A concurrent excitation and inhibition of dopaminergic subpopulations in response to nicotine
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Midbrain dopamine (DA) neurons are key players in motivation and reward processing. Increased DA release is thought to be central in the initiation of drug addiction. Whereas dopamine neurons are generally considered to be activated by drugs such as nicotine, we report here that nicotine not only induces excitation of ventral tegmental area (VTA) DA cells but also induces inhibition of a subset of VTA DA neurons that are anatomically segregated in the medial part of the VTA. These opposite responses do not correlate with the inhibition and excitation induced by noxious stimuli. We show that this inhibition requires D2 receptor (D2-R) activation, suggesting that a dopaminergic release is involved in the mechanism. Our findings suggest a principle of concurrent excitation and inhibition of VTA DA cells in response to nicotine. It promotes unexplored roles for DA release in addiction contrasting with the classical views of reinforcement and motivation and give rise to a new interpretation of the mode of operation of the reward system.
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Nicotine in adolescence is poised to alter DA development because it acts directly on VTA DA neurons through their expression of nAChRs, modulating their firing rate in a population-specific manner in adult rodents.
“Nicotine in adolescence is thus poised to alter DA development, as it acts directly on VTA DA neurons through their expression of nAChRs, modulating their firing rate in a population-specific manner in adult rodents [72, 137–139].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [138]
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Nicotine in adolescence freezes dopamine circuits in an immature statePreprint
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Morris, L. S., Beltran, J., Murrough, J. W., & Morel, C. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.02.008
Self-citationAltered acetylcholine modulations and corticoaccumbal pathway in P11-linked social dysfunction
Dautan, D., Camargo, A., Branzell, N., Brioschi, V. I., Doyon, D., Covatta, E., Marongiu, R., Kaplitt, M. G., Chergui, K., Zhang, X., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03324-2
“In contrast, since the effects were similar regardless of whether the stimulus mice were P11-WT or P11-KO, DA and Ach release in the Nac does not appear to be crucial for social motivation.”
InfluentialSelf-citationDiversité des effets de la nicotine sur les neurones dopaminergiques de l’aire tegmentale ventrale
Nguyen, C. (2020) · theses.fr (ABES) · doi:10.70675/57dc4740z36f1z4ee7z87e7z960af8c4a43e
Dynamiques dopaminergiques dans la prise de décision : rôle dans la variabilité et l’exploration
Côme, M. (2023) · theses.fr (ABES) · doi:10.70675/a7b03d10z7e3cz45a1z817bza6c6344893af
- Authors
- Eddine, R., Valverde, S., Tolu, S., Dautan, D., Hay, A., Morel, C., Cui, Y., Lambolez, B., Venance, L., Marti, F., & Faure, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- ORCID
- Venue
- Scientific Reports
- Published
- 2015-02-02
- Volume
- 5
- Issue
- 1
- Pages
- 8184-8184
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4313096
- OpenAlex
- W2078032906
- Cited by
- 42
- References
- 39
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 8 · 2017: 3 · 2016: 4 · 2015: 3
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Agence Nationale de la Recherche
- Centre National de la Recherche Scientifique
- Fondation Bettencourt Schueller
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine, ventral tegmental area, dopaminergic neurons, dopamine D2 receptor, dopamine release, drug addiction, reward systems, noxious stimuli, midbrain dopaminergic neurons
- MeSH terms
- Action Potentials, Animals, Mice, Inbred C57BL, Nicotine, Receptors, Dopamine D2, Ventral Tegmental Area, Mice, Dopaminergic Neurons
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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