Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models
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Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.
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In two well-established rodent models of IBS that lead to visceral hyperalgesia, the enhanced visceromotor response to colorectal distension was reversed following administration of F. prausnitzii.
“Using two well-established rodent models of IBS that lead to visceral hyperalgesia in vivo, it was found that the enhanced visceromotor response to colorectal distension was reversed following administration of F. prausnitzii.”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [161]
Faecalibacterium prausnitzii is a potential source of anti-nociceptive mediators, including a PAR-4 activating serine protease.
“Subsequent studies have identified Faecalibacterium prausnitzii as a potential source of anti-nociceptive mediators, including a PAR-4 activating serine protease.”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [161]
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- Authors
- Miquel, S., Martín, R., Lashermes, A., Gillet, M., Meleine, M., Gelot, A., Eschalier, A., Ardid, D., Bermúdez-Humarán, L. G., Sokol, H., Thomas, M., Theodorou, V., Langella, P., & Carvalho, F. A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- AgroParisTech (FR)
- Inserm (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Corresponding author
- Miquel, S.
- Carvalho, F. A.
- Venue
- Scientific Reports
- Published
- 2016-01-18
- Volume
- 6
- Issue
- 1
- Pages
- 19399-19399
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4726104
- OpenAlex
- W2405482068
- Cited by
- 105
- References
- 45
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 9 · 2023: 13 · 2022: 11 · 2021: 11 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 10 · 2016: 4
- FWCI
- 12.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR‐09‐MNPS‐037‐01, ANR-09-MNPS-0037)
- European Regional Development Fund
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- Faecalibacterium prausnitzii, irritable bowel syndrome, visceral pain, colonic hypersensitivity, antinociceptive effect, neonatal maternal separation, gut dysbiosis, intestinal epithelial barrier, gut-brain axis, probiotic therapy
- MeSH terms
- Faecalibacterium prausnitzii, Animals, Colon, Disease Models, Animal, Intestinal Mucosa, Male, Maternal Deprivation, Permeability, Stress, Physiological, Irritable Bowel Syndrome, Mice
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