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Glymphatic solute transport does not require bulk flow

Asgari, Mahdi, de Zélicourt, Diane, Kurtcuoglu, Vartan·2016·Scientific Reports
DOI 10.1038/srep38635PMC PMC5144134
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Abstract

Observations of fast transport of fluorescent tracers in mouse brains have led to the hypothesis of bulk water flow directed from arterial to venous paravascular spaces (PVS) through the cortical interstitium. At the same time, there is evidence for interstitial solute transport by diffusion rather than by directed bulk fluid motion. It has been shown that the two views may be consolidated by intracellular water flow through astrocyte networks combined with mainly diffusive extracellular transport of solutes. This requires the presence of a driving force that has not been determined to date, but for which arterial pulsation has been suggested as the origin. Here we show that arterial pulsation caused by pulse wave propagation is an unlikely origin of this hypothetical driving force. However, we further show that such pulsation may still lead to fast para-arterial solute transport through dispersion, that is, through the combined effect of local mixing and diffusion in the para-arterial space.

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  • The macroscopic changes in CSF flow identified are expected to alter waste clearance, as pulsatile fluid dynamics can increase mixing and diffusion.

    “The macroscopic changes in CSF flow we identified are expected to alter waste clearance, as pulsatile fluid dynamics can increase mixing and diffusion (20, 21, 36).”

    From Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep (2019) · cites this paper as [36]

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Research works printed but not linked: 33

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Authors
Asgari, M., de Zélicourt, D., & Kurtcuoglu, V.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2016-12-08
Volume
6
Issue
1
ISSN
2045-2322
DOI
10.1038/srep38635
PMC
PMC5144134
Cited by
276
References
6
Language
en
Licence

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