Cited by 105Gastrointestinal motility and disordersGut microbiota and healthInflammatory Bowel Disease

Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models

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Miquel, S., Martín, R., Lashermes, A., Gillet, M., Meleine, M., Gelot, A., Eschalier, A., Ardid, D. +6 more·2016·Scientific Reports

Abstract

Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.

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  • In two well-established rodent models of IBS that lead to visceral hyperalgesia, the enhanced visceromotor response to colorectal distension was reversed following administration of F. prausnitzii.

    “Using two well-established rodent models of IBS that lead to visceral hyperalgesia in vivo, it was found that the enhanced visceromotor response to colorectal distension was reversed following administration of F. prausnitzii.”
  • Faecalibacterium prausnitzii is a potential source of anti-nociceptive mediators, including a PAR-4 activating serine protease.

    “Subsequent studies have identified Faecalibacterium prausnitzii as a potential source of anti-nociceptive mediators, including a PAR-4 activating serine protease.”

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Authors
Miquel, S., Martín, R., Lashermes, A., Gillet, M., Meleine, M., Gelot, A., Eschalier, A., Ardid, D., Bermúdez-Humarán, L. G., Sokol, H., Thomas, M., Theodorou, V., Langella, P., & Carvalho, F. A.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • AgroParisTech (FR)
  • Inserm (FR)
  • Université Toulouse III - Paul Sabatier (FR)
Corresponding author
  • Miquel, S.
  • Carvalho, F. A.
Venue
Scientific Reports
Published
2016-01-18
Volume
6
Issue
1
Pages
19399-19399
ISSN
2045-2322 (ISSN-L)
OpenAlex
W2405482068
Cited by
105
References
45
Citations by year
2026: 7 · 2025: 11 · 2024: 9 · 2023: 13 · 2022: 11 · 2021: 11 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 10 · 2016: 4
FWCI
12.04
Type
journal article
Language
en
Open access
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • HAL (submittedVersion)
Funders
  • Agence Nationale de la Recherche (ANR‐09‐MNPS‐037‐01, ANR-09-MNPS-0037)
  • European Regional Development Fund
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords
Faecalibacterium prausnitzii, irritable bowel syndrome, visceral pain, colonic hypersensitivity, antinociceptive effect, neonatal maternal separation, gut dysbiosis, intestinal epithelial barrier, gut-brain axis, probiotic therapy
MeSH terms
Faecalibacterium prausnitzii, Animals, Colon, Disease Models, Animal, Intestinal Mucosa, Male, Maternal Deprivation, Permeability, Stress, Physiological, Irritable Bowel Syndrome, Mice

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