Th17 responses and natural IgM antibodies are related to gut microbiota composition in systemic lupus erythematosus patients
Open accessAbstract
Intestinal dysbiosis, characterized by a reduced Firmicutes / Bacteroidetes ratio, has been reported in systemic lupus erythematosus (SLE) patients. In this study, in vitro cultures revealed that microbiota isolated from SLE patient stool samples (SLE-M) promoted lymphocyte activation and Th17 differentiation from naïve CD4 + lymphocytes to a greater extent than healthy control-microbiota. Enrichment of SLE-M with Treg-inducing bacteria showed that a mixture of two Clostridia strains significantly reduced the Th17/Th1 balance, whereas Bifidobacterium bifidum supplementation prevented CD4 + lymphocyte over-activation, thus supporting a possible therapeutic benefit of probiotics containing Treg-inducer strains in order to restore the Treg/Th17/Th1 imbalance present in SLE. In fact, ex vivo analyses of patient samples showed enlarged Th17 and Foxp3 + IL-17 + populations, suggesting a possible Treg-Th17 trans-differentiation. Moreover, analyses of fecal microbiota revealed a negative correlation between IL-17 + populations and Firmicutes in healthy controls, whereas in SLE this phylum correlated directly with serum levels of IFNγ, a Th1 cytokine slightly reduced in patients. Finally, the frequency of Synergistetes , positively correlated with the Firmicutes / Bacteroidetes ratio in healthy controls, tended to be reduced in patients when anti-dsDNA titers were increased and showed a strong negative correlation with IL-6 serum levels and correlated positively with protective natural IgM antibodies against phosphorylcholine.
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Supplementation of the gut microbiota obtained from a cohort of systemic lupus erythematosus patients with a B. bifidum strain partially corrected the altered immune response characteristic of lupus, using a dendritic cell/naive T-cell model.
“In this regard, supplementation of the gut microbiota obtained from a cohort of systemic lupus erythematosus patients with a B. bifidum strain partially corrected the altered immune response characteristic of lupus, using a dendritic cell/naive T-cell model (105).”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [105]
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- Authors
- López, P., de Paz, B., Rodríguez-Carrio, J., Hevia, A., Sánchez, B., Margolles, A., & Suárez, A.
- Affiliations
- Universidad de Oviedo (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Venue
- Scientific Reports
- Published
- 2016-04-05
- Volume
- 6
- Issue
- 1
- Pages
- 24072-24072
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4820712
- OpenAlex
- W2325771122
- Cited by
- 262
- References
- 61
- Citations by year
- 2026: 14 · 2025: 24 · 2024: 30 · 2023: 32 · 2022: 31 · 2021: 28 · 2020: 33 · 2019: 19 · 2018: 24 · 2017: 19 · 2016: 7
- FWCI
- 24.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-sa)
- Funders
- European Commission (14952)
- Ministerio de Educación, Cultura y Deporte
- Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- systemic lupus erythematosus, gut microbiota, Th17 cells, regulatory T cells, natural IgM, gut dysbiosis, Firmicutes/Bacteroidetes ratio, Clostridium, Bifidobacterium bifidum, probiotics, Th17/Treg balance, IL-17, interferon-gamma, interleukin-6, anti-dsDNA antibodies, phosphorylcholine, Synergistetes, CD4+ T cell activation
- MeSH terms
- Gastrointestinal Microbiome, Bifidobacterium bifidum, Aged, Cell Differentiation, Clostridium, Dendritic Cells, Female, Flow Cytometry, Humans, Immunoglobulin G, Immunoglobulin M, Lupus Erythematosus, Systemic, Middle Aged, Monocytes, Interleukin-6, Case-Control Studies, Cytokines, Interleukin-17, Th17 Cells
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