The DOI matches its Crossref record; 47 of the 49 references it cites were found in a registry or an index.
Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP
Abstract
Yeast two-hybrid system was employed to isolate novel proteins that physically interact with PU.1, a member of Ets family transcription factors. Sequence analyses of several isolated clones positive for beta-galactosidase activity revealed that one of these clones was confirmed to encode a transcriptional coactivator, CREB binding protein (CBP). GST binding assay showed that the interacting sites were located at the transcriptional activation domain of PU.1 through 74-122 and the region spanning residues 1283-1915 of CBP. CBP potentiated PU.1-mediated transcription of the reporter gene driven by the multimerized PU.1-binding sites, suggesting that CBP functions as a coactivator for PU.1. Considering that CBP is a limited cellular component to function as a coactivator for several transcription factors, CBP may mediate synergistic and antagonistic interactions between PU.1 and other transcription factors during the process of hematopoietic cell differentiation.
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In the citing paper
“as PU.1 can interact with CBP/p300 (refs 39, 40) and TRIM33”
From TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation (2015) · cites this paper as [39]
In the citing paper
“There is limited understanding of the mechanisms that determine coactivator versus corepressor recruitment by RUNX1 and PU.1.17–20”
From RUNX1 regulates corepressor interactions of PU.1 (2011) · cites this paper as [18]
In the citing paper
“PU.1 can interact with coactivators or corepressors to function as either a transcriptional activator or a transcriptional repressor.17–19”
From RUNX1 regulates corepressor interactions of PU.1 (2011) · cites this paper as [18]
In the citing paper
“However, the mechanisms that regulate corepressor versus coactivator interactions of RUNX1 and PU.1 are incompletely understood.17–20”
From RUNX1 regulates corepressor interactions of PU.1 (2011) · cites this paper as [18]
In the citing paper
“and CBP stimulates PU.1 activity in transient trans- fections (82).”
From Inhibition of CBP-Mediated Protein Acetylation by the Ets Family Oncoprotein PU.1 (2002) · cites this paper as [82]
In the citing paper
“PU.1 is a bifunctional protein as for instance CBP binding leads to PU.1 transcriptional activation [47], whereas TLE-4 was found to support PU.1-dependent repres-sion [46].”
From PKCδ-Induced PU.1 Phosphorylation Promotes Hematopoietic Stem Cell Differentiation to Dendritic Cells (2011) · cites this paper as [47]
In the citing paper
“GST binding assays revealed that a portion of the transcriptional activation domain of PU.1 (amino acids 74–122) directly interacts with the region spanning residues 1283–1915 of CBP (Fig. 4).”
From PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis (2009) · cites this paper as [78]
In the citing paper
“CBP enhances PU.1-mediated transcription of multimerized PU-box luciferase reporter constructs, suggesting that CBP acts as a co-activator for the transcription factor PU.1.”
From PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis (2009) · cites this paper as [78]
In the citing paper
“Because the amount of CBP is limited in cells, CBP may mediate positive and negative cross-talk between PU.1 and other transcription factors in the process of haematopoietic cell differentiation [78].”
From PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis (2009) · cites this paper as [78]
In the citing paper
“In CV-1 cells, but not in NIH 3T3 cells, cooperation between Myb and C/EBP-α depended on the integrity of the PU.1-binding site [78].”
From PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis (2009) · cites this paper as [78]
In the citing paper
“One such candidate is CBP/p300, a co-activator of PU.1 [78], which binds to the transactivation domain of PU.1.”
From PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis (2009) · cites this paper as [78]
In the citing paper
“This activation may in part be due to the recruitment of coactivator/ histone acetylase CBP/p300, since CBP/p300 can interact with PU.1 (but not ICSBP) (32, 59).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [59]
In the citing paper
“This activation seems to involve other factors, notably the coactivator/histone acetylase CBP/p300, with which PU.1 is shown to interact (59).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [59]
Citations
Cites
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559
Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R. A., Rose, D. W., Glass, C. K., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81118-6 · Cited by 2,150
Phosphorylated CREB binds specifically to the nuclear protein CBP
Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532
Nuclear protein CBP is a coactivator for the transcription factor CREB
Kwok, R. P. S., Lundblad, J. R., Chrivia, J. C., Richards, J. P., Bächinger, H. P., Brennan, R. G., Roberts, S. G. E., Green, M. R., & Goodman, R. H. (1994) · Nature · doi:10.1038/370223a0 · Cited by 1,443
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00949.x · Cited by 1,130
The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., & Maki, R. A. (1990) · Cell · doi:10.1016/0092-8674(90)90219-5 · Cited by 954
Role of CBP/P300 in nuclear receptor signalling
Chakravarti, D., LaMorte, V. J., Nelson, M. C., Nakajima, T., Schulman, I. G., Juguilon, H., Montminy, M., & Evans, R. M. (1996) · Nature · doi:10.1038/383099a0 · Cited by 932
The Ets family of transcription factors
Wasylyk, B., Hahn, S. L., & Giovane, A. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb19864.x · Cited by 839
Cited by
Sorted by citations
Molecular biology of the Ets family of transcription factors
Oikawa, T., & Yamada, T. (2003) · Gene · doi:10.1016/s0378-1119(02)01156-3 · Cited by 701
Self-citationRoe, J., Mercan, F., Rivera, K. D., Pappin, D., & Vakoc, C. R. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.04.011 · Cited by 343
“Interestingly, C/EBPa, C/EBPb, PU.1, and MYB have all been shown previously to interact with p300 or CBP (Dai et al., 1996; Mink et al., 1997; Yamamoto et al., 1999).”
BackgroundCREB-binding protein and p300: molecular integrators of hematopoietic transcription
Blobel, G. A. (2000) · Blood · doi:10.1182/blood.v95.3.745.003k05_745_755 · Cited by 257
1 ,25-dihydroxyvitamin D3 is a potent suppressor of interferon -mediated macrophage activation
Helming, L. (2005) · Blood · doi:10.1182/blood-2005-03-1029 · Cited by 252
Heterozygous PU.1 mutations are associated with acute myeloid leukemia
Mueller, B. U., Pabst, T., Osato, M., Asou, N., Johansen, L. M., Minden, M. D., Behre, G., Hiddemann, W., Ito, Y., & Tenen, D. G. (2002) · Blood · doi:10.1182/blood.v100.3.998 · Cited by 243
ETS transcription factors: Possible targets for cancer therapy
Oikawa, T. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03320.x · Cited by 191
Self-citationNguyen, V. T., & Benveniste, E. N. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002482200 · Cited by 151
Functional Cross-Antagonism between Transcription Factors FLI-1 and EKLF
Starck, J., Cohet, N., Gonnet, C., Sarrazin, S., Doubeikovskaia, Z., Doubeikovski, A., Verger, A., Duterque‐Coquillaud, M., & Morlé, F. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1390-1402.2003 · Cited by 158
“On the other hand, it has been shown very recently that the repression activity of the other ETS family protein, SPI-1/PU.1, involves protein-protein interaction with the acetyltransferase domain of CBP and inhibition of the CBP-mediated acetylation of many different nuclear factors, including GATA-1 and EKLF (29).”
BackgroundInfluentialLee, D. K., Park, S. H., Yi, Y., Choi, S.-G., Lee, C., Parks, W. T., Cho, H., de Caestecker, M. P., Shaul, Y., Roberts, A. B., et al. (2001) · Genes & Development · doi:10.1101/gad.856201 · Cited by 143
Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b
Suzuki, M., Yamada, T., Kihara-Negishi, F., Sakurai, T., Hara, E., Tenen, D. G., Hozumi, N., & Oikawa, T. (2006) · Oncogene · doi:10.1038/sj.onc.1209272 · Cited by 132
“Immunoprecipitation and immunoblotting were performed as we reported (Yamamoto et al., 1999), with minor modifications.”
BackgroundMethodInfluentialSelf-citationOikawa, T., Yamada, T., Kihara-Negishi, F., Yamamoto, H., Kondoh, N., Hitomi, Y., & Hashimoto, Y. (1999) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400534 · Cited by 109
“with the region spanning residues 1283 ± 1915 of the CREB binding protein (CBP), overlapping with the adenovirus E1A-binding site.(13) CBP and the related protein p300 have been reported to interact with a variety of transcription factors, including CREB, AP-1 (Fos/Jun), c-Myb, nuclear hormone receptors (NHRs), STATs,…”
BackgroundSelf-citationKrysinska, H., Hoogenkamp, M., Ingram, R., Wilson, N., Tagoh, H., Laslo, P., Singh, H., & Bonifer, C. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01915-06 · Cited by 102
“It has been shown previously that the activity of CBP can be regulated as well (35); it was therefore possible that CBP was recruited but was inactive.”
BackgroundInfluentialPU.1 and pRB Interact and Cooperate To Repress GATA-1 and Block Erythroid Differentiation
Rekhtman, N., Choe, K. S., Matushansky, I., Murray, S., Stopka, T., & Skoultchi, A. I. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7460-7474.2003 · Cited by 102
Fernández, L. Á., Winkler, M., & Grosschedl, R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.196-208.2001 · Cited by 97
“1 can interact with the HAT CREB-binding protein (81).”
BackgroundIndependent Repressor Domains in ZEB Regulate Muscle and T-Cell Differentiation
Postigo, A., & Dean, D. C. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.7961 · Cited by 102
NF-IL6 (C/EBPβ) Vigorously Activates il1b Gene Expression via a Spi-1 (PU.1) Protein-Protein Tether
Yang, Z., Wara-aswapati, N., Chen, C., Tsukada, J., & Auron, P. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000145200 · Cited by 92
Hu, R., Sharma, S. M., Bronisz, A., Srinivasan, R., Sankar, U., & Ostrowski, M. C. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01839-06 · Cited by 86
“Further, the N-terminal region of MITF (1-218) (MITF with aa 1 to 218), but not the C-terminal basic helix-loop-helixleucine zipper region (aa 219 to 419), formed a complex with GST-Eos (Fig.”
BackgroundTranscriptional Activation by STAT6 Requires the Direct Interaction with NCoA-1
Litterst, C. M., & Pfitzner, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108132200 · Cited by 83
Wang, J.-M., Lai, M.-Z., & Yang-Yen, H.-F. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.6.1896-1909.2003 · Cited by 90
Suzuki, M., Yamada, T., Kihara-Negishi, F., Sakurai, T., & Oikawa, T. (2003) · Oncogene · doi:10.1038/sj.onc.1207182 · Cited by 87
“In line with this, we have previously demonstrated that PU.1 interacts with CREB binding protein (CBP), which functions as a coactivator of transcription factors (Yamamoto et al., 1999).”
BackgroundMethodInfluentialSelf-citationGupta, P., Gurudutta, G. U., Saluja, D., & Tripathi, R. P. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00757.x · Cited by 74
“1 and other transcription factors in the process of haematopoietic cell differentiation [78].”
BackgroundPU.1/Interferon Regulatory Factor Interactions; Mechanisms of Transcriptional Regulation
Marecki, S., & Fenton, M. J. (2000) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:33:2:127 · Cited by 74
“1 has been reported to interact with the histone acetylase CREB binding protein (CBP) (16), implicating PU.”
BackgroundInfluentialKitajima, K., Masuhara, M., Era, T., Enver, T., & Nakano, T. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf301 · Cited by 77
Cooperation of STAT-1 and IRF-1 in Interferon-γ-induced Transcription of the gp91 Gene
Kumatori, A., Yang, D., Suzuki, S., & Nakamura, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109803200 · Cited by 72
Inhibition of CBP-Mediated Protein Acetylation by the Ets Family Oncoprotein PU.1
Hong, W., Kim, A. Y., Ky, S., Rakowski, C., Seo, S.-B., Chakravarti, D., Atchison, M., & Blobel, G. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3729-3743.2002 · Cited by 74
“1 binds to the CH3 domain of CBP (82) (Fig.”
BackgroundTRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation
Ferri, F., Parcelier, A., Petit, V., Gallouet, A.-S., Lewandowski, D., Dalloz, M., van den Heuvel, A., Kolovos, P., Soler, E., Squadrito, M. L., et al. (2015) · Nature Communications · doi:10.1038/ncomms9900 · Cited by 70
A Review of Oxidative Stress Products and Related Genes in Early Alzheimer’s Disease
Cioffi, F., Adam, R. H. I., Bansal, R., & Broersen, K. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210497 · Cited by 73
CBP and p300: versatile coregulators with important roles in hematopoietic gene expression
Blobel, G. A. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.545 · Cited by 69
Kuwata, T., Gongora, C., Kanno, Y., Sakaguchi, K., Tamura, T., Kanno, T., Basrur, V., Martinez, R., Appella, E., Golub, T., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7439-7448.2002 · Cited by 69
Review: The Role of IRF-4 in Transcriptional Regulation
Marecki, S., & Fenton, M. J. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452737 · Cited by 68
“…loss of LPS-induced transcriptional activation, suggesting that phosphorylation of serine 148 is required for inducible transcriptional activation by LPS. Phos-MARECKI phorylation of other serine residues (41, 45, 132, and 133) is required at distinct events in myeloid development and maturation.”
InfluentialAutocrine Induction of the Human Pro-IL-1β Gene Promoter by IL-1β in Monocytes
Toda, Y., Tsukada, J., Misago, M., Kominato, Y., Auron, P. E., & Tanaka, Y. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1984 · Cited by 67
Kihara-Negishi, F., Yamamoto, H., Suzuki, M., Yamada, T., Sakurai, T., Tamura, T., & Oikawa, T. (2001) · Oncogene · doi:10.1038/sj.onc.1204756 · Cited by 69
“We have previously reported that PU.1 interacts with the coactivator CBP and the interaction has been implicated in transactivation (Yamamoto et al., 1999).”
BackgroundMethodResultInfluentialSelf-citationXiong, H., Zhu, C. Y., Li, H., Chen, F., Mayer, L., Ozato, K., Unkeless, J. C., & Plevy, S. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209583200 · Cited by 64
BSAP Can Repress Enhancer Activity by Targeting PU.1 Function
Maitra, S., & Atchison, M. L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.1911-1922.2000 · Cited by 64
RUNX1 regulates corepressor interactions of PU.1
Hu, Z., Gu, X., Baraoidan, K., Ibanez, V., Sharma, A., Kadkol, S., Munker, R., Ackerman, S., Nucifora, G., & Saunthararajah, Y. (2011) · Blood · doi:10.1182/blood-2010-10-312512 · Cited by 63
c-Jun Homodimers Can Function as a Context-Specific Coactivator
Grondin, B., Lefrançois, M., Tremblay, M. R., Saint-Denis, M., Haman, A., Waga, K., Bédard, A., Tenen, D. G., & Hoang, T. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00936-06 · Cited by 62
“Together with our observations of a more efficient recruitment of RNA Pol II, we propose that maximal assembly of PIC on the IL-1 promoter is achieved by multiple interactions and recruitment of TFIID and RNA Pol II holoenzymes containing Mediator complexes, CBP/p300, and some general transcription factors by the PU.1-”
BackgroundYin Yang 1 enhancescyclooxygenase-2gene expression in macrophages
Joo, M., Wright, J. G., Hu, N. N., Sadikot, R. T., Park, G. Y., Blackwell, T. S., & Christman, J. W. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00474.2006 · Cited by 62
Oh, I., Lau, A., & Eaves, C. J. (2000) · Blood · doi:10.1182/blood.v96.13.4160 · Cited by 63
Suraweera, N., Meijne, E., Moody, J., Carvajal-Carmona, L. G., Yoshida, K., Pollard, P., Fitzgibbon, J., Riches, A., van Laar, T., Huiskamp, R., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208422 · Cited by 60
“…of the protein, this domain interacts with various proteins including GATA1 binding protein 1 (GATA1), CCAAT/enhancer binding protein beta (CEBPB), and other myeloid regulators such as c-jun and RUNX1/ AML-1 (Nagulapalli et al., 1995; Petrovick et al., 1998; Yamamoto et al., 1999).”
Backgroundvan der Stoep, N., Quinten, E., Rezende, M. M., & van den Elsen, P. J. (2004) · Blood · doi:10.1182/blood-2004-03-0790 · Cited by 58
Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils
Fischer, J., Walter, C., Tönges, A., Aleth, H., Jordão, M. J. C., Leddin, M., Gröning, V., Erdmann, T., Lenz, G., Roth, J., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0343-z · Cited by 56
Transcriptional Regulation of the Cyclooxygenase-2 Gene in Macrophages by PU.1
Joo, M., Park, G. Y., Wright, J. G., Blackwell, T. S., Atchison, M. L., & Christman, J. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306267200 · Cited by 56
Carl, V. S., Brown-Steinke, K., Nicklin, M. J. H., & Smith, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111847200 · Cited by 51
Wittwer, J., Marti-Jaun, J., & Hersberger, M. (2005) · Human Mutation · doi:10.1002/humu.20273 · Cited by 50
“…protein [Hagemeier et al., 1993], the basal transcription factor TBP [Hagemeier et al., 1993], the transcriptional coactivators CBP/p300 [Yamamoto et al., 1999], the transcription factors GATA-1 and GATA-2 [Nerlov et al., 2000; Zhang et al., 1999], and the transcription factor NFEM5/Pip…”
BackgroundEpigenetic control of hematopoiesis: the PU.1 chromatin connection
van Riel, B., & Rosenbauer, F. (2014) · Biological Chemistry · doi:10.1515/hsz-2014-0195 · Cited by 48
Lutz, P. G., Houzel-Charavel, A., Moog‐Lutz, C., & Cayre, Y. E. (2001) · Blood · doi:10.1182/blood.v97.8.2449 · Cited by 50
Transcriptional Regulation of Mouse μ Opioid Receptor Gene by PU.1
Hwang, C. K., Kim, C. S., Choi, H. S., McKercher, S. R., & Loh, H. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400755200 · Cited by 46
Hamdorf, M., Berger, A., Schüle, S., Reinhardt, J., & Flory, E. (2011) · Stem Cells · doi:10.1002/stem.564 · Cited by 46
Curik, N., Burda, P., Vargová, K., Pospíšil, V., Beličková, M., Vlckova, P., Savvulidi, F. G., Nečas, E., Hajkova, H., Haškovec, C., et al. (2012) · Leukemia · doi:10.1038/leu.2012.47 · Cited by 47
Yoshida, H., Ichikawa, H., Tagata, Y., Katsumoto, T., Ohnishi, K., Akao, Y., Naoe, T., Pandolfi, P. P., & Kitabayashi, I. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02422-06 · Cited by 45
“1 and p300/CBP can directly interact, at least in vitro (33); however, we found that their association is rather weak compared with those of other transcription factors such as AML1b.”
BackgroundGeng, C.-D., & Vedeckis, W. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508245200 · Cited by 43
PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells
Yashiro, T., Kubo, M., Ogawa, H., Okumura, K., & Nishiyama, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137699 · Cited by 43
“1 is involved in chromatin remodeling by interaction with p300/CBP [12].”
BackgroundShigeno, K., Yoshida, H., Pan, L., Luo, J. M., Fujisawa, S., Naito, K., Nakamura, S., Shinjo, K., Takeshita, A., Ohno, R., et al. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00442-7 · Cited by 41
Nakazawa, Y., Suzuki, M., Manabe, N., Yamada, T., Kihara‐Negishi, F., Sakurai, T., Tenen, D. G., Iwama, A., Mochizuki, M., & Oikawa, T. (2007) · Oncogene · doi:10.1038/sj.onc.1210140 · Cited by 39
“Cell extracts for Luc assays were prepared as described previously (Yamamoto et al., 1999).”
MethodInfluentialSelf-citationCalomme, C., Dekoninck, A., Nizet, S., Adam, E., Nguyên, T. L.-A., den Broeke, A. V., Willems, L., Kettmann, R., Burny, A., & Lint, C. M. V. (2004) · Journal of Virology · doi:10.1128/jvi.78.24.13848-13864.2004 · Cited by 39
“1/Spi-B (91, 92), USF2 (12), glucocorticoid receptor (38, 44), IRF1 (71), and IRF2 (56), have been shown to interact with acetyltransferases and/or to be acetylated.”
BackgroundThe Essential Transcriptional Function of BRD4 in Acute Myeloid LeukemiaPreprint
Roe, J., & Vakoc, C. R. (2016) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2016.81.031039 · Cited by 39
Protein Acetylation Regulates Both PU.1 Transactivation and Igκ 3′ Enhancer Activity
Bai, Y., Srinivasan, L., Perkins, L., & Atchison, M. L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5160 · Cited by 39
Baert, J., Beaudoin, C., Coutte, L., & de Launoit, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107139200 · Cited by 37
Yamada, T., Abe, M., Higashi, T., Yamamoto, H., Kihara‐Negishi, F., Sakurai, T., Shirai, T., & Oikawa, T. (2001) · Blood · doi:10.1182/blood.v97.8.2300 · Cited by 38
Self-citationHa, S.-D., Cho, W., DeKoter, R. P., & Kim, S. O. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010149 · Cited by 36
Epigenetic Regulation during B Cell Differentiation Controls CIITA Promoter Accessibility
Green, M. R., Yoon, H., & Boss, J. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.3865 · Cited by 37
Dekoninck, A., Calomme, C., Nizet, S., de Launoit, Y., Burny, A., Ghysdael, J., & Lint, C. M. V. (2003) · Oncogene · doi:10.1038/sj.onc.1206392 · Cited by 35
“Moreover, PU.1 has been shown to interact with chromatin-modifying enzymes: the histone acetyltransferase CREB binding protein (CBP) (Yamamoto et al., 1999) (which also interacts with Spi-B, Yamamoto et al., 2002) and the histone deacetylase HDAC1 (Kihara-Negishi et al., 2001), further implicating PU.1 in chromatin re…”
BackgroundFuglerud, B. M., Ledsaak, M., Rogne, M., Eskeland, R., & Gabrielsen, O. S. (2018) · Epigenetics & Chromatin · doi:10.1186/s13072-018-0208-y · Cited by 31
Sugiyama, D., Tanaka, M., Kitajima, K., Zheng, J., Yen, H., Murotani, T., Yamatodani, A., & Nakano, T. (2007) · Blood · doi:10.1182/blood-2007-08-104489 · Cited by 33
Spi-1/PU.1 Oncoprotein Affects Splicing Decisions in a Promoter Binding-dependent Manner
Guillouf, C., Gallais, I., & Moreau-Gachelin, F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512049200 · Cited by 37
Wei, P. Y., Taniguchi, S., Sakai, Y., Imamura, M., Inoguchi, T., Nawata, H., Oda, S., Nakabeppu, Y., Nishimura, J., & Ikuyama, S. (2005) · The Journal of Biochemistry · doi:10.1093/jb/mvi136 · Cited by 28
Delva, L., Gallais, I., Guillouf, C., Denis, N., Orvain, C., & Moreau-Gachelin, F. (2004) · Oncogene · doi:10.1038/sj.onc.1207578 · Cited by 26
“Some of these proteins are ubiquitous factors such as the basal transcription factor TFIID (Hagemeier et al., 1993) and the co-activator/integrator CBP (Yamamoto et al., 1999).”
BackgroundTranscriptional Regulation of the p67 Gene
Li, S.-L., Valente, A. J., Wang, L., Gamez, M. J., & Clark, R. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106111200 · Cited by 27
Modeling the Hematopoietic Landscape
Brown, G., & Ceredig, R. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00104 · Cited by 27
“1 binds the histone acetyltransferases CREB-binding protein and p300 (Yamamoto et al., 1999; Bai et al., 2005) and a histone deacetylase complex consisting of histone deacetylase 1 and mammalian Sin3a (Kihara-Negishi et al.”
BackgroundAP-1 is essential for p67phoxpromoter activity
Gauss, K. A., Bunger, P. L., & Quinn, M. T. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.1.163 · Cited by 25
Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBPα
Lian, T., Guan, R., Zhou, B., & Bai, Y. (2024) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01189-z · Cited by 26
“The N-terminal regions of both PU.1 and C/EBPα interact with basal transcription factors such as TFIID, TFIIB and TBP 28,29 , histone acetyltransferases CREB-binding protein (CBP) 30,31 , as well as SWI/SNF chromatin remodelers 29,32 .”
Yamamoto, H., Kihara‐Negishi, F., Yamada, T., Suzuki, M., Nakano, T., & Oikawa, T. (2002) · PubMed · Cited by 24
Self-citationBisphenol A significantly enhances the neutrophilic differentiation of promyelocytic HL-60 cells
Watanabe, H., Adachi, R., Kusui, K., Hirayama, A., Kasahara, T., & Suzuki, K. (2003) · International Immunopharmacology · doi:10.1016/s1567-5769(03)00182-6 · Cited by 23
Kwan, M., Powell, D. R., Nachman, T. Y., & Brown, M. A. (2005) · European Journal of Immunology · doi:10.1002/eji.200425619 · Cited by 22
Listman, J. A., Wara-aswapati, N., Race, J. E., Blystone, L. W., Walker‐Kopp, N., Yang, Z., & Auron, P. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509143200 · Cited by 21
PU.1 Regulates Positive Regulatory Domain I-Binding Factor 1/Blimp-1 Transcription in Lymphoma Cells
Desai, S., Bolick, S. C. E., Maurin, M. M., & Wright, K. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901120 · Cited by 21
Context-dependent Pax-5 repression of a PU.1/NF-κB regulated reporter gene in B lineage cells
Linderson, Y., French, N. S., Neurath, M. F., & Pettersson, S. (2001) · Gene · doi:10.1016/s0378-1119(00)00546-1 · Cited by 19
Pub, a novel PU.1 binding protein, regulates the transcriptional activity of PU.1
Hirose, S., Nishizumi, H., & Sakano, H. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.212 · Cited by 18
Molecular basis of Stat1 and PU.1 cooperation in cytokine-induced Fc receptor I promoter activation
Aittomäki, S. (2004) · International Immunology · doi:10.1093/intimm/dxh037 · Cited by 18
Nguyên, T. L.-A., Calomme, C., Wijmeersch, G., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404081200 · Cited by 16
Luo, L., Chen, W., Yin, J. Q., & Xu, R. (2017) · Scientific Reports · doi:10.1038/srep40463 · Cited by 16
SPI-C and STAT6 can cooperate to stimulate IgE germline transcription
Carlsson, R., Thorell, K., Liberg, D., & Leanderson, T. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.04.026 · Cited by 15
Koli, S., Mukherjee, A., & Reddy, K. V. R. (2015) · Reproduction Fertility and Development · doi:10.1071/rd15145 · Cited by 14
Roullet, M. R., & Bagg, A. (2007) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.7.6.805 · Cited by 14
Kihara-Negishi, F., Suzuki, M., Yamada, T., Sakurai, T., & Oikawa, T. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.098 · Cited by 15
Self-citationYamada, T., Suzuki, M., Satoh, H., Kihara‐Negishi, F., Nakano, H., & Oikawa, T. (2003) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.10.023 · Cited by 13
Self-citationAittomäki, S., Yang, J., Scott, E. W., Simon, M. C., & Silvennoinen, O. (2002) · Blood · doi:10.1182/blood-2001-12-0236 · Cited by 13
Yamada, T., Shimizu, T., Suzuki, M., Kihara‐Negishi, F., Nanashima, N., Sakurai, T., Yang, F., Akita, M., Oikawa, T., & Tsuchida, S. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.11.005 · Cited by 11
Self-citationPlant, E., Bellefroid, M., & Lint, C. M. V. (2023) · Retrovirology · doi:10.1186/s12977-023-00623-w · Cited by 11
“1 [148, 149], or the weakly bound CREB/ATF factors, reinforcing the open chromatin state by acetylating the H3 and H4 histone tails.”
BackgroundZhang, K., Lv, D., & Li, R. (2019) · Virology · doi:10.1016/j.virol.2019.11.011 · Cited by 9
“1 also interacts with CRE-binding protein (CBP) or p300 and functions as a coactivator for several other transcription factors (Yamamoto et al., 1999).”
BackgroundOh, I., Lau, A., & Eaves, C. J. (2000) · Blood · doi:10.1182/blood.v96.13.4160.h8004160_4160_4168 · Cited by 9
Genetic determination of the role of PU.1 in macrophage gene expression
Joo, M., Kwon, M., Azim, A. C., Sadikot, R. T., Blackwell, T. S., & Christman, J. W. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.189 · Cited by 9
Shen, X., Li, X., Wu, T., Guo, T., Lv, J., He, Z., Luo, M., Zhu, X., Tian, Y., Lai, W., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01179-1 · Cited by 8
“PU.1 activates transcription by recruiting CREB-binding protein (CBP) to bridge the basal transcription machinery and promote regional H3K27ac intensity [74, 75].”
BackgroundLemieux, M. E., Cheng, Z., Zhou, Q., White, R., Cornell, J. E., Kung, A. L., & Rebel, V. I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024153 · Cited by 7
Carter, M. J., Bogdanov, Y. D., Smith, R. C. G., Cox, K. L., Frampton, S., Ferson, L., Foxall, R. B., Hussain, K., Strefford, J. C., Beers, S. A., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf109 · Cited by 6
Ishii, H., Sen, R., & Pazin, M. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308973200 · Cited by 6
Park, J., Jung, S.-H., Seo, H., & Kim, H.-S. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.005 · Cited by 4
PU.1, a Versatile Transcription Factor and a Suppressor of Myeloid Leukemia
Takahashi, S. (2011) · InTech eBooks · doi:10.5772/25853 · Cited by 3
“…of PU.1 with the transcriptional coactivator CBP, which www.intechopen.com (Inomata et al., 2006), Flt3 may be classified into the upper group, although direct binding of PU.1 to the Flt3 gene promoter has not been examined. enhances the transcriptional activity of PU.1 (Yamamoto et al., 1999).”
BackgroundInfluentialBatista, C. R., & DeKoter, R. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101960 · Cited by 2
Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP⍺Preprint
Lian, T., Guan, R., Zhou, B., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.25.554718 · Cited by 2
Metadata
- Authors
- Yamamoto, H., Kihara-Negishi, F., Yamada, T., Hashimoto, Y., & Oikawa, T.
- Affiliations
- Sasaki Institute (JP)
- ORCID
- Yamada, Toshiyuki
- Venue
- Oncogene
- Published
- 1999-02-18
- Volume
- 18
- Issue
- 7
- Pages
- 1495-1501
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2318149005
- Semantic Scholar
- b28b07fc5cb5ab0b001e5a4822b86f270638d7f1
- Cited by
- 113
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- PU.1, CREB-binding protein, CBP, transcriptional coactivator, ETS transcription factors, protein-protein interaction, transactivation domain, transcriptional activation, hematopoietic differentiation, transcription factor interaction
- MeSH terms
- Proto-Oncogene Protein Spi-1, Animals, Nuclear Proteins, Proto-Oncogene Proteins, Recombinant Fusion Proteins, Trans-Activators, CREB-Binding Protein, Mice
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