Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome

Zhou, QiQi; Zhang, Buyi; Verne, Nicholas G.

doi:10.1016/j.pain.2009.06.017

Cited by 373Gastrointestinal motility and disordersGut microbiota and healthInflammatory Bowel Disease

Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome

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Zhou, QiQi, Zhang, Buyi, Verne, Nicholas G.·2009·Pain

DOI 10.1016/j.pain.2009.06.017PMC PMC2763174

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Abstract

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder in which the underlying pathophysiology is poorly understood; however, increased intestinal permeability in diarrhea-predominant IBS patients has been reported. Here we demonstrate that diarrhea-predominant IBS (D-IBS) patients display increased intestinal permeability. We have also found that increased intestinal membrane permeability is associated with visceral and thermal hypersensitivity in this subset of D-IBS patients. We evaluated 54 D-IBS patients and 22 controls for intestinal membrane permeability using the lactulose/mannitol method. All subjects ingested 5g of lactulose and 2g of mannitol in 100ml of water after which their urine was collected. We also evaluated the mean mechanical visual analogue scale (M-VAS) pain rating to nociceptive thermal and visceral stimulation in all subjects. All study participants also completed the FBDSI scale. Approximately 39% of diarrhea-predominant IBS patients had increased intestinal membrane permeability as measured by the lactulose/mannitol ratio. These IBS patients also demonstrated higher M-VAS pain intensity reading scale. Interestingly, the IBS patients with hypersensitivity and increased intestinal permeability had a higher FBDSI score (100.8 + or - 5.4) than IBS patients with normal membrane permeability and sensitivity (51.6 + or - 12.7) and controls (6.1 + or - 5.6) (p<0.001). A subset of D-IBS patients had increased intestinal membrane permeability that was associated with an increased FBDSI score and increased hypersensitivity to visceral and thermal nociceptive pain stimuli. Thus, increased intestinal membrane permeability in D-IBS patients may lead to more severe IBS symptoms and hypersensitivity to somatic and visceral stimuli.

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Authors: Zhou, Q., Zhang, B., & Verne, N. G.
Affiliations: The Ohio State University (US)
Cincinnati VA Medical Center (US)
Corresponding author: Verne, Nicholas G.
ORCID: Zhou, QiQi
Zhang, Buyi
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-11
Volume: 146
Issue: 1
Pages: 41-46
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/j.pain.2009.06.017
PMC: PMC2763174
OpenAlex: W1967139826
Cited by: 373
References: 48
Citations by year: 2026: 15 · 2025: 12 · 2024: 18 · 2023: 15 · 2022: 20 · 2021: 36 · 2020: 26 · 2019: 25 · 2018: 29 · 2017: 25 · 2016: 22 · 2015: 18 · 2014: 29 · 2013: 25 · 2012: 21
FWCI: 20.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS053090)
National Center for Research Resources (M01RR000082)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords: irritable bowel syndrome, diarrhea-predominant irritable bowel syndrome, intestinal permeability, visceral hypersensitivity, thermal hypersensitivity, lactulose/mannitol test, visceral pain, IBS symptom severity, gut-brain axis
MeSH terms: Adult, Catheterization, Cell Membrane Permeability, Diarrhea, Female, Hot Temperature, Humans, Hypersensitivity, Intestinal Mucosa, Male, Pain, Pain Measurement, Physical Stimulation, Severity of Illness Index, Irritable Bowel Syndrome

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

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