Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment
Open accessAbstract
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.
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Carboxymethyl cellulose is capable of forming thermo-responsive hydrogel.
“The carbomethyl cellulose, which is another functional derivative of cellulose, is capable of forming thermo-responsive hydrogel.”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [43]
The Methods (Materials; Preparation of P407/CMCs composite hydrogel, pages unavailable) identify CMCs as carboxymethyl cellulose sodium and describe adding it to poloxamer 407 to make a composite hydrogel. The Results (Phase transition analysis, page unavailable) show that the composite is thermo-responsive, but do not establish that carboxymethyl cellulose forms a thermo-responsive hydrogel on its own. (LLM, conf=0.86)
Experimental — accuracy not yet measuredTextile-based transdermal therapy using drug-loaded hydrogels made of stimuli-responsive polymers has become an effective means of skin care.
“Textile-based transdermal therapy using drug loaded hydrogels made of stimuli-responsive polymers has become an effective means of skin care [35,43,44,45].”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [43]
The Discussion (page not provided) describes a thermosensitive, drug-loaded hydrogel that could supply both moisture and medication to skin affected by atopic dermatitis. It says the formulation may be used in hydrogel-coated fabrics, but calls the therapy promising and states that its clinical effectiveness remains to be validated. It therefore does not establish that textile-based hydrogel therapy has become an effective means of skin care. (LLM, conf=0.88)
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Cited by
Sorted by citations
Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application
CHATTERJEE, S., & Chi-leung HUI, P. (2019) · Molecules · doi:10.3390/molecules24142547 · Cited by 201 · see citing works
“[43,44] developed PF127based thermo-responsive hydrogels to load water soluble traditional Chinese drug Cortex moutan, which has been reported to be effective against pathogenesis related to atopic dermatitis and the transdermal therapy using their system seems to be an effective means to fight against this disease us…”
BackgroundMethodInfluentialSelf-citationChatterjee, S., Hui, P. C.-L., & Kan, C.-W. (2018) · Polymers · doi:10.3390/polym10050480 · Cited by 196 · see citing works
Self-citationEnhanced Transdermal Permeability via Constructing the Porous Structure of Poloxamer-Based Hydrogel
Wang, W.-Y., Hui, P., Wat, E., Ng, F., Kan, C.-W., Lau, C., & Leung, P.-C. (2016) · Polymers · doi:10.3390/polym8110406 · Cited by 44 · see citing works
Self-citationFunctionalized Textile Based Therapy for the Treatment of Atopic Dermatitis
Wang, W., Hui, P., & Kan, C.-W. (2017) · Coatings · doi:10.3390/coatings7060082 · Cited by 22 · see citing works
Self-citation
- Authors
- Wang, W., Wat, E., Hui, P. C. L., Chan, B., Ng, F. S. F., Kan, C.-W., Wang, X., Hu, H., Wong, E. C. W., Lau, C. B. S., & Leung, P.-C.
- Affiliations
- Hong Kong Polytechnic University (HK)
- Chinese University of Hong Kong (HK)
- Corresponding author
- Kan, Chi-Wai
- ORCID
- Venue
- Scientific Reports
- Published
- 2016-04-19
- Volume
- 6
- Issue
- 1
- Pages
- 24112-24112
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4835724
- OpenAlex
- W2341085343
- Cited by
- 130
- References
- 57
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 14 · 2023: 14 · 2022: 19 · 2021: 19 · 2020: 16 · 2019: 10 · 2018: 8 · 2017: 4 · 2016: 4
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- PolyU Institutional Research Archive (Hong Kong Polytechnic University) (submittedVersion, cc-by)
- Funders
- Zhejiang Sci-Tech University
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- atopic dermatitis, transdermal drug delivery, thermosensitive hydrogel, Pluronic F127, carboxymethyl cellulose, composite hydrogels, skin hydration, controlled drug release, percutaneous absorption, cytotoxicity, rheological properties
- MeSH terms
- Administration, Cutaneous, Dermatitis, Atopic, Humans, Rheology, Skin, Temperature, Drug Delivery Systems, Hydrogel, Polyethylene Glycol Dimethacrylate, Poloxamer, Drug Liberation
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