Corticotropin releasing factor antagonist, α-helical CRF9–41, reverses nicotine-induced conditioned, but not unconditioned, anxiety
Abstract
Rationale Unconditioned anxiogenic effects of nicotine have been observed in the social interaction (SI) test 5 min after injection of a low dose and both 5 min and 30 min after injection of a high dose. Conditioned anxiety has also been observed 24 h after testing in the SI with a high dose of nicotine.Objectives In order to determine whether these three anxiogenic effects shared a common mechanism, we investigated the role of corticotropin releasing factor (CRF). We therefore examined whether the CRF antagonist alpha-helical CRF(9-41) could block these three anxiogenic effects of nicotine.Methods To test the unconditioned anxiogenic effects, pairs of male rats were tested in SI 5 min after s.c. vehicle or nicotine (0.1 mg/kg) or 30 min after s.c. vehicle or nicotine (0.45 mg/kg), and 30 min after i.c.v. artificial cerebrospinal fluid (aCSF) or alpha-helical CRF(9-41). To test conditioned anxiety, rats were exposed to the SI test on day 1, 5 min after vehicle or nicotine (0.1 mg/kg). On day 2, they were re-tested in SI 30 min after i.c.v. aCSF or alpha-helical CRF(9-41) (5 microg).Results alpha-Helical CRF(9-41) did not block the unconditioned anxiogenic effect of either dose of nicotine. Nicotine (0.1 mg/kg, 5 min) elicited a conditioned anxiogenic response that was significantly reversed by alpha-helical CRF(9-41). The CRF antagonist alone had no effect.Conclusions CRF is an important mediator of the conditioned anxiety to nicotine, but may not play a role in mediating the acute anxiogenic effects.
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This CRF release produces a withdrawal-induced anxiety state that is reversed by CRF-R1 antagonists.
“This CRF release produces a withdrawal-induced anxiety state that is reversed by CRF-R1 antagonists (Sarnyai et al 1995; Tucci et al 2003; Knapp et al 2004; Skelton et al 2007).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Tucci et al 2003
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Self-citation
- Authors
- Tucci, S., Cheeta, S., Seth, P., & File, S. E.
- Affiliations
- King's College London (GB)
- Corresponding author
- Tucci, Sonia
- ORCID
- Cheeta, Survjit
- Venue
- Psychopharmacology
- Published
- 2003-04-01
- Volume
- 167
- Issue
- 3
- Pages
- 251-256
- ISSN
- 0033-3158 (ISSN-L)
- OpenAlex
- W2161481282
- Cited by
- 38
- References
- 52
- Citations by year
- 2023: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Consejo Nacional para Investigaciones Científicas y Tecnológicas
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine, conditioned anxiety, corticotropin-releasing factor, alpha-helical CRF(9-41), CRF antagonist, social interaction test, anxiogenic effects
- MeSH terms
- Animals, Anxiety, Conditioning, Psychological, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Drug Administration Routes, Drug Interactions, Interpersonal Relations, Male, Motor Activity, Nicotine, Peptide Fragments, Time Factors, Nicotinic Agonists, Rats
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