Meditation and vacation effects have an impact on disease-associated molecular phenotypes
Open accessAbstract
Meditation is becoming increasingly practiced, especially for stress-related medical conditions. Meditation may improve cellular health; however, studies have not separated out effects of meditation from vacation-like effects in a residential randomized controlled trial. We recruited healthy women non-meditators to live at a resort for 6 days and randomized to either meditation retreat or relaxing on-site, with both groups compared with ‘regular meditators’ already enrolled in the retreat. Blood drawn at baseline and post intervention was assessed for transcriptome-wide expression patterns and aging-related biomarkers. Highly significant gene expression changes were detected across all groups (the ‘vacation effect’) that could accurately predict (96% accuracy) between baseline and post-intervention states and were characterized by improved regulation of stress response, immune function and amyloid beta (Aβ) metabolism. Although a smaller set of genes was affected, regular meditators showed post-intervention differences in a gene network characterized by lower regulation of protein synthesis and viral genome activity. Changes in well-being were assessed post intervention relative to baseline, as well as 1 and 10 months later. All groups showed equivalently large immediate post-intervention improvements in well-being, but novice meditators showed greater maintenance of lower distress over time compared with those in the vacation arm. Regular meditators showed a trend toward increased telomerase activity compared with randomized women, who showed increased plasma Aβ42/Aβ40 ratios and tumor necrosis factor alpha (TNF-α) levels. This highly controlled residential study showed large salutary changes in gene expression networks due to the vacation effect, common to all groups. For those already trained in the practice of meditation, a retreat appears to provide additional benefits to cellular health beyond the vacation effect.
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Meditation can impact the expression of multiple telomere-related genes, especially producing more positive effects on telomere regulation in meditation training.
“In addition, meditation can also impact the expression of multiple telomere-related genes,36 especially producing more positive effects on telomere regulation in meditation training.37”
From Biological mechanism study of meditation and its application in mental disorders (2020) · cites this paper as [36]
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- Authors
- Epel, E. S., Puterman, E., Lin, J., Blackburn, E. H., Lum, P. Y., Beckmann, N. D., Zhu, J., Lee, E., Gilbert, A., Rissman, R. A., Tanzi, R. E., & Schadt, E. E.
- Affiliations
- University of California, San Francisco (US)
- Palo Alto Medical Foundation (US)
- Icahn School of Medicine at Mount Sinai (US)
- University of California San Diego (US)
- Harvard University (US)
- Corresponding author
- Schadt, E E
- ORCID
- Venue
- Translational Psychiatry
- Published
- 2016-08-30
- Volume
- 6
- Issue
- 8
- Pages
- e880-e880
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC5022094
- OpenAlex
- W2510294025
- Cited by
- 105
- References
- 49
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 7 · 2023: 15 · 2022: 11 · 2021: 4 · 2020: 14 · 2019: 10 · 2018: 14 · 2017: 12 · 2015: 1
- FWCI
- 16.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Translational Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (1s10od018522-01)
- University of California, San Diego
- University of California, San Francisco
- National Human Genome Research Institute (U01HG008451)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Physiology › Biofield Effects and Biophysics
- Social Sciences › Health › Religion, Spirituality, and Psychology
- Keywords
- meditation, meditation retreats, gene expression, transcriptome, stress response, immune function, amyloid-beta metabolism, aging biomarkers, telomerase activity, TNF-α, well-being, protein synthesis
- MeSH terms
- Adult, Aging, Female, Holidays, Humans, Immunity, Mental Health, Middle Aged, Peptide Fragments, Phenotype, Stress, Physiological, Stress, Psychological, Tumor Necrosis Factor-alpha, Amyloid beta-Peptides, Meditation, Gene Expression Profiling, Gene Regulatory Networks
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