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Alcoholism: Allostasis and Beyond

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Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide

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Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty

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Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2

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Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal

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Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2

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Alcohol dependence and anxiety disorders: what is the relationship?

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Chemical and Biological Characterization of Corticotropin Releasing Factor

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CRF antagonist reverses the “anxiogenic” response to ethanol withdrawal in the rat

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Excessive Ethanol Drinking Following a History of Dependence Animal Model of Allostasis

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Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats

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Corticotropin-Releasing Factor*

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Stress, Corticotropin‐releasing Factor, and Drug Addiction

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Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 11Published on the World Wide Web on 27 November 1998.1

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Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents

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High-priority communication I Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence

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Time-dependent quantifiable withdrawal from ethanol in the rat: Effect of method of dependence induction

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Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat

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Comorbidity in Generalized Anxiety Disorder

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Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide

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Corticotropin releasing factor, stress and behavior

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Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist

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Lateral and Medial Septal Lesions Reduce Anxiety in the Plus-Maze and Probe-Burying Tests

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The Edinger-Westphal–Lateral Septum Urocortin Pathway and Its Relationship to Alcohol Consumption

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Chronic Daily Ethanol and Withdrawal: 2. Behavioral Changes During Prolonged Abstinence

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Operant Self‐Administration of Sweetened Versus Unsweetened Ethanol: Effects on Blood Alcohol Levels

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The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism

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Human Urocortin II, a Selective Agonist for the Type 2 Corticotropin-Releasing Factor Receptor, Decreases Feeding and Drinking in the Rat

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Effects of Chronic Ethanol Exposure on Oral Self‐Administration of Ethanol or Saccharin by Wistar Rats

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Altered Amygdalar CRF Release and Increased Anxiety-Like Behavior in Sardinian Alcohol-Preferring Rats: A Microdialysis and Behavioral Study

Richter, R. M., Zorrilla, E. P., Basso, A. M., Koob, G. F., & Weiss, F. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb01979.x · Cited by 82 · see citing works

The CRF1 receptor antagonist antalarmin reduces volitional ethanol consumption in isolation-reared fawn-hooded rats

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Exacerbation of Ethanol Withdrawal Seizures in Mice With a History of Multiple Withdrawal Experience

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Alcohol increases the expression of type 1, but not type 2α corticotropin-releasing factor (CRF) receptor messenger ribonucleic acid in the rat hypothalamus

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GABAergic organization of the cat medial geniculate body

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Chronic ethanol exposure potentiates the locomotor-activating effects of corticotropin-releasing factor (CRF) in rats

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Posterodorsal amygdala lesions reduce feeding stimulated by 8-OH-DPAT

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Alcohol Withdrawal Symptoms: Phenomenology and Implications

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Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse

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A Role for Brain Stress Systems in Addiction

Koob, G. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.012 · Cited by 1,056 · see citing works

Neurobiological mechanisms for opponent motivational processes in addiction

Koob, G. F., & Moal, M. L. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0094 · Cited by 702 · see citing works

Addiction as a stress surfeit disorder

Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.024 · Cited by 483 · see citing works

Role of Corticotropin-Releasing Factor in Drug Addiction

Logrip, M. L., Koob, G. F., & Zorrilla, E. P. (2011) · CNS Drugs · doi:10.2165/11587790-000000000-00000 · Cited by 476 · see citing works

Neurobiological substrates for the dark side of compulsivity in addiction

Koob, G. F. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.043 · Cited by 458 · see citing works

Theoretical Frameworks and Mechanistic Aspects of Alcohol Addiction: Alcohol Addiction as a Reward Deficit Disorder

Koob, G. F. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_129 · Cited by 428 · see citing works

Brain stress systems in the amygdala and addiction

Koob, G. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.038 · Cited by 388 · see citing works

Pharmacological treatment of alcohol dependence: Target symptoms and target mechanisms

Heilig, M. A., & Egli, M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.02.001 · Cited by 378 · see citing works

The CRF system, stress, depression and anxiety—insights from human genetic studies

Binder, E. B., & Nemeroff, C. B. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.141 · Cited by 379 · see citing works

Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence

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The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction

Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307 · see citing works

The role of CRF and CRF-related peptides in the dark side of addiction

Koob, G. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.008 · Cited by 290 · see citing works

The Dopamine Hypothesis of Drug Addiction: Hypodopaminergic State

Melis, M., Spiga, S., & Diana, M. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)63005-x · Cited by 271 · see citing works

Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse

Breese, G. R., Sinha, R., & Heilig, M. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.09.007 · Cited by 262 · see citing works

Corticotropin releasing factor: A key role in the neurobiology of addiction

Zorrilla, E. P., Logrip, M. L., & Koob, G. F. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.01.001 · Cited by 255 · see citing works

The Kappa Opioid Receptor: From Addiction to Depression, and Back

Lalanne, L., Ayrancı, G., Kieffer, B. L., & Lutz, P.-É. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00170 · Cited by 227 · see citing works

Neurocircuitry of alcohol addiction

Koob, G. F. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00003-3 · Cited by 227 · see citing works

Preclinical studies of alcohol binge drinking

Crabbe, J. C., Harris, R. A., & Koob, G. F. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05895.x · Cited by 221 · see citing works

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

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Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: role of CRF receptor subtypes

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Influence of stress associated with chronic alcohol exposure on drinking

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