Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

Takimoto, R; El-Deiry, W S

doi:10.1038/sj.onc.1203489

Cited by 360Cancer-related Molecular PathwaysCell death mechanisms and regulationGenomics and Chromatin Dynamics

Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

Takimoto, R, El-Deiry, W S·2000·Oncogene

DOI 10.1038/sj.onc.1203489

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Abstract

KILLER/DR5, a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor gene, has been shown to be induced by DNA damaging agents and radiation in a p53-dependent manner. Although TRAIL is a potential therapeutic agent for cancer, the induction mechanism of its receptors is poorly understood. Here we show the identification of three p53 DNA-binding sites in the KILLER/DR5 genomic locus located upstream (BS1; -0.82 Kb) of the ATG site, within Intron 1 (BS2; +0.25 Kb downstream of the ATG) and within Intron 2 (BS3; +1.25 Kb downstream of the ATG). A modified p53-binding and immunoselection protocol using a wild-type p53-expressing adenovirus vector (Ad-p53) was used to identify the binding sites and to show that each binding site can bind specifically to wild-type p53 protein (wt-p53). A reporter assay revealed that only BS2 could enhance luciferase expression driven by a basal promoter. We constructed a reporter plasmid carrying the genomic regulatory region of KILLER/DR5 including the three p53 DNA-binding sites but no additional basal promoter. The genomic fragment showed basal transcriptional activity which was induced by wt-p53 but not by mutant p53, and human papilloma virus E6 inhibited the p53-dependent activation. Mutation of BS2 abrogated not only the binding activity of wt-p53 but also the induction of the KILLER/DR5 genomic promoter-reporter gene, indicating that BS2 is responsible for the p53-dependent transactivation of KILLER/ DR5. In p53-wild-type but not -mutant or -null cell lines, doxorubicin treatment stabilized p53 protein, and increased specific binding to BS2 as revealed by EMSA, and upregulated the KILLER/DR5 promoter-luciferase reporter gene. These results suggest that the transactivation of KILLER/DR5 is directly regulated by exogenous or endogenous wt-p53 and establishes KILLER/DR5 as a p53 target gene that can signal apoptotic death.

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TNF receptors include the p53-induced targets FAS and TNFRSF10A-D; these can be activated by external stimuli such as binding with FASL or TNF-α, thereby leading to caspase-dependent apoptosis.
“TNF receptors include the p53-induced targets FAS47, 48, 49 and TNFRSF10A–D;38, 39 these can be activated by external stimuli such as binding with FASL or TNF-α, thereby leading to caspase-dependent apoptosis.178”
From Census and evaluation of p53 target genes (2017) · cites this paper as [38]

Mitochondria and Apoptosis
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,998 · see citing works
WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321 · see citing works
Self-citation
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866 · see citing works
Apoptosis by Death Factor
Nagata, S. (1997) · Cell · doi:10.1016/s0092-8674(00)81874-7 · Cited by 4,908 · see citing works
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063 · see citing works
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047 · see citing works
Self-citation
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
Lowe, S. W., Ruley, H. E., Jacks, T., & Housman, D. E. (1993) · Cell · doi:10.1016/0092-8674(93)90719-7 · Cited by 2,911 · see citing works
Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900 · see citing works
A model for p53-induced apoptosis
Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500 · see citing works
Definition of a consensus binding site for p53
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985 · see citing works
Self-citation
The p53-mdm-2 autoregulatory feedback loop.
Wu, X., Bayle, J. H., Olson, D., & Levine, A. J. (1993) · Genes & Development · doi:10.1101/gad.7.7a.1126 · Cited by 1,801 · see citing works
Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family
Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., & Ashkenazi, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.12687 · Cited by 1,777 · see citing works
Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors
Sheridan, J. P., Marsters, S. A., Pitti, R. M., Gurney, A. L., Skubatch, M., Baldwin, D. T., Ramakrishnan, L., Gray, C. L., Baker, K. P., Wood, W. I., et al. (1997) · Science · doi:10.1126/science.277.5327.818 · Cited by 1,664 · see citing works
An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL
Pan, G., Ni, J., Wei, Y.-F., Yu, G.-L., Gentz, R., & Dixit, V. M. (1997) · Science · doi:10.1126/science.277.5327.815 · Cited by 1,486 · see citing works
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
Oliner, J. D., Pietenpol, J. A., Thiagalingam, S., Gyuris, J., Kinzler, K. W., & Vogelstein, B. (1993) · Nature · doi:10.1038/362857a0 · Cited by 1,447 · see citing works
KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene
Wu, G. S., Burns, T. F., McDonald, E. R., Jiang, W., Meng, R., Krantz, I. D., Kao, G., Gan, D.-D., Zhou, J.-Y., Muschel, R. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1097-141 · Cited by 1,081 · see citing works
Self-citation
Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen
Smith, M. L., Chen, I. T., Zhan, Q., Bae, I., Chen, C.-Y., Gilmer, T. M., Kastan, M. B., O'Connor, P. M., & Fornace, A. J. (1994) · Science · doi:10.1126/science.7973727 · Cited by 946 · see citing works
p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs
Müller, M., Wilder, S., Bannasch, D., Israeli, D., Lehlbach, K., Li-Weber, M., Friedman, S. L., Galle, P. R., Stremmel, W., Oren, M., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.11.2033 · Cited by 878 · see citing works
The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain
Degli‐Esposti, M. A., Dougall, W. C., Smolak, P. J., Waugh, J. Y., Smith, C. A., & Goodwin, R. G. (1997) · Immunity · doi:10.1016/s1074-7613(00)80399-4 · Cited by 815 · see citing works
Regulation ofp53downstream genes
El‐Deiry, W. S. (1998) · Seminars in Cancer Biology · doi:10.1006/scbi.1998.0097 · Cited by 797 · see citing works
Self-citation
Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway
Chaudhary, P. M., Eby, M. T., Jasmin, A., Bookwalter, A., Murray, J. M., & Hood, L. (1997) · Immunity · doi:10.1016/s1074-7613(00)80400-8 · Cited by 712 · see citing works
A novel receptor for Apo2L/TRAIL contains a truncated death domain
Marsters, S. A., Sheridan, J. P., Pitti, R. M., Huang, A. J. Y., Skubatch, M., Baldwin, D. T., Yuan, J., Gurney, A. L., Goddard, A. D., Godowski, P. J., et al. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00422-2 · Cited by 654 · see citing works
Cloning and Characterization of TRAIL-R3, a Novel Member of the Emerging TRAIL Receptor Family
Degli‐Esposti, M. A., Smolak, P. J., Walczak, H., Waugh, J. Y., Huang, C.-P., DuBose, R. F., Goodwin, R. G., & Smith, C. A. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.7.1165 · Cited by 630 · see citing works
Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL
MacFarlane, M., Ahmad, M., Srinivasula, S. M., Fernandes‐Alnemri, T., Cohen, G. M., & Alnemri, E. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25417 · Cited by 558 · see citing works
Cyclin G is a transcriptional target of the p53 tumor suppressor protein.
Okamoto, K., & Beach, D. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06807.x · Cited by 455 · see citing works
Sequence-specific transcriptional activation is essential for growth suppression by p53.
Pietenpol, J. A., Tokino, T., Thiagalingam, S., El‐Deiry, W. S., Kinzler, K. W., & Vogelstein, B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.1998 · Cited by 406 · see citing works
Self-citation
TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL
Screaton, G. R., Mongkolsapaya, J., Xu, X., Cowper, A. E., McMichael, A. J., & Bell, J. I. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00297-1 · Cited by 325 · see citing works
Characterization of two receptors for TRAIL1
Schneider, P., Bodmer, J.-L., Thome, M., Hofmann, K., Holler, N., & Tschopp, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01231-3 · Cited by 290 · see citing works
A functional p53-responsive intronic promoter is contained within the human<i>mdm2</i>gene
Zauberman, A., Flusberg, D., Haupt, Y., Barak, Y., & Oren, M. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.14.2584 · Cited by 276 · see citing works
Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.
Wu, G. S., Burns, T. F., Zhan, Y.-A., Alnemri, E. S., & El‐Deiry, W. S. (1999) · PubMed · Cited by 238 · see citing works
Self-citation
Potential role for Cathepsin D in p53-dependent tumor suppression and chemosensitivity
Wu, G. S., Säftig, P., Peters, C., & El‐Deiry, W. S. (1998) · Oncogene · doi:10.1038/sj.onc.1201755 · Cited by 226 · see citing works
Self-citation
Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting regionSelfcloseTable
Somasundaram, K., & El‐Deiry, W. S. (1997) · Oncogene · doi:10.1038/sj.onc.1201002 · Cited by 172 · see citing works
Self-citation
Sequence‐specific DNA binding by p53: identification of target sites and lack of binding to p53 ‐ MDM2 complexes.
Zauberman, A., Barak, Y., Ragimov, N., Levy, N., & Oren, M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05941.x · Cited by 151 · see citing works
The TRAIL Decoy Receptor TRUNDD (DcR2, TRAIL-R4) Is Induced by Adenovirus-p53 Overexpression and Can Delay TRAIL-, p53-, and KILLER/DR5-Dependent Colon Cancer Apoptosis
Meng, R. D., McDonald, E. R., Sheikh, M. S., Fornace, A. J., & El‐Deiry, W. S. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0025 · Cited by 119 · see citing works
Self-citation
Cutting Edge: Lymphocyte Inhibitor of TRAIL (TNF-Related Apoptosis-Inducing Ligand): A New Receptor Protecting Lymphocytes from the Death Ligand TRAIL
Mongkolsapaya, J., Cowper, A. E., Xu, X., Morris, G. M., McMichael, A. J., Bell, J. I., & Screaton, G. R. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.1.3 · Cited by 116 · see citing works
Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest
Wu, G. S., Burns, T. F., McDonald, E. R., Meng, R. D., Kao, G. D., Muschel, R. J., Yen, T. J., & El‐Deiry, W. S. (1999) · Oncogene · doi:10.1038/sj.onc.1203025 · Cited by 109 · see citing works
Self-citation
p53 and chemosensitivity
Wu, G. S., & El‐Deiry, W. S. (1996) · Nature Medicine · doi:10.1038/nm0396-255a · Cited by 90 · see citing works
Self-citation
Identification of an additional p53-responsive site in the human epidermal growth factor receptor gene promotor
Sheikh, M. S., Carrier, F., Johnson, A. C., Ogdon, S. E., & Fornace, A. J. (1997) · Oncogene · doi:10.1038/sj.onc.1201264 · Cited by 47 · see citing works
Detection and Analysis of Living, Growth-Inhibited Mammalian Cells Following Transfection
Zeng, Y., Somasundaram, K., Prabhu, N. S., Krishnadasan, R., & El‐Deiry, W. S. (1997) · BioTechniques · doi:10.2144/97231bm19 · Cited by 12 · see citing works
Self-citation

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Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921 · see citing works
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Zinkel, S. S., Gross, A., & Yang, E. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401987 · Cited by 475 · see citing works
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Ellisen, L. W., Ramsayer, K. D., Johannessen, C. M., Yang, A., Beppu, H., Minda, K., Oliner, J. D., McKeon, F., & Haber, D. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00706-2 · Cited by 474 · see citing works
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Nakata, S., Yoshida, T., Horinaka, M., Shiraishi, T., Wakada, M., & Sakai, T. (2004) · Oncogene · doi:10.1038/sj.onc.1207830 · Cited by 268 · see citing works
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Apoptosis regulators and their role in tumorigenesis
Zörnig, M., Hueber, A., Baum, W., & Evan, G. I. (2001) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(01)00031-2 · Cited by 239 · see citing works
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Malhi, H., Barreyro, F. J., Isomoto, H., Bronk, S. F., & Gores, G. J. (2007) · Gut · doi:10.1136/gut.2006.118059 · Cited by 212 · see citing works
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Long, J. S., & Ryan, K. M. (2012) · Oncogene · doi:10.1038/onc.2012.7 · Cited by 213 · see citing works
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Self-citation
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Liu, X., Yue, P., Khuri, F. R., & Sun, S.-Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1195 · Cited by 184 · see citing works
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Horinaka, M., Yoshida, T., Shiraishi, T., Nakata, S., Wakada, M., Nakanishi, R., Nishino, H., Matsui, H., & Sakai, T. (2005) · Oncogene · doi:10.1038/sj.onc.1208874 · Cited by 180 · see citing works
TNF-related apoptosis-inducing ligand (TRAIL): A new path to anti-cancer therapies
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DANIELS, R. A., Turley, H., Kimberley, F. C., Xue Song, L. I. U., Mongkolsapaya, J., CH'EN, P., Xu, X. N., Jin, B., Pezzella, F., & Screaton, G. R. (2005) · Cell Research · doi:10.1038/sj.cr.7290311 · Cited by 173 · see citing works
Chemoresistance in solid tumours
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Zou, W., Liu, X., Yue, P., Zhou, Z., Sporn, M. B., Lotan, R., Khuri, F. R., & Sun, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1238 · Cited by 167 · see citing works
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Rubio-Moscardo, F. (2005) · Blood · doi:10.1182/blood-2005-05-2013 · Cited by 157 · see citing works
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Galligan, L., Longley, D. B., McEwan, M. V., Wilson, T. R., McLaughlin, K. M., & Johnston, P. G. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0262 · Cited by 155 · see citing works
P53 protein in proliferation, repair and apoptosis of cells
Wawryk‐Gawda, E., Chylińska‐Wrzos, P., Lis-Sochocka, M., Chłapek, K., Bulak, K., Jędrych, M., & Jodłowska‐Jędrych, B. (2013) · PROTOPLASMA · doi:10.1007/s00709-013-0548-1 · Cited by 155 · see citing works
The transcription factor p53: Not a repressor, solely an activator.
Fischer, M., Steiner, L., & Engeland, K. (2014) · Cell Cycle · doi:10.4161/15384101.2014.949083 · Cited by 153 · see citing works
NF‐κB pathway: a target for preventing β‐amyloid (Aβ)‐induced neuronal damage and Aβ42 production
Valerio, A., Boroni, F., Benarese, M., Sarnico, I., Ghisi, V., Bresciani, L. G., Ferrario, M., Borsani, G., Spano, P., & Pizzi, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04722.x · Cited by 148 · see citing works
Rational bases for the development of EGFR inhibitors for cancer treatment
Bianco, R., Gelardi, T., Damiano, V., Ciardiello, F., & Tortora, G. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.05.008 · Cited by 144 · see citing works
Targeting apoptotic pathways for cancer therapy
Tian, X., Srinivasan, P. R., Tajiknia, V., Uruchurtu, A. F. S. S., Seyhan, A. A., Carneiro, B. A., Cruz, A. D. L., Pinho-Schwermann, M. P., George, A., Zhao, S., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci179570 · Cited by 149 · see citing works
Self-citation
Apoptosis in cancer—implications for therapy
Schulze‐Bergkamen, H., & Krammer, P. H. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2003.11.006 · Cited by 144 · see citing works
Bile Acids Up-regulate Death Receptor 5/TRAIL-receptor 2 Expression via a c-Jun N-terminal Kinase-dependent Pathway Involving Sp1
Higuchi, H., Grambihler, A., Canbay, A. E., Bronk, S. F., & Gores, G. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309476200 · Cited by 140 · see citing works
TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy
Wajant, H., Pfizenmaier, K., & Scheurich, P. (2002) · APOPTOSIS · doi:10.1023/a:1020039225764 · Cited by 142 · see citing works
The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor
Renault, V. M., Thekkat, P. U., Hoang, K., White, J. L., Brady, C. A., Brož, D. K., Venturelli, O. S., Johnson, T. M., Oskoui, P. R., Xuan, Z., et al. (2011) · Oncogene · doi:10.1038/onc.2011.35 · Cited by 138 · see citing works
Expression of TRAIL and TRAIL death receptors in stage III non-small cell lung cancer tumors.
Spierings, D. C. J., de Vries, E. G. E., Timens, W., Groen, H. J. M., Boezen, H. M., & de Jong, S. (2003) · PubMed · Cited by 138 · see citing works
Transcription Factor NF-κB Differentially Regulates Death Receptor 5 Expression Involving Histone Deacetylase 1
Shetty, S., Graham, B. A., Brown, J. G., Hu, X., Vegh-Yarema, N., Harding, G. A., Paul, J. T., & Gibson, S. B. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5404-5416.2005 · Cited by 136 · see citing works
Regulation of p53 tumour suppressor target gene expression by the p52 NF‐κB subunit
Schumm, K., Rocha, S., Caamaño, J., & Perkins, N. D. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601343 · Cited by 135 · see citing works
Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling
El‐Deiry, W. S. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400943 · Cited by 136 · see citing works
Self-citation
Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5
Carter, B. Z., Mak, D. H. F., Schober, W. D., Dietrich, M. F., Pinilla, C., Vassilev, L. T., Reed, J. C., & Andreeff, M. (2008) · Blood · doi:10.1182/blood-2007-05-091504 · Cited by 134 · see citing works
Evidence that the death receptor DR4 is a DNA damage‐inducible, p53‐regulated gene
Guan, B., Yue, P., Clayman, G. L., & Sun, S. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1101 · Cited by 135 · see citing works
Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo
Burns, T. F., Bernhard, E. J., & El‐Deiry, W. S. (2001) · Oncogene · doi:10.1038/sj.onc.1204484 · Cited by 133 · see citing works
Self-citation
Baicalein Overcomes Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Resistance via Two Different Cell-Specific Pathways in Cancer Cells but not in Normal Cells
Taniguchi, H., Yoshida, T., Horinaka, M., Yasuda, T., Goda, A. E., Konishi, M., Wakada, M., Kataoka, K., Yoshikawa, T., & Sakai, T. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1120 · Cited by 132 · see citing works
The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis
Takimoto, R., Wang, W., Dicker, D. T., Rastinejad, F., Lyssikatos, J. P., & El‐Deiry, W. S. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.1.1.41 · Cited by 128 · see citing works
Self-citation
The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor–related apoptosis-inducing ligand
Horinaka, M., Yoshida, T., Shiraishi, T., Nakata, S., Wakada, M., & Sakai, T. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0431 · Cited by 127 · see citing works
Ursolic Acid, a Pentacyclin Triterpene, Potentiates TRAIL-induced Apoptosis through p53-independent Up-regulation of Death Receptors
Prasad, S., Yadav, V. R., Kannappan, R., & Aggarwal, B. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.183699 · Cited by 126 · see citing works
Retracted
Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance
Zingoni, A., Fionda, C., Borrelli, C., Cippitelli, M., Santoni, A., & Soriani, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01194 · Cited by 126 · see citing works
DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells
Li, T., Su, L., Lei, Y., Liu, X., Zhang, Y., & Liu, X. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.645333 · Cited by 123 · see citing works
Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL‐R2 gene 1
Yoshida, T., Maeda, A., Tani, N., & Sakai, T. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02947-7 · Cited by 124 · see citing works
Coupling of Endoplasmic Reticulum Stress to CDDO-Me–Induced Up-regulation of Death Receptor 5 via a CHOP–Dependent Mechanism Involving JNK Activation
Zou, W., Yue, P., Khuri, F. R., & Sun, S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1318 · Cited by 119 · see citing works
Identification of Novel p53 Target Genes in Ionizing Radiation Response
Jen, K., & Cheung, V. G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1039 · Cited by 119 · see citing works
Rel/NF-κB Transcription Factors Protect against Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis by Up-regulating the TRAIL Decoy Receptor DcR1
Bernard, D., Quatannens, B., Vandenbunder, B., & Abbadie, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011183200 · Cited by 120 · see citing works
Death to the bad guys: Targeting cancer via Apo2L/TRAIL
Bouralexis, S., Findlay, D. M., & Evdokiou, A. (2005) · APOPTOSIS · doi:10.1007/s10495-005-6060-0 · Cited by 119 · see citing works
Targeted Therapies to Improve Tumor Immunotherapy
Begley, J. L., & Ribas, A. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4804 · Cited by 118 · see citing works
Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation
Zhou, J., Lu, G., Ong, C.-S., Ong, C. N., & Shen, H. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0071 · Cited by 115 · see citing works
The biological role of the Fas/FasL system during tumor formation and progression
Ernst Reichmann, A. (2002) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(02)00017-2 · Cited by 116 · see citing works
Death squads enlisted by the tumour suppressor p53
Michalak, E. M., Villunger, A., Erlacher, M., & Strasser, A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.183 · Cited by 114 · see citing works
Apoptotic Pathways and Therapy Resistance in Human Malignancies
Viktorsson, K., Lewensohn, R., & Zhivotovsky, B. (2005) · Advances in cancer research · doi:10.1016/s0065-230x(05)94004-9 · Cited by 108 · see citing works
Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors.
Terui, T., Murakami, K., Takimoto, R., Takahashi, M., Takada, K., Murakami, T., Minami, S., Matsunaga, T., Takayama, T., Kato, J., et al. (2003) · PubMed · Cited by 104 · see citing works
Self-citation
Inducible Silencing of KILLER/DR5 In vivo Promotes Bioluminescent Colon Tumor Xenograft Growth and Confers Resistance to Chemotherapeutic Agent 5-Fluorouracil
Wang, S., & El‐Deiry, W. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1734 · Cited by 104 · see citing works
Self-citation
On the TRAIL to apoptosis
Baetu, T. M., & Hiscott, J. B. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(02)00006-0 · Cited by 103 · see citing works
Oligodendrocyte injury in multiple sclerosis: a role for p53
Wosik, K., Antel, J. P., Kuhlmann, T., Brück, W., Bernard Massie, B., & Nalbantoglu, J. N. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01674.x · Cited by 102 · see citing works
RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53
Sohr, S., & Engeland, K. (2008) · Cell Cycle · doi:10.4161/cc.7.21.7014 · Cited by 99 · see citing works
Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression
Ivanov, V. N., Partridge, M. A., Johnson, G. E., Huang, S. X. L., Zhou, H., & Hei, T. K. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.12.012 · Cited by 98 · see citing works
Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB.
Yang, X., Merchant, M. S., Romero, M. E., Tsokos, M., Wexler, L. H., Kontny, U., Mackall, C. L., & Thiele, C. J. (2003) · PubMed · Cited by 96 · see citing works
Regulation of Programmed Cell Death by the P53 Pathway
Kuribayashi, K., & El‐Deiry, W. S. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-1-4020-6554-5_10 · Cited by 95 · see citing works
Self-citation
Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway
He, Q., Lee, D. I., Rong, R., Yu, M., Luo, X., Klein, M., El‐Deiry, W. S., Huang, Y. K., Hussain, A., & Sheikh, M. S. (2002) · Oncogene · doi:10.1038/sj.onc.1205345 · Cited by 94 · see citing works
Self-citation
Parthenolide sensitizes hepatocellular carcinoma cells to trail by inducing the expression of death receptors through inhibition of STAT3 activation
Carlisi, D., D’Anneo, A., Angileri, L., Lauricella, M., Emanuele, S., Santulli, A., Vento, R., & Tesoriere, G. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22494 · Cited by 93 · see citing works
A global suppressor motif for p53 cancer mutants
Baroni, T. E., Wang, T., Hua, Q., Dearth, L. R., Truong, L. N., Zeng, J., Denes, A. E., Chen, S. W., & Brachmann, R. K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401162101 · Cited by 93 · see citing works
mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation
He, K., Zheng, X., Li, M., Zhang, L., & Yu, J. (2015) · Oncogene · doi:10.1038/onc.2015.79 · Cited by 92 · see citing works
Studies on search for bioactive natural products targeting TRAIL signaling leading to tumor cell apoptosis
Ishibashi, M., & Ohtsuki, T. (2008) · Medicinal Research Reviews · doi:10.1002/med.20123 · Cited by 92 · see citing works
Decoy Receptor 2 ( DcR2 ) Is a p53 Target Gene and Regulates Chemosensitivity
Liu, X., Yue, P., Khuri, F. R., & Sun, S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0939 · Cited by 92 · see citing works
Gene-specific repression of the p53 target gene PUMA via intragenic CTCF–Cohesin bindingPreprint
Gomes, N. P., & Espinosa, J. M. (2010) · Genes & Development · doi:10.1101/gad.1881010 · Cited by 92 · see citing works
Spatial dynamics of TRAIL death receptors in cancer cells
Twomey, J. D., Kim, S.-R., Zhao, L., Bozza, W. P., & Zhang, B. (2015) · Drug Resistance Updates · doi:10.1016/j.drup.2015.02.001 · Cited by 91 · see citing works
Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells
Obad, S., Brunnström, H., Vallon-Christersson, J., Borg, Å., Drott, K., & Gullberg, U. (2004) · Oncogene · doi:10.1038/sj.onc.1207524 · Cited by 90 · see citing works
The p53 network: p53 and its downstream genes
Shu, K., Li, B., & Wu, L. (2006) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2006.11.003 · Cited by 89 · see citing works
Notch1 Signaling Sensitizes Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Human Hepatocellular Carcinoma Cells by Inhibiting Akt/Hdm2-mediated p53 Degradation and Up-regulating p53-dependent DR5 Expression
Wang, C., Qi, R., Li, N., Wang, Z., An, H., Zhang, Q., Yu, Y., & Cao, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.002105 · Cited by 89 · see citing works
Retracted
Cholestasis Increases Tumor Necrosis Factor-Related Apoptotis-Inducing Ligand (TRAIL)-R2/DR5 Expression and Sensitizes the Liver to TRAIL-Mediated Cytotoxicity
Higuchi, H., Bronk, S. F., Taniai, M., Canbay, A. E., & Gores, G. J. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.040030 · Cited by 89 · see citing works
Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor α expression via activation of nuclear factor-κB
Sato, Y., Kato, J., Takimoto, R., Takada, K., Kawano, Y., Miyanishi, K., Kobune, M., Sato, Y., Takayama, T., Matunaga, T., et al. (2006) · Gut · doi:10.1136/gut.2005.070417 · Cited by 87 · see citing works
Self-citation
Wogonin and Related Natural Flavones Overcome Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Protein Resistance of Tumors by Down-regulation of c-FLIP Protein and Up-regulation of TRAIL Receptor 2 Expression
Ding, J., Polier, G., Köhler, R., Giaisi, M., Krammer, P. H., & Li‐Weber, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.286526 · Cited by 85 · see citing works
Transcriptomic profiling reveals p53 as a key regulator of doxorubicin-induced cardiotoxicity
McSweeney, K. M., Bozza, W. P., Alterovitz, W.-L., & Zhang, B. (2019) · Cell Death Discovery · doi:10.1038/s41420-019-0182-6 · Cited by 86 · see citing works
Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression
Du, J., Liang, X., Liu, Y., Qu, Z., Gao, L., Han, L., Liu, S., Cui, M., Shi, Y., Zhang, Z., et al. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.144 · Cited by 87 · see citing works
Nitric oxide sensitizes tumor cells to TRAIL-induced apoptosis via inhibition of the DR5 transcription repressor Yin Yang 1
Huerta‐Yépez, S., Vega, M. I., Escoto-Chavez, S. E., Murdock, B. J., Sakai, T., Baritaki, S., & Bonavida, B. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.08.001 · Cited by 86 · see citing works
TRAIL combinations: The new ‘trail’ for cancer therapy (Review)
Refaat, A., Abdrabou, A., & Reda, A. M. (2014) · Oncology Letters · doi:10.3892/ol.2014.1922 · Cited by 85 · see citing works
BRCA1 Transcriptionally Regulates Damaged DNA Binding Protein (DDB2) In the DNA Repair Response Following UV-Irradiation
Takimoto, R., MacLachlan, T. K., Dicker, D. T., Niitsu, Y., Mori, T., & El‐Deiry, W. S. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.65 · Cited by 84 · see citing works
Self-citation

p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.
Sheikh, M. S., Burns, T. F., Huang, Y., Wu, G. S., Amundson, S. A., Brooks, K., Fornace, A. J., & El‐Deiry, W. S. (1998) · PubMed · Cited by 362 · see citing works
Self-citation
p53 Upregulates Death Receptor 4 Expression through an Intronic p53 Binding Site
Liu, X., Yue, P., Khuri, F. R., & Sun, S.-Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1195 · Cited by 184 · see citing works
Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest
Wu, G. S., Burns, T. F., McDonald, E. R., Meng, R. D., Kao, G. D., Muschel, R. J., Yen, T. J., & El‐Deiry, W. S. (1999) · Oncogene · doi:10.1038/sj.onc.1203025 · Cited by 109 · see citing works
Self-citation
P3-009: Immunohistochemical study for the expression of DR5 TRAIL receptor in non-small cell lung cancer
Lee, K. Y., Lee, T. H., & Yoo, G. H. (2007) · Journal of Thoracic Oncology · doi:10.1097/01.jto.0000283495.58398.34
Analysis of p53 transactivation through high-affinity binding sites.
Chumakov, A. M., Cw, M., Chen, D. L., & Koeffler, H. P. (1993) · PubMed · Cited by 35 · see citing works

Authors: Takimoto, R., & El-Deiry, W. S.
Affiliations: Howard Hughes Medical Institute (US)
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2000-03-30
Volume: 19
Issue: 14
Pages: 1735-1743
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1203489
OpenAlex: W2053301688
Cited by: 360
References: 39
Citations by year: 2026: 3 · 2025: 6 · 2024: 3 · 2023: 12 · 2022: 5 · 2021: 6 · 2020: 11 · 2019: 10 · 2018: 7 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 12 · 2013: 8 · 2012: 18
FWCI: 7.78
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Japan Health Sciences Foundation
National Cancer Institute (P01CA075138, P01 CA75138-01)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: p53, DR5, TRAIL, p53 target genes, intronic enhancer, transcriptional activation, doxorubicin, p53 stabilization, apoptosis, E6 oncoprotein
MeSH terms: Binding Sites, DNA, DNA Damage, Doxorubicin, Humans, Introns, Oncogene Proteins, Viral, Promoter Regions, Genetic, Tumor Cells, Cultured, Transcriptional Activation, Gene Expression, Tumor Suppressor Protein p53, Mutagenesis, Apoptosis, Genes, Reporter, Receptors, Tumor Necrosis Factor, Receptors, TNF-Related Apoptosis-Inducing Ligand

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Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

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