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Cited by 291

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed

Open access
Gauron, Carole, Rampon, Christine, Bouzaffour, Mohamed, Ipendey, Eliane, Teillon, Jérémie, Volovitch, Michel, Vriz, Sophie·2013·Scientific Reports
DOI 10.1038/srep02084
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Abstract

A major issue in regenerative medicine is the role of injury in promoting cell plasticity. Here we explore the function of reactive oxygen species (ROS) induced through lesions in adult zebrafish. We show that ROS production, following adult fin amputation, is tightly regulated in time and space for at least 24 hours, whereas ROS production remains transient (2 hours) in mere wound healing. In regenerative tissue, ROS signaling triggers two distinct parallel pathways: one pathway is responsible for apoptosis, and the other pathway is responsible for JNK activation. Both events are involved in the compensatory proliferation of stump epidermal cells and are necessary for the progression of regeneration. Both events impact the Wnt, SDF1 and IGF pathways, while apoptosis only impacts progenitor marker expression. These results implicate oxidative stress in regeneration and provide new insights into the differences between healing and regeneration.

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Crossref · 10.1038/srep02084

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Metadata

Authors
Gauron, C., Rampon, C., Bouzaffour, M., Ipendey, E., Teillon, J., Volovitch, M., & Vriz, S.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2013-06-27
Volume
3
Issue
1
Pages
2084-2084
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep02084
OpenAlex
W2027827026
Cited by
291
References
52
FWCI
7.67
Type
journal article
Language
en
Open access
gold

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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