Cited by 125Nicotinic Acetylcholine Receptors StudyNeurotransmitter Receptor Influence on BehaviorSmoking Behavior and Cessation

Role of nicotinic acetylcholine receptors in regulating dopamine neuron activity

Faure, P., Tolu, S., Valverde, S., Naudé, J.·2014·Neuroscience

Abstract

Midbrain dopamine (DA) neurons play a central role in a wide range of behaviors, from attention and motivation to motor control and reinforcement. The release of DA is modulated by a number of factors, and its deregulation has been implicated in multiple psychiatric disorders, such as addiction. In particular, nicotinic acetylcholine receptors (nAChRs) are key modulators of DA cells. Nicotine, the main addictive component in tobacco, strongly interacts with these receptors in the midbrain DA systems, resulting in reinforcing effects that are at the core of tobacco addiction. nAChRs are virtually expressed on every cell of the DA system, both at pre-, post- and extra-synaptic locations. The complex issue of interpreting the role of the large portfolio of different nAChR subtypes expressed on ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) neurons, and especially their role in defining functional DAergic subpopulations, is far from being solved. In this review we will try to provide the reader with an integrative view of the nicotinic modulation of DA neurons and its influence at the cellular, systemic and behavioral levels (exploratory behavior), as well as its implication in the reinforcing effects of nicotine.

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Crossref · 10.1016/j.neuroscience.2014.05.040

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Authors
Faure, P., Tolu, S., Valverde, S., & Naudé, J.
Affiliations
Centre National de la Recherche Scientifique (FR)
Venue
Neuroscience
Publisher
Elsevier BV
Published
2014-12
Volume
282
Pages
86-100
ISSN
0306-4522 (ISSN-L)
OpenAlex
W2030372520
Cited by
125
References
145
Citations by year
2026: 5 · 2025: 9 · 2024: 17 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 11 · 2019: 12 · 2018: 13 · 2017: 6 · 2016: 14 · 2015: 10 · 2014: 5
FWCI
1.10
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords
nicotinic acetylcholine receptors, dopaminergic neurons, midbrain dopamine system, nicotine, tobacco dependence, nicotine reinforcement, ventral tegmental area, substantia nigra pars compacta, exploratory behavior
MeSH terms
Animals, Behavior, Animal, Nicotine, Receptors, Nicotinic, Substantia Nigra, Ventral Tegmental Area, Dopaminergic Neurons

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