Glycerol Monolaurate (GML) inhibits human T cell signaling and function by disrupting lipid dynamics

T Cell Activation

Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144 · see citing works

Membrane Compartmentation Is Required for Efficient T Cell Activation

Xavier, R. J., Brennan, T. V., Li, Q. S., McCormack, C., & Seed, B. (1998) · Immunity · doi:10.1016/s1074-7613(00)80577-4 · Cited by 907 · see citing works

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

Janes, P. W., Ley, S. C., & Magee, A. I. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.447 · Cited by 797 · see citing works

The Fluid—Mosaic Model of Membrane Structure: Still relevant to understanding the structure, function and dynamics of biological membranes after more than 40years

Nicolson, G. L. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.10.019 · Cited by 741 · see citing works

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76

Yokosuka, T., Sakata-Sogawa, K., Kobayashi, W., Hiroshima, M., Hashimoto, A. S., Tokunaga, M., Dustin, M. L., & Saito, T. (2005) · Nature Immunology · doi:10.1038/ni1272 · Cited by 702 · see citing works

Glycerol monolaurate prevents mucosal SIV transmission

Li, Q., Estes, J. D., Schlievert, P. M., Duan, L., Brosnahan, A. J., Southern, P. J., Reilly, C., Peterson, M. L., SCHULTZ‐DARKEN, N. J., Brunner, K. G., et al. (2009) · Nature · doi:10.1038/nature07831 · Cited by 638 · see citing works

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

Bunnell, S. C., Hong, D. I., Kardon, J. R., Yamazaki, T., McGlade, C. J., Barr, V. A., & Samelson, L. E. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200203043 · Cited by 633 · see citing works

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

Finco, T. S., Kadlecek, T. A., Zhang, W., Samelson, L. E., & Weiss, A. (1998) · Immunity · doi:10.1016/s1074-7613(00)80659-7 · Cited by 497 · see citing works

Inhibition of Protein Palmitoylation, Raft Localization, and T Cell Signaling by 2-Bromopalmitate and Polyunsaturated Fatty Acids

Webb, Y., Hermida-Matsumoto, L., & Resh, M. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.261 · Cited by 475 · see citing works

Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

Zhang, W., Trible, R. P., Zhu, M., Liu, S. K., McGlade, C. J., & Samelson, L. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000404200 · Cited by 407 · see citing works

Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

Sherman, E., Barr, V. A., Manley, S., Patterson, G. H., Balagopalan, L., Akpan, I. O., Regan, C. K., Merrill, R. K., Sommers, C. L., Lippincott‐Schwartz, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.10.004 · Cited by 311 · see citing works

A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation

Sommers, C. L., Park, C., Lee, J., Feng, C., Fuller, C. L., Grinberg, A., Hildebrand, J. A., Lacaná, E., Menon, R. K., Shores, E. W., et al. (2002) · Science · doi:10.1126/science.1069066 · Cited by 283 · see citing works

Characterization and Application of a New Optical Probe for Membrane Lipid Domains

Jin, L., Millard, A. C., Wuskell, J. P., Dong, X., Wu, D., Clark, H. A., & Loew, L. M. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.072884 · Cited by 234 · see citing works

Breast milk composition and infant nutrient intakes during the first 12 months of life

Grote, V., Verduci, E., Scaglioni, S., Vecchi, F., Contarini, G., Giovannini, M., Koletzko, B. V., Agostoni, C. V., & for the European Childhood Obesity Project (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.162 · Cited by 231 · see citing works

Fatty acid composition of mature human milk in Germany

Koletzko, B. V., Mrotzek, M., & Hj, B. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/47.6.954 · Cited by 222 · see citing works

Glycerol monolaurate antibacterial activity in broth and biofilm cultures.

Schlievert, P. M., & Peterson, M. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040350 · Cited by 198 · see citing works

Interaction of monolaurin, eugenol and sodium citrate on growth of common meat spoilage and pathogenic organisms

Blaszyk, M. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(97)00134-7 · Cited by 185 · see citing works

Glycerol monolaurate inhibits the production of beta-lactamase, toxic shock toxin-1, and other staphylococcal exoproteins by interfering with signal transduction

Projan, S. J., Brown-Skrobot, S., Schlievert, P. M., Vandenesch, F., & Novick, R. P. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.14.4204-4209.1994 · Cited by 151 · see citing works

Lipid raft domains and protein networks in T-cell receptor signal transduction

Harder, T. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.03.013 · Cited by 145 · see citing works

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters

Balagopalan, L., Kortum, R. L., Coussens, N. P., Barr, V. A., & Samelson, L. E. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.665869 · Cited by 136 · see citing works

Effect of glycerol monolaurate on bacterial growth and toxin production

Schlievert, P. M., Deringer, J. R., Kim, M. H., Projan, S. J., & Novick, R. P. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.3.626 · Cited by 127 · see citing works

Functional Implications of Plasma Membrane Condensation for T Cell Activation

Rentero, C., Zech, T., Quinn, C. M., Engelhardt, K. R., Williamson, D. J., Grewal, T., Jessup, W., Harder, T., & Gaus, K. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002262 · Cited by 115 · see citing works

Early Phosphorylation Kinetics of Proteins Involved in Proximal TCR-Mediated Signaling Pathways

Houtman, J. C. D., Houghtling, R. A., Barda‐Saad, M., Toda, Y., & Samelson, L. E. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2449 · Cited by 108 · see citing works

CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76

Hassan, N. J., Simmonds, S. J., Clarkson, N. G., Hanrahan, S. J., Puklavec, M. J., Bomb, M., Barclay, A. N., & Brown, M. H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00688-06 · Cited by 106 · see citing works

Comparison of T Cell Receptor-Induced Proximal Signaling and Downstream Functions in Immortalized and Primary T Cells

Bartelt, R. R., Cruz‐Orcutt, N., Collins, M., & Houtman, J. C. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005430 · Cited by 102 · see citing works

Exogenous Administration of Gangliosides Displaces GPI-anchored Proteins from Lipid Microdomains in Living Cells

Simons, M., Friedrichson, T., Schulz, J. B., Pitto, M., Masserini, M., & Kurzchalia, T. V. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.10.3187 · Cited by 93 · see citing works

Glycerol Monolaurate Inhibits the Effects of Gram-Positive Select Agents on Eukaryotic Cells

Peterson, M. L., & Schlievert, P. M. (2006) · Biochemistry · doi:10.1021/bi051992u · Cited by 91 · see citing works

High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells

Owen, D. M., Oddos, S., Kumar, S., Davis, D. M., Neil, M. A. A., French, P. M. W., Dustin, M. L., Magee, A. I., & Cebecauer, M. (2010) · Molecular Membrane Biology · doi:10.3109/09687688.2010.495353 · Cited by 83 · see citing works

Involvement of Lat, Gads, and Grb2 in Compartmentation of Slp-76 to the Plasma Membrane

Ishiai, M., Kurosaki, M., Inabe, K., Chan, A. C., Sugamura, K., & Kurosaki, T. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.6.847 · Cited by 78 · see citing works

Glycerol Monolaurate Inhibits Candida and Gardnerella vaginalis In Vitro and In Vivo but Not Lactobacillus

Strandberg, K. L., Peterson, M. L., Lin, Y., Pack, M. C., Chase, D. J., & Schlievert, P. M. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01151-09 · Cited by 69 · see citing works

Modulation of immune cell proliferation by glycerol monolaurate

Witcher, K. J., Novick, R. P., & Schlievert, P. M. (1996) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.3.1.10-13.1996 · Cited by 68 · see citing works

Mechanism of Tyrosine Phosphorylation and Activation of Phospholipase C-γ1

Sekiya, F., Poulin, B., Kim, Y. J., & Rhee, S. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405116200 · Cited by 67 · see citing works

The Role of the LAT–PLC-γ1 Interaction in T Regulatory Cell Function

Chuck, M. I., Zhu, M., Shen, S., & Zhang, W. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902876 · Cited by 60 · see citing works

Effect of antimicrobial factors in human milk on rhinoviruses and milk-borne cytomegalovirus in vitro

CLARKE, N. M., & MAY, J. T. (2000) · Journal of Medical Microbiology · doi:10.1099/0022-1317-49-8-719 · Cited by 59 · see citing works

Cutting Edge: Cell Surface Linker for Activation of T Cells Is Recruited to Microclusters and Is Active in Signaling

Balagopalan, L., Barr, V. A., Kortum, R. L., Park, A. K., & Samelson, L. E. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202760 · Cited by 52 · see citing works

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

Coussens, N. P., Hayashi, R., Brown, P. H., Balagopalan, L., Balbo, A., Akpan, I. O., Houtman, J. C. D., Barr, V. A., Schuck, P., Appella, E., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00410-13 · Cited by 49 · see citing works

The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from Its Guanine Nucleotide Exchange Activity in Vivo

Kortum, R. L., Balagopalan, L., Alexander, C. P., Garcia, J., Pinski, J. M., Merrill, R. K., Nguyen, P. H., Li, W., Agarwal, I., Akpan, I. O., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004494 · Cited by 47 · see citing works

Role of Two Adaptor Molecules SLP-76 and LAT in the PI3K Signaling Pathway in Activated T Cells

Shim, E. K., Jung, S. H., & Lee, J. R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001785 · Cited by 46 · see citing works

Glycerol Monolaurate Microbicide Protection against Repeat High-Dose SIV Vaginal Challenge

Haase, A. T., Rakasz, E. G., SCHULTZ‐DARKEN, N. J., Nephew, K. R., Weisgrau, K. L., Reilly, C., Li, Q., Southern, P. J., Rothenberger, M. K., Peterson, M. L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129465 · Cited by 38 · see citing works

Focal Adhesion Kinase Negatively Regulates Lck Function Downstream of the T Cell Antigen Receptor

Chapman, N. M., Connolly, S. F., Reinl, E. L., & Houtman, J. C. D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301587 · Cited by 37 · see citing works

Association of the Src homology 2 domain‐containing leukocyte phosphoprotein of 76 kD (SLP‐76) with the p85 subunit of phosphoinositide 3‐kinase

Shim, E. K., Moon, C., Lee, G. Y., Ha, Y. J., Chae, S., & Lee, J. R. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.090 · Cited by 35 · see citing works

Reduction inStaphylococcus aureusGrowth and Exotoxin Production and in Vaginal Interleukin 8 Levels Due to Glycerol Monolaurate in Tampons

Strandberg, K. L., Peterson, M. L., Schaefers, M. M., Case, L. C., Pack, M. C., Chase, D. J., & Schlievert, P. M. (2009) · Clinical Infectious Diseases · doi:10.1086/644614 · Cited by 34 · see citing works

Non-Aqueous Glycerol Monolaurate Gel Exhibits Antibacterial and Anti-Biofilm Activity against Gram-Positive and Gram-Negative Pathogens

Mueller, E. A., & Schlievert, P. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120280 · Cited by 33 · see citing works

Quantitative Phosphoproteome Analysis Unveils LAT as a Modulator of CD3ζ and ZAP-70 Tyrosine Phosphorylation

Salek, M., McGowan, S. J., Trudgian, D. C., Dushek, O., de Wet, B., Efstathiou, G., & Acuto, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077423 · Cited by 28 · see citing works

GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production

Bilal, M. Y., & Houtman, J. C. D. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00141 · Cited by 27 · see citing works

Lipid raft-based membrane order is important for antigen-specific clonal expansion of CD4+ T lymphocytes

Schieffer, D., Naware, S., Bakun, W., & Bamezai, A. K. (2014) · BMC Immunology · doi:10.1186/s12865-014-0058-8 · Cited by 27 · see citing works

Proline-rich tyrosine kinase 2 controls PI3-kinase activation downstream of the T cell antigen receptor in human T cells

Chapman, N. M., Yoder, A. N., ́n, K. M. B., Bilal, M. Y., Connolly, S. F., & Houtman, J. C. D. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.2a1013-568rrr · Cited by 18 · see citing works

GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells

Bilal, M. Y., Zhang, E. Y., Dinkel, B. A., Hardy, D., Yankee, T. M., & Houtman, J. C. D. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.01.012 · Cited by 18 · see citing works

Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes

Cruz‐Orcutt, N., Vacaflores, A., Connolly, S. F., Bunnell, S. C., & Houtman, J. C. D. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2013.12.022 · Cited by 17 · see citing works

Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario

Borrelli, L., Varriale, L., Dipineto, L., Pace, A., Menna, L. F., & Fioretti, A. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.620798 · Cited by 159 · see citing works

Medium-chain fatty acids and monoglycerides as feed additives for pig production: towards gut health improvement and feed pathogen mitigation.

Jackman, J. A., Boyd, R. D., & Elrod, C. C. (2020) · Journal of Animal Science and Biotechnology · doi:10.1186/s40104-020-00446-1 · Cited by 156 · see citing works

Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells

Upadhyay, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00819 · Cited by 143 · see citing works

Antimicrobial Emulsifier–Glycerol Monolaurate Induces Metabolic Syndrome, Gut Microbiota Dysbiosis, and Systemic Low‐Grade Inflammation in Low‐Fat Diet Fed Mice

Jiang, Z., Zhao, M., Zhang, H., Yang, L., Liu, M., & Feng, F. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700547 · Cited by 125 · see citing works

The dietary sweetener sucralose is a negative modulator of T cell-mediated responses

Zani, F., Blagih, J., Gruber, T., Buck, M. D., Jones, N., Hennequart, M., Newell, C. L., Pilley, S. E., Soro-Barrio, P., Kelly, G. P., et al. (2023) · Nature · doi:10.1038/s41586-023-05801-6 · Cited by 116 · see citing works

Modulation of the Gut Microbiota during High-Dose Glycerol Monolaurate-Mediated Amelioration of Obesity in Mice Fed a High-Fat Diet

Zhao, M., Jiang, Z., Cai, H., Li, Y., Mo, Q., Deng, L., Zhong, H., Liu, T., Zhang, H., Kang, J. X., et al. (2020) · mBio · doi:10.1128/mbio.00190-20 · Cited by 96 · see citing works

Glycerol Monolaurate Contributes to the Antimicrobial and Anti-inflammatory Activity of Human Milk

Schlievert, P. M., Kilgore, S. H., Seo, K. S., & Leung, D. Y. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-51130-y · Cited by 75 · see citing works

Food Emulsifiers and Metabolic Syndrome: The Role of the Gut Microbiota

Siena, M. D., Raoul, P. C., Costantini, L., Scarpellini, E., Cintoni, M., Gasbarrini, A., Rinninella, E., & Mele, M. C. (2022) · Foods · doi:10.3390/foods11152205 · Cited by 75 · see citing works

Glycerol Monolaurate Ameliorated Intestinal Barrier and Immunity in Broilers by Regulating Intestinal Inflammation, Antioxidant Balance, and Intestinal Microbiota

Kong, L., Wang, Z., Xiao, C., Zhu, Q., & Song, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.713485 · Cited by 71 · see citing works

Glycerol‐Monolaurate‐Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High‐Fat‐Diet‐Fed Mice

Zhao, M., Cai, H., Jiang, Z., Li, Y., Zhong, H., Zhang, H., & Feng, F. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801417 · Cited by 67 · see citing works

High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights into Its Antimicrobial Potential

Mo, Q., Fu, A., Deng, L., Zhao, M., Li, Y., Zhang, H., & Feng, F. (2019) · Nutrients · doi:10.3390/nu11091981 · Cited by 64 · see citing works

The lipid membrane of HIV-1 stabilizes the viral envelope glycoproteins and modulates their sensitivity to antibody neutralization

Salimi, H., Johnson, J., Flores, M. G., Zhang, M. S., O’Malley, Y., Houtman, J. C. D., Schlievert, P. M., & Haim, H. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009481 · Cited by 57 · see citing works

Integrating Serum Metabolome and Gut Microbiome to Evaluate the Benefits of Lauric Acid on Lipopolysaccharide- Challenged Broilers

Wu, Y., Li, Q., Liu, J., Liu, Y., Xu, Y., Zhang, R., Yu, Y., Wang, Y., & Yang, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.759323 · Cited by 56 · see citing works

Remodelling of primary human CD4+T cell plasma membrane order byn-3 PUFA

Fan, Y.-Y., Fuentes, N. R., Hou, T. Y., Barhoumi, R., Li, X. C., Deutz, N. E. P., ENGELEN, M. P. K. J., McMurray, D. N., & Chapkin, R. S. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517003385 · Cited by 51 · see citing works

Glycerol Monolaurate, an Analogue to a Factor Secreted by Lactobacillus , Is Virucidal against Enveloped Viruses, Including HIV-1

Welch, J. L., Xiang, J., Okeoma, C. M., Schlievert, P. M., & Stapleton, J. T. (2020) · mBio · doi:10.1128/mbio.00686-20 · Cited by 51 · see citing works

Novel Gut Microbiota Patterns Involved in the Attenuation of Dextran Sodium Sulfate-Induced Mouse Colitis Mediated by Glycerol Monolaurate via Inducing Anti-inflammatory Responses

Mo, Q., Liu, T., Fu, A., Ruan, S., Zhong, H., Tang, J., Zhao, M., Li, Y., Zhu, S., Cai, H., et al. (2021) · mBio · doi:10.1128/mbio.02148-21 · Cited by 49 · see citing works

Effects of α-glycerol monolaurate on intestinal morphology, nutrient digestibility, serum profiles, and gut microbiota in weaned piglets

Li, L., Wang, H., Zhang, N., Zhang, T., & Ma, Y. (2022) · Journal of Animal Science · doi:10.1093/jas/skac046 · Cited by 48 · see citing works

Food Additives Associated with Gut Microbiota Alterations in Inflammatory Bowel Disease: Friends or Enemies?

Liu, C., Zhan, S., Tian, Z., Li, N., Li, T., Wu, D., Zeng, Z., & Zhuang, X. (2022) · Nutrients · doi:10.3390/nu14153049 · Cited by 49 · see citing works

Phytonutrient and Nutraceutical Action against COVID-19: Current Review of Characteristics and Benefits

Pastor, N., Collado, M. C., & Manzoni, P. (2021) · Nutrients · doi:10.3390/nu13020464 · Cited by 39 · see citing works

Understanding protection from SARS-CoV-2 using metabolomics

Barberis, E., Amede, E., Tavecchia, M., Marengo, E., Cittone, M. G., Rizzi, E., Pedrinelli, A. R., Tonello, S., Minisini, R., Pirisi, M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-93260-2 · Cited by 39 · see citing works

Glycerol monolaurate beyond an emulsifier: Synthesis, in vivo fate, food quality benefits and health efficacies

Luo, X., Liu, W., Zhao, M., Huang, Y. S., & Feng, F. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.05.017 · Cited by 38 · see citing works

Effects of dietary glycerol monolaurate on the growth performance, digestive enzymes, body composition and non-specific immune response of white shrimp (Litopenaeus vannamei)

Wang, Y., Abdullah, Zhang, C., Li, Y., Zhang, H., Wang, J., & Feng, F. (2020) · Aquaculture Reports · doi:10.1016/j.aqrep.2020.100535 · Cited by 37 · see citing works

Effects of α-glyceryl monolaurate on growth, immune function, volatile fatty acids, and gut microbiota in broiler chickens

Lan, J., Chen, G., Cao, G., Tang, J., Li, Q., Zhang, B., & Yang, C. (2020) · Poultry Science · doi:10.1016/j.psj.2020.11.052 · Cited by 37 · see citing works

Bioactive monolaurin as an antimicrobial and its potential to improve the immune system and against COVID-19: a review

Subroto, E., & Indiarto, R. (2020) · Food Research · doi:10.26656/fr.2017.4(6).324 · Cited by 35 · see citing works

Lactobacillus plantarum helps to suppress body weight gain, improve serum lipid profile and ameliorate low-grade inflammation in mice administered with glycerol monolaurate

Li, Y., Liu, T., Zhang, X., Zhao, M., Zhang, H., & Feng, F. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.12.015 · Cited by 31 · see citing works

Glycerol monolaurate induces filopodia formation by disrupting the association between LAT and SLP-76 microclusters

Zhang, M. S., Tran, P. M., Wolff, A. J., Tremblay, M. M., Fosdick, M. G., & Houtman, J. C. D. (2018) · Science Signaling · doi:10.1126/scisignal.aam9095 · Cited by 29 · see citing works

Mechanistic Evaluation of Antimicrobial Lipid Interactions with Tethered Lipid Bilayers by Electrochemical Impedance Spectroscopy

Tan, S. W., Jeon, W., Yoon, B. K., & Jackman, J. A. (2022) · Sensors · doi:10.3390/s22103712 · Cited by 23 · see citing works

Effect of Membrane Curvature Nanoarchitectonics on Membrane-Disruptive Interactions of Antimicrobial Lipids and Surfactants

Moon, S., Yoon, B. K., & Jackman, J. A. (2022) · Langmuir · doi:10.1021/acs.langmuir.1c03384 · Cited by 21 · see citing works

Glycerol Monolaurate (GML) and a Nonaqueous Five-Percent GML Gel Kill <i>Bacillus</i> and <i>Clostridium</i> Spores

Schlievert, P. M., Kilgore, S. H., Kaus, G. M., Ho, T. D., & Ellermeier, C. D. (2018) · mSphere · doi:10.1128/mspheredirect.00597-18 · Cited by 21 · see citing works

Dietary glycerol monolaurate supplementation for the modification of functional properties of egg white protein

Zhao, M., Cai, H., Liu, M., Deng, L., Li, Y., Zhang, H., & Feng, F. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9607 · Cited by 19 · see citing works

Maternal supplementation with glycerol monolaurate improves the intestinal health of suckling piglets by inhibiting the NF-κB/MAPK pathways and improving oxidative stability

Zhao, H., Tian, M., Xiong, L., Lin, T., Zhang, S., Yue, X., Liu, X., Chen, F., Zhang, S., & Guan, W. (2023) · Food & Function · doi:10.1039/d3fo00068k · Cited by 19 · see citing works

Supplementation with alpha-glycerol monolaurate during late gestation and lactation enhances sow performance, ameliorates milk composition, and improves growth of suckling piglets

Li, L., Wang, H., Dong, S., & Ma, Y. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00848-x · Cited by 18 · see citing works

A comprehensive review of medium chain monoglycerides on metabolic pathways, nutritional and functional properties, nanotechnology formulations and applications in food system

Yang, M., Zhang, J., Yan, H., Pan, Y., Zhou, J., Zhong, H., Wang, J., Cai, H., Feng, F., & Zhao, M. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2353403 · Cited by 19 · see citing works

Modulating hydrophobic and antimicrobial gelatin-zein protein-based bilayer films by incorporating glycerol monolaurate and TiO2 nanoparticles

Easdani, M., Liu, F., van Impe, J. F. M., Ahammed, S., Chen, M., & Zhong, F. (2024) · Food Packaging and Shelf Life · doi:10.1016/j.fpsl.2024.101393 · Cited by 17 · see citing works

Glycerol monolaurate (GML), a medium-chain fatty acid derivative, ameliorate growth performance, immune function, disease resistance and intestinal microbiota in juvenile hybrid grouper (Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus♂)

Li, X., Ray, G. W., Kou, S., Liang, M., Yang, Q., Tan, B., & Chi, S. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.08.024 · Cited by 16 · see citing works

Effects of glycerol-esters of saturated short- and medium chain fatty acids on immune, health and growth variables in veal calves

Masmeijer, C., Rogge, T., van Leenen, K., Cremer, L. D., Deprez, P. R., Cox, E., Devriendt, B., & Pardon, B. (2020) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2020.104983 · Cited by 16 · see citing works

Human Serum Albumin (HSA) Suppresses the Effects of Glycerol Monolaurate (GML) on Human T Cell Activation and Function

Zhang, M. S., & Houtman, J. C. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165083 · Cited by 16 · see citing works

Preventative and therapeutic potential of animal milk components against COVID‐19: A comprehensive review

Singh, P., Rauda, R. H., & Peña‐Rodas, O. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3314 · Cited by 14 · see citing works

The roles of B cells in cardiovascular diseases

Ma, J., Wang, X., Jia, Y., Tan, F., Yuan, X., & Du, J. (2024) · Molecular Immunology · doi:10.1016/j.molimm.2024.05.002 · Cited by 14 · see citing works

Complete kinetic model for esterification reaction of lauric acid with glycerol to synthesize glycerol monolaurate

Hu, H.-Q., Zhang, Y., Fan, M., Cai, Y., Chu, G.-W., & Zhang, L. (2024) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2024.03.013 · Cited by 12 · see citing works

Supported lipid bilayer platform for characterizing the optimization of mixed monoglyceride nano-micelles

Yoon, B. K., Park, S.-H., Jackman, J. A., & Cho, N. (2020) · Applied Materials Today · doi:10.1016/j.apmt.2020.100598 · Cited by 12 · see citing works

Effects of dietary supplementation of glycerol monolaurate on laying performance, egg quality, antioxidant capacity, intestinal morphology and immune function in late-phase laying hens

Wang, Q., Li, B., Wen, Y., Liu, Q., Xia, Z., Liu, H., He, L., Zhang, X., Deng, Q., Miao, Z., et al. (2024) · Poultry Science · doi:10.1016/j.psj.2024.103644 · Cited by 11 · see citing works

Effects of oral of administration of monoglycide laurate on virus load and inflammation in PEDV infected porcine

Liu, Z., Zhu, L., Zhao, X., Liu, J., Cheng, H., Zhang, L., Tang, H., Sun, X., Hu, Y., & Xu, Z. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.980381 · Cited by 12 · see citing works

Effect of Dietary Inclusion of Alpha-Monolaurin on the Growth Performance, Lipid Peroxidation, and Immunity Response in Broilers

Saleh, A. A., El-Gharabawy, B., Hassan, A. M., Badawi, N. A., Eid, Y. Z., Selim, S., Shukry, M., & Dawood, M. A. O. (2021) · Sustainability · doi:10.3390/su13095231 · Cited by 12 · see citing works

Comparative Effects of Dietary Supplementations with Microencapsulated Sodium Butyrate, Glycerol Monolaurate and Tributyrin on Growth, Immunity, and Gut Health in Black Sea Bream

Ullah, S., Feng, F., Zhao, M., Zhang, J., & Shao, Q. (2025) · Animals · doi:10.3390/ani15060810 · Cited by 10 · see citing works

Suppression of human T cell activation by derivatives of glycerol monolaurate

Fosdick, M. G., Chheda, P. R., Tran, P. M., Wolff, A., Peralta, R. M., Zhang, M. Y., Kerns, R. J., & Houtman, J. C. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-88584-y · Cited by 10 · see citing works

Effects of a tributyrin and monolaurin blend compared to high ZnO levels on growth performance, faecal microbial counts, intestinal histomorphometry and immunohistochemistry in weaned piglets: A field study in two pig herds

Papadopoulos, G. Α., Poutahidis, T., Chalvatzi, S., Kroustallas, F. G., Karavanis, E., & Fortomaris, P. D. (2022) · Research in Veterinary Science · doi:10.1016/j.rvsc.2022.01.011 · Cited by 10 · see citing works

Glycerides of lauric acid supplementation in the chicken diet enhances the humoral and cellular immune response to infectious bronchitis virus

Mellouk, A., Michel, V., Lemâle, O., Goossens, T., & Consuegra, J. (2024) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2024.110802 · Cited by 9 · see citing works

Glycerol monolaurate inhibition of human B cell activation

Fosdick, M. G., Loftus, S. N., Phillips, I., Zacharias, Z. R., & Houtman, J. C. D. (2022) · Scientific Reports · doi:10.1038/s41598-022-17432-4 · Cited by 9 · see citing works

Glycerol monolaurate regulates apoptosis and inflammation by suppressing lipopolysaccharide-induced ROS production and NF-κB activation in avian macrophages

Kong, L.-L., Sun, P., Pan, X., Xiao, C., Song, B., & Song, Z.-G. (2024) · Poultry Science · doi:10.1016/j.psj.2024.103870 · Cited by 10 · see citing works

Effects of formic acid and glycerol monolaurate on weanling pig growth performance, fecal consistency, fecal microbiota, and serum immunity

Dahmer, P. L., Harrison, O. L., & Jones, C. K. (2022) · Translational Animal Science · doi:10.1093/tas/txac145 · Cited by 9 · see citing works

Effects of Monolaurin on Oral Microbe–Host Transcriptome and Metabolome

Silva, V. D. O., Pereira, L. J., Pasetto, S., da Silva, M. P., Meyers, J. C., & Murata, R. M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02638 · Cited by 9 · see citing works

Engineered lipid bicelle nanostructures for membrane-disruptive antibacterial applications

Sut, T. N., Valle‐González, E. R., Yoon, B. K., Park, S.-H., Jackman, J. A., & Cho, N. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2021.100947 · Cited by 9 · see citing works

Effect of Dietary Supplementation of Glycerol Monolaurate on Growth Performance, Digestive Enzymes, Serum Immune and Antioxidant Parameters, and Intestinal Morphology in Black Sea Bream

Ullah, S., Zhang, J., Feng, F., Shen, F., Qiufen, M., Wang, J., Rahman, T. U., Haleem, A., Zhao, M., & Shao, Q. (2024) · Animals · doi:10.3390/ani14202963 · Cited by 8 · see citing works

Mitigation Strategies for African Swine Fever Virus Biosecurity: From Virus Inactivation to Pig Health

Jackman, J. A., Yoon, B. K., & Elrod, C. C. (2025) · Transboundary and Emerging Diseases · doi:10.1155/tbed/7162567 · Cited by 8 · see citing works

Improved Synthesis of α-Glycerol Monolaurate Using Lipozyme TL IM

Nitbani, F. O., Angwarmasse, L. S., Bessy, E. Y., Wogo, H. E., Detha, A. I. R., & Tjitda, P. J. P. (2022) · Journal of Oleo Science · doi:10.5650/jos.ess21312 · Cited by 8 · see citing works

Inflammation, HIV, and Immune Quiescence: Leveraging on Immunomodulatory Products to Reduce HIV Susceptibility

Cromarty, R. T., & Archary, D. (2020) · AIDS Research and Treatment · doi:10.1155/2020/8672850 · Cited by 8 · see citing works

Effects of Glyceryl Monolaurate on Production Performance, Egg Quality, Oviduct Cytokines and Intestinal Microflora of 66 Weeks Old Laying Hens

Cui, Z., Zhang, R., Dai, B., Fu, C., Zhao, G., Xu, Y., & Yang, C. (2023) · Animals · doi:10.3390/ani13020215 · Cited by 8 · see citing works

Enzymatic esterification of lauric acid to give monolaurin in a microreactor

Miao, S., & Li, X. (2021) · Journal of Chemical Research · doi:10.1177/1747519820977164 · Cited by 8 · see citing works

Monolaurin inhibits antibiotic-resistant Staphylococcus aureus in patients with atopic dermatitis

Laowansiri, M., Suwanchote, S., Wannigama, D. L., Badavath, V. N., Hongsing, P., Edwards, S. W., Suratannon, N., Chatchatee, P., Lertpichitkul, P., Rerknimitr, P., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-05667-w · Cited by 8 · see citing works

Dynamic remodeling of giant unilamellar vesicles induced by monoglyceride nano-micelles: Insights into supramolecular organization

Yoon, B. K., Kim, M. C., Jackman, J. A., & Cho, N. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2021.101099 · Cited by 7 · see citing works

In Silico Characterization and Structural Modeling of Dermacentor andersoni p36 Immunosuppressive Protein

Oyugi, M. O., Kinyua, J. K., Magiri, E. N., Kigoni, M. W., Costa, E. P., & Githaka, N. (2018) · Advances in Bioinformatics · doi:10.1155/2018/7963401 · Cited by 6 · see citing works

Physicochemical properties and sensory acceptability of recombined butter substituted by fat rich in mono- and diacylglycerol from coconut stearin

Subroto, E., Sholihat, A. A., Cahyana, Y., Indiarto, R., Harlina, P. W., Andoyo, R., & Geng, F. (2024) · International Journal of Food Properties · doi:10.1080/10942912.2024.2330516 · Cited by 5 · see citing works

Glycerol Monolaurate Complex Improved Antioxidant, Anti-Inflammation, and Gut Microbiota Composition of Offspring in a Sow–Piglet Model

Li, D., Yang, M., Ma, Z., Che, L., Feng, B., Fang, Z., Xu, S., Zhuo, Y., Li, J., Wang, J., et al. (2025) · Veterinary Sciences · doi:10.3390/vetsci12010024 · Cited by 4 · see citing works

Applied Research Note: Alpha-monolaurin stimulates the antibody response elicited upon infectious bronchitis vaccination of broilers

Gussem, M. D., Dedeurwaerder, A., Christiaens, I., Damen, E. P. C. W., & Dansen, O. (2021) · The Journal of Applied Poultry Research · doi:10.1016/j.japr.2021.100153 · Cited by 4 · see citing works

Dietary supplementation of blend of organic acids and monoglycerides alleviated diarrhea and systemic inflammation of weaned pigs experimentally infected with enterotoxigenic Escherichia coli F18

Park, S., Sun, S., Wongchanla, S., Chen, Y., Li, X., & Liu, Y. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-024-01148-8 · Cited by 3 · see citing works

A novel LC-MS/MS method to characterize the antimicrobial lipid glycerol monolaurate in global human milk

Vennard, T. R., Meredith, N. A., Maria, S., Brink, L., Shah, N., Morrow, A. L., Simmons, R., Gray, M. A., & Phillips, S. C. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115817 · Cited by 3 · see citing works

Development of a water-dispersible antimicrobial lipid mixture to inhibit African swine fever virus and other enveloped viruses

Jackman, J. A., Izmailyan, R. A., Grigoryan, R., Sut, T. N., Taye, A., Zakaryan, H. S., & Elrod, C. C. (2024) · Virus Research · doi:10.1016/j.virusres.2024.199516 · Cited by 3 · see citing works

Glycerol monolaurate inhibits Francisella novicida growth and is produced intracellularly in an ISG15-dependent manner

Upton, E. M., Schlievert, P. M., Zhang, Y., Rauckhorst, A. J., Taylor, E. B., & Radoshevich, L. (2023) · PubMed Central · doi:10.17912/micropub.biology.000905 · Cited by 2 · see citing works

Effects of Dietary Glycerol Monolaurate on Growth Performance, Bile Acid Metabolism, and Intestinal Health in Asian Swamp Eel (Monopterus albus)

LIU, H. J., Yang, H., Guo, X., Lin, M. F., Zhao, M., Zhou, W., & Cai, H. (2026) · Animals · doi:10.3390/ani16111575 · Cited by 1 · see citing works

Gastrointestinal microbiome engineering in pig

Veerapagu, M., Jeya, K. R., & Narayanan, A. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22348-8.00016-7 · Cited by 1 · see citing works

Biophysical characterization of natural antimicrobials towards development of antibacterial skin therapies

Valle‐González, E. R. (2020) · doi:10.32657/10356/145963

Inflammation, HIV, and Immune Quiescence: Leveraging on Immunomodulatory Products to Reduce HIV Susceptibility

Archary, D., & Cromarty, R. T. (2022) · Advanced Biomedicine · doi:10.54730/abm.2022.040101

Effects of supplementing varying levels of 1,3-diacylglycerol (DAG) on growth performance, apparent nutrient digestibility and selected fecal microbial populations in growing pigs

Liu, W. C., Yun, K. S., & Kim, I. H. (2018) · The Thai Journal of Veterinary Medicine · doi:10.56808/2985-1130.2961

Feed Additives as Immune-Boosting Factors in Swine Health

Tassis, P. D. (2023) · Springer eBooks · doi:10.1007/978-3-031-42855-5_25

Immune modulation by human milk

Murray, E., & Järvinen, K. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-96018-2.00070-5

Concentration of α-Glycerol Monolaurate and Tributyrate Glyceryl and Their Ratio Affected Growth Performance, Gut Microbiota and Immune Function of Weaned PigletsPreprint

Dong, S., Zhang, N., Peng, S., Zhang, Y., Wang, J., Cao, Y., Dong, B., Johnston, L. J., Levesque, C. L., & Ma, Y. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4839393

Lauric Acid and Glycerol Monolaurate Inhibit the Activity of Cyprinid Herpesvirus 2 and Enhance Host Immune Reaction

Zhang, J., Qin, Y., Ma, M., Xu, T., Zhang, Y., Gui, L., Lu, L., & Xu, D. (2026) · Journal of Fish Diseases · doi:10.1111/jfd.70174

Rôle des polysaccharides fongiques et du microbiote intestinal dans la clairance digestive de Candida glabrata

Charlet, R. (2022) · doi:10.70675/11b08f90z8d0dz43efz96ffzf2527c076034

Effective Inhibition of Microbial Spoilage of Fresh Meat Using Highly Transparent Polyvinyl Acetate Coatings Containing Glycerol Monolaurate

Qi, J., Yang, Z., Zhi, X., Yuan, S., & Du, B. (2026) · Journal of Applied Polymer Science · doi:10.1002/app.70980

FAs and their metabolites as antibacterial agents: mechanisms, food applications, and translational opportunities

Baindara, P., Paul, D., Mondal, S. K., Dinata, R., Chakraborty, S., Kumari, S., & Mandal, S. M. (2026) · Food & Function · doi:10.1039/d6fo03064e

Glycerol Monolaurate (GML) inhibits human T cell signaling, metabolism, and function by disrupting lipid dynamics

Zhang, M. S., Sandouk, A., & Houtman, J. C. D. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.196.supp.57.4

Characterizing how glycerol monolaurate (GML) affects human T cell signaling and function

Zhang, M. S., Colgan, J. D., Perlman, S. M., Schlievert, P. M., Houtman, J. C. D., & Bishop, G. A. (2018) · doi:10.17077/etd.mzucnvs8 · Cited by 5 · see citing works

Suppression of human T cell activation by derivatives of glycerol monolaurate

Fosdick, M. G., Chheda, P. R., Tran, P. M., Wolff, A., Peralta, R. M., Zhang, M. Y., Kerns, R. J., & Houtman, J. C. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-88584-y · Cited by 10 · see citing works

Glycerol monolaurate induces filopodia formation by disrupting the association between LAT and SLP-76 microclusters

Zhang, M. S., Tran, P. M., Wolff, A. J., Tremblay, M. M., Fosdick, M. G., & Houtman, J. C. D. (2018) · Science Signaling · doi:10.1126/scisignal.aam9095 · Cited by 29 · see citing works

Defining mechanisms of lymphocyte inhibition by Glycerol Monolaurate

Fosdick, M. G. (2022) · Iowa Research Online (The University of Iowa) · doi:10.25820/etd.006629