Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety
Open accessAbstract
Stress has been shown to facilitate ethanol withdrawal-induced anxiety. Defining neurobiological mechanisms through which stress has such actions is important given the associated risk of relapse. While CRF has long been implicated in the action of stress, current results show that stress elevates the cytokine TNFα in the rat brain and thereby implicates cytokines in stress effects. In support of this view, prior TNFα microinjection into the central amygdala (CeA) of rats facilitated ethanol withdrawal-induced anxiety-a response that could not be attributed to an increase in plasma corticosterone. To test for a possible interaction between cytokines and CRF, a CRF1-receptor antagonist (SSR125543) administered prior to the repeated administration of TNFα or MCP-1/CCL2 reduced the magnitude of the withdrawal-induced anxiety. This finding provided evidence for cytokine action being dependent upon CRF. Additionally, the sensitizing effect of stress on withdrawal-induced anxiety was reduced by treating the repeated stress exposure prior to ethanol with the MEK inhibitor SL327. Consistent with cytokines having a neuromediator function distinct from a neuroimmune action, TNFα increased firing rate and GABA release from CeA neurons. Thus, an interaction of glial and neuronal function is proposed to contribute to the interaction of stress and chronic ethanol. Interrupting this potential glial-neuronal interaction could provide a novel means by which to alter the development of emotional states induced by stress that predict relapse in the alcoholic.
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Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396 · see citing works
Regier, D. A. (1990) · JAMA · doi:10.1001/jama.1990.03450190043026 · Cited by 3,962 · see citing works
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
Regier, D. A., Farmer, M. E., Rae, D. S., et al. (1990) · PubMed · Cited by 1,913 · see citing works
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297 · see citing works
Kawasaki, Y., Zhang, L., Cheng, J.-K., & Ji, R.-R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3338-07.2008 · Cited by 1,162 · see citing works
CAN SOCIAL INTERACTION BE USED TO MEASURE ANXIETY?
File, S. E., & Hyde, J. R. G. (1978) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1978.tb07001.x · Cited by 808 · see citing works
A review of 25 years of the social interaction test
File, S. E., & Seth, P. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01273-1 · Cited by 744 · see citing works
Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage
Alfonso-Loeches, S., Pascual-Lucas, M., Blanco, A. M., Sanchez-Vera, I., & Guerri, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0976-10.2010 · Cited by 579 · see citing works
Qin, L., He, J., Hanes, R. N., Pluzarev, O., Hong, J.-S., & Crews, F. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-10 · Cited by 532 · see citing works
Epigenetic and immune function profiles associated with posttraumatic stress disorder
Uddin, M., Aiello, A. E., Wildman, D. E., Koenen, K. C., Pawelec, G., de los Santos, R., Goldmann, E., & Galea, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910794107 · Cited by 518 · see citing works
Increased MCP-1 and microglia in various regions of the human alcoholic brain
He, J., & Crews, F. T. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.11.017 · Cited by 516 · see citing works
A key role for corticotropin-releasing factor in alcohol dependence
Heilig, M., & Koob, G. F. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.006 · Cited by 503 · cited 1× · see citing works
“Overall, these experiments are consistent with a growing body of evidence implicating CRF in stress and chronic ethanol effects that influence emotional behavior and ethanol consumption (Breese et al., 2010; Heilig and Koob, 2007 for reviews).”
ResultSINHA, R., & LI, C. ‐. R. (2007) · Drug and Alcohol Review · doi:10.1080/09595230601036960 · Cited by 497 · see citing works
Sinha, R., Fox, H. C., Hong, K. A., Bergquist, K., Bhagwagar, Z., & Siedlarz, K. M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.78 · Cited by 466 · see citing works
Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat
Nguyen, K. T., Deak, T., Owens, S. M., Kohno, T., Fleshner, M., Watkins, L. R., & Maier, S. F. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02239.1998 · Cited by 460 · see citing works
Cytokines as mediators of depression: what can we learn from animal studies?
Dunn, A. J., Swiergiel, A. H., & Beaurepaire, R. D. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.023 · Cited by 459 · see citing works
The neuropoietic cytokine family in development, plasticity, disease and injury
Bauer, Š., Kerr, B. J., & Patterson, P. H. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2054 · Cited by 412 · see citing works
Brain stress systems in the amygdala and addiction
Koob, G. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.038 · Cited by 388 · see citing works
Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02448.x · Cited by 387 · see citing works
Stress and Alcohol Interaction: An Update of Human Research
Pohorecky, L. A. (1991) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1991.tb00543.x · Cited by 341 · see citing works
Hauger, R., Risbrough, V. B., Brauns, O., & Dautzenberg, F. M. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706777950684 · Cited by 341 · see citing works
Hayley, S., Poulter, M. O., Merali, Z., & Anisman, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.051 · Cited by 324 · see citing works
Chemokines: a new class of neuromodulator?
Rostène, W. H., Kitabgi, P., & Parsadaniantz, S. M. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2255 · Cited by 321 · see citing works
Bajetto, A., Bonavia, R., Barbero, S., & Schettini, G. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01091.x · Cited by 318 · see citing works
Stress‐Induced and Alcohol Cue‐Induced Craving in Recently Abstinent Alcohol‐Dependent Individuals
Fox, H. C., Bergquist, K. L., Hong, K., & Sinha, R. (2007) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00320.x · Cited by 315 · see citing works
Frank, M. G., Miguel, Z. D., Watkins, L. R., & Maier, S. F. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.07.008 · Cited by 303 · see citing works
Cytokines, stress and depressive illness: Brain-immune interactions.
Anisman, H., & Merali, Z. (2003) · Annals of Medicine · doi:10.1080/07853890310004075 · Cited by 302 · see citing works
The role of CRF and CRF-related peptides in the dark side of addiction
Koob, G. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.008 · Cited by 290 · see citing works
Breese, G. R., Sinha, R., & Heilig, M. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.09.007 · Cited by 262 · see citing works
Self-citationImmobilization stress induces interleukin-1β mRNA in the rat hypothalamus
Minami, M., Kuraishi, Y., Yamaguchi, T., Nakai, S., Hirai, Y., & Satoh, M. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90944-o · Cited by 258 · see citing works
Monocyte chemoattractant protein‐1 functions as a neuromodulator in dorsal root ganglia neurons
Jung, H., Tóth, P. T., White, F. A., & Miller, R. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04969.x · Cited by 247 · see citing works
Peripheral and central proinflammatory cytokine response to a severe acute stressor
O'Connor, K. A., Johnson, J. D., Hansen, M. K., Wieseler Frank, J. L., Maksimova, E., Watkins, L. R., & Maier, S. F. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.006 · Cited by 247 · see citing works
The interaction of alcohol and stress A review
Pohorecky, L. A. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90003-8 · Cited by 239 · see citing works
Role of CRF Receptor Signaling in Stress Vulnerability, Anxiety, and Depression
Hauger, R. L., Risbrough, V., Oakley, R. H., Olivares‐Reyes, J. A., & Dautzenberg, F. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05011.x · Cited by 217 · see citing works
Smith, R. J., & Aston-Jones, G. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0191-3 · Cited by 206 · see citing works
Valdez, G. R., Roberts, A., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · PubMed · doi:10.1097/01.alc.0000033120.51856.f0 · Cited by 187 · see citing works
Synaptic physiology of central CRH system
Gallagher, J. P., Orozco-Cabal, L. F., Liu, J., & Shinnick‐Gallagher, P. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.075 · Cited by 177 · see citing works
Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors
Overstreet, D. H. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.11.010 · Cited by 169 · see citing works
Self-citationMunhoz, C. D., Sorrells, S. F., Caso, J. R., Scavone, C., & Sapolsky, R. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0303-09.2010 · Cited by 169 · see citing works
Conceptual framework for the etiology of alcoholism: a “kindling”/stress hypothesis
Breese, G. R., Overstreet, D. H., & Knapp, D. J. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2016-2 · Cited by 167 · see citing works
Self-citationAccentuated Decrease in Social Interaction in Rats Subjected to Repeated Ethanol Withdrawals
Overstreet, D. H., Knapp, D. J., & Breese, G. R. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02665.x · Cited by 160 · see citing works
Self-citationPlata‐Saláman, C. R., Sonti, G., Borkoski, J. P., Wilson, C. D., & ffrench‐Mullen, J. M. H. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(96)00148-5 · Cited by 158 · see citing works
Stress-induced increases in hypothalamic IL-1: a systematic analysis of multiple stressor paradigms
Terrence Deak, B., Bordner, K. A., McElderry, N. K., Barnum, C. J., Blandino, P., Deak, M. M., & Tammariello, S. P. (2004) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.11.003 · Cited by 143 · see citing works
Szabó, G., Dolganiuc, A., Dai, Q., & Pruett, S. B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1243 · Cited by 137 · see citing works
Breese, G. R., Overstreet, D. H., Knapp, D. J., & Navarro, M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300706 · Cited by 124 · see citing works
Self-citationViewing chemokines as a third major system of communication in the brain
Adler, M. W., Geller, E. B., Chen, X., & Rogers, T. J. (2005) · The AAPS Journal · doi:10.1208/aapsj070484 · Cited by 117 · see citing works
Breese, G. R., Knapp, D. J., & Overstreet, D. H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300282 · Cited by 115 · see citing works
Self-citationHuang, M. M., Overstreet, D. H., Knapp, D. J., Angel, R. A., Wills, T. A., Navarro, M., Rivier, J., Vale, W., & Breese, G. R. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.159186 · Cited by 111 · see citing works
Self-citationBreese, G. R., Knapp, D. J., Overstreet, D. H., Navarro, M., Wills, T. A., & Angel, R. A. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301468 · Cited by 110 · see citing works
Self-citationJohnson, J. D., O’Connor, K., Watkins, L. R., & Maier, S. F. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.046 · Cited by 107 · see citing works
Hains, L. E., Loram, L. C., Weiseler, J. L., Frank, M. G., Bloss, E. B., Sholar, P. W., Taylor, F. R., Harrison, J. A., Martin, T. J., Eisenach, J. C., et al. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.01.271 · Cited by 94 · see citing works
Acute Ethanol Treatment Modulates Toll‐like Receptor‐4 Association with Lipid Rafts
Dolganiuc, A., Bakis, G., Kodys, K., Mandrekar, P., & Szabó, G. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00003.x · Cited by 94 · see citing works
Sensitization associated with stressors and cytokine treatments
Anisman, H., Merali, Z., & Hayley, S. P. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00100-9 · Cited by 89 · see citing works
Brain cytokines as neuromodulators in cardiovascular control
Shi, P. D., Raizada, M. K., & Sumners, C. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05234.x · Cited by 86 · see citing works
Role of interleukin-1 in stress responses
Shintani, F., Nakaki, T., Kanba, S., Kato, R., & Asai, M. (1995) · Molecular Neurobiology · doi:10.1007/bf02740837 · Cited by 85 · see citing works
Overstreet, D. H., Knapp, D. J., Moy, S. S., & Breese, G. R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1425-y · Cited by 83 · see citing works
Self-citationJara, J. H., Singh, B. B., Floden, A. M., & Combs, C. K. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04330.x · Cited by 83 · see citing works
The association of alcoholism and anxiety
Brady, K. T., & Lydiard, R. B. (1993) · Psychiatric Quarterly · doi:10.1007/bf01065866 · Cited by 80 · see citing works
Chemokines/intercrines and central regulation of feeding
Plata‐Saláman, C. R., & Borkoski, J. P. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.5.r1711 · Cited by 78 · see citing works
Wang, W., Ji, P., & Dow, K. E. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01544.x · Cited by 77 · see citing works
Lowery, E., & Thiele, T. E. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710790966605 · Cited by 71 · see citing works
Zhang, Z., Morse, A. C., Koob, G. F., & Schulteis, G. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00483.x · Cited by 70 · see citing works
Zhu, W., Zheng, H.-H., Shao, X.-L., Wang, W., Yao, Q., & Li, Z.-L. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06763.x · Cited by 68 · see citing works
Wills, T. A., Knapp, D. J., Overstreet, D. H., & Breese, G. R. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00856.x · Cited by 59 · see citing works
Self-citationOverstreet, D. H., Knapp, D. J., Angel, R. A., Navarro, M., & Breese, G. R. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0389-0 · Cited by 58 · see citing works
Self-citationShizuya, K., Komori, T., Fujiwara, R., Miyahara, S., Ohmori, M., & Nomura, J. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00608-5 · Cited by 55 · see citing works
Suzuki, E., Shintani, F., Kanba, S., Asai, M., & Nakaki, T. (1997) · Cellular and Molecular Neurobiology · doi:10.1023/a:1026319107528 · Cited by 51 · see citing works
Plata‐Saláman, C. R. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00148-5 · Cited by 50 · see citing works
Unkind cytokines: Current evidence for the potential role of cytokines in immune-mediated depression
Pucak, M. L., & Kaplin, A. I. (2005) · International Review of Psychiatry · doi:10.1080/02646830500381757 · Cited by 48 · see citing works
Functional expression of corticotropin‐releasing hormone (CRH) receptor 1 in cultured rat microglia
Wang, W., Ji, P., Riopelle, R. J., & Dow, K. E. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00687.x · Cited by 46 · see citing works
Knapp, D. J., Overstreet, D. H., & Breese, G. R. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000158840.07475.97 · Cited by 43 · see citing works
Self-citationdel Cerro, S., & Borrell, J. I. (1990) · Brain Research · doi:10.1016/0006-8993(90)90212-t · Cited by 41 · see citing works
Wills, T. A., Knapp, D. J., Overstreet, D. H., & Breese, G. R. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00709.x · Cited by 36 · see citing works
Self-citationBorsody, M. K., & Weiss, J. M. (2002) · NeuroImmunoModulation · doi:10.1159/000065186 · Cited by 34 · see citing works
Knapp, D. J., Overstreet, D. H., Angel, R. A., Navarro, M., & Breese, G. R. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00514.x · Cited by 34 · see citing works
Self-citationKohman, R. A., Tarr, A. J., Sparkman, N. L., Day, C. E., Paquet, A. J., Akkaraju, G. R., & Boehm, G. W. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.01.009 · Cited by 31 · see citing works
Corticosterone basal levels and vulnerability to LPS-induced neuroinflammation in the rat brain
Perez‐Nievas, B. G., Madrigal, J. L. M., García‐Bueno, B., Zoppi, S., & Leza, J. C. (2009) · Brain Research · doi:10.1016/j.brainres.2009.12.014 · Cited by 26 · see citing works
Interleukin-1β has excitatory effects on neurons of the bed nucleus of the stria terminalis
Wilkinson, M. F., Matheison, W. B., & Pittman, Q. J. (1993) · Brain Research · doi:10.1016/0006-8993(93)91079-8 · Cited by 24 · see citing works
Flagged first, then by citations
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Sorted by citations
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works
Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework
Koob, G. F., & Colrain, I. M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0446-0 · Cited by 280 · see citing works
Neuroimmune Mechanisms of Alcohol and Drug Addiction
Cui, C., Shurtleff, D., & Harris, R. A. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00001-4 · Cited by 163 · see citing works
Hueston, C. M., & Terrence Deak, B. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.10.035 · Cited by 122 · see citing works
Munshi, S., Loh, M. K., Ferrara, N., DeJoseph, M. R., Ritger, A., Padival, M., Record, M. J., Urban, J. H., & Rosenkranz, J. A. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.11.023 · Cited by 117 · see citing works
Rathbone, A. T. L., Tharmaradinam, S., Jiang, S., Rathbone, M. P., & Kumbhare, D. A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.02.009 · Cited by 95 · see citing works
Wallace, C. W., & Fordahl, S. C. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000196 · Cited by 92 · see citing works
Doremus‐Fitzwater, T. L., Buck, H. M., Bordner, K. A., Richey, L., Jones, M. E., & Terrence Deak, B. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12481 · Cited by 85 · see citing works
Whitman, B. A., Knapp, D. J., Werner, D. F., Crews, F. T., & Breese, G. R. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12189 · Cited by 79 · see citing works
Self-citationAlcohol Hangover: Underlying Biochemical, Inflammatory and Neurochemical Mechanisms
Palmer, E. O. C., Tyacke, R. J., Sastre, M., Lingford-Hughes, A. R., Nutt, D., & Ward, R. J. (2019) · Alcohol and Alcoholism · doi:10.1093/alcalc/agz016 · Cited by 79 · see citing works
The amygdala, a relay station for switching on and off pain
Rouwette, T., Vanelderen, P., Roubos, E. W., Kozicz, T., & Vissers, K. C. P. (2011) · European Journal of Pain · doi:10.1002/j.1532-2149.2011.00071.x · Cited by 70 · see citing works
Xu, J., Ma, H., Liu, X., Rosenthal, S. B., Baglieri, J., McCubbin, R., Sun, M., Koyama, Y., Geoffroy, C. G., Saijo, K., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.131277 · Cited by 67 · see citing works
Ethanol and Cytokines in the Central Nervous System
Roberto, M., Patel, R. R., & Bajo, M. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_77 · Cited by 71 · see citing works
Centanni, S. W., Bedse, G., Patel, S., & Winder, D. G. (2019) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.14178 · Cited by 58 · see citing works
“In particular, TNFα increases firing rate and GABA release in the CeA and intra-CeA TNFα can sensitize mice to anxietylike behavior induced by subsequent withdrawal episodes (Knapp et al., 2011).”
BackgroundFreeman, K., Brureau, A., Vadigepalli, R., Staehle, M. M., Morin‐Brureau, M., Gonye, G. E., Hoek, J. B., Hooper, D. C., & Schwaber, J. S. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-97 · Cited by 57 · see citing works
Dissecting the Relationship Between Neuropsychiatric and Neurodegenerative Disorders
Gupta, R. V., Advani, D., Yadav, D., Ambasta, R. K., & Kumar, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03502-9 · Cited by 58 · see citing works
Jiang, Y., Peng, T., Gaur, U., Silva, M., Little, P. J., Chen, Z., Qiu, W., Zhang, Y., & Zheng, W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00290 · Cited by 53 · see citing works
Sex Differences in the Inflammatory Consequences of Stress: Implications for Pharmacotherapy
Martínez-Muñiz, G. A., & Wood, S. K. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.266205 · Cited by 47 · see citing works
Phillips, T. J., Reed, C. L., & Pastor, R. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12189 · Cited by 46 · see citing works
Vecchiarelli, H. A., Gandhi, C. P., Gray, J. M., Morena, M., Hassan, K. I., & Hill, M. N. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.026 · Cited by 45 · see citing works
Pan, Y.-Q., Lin, W.-J., Wang, W.-W., Qi, X.-L., Wang, D.-L., & Tang, M.-M. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.03.031 · Cited by 47 · see citing works
Agoglia, A. E., Sharko, A. C., Psilos, K. E., Holstein, S. E., Reid, G. T., & Hodge, C. W. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12645 · Cited by 44 · see citing works
Knapp, D. J., Harper, K. M., Whitman, B. A., Zimomra, Z. R., & Breese, G. R. (2016) · Brain Sciences · doi:10.3390/brainsci6030025 · Cited by 43 · see citing works
Self-citationKoob, G. F., & Vendruscolo, L. F. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2023_424 · Cited by 44 · see citing works
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Quadros, I. M., Macedo, G. C., Domingues, L. P., & Favoretto, C. A. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00134 · Cited by 42 · see citing works
Li, C., Huang, B., & Zhang, Y. (2021) · Pharmaceuticals · doi:10.3390/ph14010065 · Cited by 33 · see citing works
Helms, C. M., Messaoudi, I., Jeng, S., Freeman, W. M., Vrana, K. E., & Grant, K. A. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01685.x · Cited by 32 · see citing works
Munshi, S., & Rosenkranz, J. A. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.08.017 · Cited by 31 · see citing works
Micheli, L., Spitoni, S., Mannelli, L. D. C., Bilia, A. R., Ghelardini, C., & Pallanti, S. (2020) · Phytotherapy Research · doi:10.1002/ptr.6684 · Cited by 31 · see citing works
Knapp, D. J., Overstreet, D. H., Huang, M. M., Wills, T. A., Whitman, B. A., Angel, R. A., Sinnett, S. E., & Breese, G. R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2366-5 · Cited by 31 · see citing works
Self-citationDoremus‐Fitzwater, T. L., Paniccia, J. E., Gano, A., Vore, A. S., & Deak, T. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.02.009 · Cited by 23 · see citing works
Smiley, C. E., & Wood, S. K. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108212 · Cited by 23 · see citing works
O’Sullivan, S. J., & Schwaber, J. S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.033 · Cited by 21 · see citing works
Harper, K. M., Knapp, D. J., & Breese, G. R. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12898 · Cited by 19 · see citing works
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Cui, C., Grandison, L., & Noronha, A. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.03.005 · Cited by 19 · see citing works
Ming, Z., Criswell, H. E., & Breese, G. R. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.06.001 · Cited by 18 · see citing works
Self-citationBreese, G. R., & Knapp, D. J. (2016) · Alcohol · doi:10.1016/j.alcohol.2016.01.005 · Cited by 15 · see citing works
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Knapp, D. J., & Breese, G. R. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_444 · Cited by 15 · see citing works
Self-citationBray, J. G., Roberts, A. J., & Gruol, D. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.009 · Cited by 15 · see citing works
Harper, K. M., Knapp, D. J., Park, M. A., & Breese, G. R. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4439-y · Cited by 13 · see citing works
Self-citationMichalak, A., Wnorowski, A., Berardinelli, A., Zinato, S., Rusinek, J., & Budzyńska, B. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108302 · Cited by 11 · see citing works
García‐Pérez, D., Laorden, M. L., & Milanés, M. V. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv077 · Cited by 11 · see citing works
Zhao, Z., Kim, S. C., Jiao, Y., Wang, Y., Lee, B. H., Kim, H. Y., Lee, C. W., Yang, C. H., & Zhao, R. (2021) · Behavioural Neurology · doi:10.1155/2021/2149371 · Cited by 10 · see citing works
García‐Pérez, D., Laorden, M. L., & Milanés, M. V. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9631-2 · Cited by 10 · see citing works
Lee, S., Kim, S. Y., Lee, S., Jang, S., Hwang, S., Kwon, Y., Choi, J., & Kwon, O. (2024) · iScience · doi:10.1016/j.isci.2024.109675 · Cited by 9 · see citing works
Mason, B. J., Estey, D., Roberts, A. J., de Guglielmo, G., George, O., Light, J. M., Stoolmiller, M., Quello, S. B., Skinner, M., Shadan, F. F., et al. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100604 · Cited by 8 · see citing works
Harper, K. M., Knapp, D. J., Park, M. A., & Breese, G. R. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.03.007 · Cited by 8 · see citing works
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Melkumyan, M., Randall, P. A., & Silberman, Y. (2024) · Addiction Neuroscience · doi:10.1016/j.addicn.2024.100194 · Cited by 7 · see citing works
Neurobiology of negative reinforcement as a driving force in alcohol addiction
Vendruscolo, L. F., & Koob, G. F. (2026) · Neuron · doi:10.1016/j.neuron.2026.04.038 · Cited by 4 · see citing works
The Mental Burden of Immunoperception
Saghazadeh, A., Hafizi, S., & Rezaei, N. (2019) · Springer eBooks · doi:10.1007/978-3-030-10620-1_9 · Cited by 3 · see citing works
The Immunoemotional Regulatory System
Saghazadeh, A., & Rezaei, N. (2019) · Springer eBooks · doi:10.1007/978-3-030-10620-1_11 · Cited by 2 · see citing works
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Knapp, D. J., Daws, L. C., & Overstreet, D. H. (2014) · World Journal of Neuroscience · doi:10.4236/wjns.2014.43026 · Cited by 2 · see citing works
Self-citationMcElhinny, C. J., Lewin, A. H., Brieaddy, L., Fix, S. E., Imler, G. H., Deschamps, J. R., Mascarella, S. W., Seltzman, H. H., Reddy, P. A., & Carroll, F. I. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104955 · Cited by 1 · see citing works
Calcineurin signaling as a target for the treatment of alcohol abuse and neuroinflammatory disorders
Ronan, P. J., Flynn, S., & Beresford, T. P. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.06.008 · Cited by 1 · see citing works
Gruol, D. L. (2017) · MDPI eBooks · doi:10.3390/books978-3-03842-571-7 · Cited by 1 · see citing works
Rouwette, T., Vanelderen, P., Roubos, E. W., Kozicz, T., & Vissers, K. C. P. (2013) · Neuropraxis · doi:10.1007/s12474-013-0002-3
Cannady, R. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/2zjq-y805
(2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816793-9.00001-3
Ge, Y., Yuan, Y.-H., Li, M., Huang, Z.-X., Zhang, C.-L., Yu, C.-Y., Xu, J.-Y., Zhang, S., Guo, H.-W., Zhang, X., et al. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1829878
- Authors
- Knapp, D. J., Whitman, B. A., Wills, T. A., Angel, R. A., Overstreet, D. H., Criswell, H. E., Ming, Z., & Breese, G. R.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Knapp, Darin J.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 25
- Pages
- S146-S154
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3138123
- OpenAlex
- W2125222220
- Cited by
- 60
- References
- 78
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 6 · 2019: 9 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Sanofi
- National Institute on Alcohol Abuse and Alcoholism (P50AA011605, R01AA014949, AA011605, AA 14949, R01AA017462, AA017462, P60AA011605)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- stress, corticotropin-releasing factor, cytokines, TNF-α, CCL2/MCP-1, CRF1 receptor antagonist, central amygdala, MEK inhibition, SL327, GABA release, neuron-glia interactions, relapse, chronic ethanol exposure
- MeSH terms
- Adaptation, Psychological, Ethanol, Alcohols, Amygdala, Analysis of Variance, Animals, Anxiety, Corticosterone, Corticotropin-Releasing Hormone, Electrophysiology, Hydrocarbons, Halogenated, Male, Microinjections, Restraint, Physical, Stress, Physiological, Substance Withdrawal Syndrome, Thiazines, Tumor Necrosis Factor-alpha, Cytokines, Rats, Sprague-Dawley, Receptors, Corticotropin-Releasing Hormone, Rats
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