & Koob, G. F. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.02.011 · Cited by 167 · see citing works
Neurobiology of dysregulated motivational systems in drug addiction
Edwards, S., & Koob, G. F. (2010) · Future Neurology · doi:10.2217/fnl.10.14 · Cited by 157 · see citing works
Development of pharmacotherapies for drug addiction: a Rosetta stone approach
Koob, G. F., Kenneth Lloyd, G., & Mason, B. J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2828 · Cited by 154 · see citing works
Escalation of drug self-administration as a hallmark of persistent addiction liability
Edwards, S., & Koob, G. F. (2013) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283644d15 · Cited by 151 · see citing works
Gilpin, N. W., Karanikas, C. A., & Richardson, H. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031466 · Cited by 146 · see citing works
Research on alcohol and adolescent brain development: opportunities and future directions
Witt, E. D. (2010) · Alcohol · doi:10.1016/j.alcohol.2009.08.011 · Cited by 125 · see citing works
Operant Behavior and Alcohol Levels in Blood and Brain of Alcohol‐Dependent Rats
Gilpin, N. W., Smith, A. D., Cole, M., Weiss, F., Koob, G. F., & Richardson, H. N. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01051.x · Cited by 122 · see citing works
Heilig, M., Thorsell, A., Sommer, W. H., Hansson, A. C., Ramchandani, V. A., George, D. T., Hommer, D., & Barr, C. S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.018 · Cited by 117 · see citing works
How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective.
Clapp, P., Bhave, S. V., & Hoffman, P. L. (2008) · PubMed Central · Cited by 116 · see citing works
Huang, M. M., Overstreet, D. H., Knapp, D. J., Angel, R. A., Wills, T. A., Navarro, M., Rivier, J., Vale, W., & Breese, G. R. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.159186 · Cited by 111 · see citing works
Self-citationBreese, G. R., Knapp, D. J., Overstreet, D. H., Navarro, M., Wills, T. A., & Angel, R. A. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301468 · Cited by 110 · see citing works
Self-citationZorrilla, E. P., Heilig, M. A., de Wit, H., & Shaham, Y. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.12.017 · Cited by 110 · see citing works
Neuroimmune Interface in the Comorbidity between Alcohol Use Disorder and Major Depression
Neupane, S. P. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00655 · Cited by 97 · see citing works
Role of the Serotonergic System in Alcohol Dependence
Sari, Y., Johnson, V. R., & Weedman, J. M. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385506-0.00010-7 · Cited by 91 · see citing works
Brain reward deficits accompany withdrawal (hangover) from acute ethanol in rats
Schulteis, G., & Liu, J. (2006) · Alcohol · doi:10.1016/j.alcohol.2006.06.008 · Cited by 91 · see citing works
Hansson, A. C., Cippitelli, A., Sommer, W. H., Ciccocioppo, R., & Heilig, M. A. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00050.x · Cited by 88 · see citing works
Knapp, D. J., Overstreet, D. H., & Breese, G. R. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00342.x · Cited by 85 · see citing works
Self-citationNeurochemical mechanisms of alcohol withdrawal
Becker, H. C., & Mulholland, P. J. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00009-4 · Cited by 83 · see citing works
Functional CRH variation increases stress-induced alcohol consumption in primates
Barr, C. S., Dvoskin, R. L., Gupte, M., Sommer, W. H., Sun, H., Schwandt, M. L., Lindell, S. G., Kasckow, J., Suomi, S. J., Goldman, D. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902863106 · Cited by 80 · see citing works
Sex differences in neuroadaptation to alcohol and withdrawal neurotoxicity
Sharrett-Field, L. J., Butler, T. R., Reynolds, A. R., Berry, J. N., & Prendergast, M. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1266-4 · Cited by 77 · see citing works
Lowery, E., & Thiele, T. E. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710790966605 · Cited by 71 · see citing works
Pastor, R., McKinnon, C. S., Scibelli, A. C., Burkhart‐Kasch, S., Reed, C. L., Ryabinin, A. E., Coste, S. C., Stenzel‐Poore, M. P., & Phillips, T. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710181105 · Cited by 63 · see citing works
Walker, B. M., Drimmer, D. A., Walker, J. L., Liu, T., Mathé, A. A., & Ehlers, C. L. (2010) · Alcohol · doi:10.1016/j.alcohol.2010.06.006 · Cited by 63 · see citing works
Knapp, D. J., Whitman, B. A., Wills, T. A., Angel, R. A., Overstreet, D. H., Criswell, H. E., Ming, Z., & Breese, G. R. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.02.018 · Cited by 60 · see citing works
Self-citationWills, T. A., Knapp, D. J., Overstreet, D. H., & Breese, G. R. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00856.x · Cited by 59 · see citing works
Self-citationCorticotropin-Releasing Factor (CRF) and Addictive Behaviors
Roberto, M., Spierling, S. R., Kirson, D., & Zorrilla, E. P. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.06.004 · Cited by 58 · see citing works
Williams, A. M., Reis, D. J., Powell, A. S., Neira, L. J., Nealey, K. A., Ziegler, C. E., Kloss, N. D., Bilimoria, J. L., Smith, C. E., & Walker, B. M. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2691-3 · Cited by 53 · see citing works
Wolitzky-Taylor, K. B., Operskalski, J. T., Ries, R., Craske, M., & Roy-Byrne, P. (2011) · Journal of addiction medicine · doi:10.1097/adm.0b013e31823276d7 · Cited by 47 · see citing works
Belmer, A., Patkar, O. L., Lanoue, V., & Bartlett, S. E. (2018) · Scientific Reports · doi:10.1038/s41598-018-20504-z · Cited by 48 · see citing works
Phillips, T. J., Reed, C. L., & Pastor, R. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12189 · Cited by 46 · see citing works
Brain pathways to recovery from alcohol dependence
Cui, C., Noronha, A., Warren, K. R., Koob, G. F., Sinha, R., Thakkar, M. M., Matochik, J. A., Crews, F. T., Chandler, L. J., Pfefferbaum, A., et al. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.04.006 · Cited by 45 · see citing works
Mejía-Toiber, J., Boutros, N., Markou, A., & Semenova, S. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.019 · Cited by 45 · see citing works
Ayanwuyi, L. O., Carvajal, F., Lerma-Cabrera, J. M., Domi, E., Björk, K., Ubaldi, M., Heilig, M. A., Roberto, M., Ciccocioppo, R., & Cippitelli, A. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00023 · Cited by 44 · see citing works
Knapp, D. J., Harper, K. M., Whitman, B. A., Zimomra, Z. R., & Breese, G. R. (2016) · Brain Sciences · doi:10.3390/brainsci6030025 · Cited by 43 · see citing works
Self-citationKoob, G. F., & Vendruscolo, L. F. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2023_424 · Cited by 44 · see citing works
Serotonergic Neuroplasticity in Alcohol Addiction
Belmer, A., Patkar, O. L., Pitman, K. M., & Bartlett, S. E. (2015) · Brain Plasticity · doi:10.3233/bpl-150022 · Cited by 42 · see citing works
An Update on CRF Mechanisms Underlying Alcohol Use Disorders and Dependence
Quadros, I. M., Macedo, G. C., Domingues, L. P., & Favoretto, C. A. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00134 · Cited by 42 · see citing works
Läck, A. K., Christian, D., Diaz, M. R., & McCool, B. A. (2009) · Alcohol · doi:10.1016/j.alcohol.2008.11.002 · Cited by 42 · see citing works
Buck, H. M., Hueston, C. M., Bishop, C., & Terrence Deak, B. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2388-z · Cited by 41 · see citing works
Endocannabinoid signaling in neurotoxicity and neuroprotection
Pope, C., Mechoulam, R., & Parsons, L. H. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.12.002 · Cited by 40 · see citing works
A selective ALDH-2 inhibitor reduces anxiety in rats
Overstreet, D. H., Knapp, D. J., Breese, G. R., & Diamond, I. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.09.004 · Cited by 40 · see citing works
Self-citationGilpin, N. W. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.08.001 · Cited by 38 · see citing works
Episodic Withdrawal Promotes Psychomotor Sensitization to Morphine
Rothwell, P. E., Gewirtz, J. C., & Thomas, M. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.134 · Cited by 38 · see citing works
Zamora-Martinez, E. R., & Edwards, S. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2014.00024 · Cited by 37 · see citing works
Wills, T. A., Knapp, D. J., Overstreet, D. H., & Breese, G. R. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00709.x · Cited by 36 · see citing works
Self-citationPrendergast, M., & Mulholland, P. J. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00375.x · Cited by 35 · see citing works
Knapp, D. J., Overstreet, D. H., Angel, R. A., Navarro, M., & Breese, G. R. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00514.x · Cited by 34 · see citing works
Self-citationVasopressin and alcohol: a multifaceted relationship
Harper, K. M., Knapp, D. J., Criswell, H. E., & Breese, G. R. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5099-x · Cited by 34 · see citing works
Self-citationGammie, S. C., & Stevenson, S. A. (2006) · Stress · doi:10.1080/10253890600969106 · Cited by 33 · see citing works
Interactions of Stress and CRF in Ethanol‐Withdrawal Induced Anxiety in Adolescent and Adult Rats
Wills, T. A., Knapp, D. J., Overstreet, D. H., & Breese, G. R. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01245.x · Cited by 33 · see citing works
Self-citationHomer2 regulates alcohol and stress cross-sensitization
Quadir, S. G., dos Santos, J. R. B., Campbell, R. R., Wroten, M. G., Singh, N., Holloway, J. J., Bal, S. K., Camarini, R., & Szumlinski, K. K. (2015) · Addiction Biology · doi:10.1111/adb.12252 · Cited by 32 · see citing works
Biobehavioral Interactions Between Stress and Alcohol
Weera, M. M. (2019) · Alcohol research · doi:10.35946/arcr.v40.1.04 · Cited by 32 · see citing works
Genetic Variation and Brain Gene Expression in Rodent Models of Alcoholism
Björk, K., Hansson, A. C., & Sommer, W. H. (2010) · International review of neurobiology · doi:10.1016/s0074-7742(10)91005-2 · Cited by 32 · see citing works
Knapp, D. J., Overstreet, D. H., Huang, M. M., Wills, T. A., Whitman, B. A., Angel, R. A., Sinnett, S. E., & Breese, G. R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2366-5 · Cited by 31 · see citing works
Self-citationAlcohol dose effects on stress response to cued threat vary by threat intensity
Moberg, C. A., Weber, S. M., & Curtin, J. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2304-6 · Cited by 27 · see citing works
Rasmussen, D. D., Kincaid, C., & Froehlich, J. C. (2016) · Alcohol and Alcoholism · doi:10.1093/alcalc/agw082 · Cited by 28 · see citing works
Albrechet‐Souza, L., Viola, T. W., Grassi‐Oliveira, R., Miczek, K. A., & de Almeida, R. M. M. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00762 · Cited by 28 · see citing works
Tanaka, K., Kunishige-Yamamoto, A., Hashimoto, H., Shintani, N., Hayata, A., & Baba, A. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.136 · Cited by 24 · see citing works
Barkley‐Levenson, A. M., & Crabbe, J. C. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.07.022 · Cited by 22 · see citing works
Morisot, N., Moine, C. L., Millan, M. J., & Contarino, A. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000625 · Cited by 21 · see citing works
Morisot, N., Monier, R., Moine, C. L., Millan, M. J., & Contarino, A. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14159 · Cited by 26 · see citing works
Harper, K. M., Knapp, D. J., Butler, R. K., Cook, C. A., Criswell, H. E., Stuber, G. D., & Breese, G. R. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14163 · Cited by 21 · see citing works
Self-citationNeira, S., Hassanein, L. A., Stanhope, C. M., Buccini, M. C., D’Ambrosio, S., Flanigan, M. E., Haun, H. L., Boyt, K. M., Bains, J. S., & Kash, T. L. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14901 · Cited by 18 · see citing works
Ming, Z., Criswell, H. E., & Breese, G. R. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.06.001 · Cited by 18 · see citing works
Self-citationHow Adaptation of the Brain to Alcohol Leads to Dependence
Clapp, P., Bhave, S. V., Hoffman, P. L., & de Paula, L. F. (2008) · Cited by 18 · see citing works
Maldonado‐Devincci, A. M., Kampov-Polevoi, A., McKinley, R. E., Morrow, D., O’Buckley, T. K., & Morrow, A. L. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00040 · Cited by 17 · see citing works
Breese, G. R., & Knapp, D. J. (2016) · Alcohol · doi:10.1016/j.alcohol.2016.01.005 · Cited by 15 · see citing works
Self-citationMorisot, N., & Contarino, A. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.021 · Cited by 16 · see citing works
Reilly, M. T., Noronha, A., & Warren, K. R. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00002-1 · Cited by 16 · see citing works
Koob, G. F., & Moal, M. L. (2006) · Elsevier eBooks · doi:10.1016/b978-012419239-3/50042-4 · Cited by 15 · see citing works
Can CRF1receptor antagonists become antidepressant and/or anxiolytic agents?
Overstreet, D. H., Knapp, D. J., & Breese, G. R. (2005) · Drug Development Research · doi:10.1002/ddr.20023 · Cited by 14 · see citing works
Self-citationHarper, K. M., Knapp, D. J., Park, M. A., & Breese, G. R. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4439-y · Cited by 13 · see citing works
Self-citationEmerging targets for addiction neuropharmacology
Ubaldi, M., Cannella, N., & Ciccocioppo, R. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.07.018 · Cited by 11 · see citing works
Animal Models of Drug Dependence: Motivational Perspective
Koob, G. F. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0338-9_15 · Cited by 10 · see citing works
- Authors
- Breese, G. R., Overstreet, D. H., Knapp, D. J., & Navarro, M.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Breese, George R
- Venue
- Neuropsychopharmacology
- Published
- 2005-02-23
- Volume
- 30
- Issue
- 9
- Pages
- 1662-1669
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC2864139
- OpenAlex
- W1979024772
- Cited by
- 124
- References
- 41
- Citations by year
- 2025: 2 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 7 · 2018: 4 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 10 · 2013: 8 · 2012: 6
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA014284, AA-14284, P50AA011605, AA 11605, R01AA014949, AA 14949, P60AA011605)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- ethanol withdrawal, stress-induced anxiety, restraint stress, social interaction, CRF1 receptor antagonist, benzodiazepine antagonists, 5-HT1A receptor agonist, alcohol craving, relapse, alcoholism
- MeSH terms
- Ethanol, Analysis of Variance, Animals, Anxiety, Behavior, Animal, Buspirone, Central Nervous System Depressants, Drug Interactions, Flumazenil, Food, Formulated, Interpersonal Relations, Male, Pyrimidines, Pyrroles, Restraint, Physical, Stress, Psychological, Substance Withdrawal Syndrome, Time Factors, Anti-Anxiety Agents, Rats, Sprague-Dawley, Serotonin Receptor Agonists, Receptors, Corticotropin-Releasing Hormone, GABA Modulators, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
