Insight meditation and telomere biology: The effects of intensive retreat and the moderating role of personality
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Abstract
A growing body of evidence suggests that meditation training may have a range of salubrious effects, including improved telomere regulation. Telomeres and the enzyme telomerase interact with a variety of molecular components to regulate cell-cycle signaling cascades, and are implicated in pathways linking psychological stress to disease. We investigated the effects of intensive meditation practice on these biomarkers by measuring changes in telomere length (TL), telomerase activity (TA), and telomere-related gene (TRG) expression during a 1-month residential Insight meditation retreat. Multilevel analyses revealed an apparent TL increase in the retreat group, compared to a group of experienced meditators, similarly comprised in age and gender, who were not on retreat. Moreover, personality traits predicted changes in TL, such that retreat participants highest in neuroticism and lowest in agreeableness demonstrated the greatest increases in TL. Changes observed in TRGs further suggest retreat-related improvements in telomere maintenance, including increases in Gar1 and HnRNPA1, which encode proteins that bind telomerase RNA and telomeric DNA. Although no group-level changes were observed in TA, retreat participants' TA levels at post-assessment were inversely related to several indices of retreat engagement and prior meditation experience. Neuroticism also predicted variation in TA across retreat. These findings suggest that meditation training in a retreat setting may have positive effects on telomere regulation, which are moderated by individual differences in personality and meditation experience. (ClinicalTrials.gov #NCT03056105).
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Meditation can impact the expression of multiple telomere-related genes, especially producing more positive effects on telomere regulation in meditation training.
“In addition, meditation can also impact the expression of multiple telomere-related genes,36 especially producing more positive effects on telomere regulation in meditation training.37”
From Biological mechanism study of meditation and its application in mental disorders (2020) · cites this paper as [37]
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
(1970) · Cited by 24,983 · see citing works
(1999) · Cited by 7,995 · see citing works
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
The structure of phenotypic personality traits.
Goldberg, L. R. (1993) · American Psychologist · doi:10.1037//0003-066x.48.1.26 · Cited by 4,816 · see citing works
The structure of phenotypic personality traits.
Goldberg, L. R. (1993) · American Psychologist · doi:10.1037/0003-066x.48.1.26 · Cited by 4,816 · see citing works
Personality trait structure as a human universal.
McCrae, R. R., & Costa, P. T. (1997) · American Psychologist · doi:10.1037/0003-066x.52.5.509 · Cited by 4,234 · see citing works
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596 · see citing works
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,492 · see citing works
Adaptive linear step-up procedures that control the false discovery rate
Benjamini, Y., Krieger, A. M., & Yekutieli, D. (2006) · Biometrika · doi:10.1093/biomet/93.3.491 · Cited by 3,228 · see citing works
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002 · see citing works
Self-citationCarver, C. S., & Connor-Smith, J. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100352 · Cited by 2,424 · see citing works
Meditation Programs for Psychological Stress and Well-being: A Systematic Review and Meta-analysis
Goyal, M., Singh, S., Sibinga, E. M. S., Gould, N. F., Rowland-Seymour, A., Sharma, R., Berger, Z., Sleicher, D., Maron, D. D., Shihab, H. M., et al. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.13018 · Cited by 2,380 · see citing works
Identifying differentially expressed genes using false discovery rate controlling procedures
Reiner, A., Yekutieli, D., & Benjamini, Y. (2003) · Bioinformatics · doi:10.1093/bioinformatics/btf877 · Cited by 1,765 · see citing works
Mindfulness-based stress reduction for healthy individuals: A meta-analysis
Khoury, B., Sharma, M., Rush, S. E., & Fournier, C. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.03.009 · Cited by 1,617 · cited 1× · see citing works
“Moreover, a recent review of meditation retreats suggests that there may be added benefits to practicing in the retreat format (Khoury et al., 2015).”
BackgroundThe Health-Promoting Lifestyle Profile: development and psychometric characteristics.
Walker, S. N., Sechrist, K. R., & Pender, N. J. (1987) · PubMed · Cited by 1,602 · see citing works
Blackburn, E. H., Epel, E. S., & Lin, J. (2015) · Science · doi:10.1126/science.aab3389 · Cited by 1,596 · see citing works
Self-citationTelomere length measurement by a novel monochrome multiplex quantitative PCR method
Cawthon, R. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn1027 · Cited by 1,414 · see citing works
Telomere states and cell fates
Blackburn, E. H. (2000) · Nature · doi:10.1038/35040500 · Cited by 1,372 · see citing works
Identification of seven loci affecting mean telomere length and their association with disease
CARDIoGRAM consortium, Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., Hottenga, J. J., Fischer, K., Esko, T., et al. (2013) · Nature Genetics · doi:10.1038/ng.2528 · Cited by 933 · see citing works
Telomeres and telomerase: Their mechanisms of action and the effects of altering their functions
Blackburn, E. H. (2005) · FEBS Letters · doi:10.1016/j.febslet.2004.11.036 · Cited by 838 · see citing works
Reconstructing and deconstructing the self: cognitive mechanisms in meditation practice
Dahl, C. J., Lutz, A., & Davidson, R. J. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.07.001 · Cited by 809 · see citing works
Pace, T. W. W., Negi, L. T., Adame, D. D., Cole, S. P., Sivilli, T. I., Brown, T. D., Issa, M. J., & Raison, C. L. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.011 · Cited by 748 · see citing works
Lutz, A., Jha, A. P., Dunne, J. D., & Saron, C. D. (2015) · American Psychologist · doi:10.1037/a0039585 · Cited by 697 · cited 2× · see citing works
“From this perspective, Insight retreats can be conceived of as comprehensive well-being interventions that pair periods of formal meditation practice (e.g., sitting or walking) with a contemplative way of life or ‘‘stance toward experience” (Lutz et al., 2015).”
BackgroundSelf-citationMental balance and well-being: building bridges between Buddhism and Western psychology
Wallace, B. A., & Shapiro, S. L. (2006) · American Psychologist · doi:10.1037/0003-066x.61.7.690 · Cited by 605 · see citing works
Dhabhar, F. S., Malarkey, W. B., Neri, E., & McEwen, B. S. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.008 · Cited by 589 · cited 1× · see citing works
“Lymphocyte redistribution, which can occur temporarily in response to acute stress (Dhabhar, 2011; Dhabhar et al., 2012; Rosenberger et al., 2009) may lead to ‘‘pseu do-lengthening,” whereby average TL measurements increase due to an increase in cell types having longer telomeres (Epel, 2012).”
BackgroundThe Handbook of Stress Science: Biology, Psychology, and Health
Contrada, R. J., & Baum, A. E. (2010) · Cited by 527 · see citing works
A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
Venteicher, A. S., Abreu, E. B., Meng, Z., McCann, K. E., Terns, R. M., Veenstra, T. D., Terns, M. P., & Artandi, S. E. (2009) · Science · doi:10.1126/science.1165357 · Cited by 522 · see citing works
Gender and telomere length: Systematic review and meta-analysis
Gardner, M. P., Bann, D., Wiley, L., Cooper, R., Hardy, R., Nitsch, D., Martin-Ruiz, C. M., Shiels, P. G., Sayer, A. A., Barbieri, M., et al. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.12.004 · Cited by 513 · see citing works
Lei, M., Podell, E., & Cech, T. (2004) · Nature Structural &Molecular Biology · doi:10.1038/nsmb867 · Cited by 503 · see citing works
A systematic review of leukocyte telomere length and age in adults
Müezzinler, A., Zaineddin, A. K., & Brenner, H. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.003 · Cited by 474 · see citing works
Intensive meditation training, immune cell telomerase activity, and psychological mediators
Jacobs, T. L., Epel, E. S., Lin, J., Blackburn, E. H., Wolkowitz, O. M., Bridwell, D. A., Zanesco, A. P., Aichele, S. R., Sahdra, B. K., MacLean, K. A., et al. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.010 · Cited by 432 · cited 5× · see citing works
“Unfortunately, because TA was only measured at the end of retreat, this study was unable to rule out pre-existing group differences or to determine if TA increased over the course of the intervention (Jacobs et al., 2011).”
BackgroundResultInfluentialSelf-citationIncreased telomerase activity and comprehensive lifestyle changes: a pilot study
Ornish, D., Lin, J., Daubenmier, J., Weidner, G., Epel, E., Kemp, C., Magbanua, M. J. M., Marlin, R., Yglecias, L., Carroll, P. R., et al. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70234-1 · Cited by 430 · see citing works
Self-citationLin, J., Epel, E., Cheon, J., Kroenke, C., Sinclair, E., Bigos, M., Wolkowitz, O., Mellon, S., & Blackburn, E. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.09.012 · Cited by 426 · see citing works
Self-citationWolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421 · see citing works
Self-citationStress and telomere biology: a lifespan perspective
Shalev, I., Entringer, S., Wadhwa, P. D., Wolkowitz, O. M., Puterman, E., Lin, J., & Epel, E. S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.010 · Cited by 400 · see citing works
Self-citationOrnish, D., Lin, J., Chan, J. M., Epel, E., Kemp, C., Weidner, G., Marlin, R., Frenda, S. J., Magbanua, M. J. M., Daubenmier, J., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70366-8 · Cited by 390 · see citing works
Self-citationThe TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity
Nandakumar, J., Bell, C., Weidenfeld, I., Zaug, A. J., Leinwand, L. A., & Cech, T. R. (2012) · Nature · doi:10.1038/nature11648 · Cited by 351 · see citing works
Rosenkranz, M. A., Davidson, R. J., MacCoon, D. G., Sheridan, J. F., Kalin, N. H., & Lutz, A. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.013 · Cited by 307 · see citing works
Bhasin, M. K., Dusek, J. A., Chang, B.-H., Joseph, M. G., Denninger, J. W., Fricchione, G. L., Benson, H., & Libermann, T. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062817 · Cited by 304 · see citing works
Lavretsky, H., Epel, E. S., Siddarth, P., Nazarian, N., Cyr, N. S., Khalsa, D. S., Lin, J., Blackburn, E., & Irwin, M. R. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3790 · Cited by 298 · see citing works
Self-citationBuddhist and psychological perspectives on emotions and well-being
Ekman, P., Davidson, R. J., Ricard, M., & Alan Wallace, B. (2005) · Current Directions in Psychological Science · doi:10.1111/j.0963-7214.2005.00335.x · Cited by 295 · see citing works
Clynes, D., Jelinska, C., Xella, B., Ayyub, H., Scott, C., Mitson, M., Taylor, S., Higgs, D. R., & Gibbons, R. J. (2015) · Nature Communications · doi:10.1038/ncomms8538 · Cited by 293 · see citing works
Mental Training as a Tool in the Neuroscientific Study of Brain and Cognitive Plasticity
Slagter, H. A., Davidson, R. J., & Lutz, A. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00017 · Cited by 288 · see citing works
Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita
Zhong, F., Savage, S. A., Shkreli, M., Giri, N., Jessop, L., Myers, T., Chen, R., Alter, B. P., & Artandi, S. E. (2011) · Genes & Development · doi:10.1101/gad.2006411 · Cited by 262 · see citing works
Creswell, J. D., Myers, H. F., Cole, S. W., & Irwin, M. R. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.07.004 · Cited by 238 · see citing works
Dynamics of telomerase activity in response to acute psychological stress
Epel, E. S., Lin, J., Dhabhar, F. S., Wolkowitz, O. M., Puterman, E. M., Karan, L. D., & Blackburn, E. H. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.11.018 · Cited by 218 · see citing works
Self-citationSeeking the Heart of Wisdom: The Path of Insight Meditation
Goldstein, J., Kornfield, J., & Bstan-ʾdzin-rgya-mtsho, D. L. X. (1987) · Medical Entomology and Zoology · Cited by 217 · see citing works
Telomerase Mechanism of Telomere Synthesis
Wu, R. A., Upton, H. E., Vogan, J. M., & Collins, K. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-045019 · Cited by 208 · see citing works
Does cellular aging relate to patterns of allostasis?
Tomiyama, A. J., O’Donovan, A., Lin, J., Puterman, E. M., Lazaro, A., Chan, J. L., Dhabhar, F. S., Wolkowitz, O. M., Kirschbaum, C., Blackburn, E. H., et al. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.11.016 · Cited by 206 · see citing works
Self-citationSudsuang, R., Chentanez, V., & Veluvan, K. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90543-w · Cited by 198 · see citing works
Sahdra, B. K., MacLean, K. A., Ferrer, E., Shaver, P. R., Rosenberg, E. L., Jacobs, T. L., Zanesco, A. P., King, B. G., Aichele, S. R., Bridwell, D. A., et al. (2011) · Emotion · doi:10.1037/a0022764 · Cited by 197 · see citing works
Self-citationDNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
Lei, M., Podell, E. R., Baumann, P., & Cech, T. R. (2003) · Nature · doi:10.1038/nature02092 · Cited by 195 · see citing works
Carlson, L. E., Beattie, T. L., Giese‐Davis, J., Faris, P., Tamagawa, R., Fick, L. J., Degelman, E. S., & Speca, M. (2015) · Cancer · doi:10.1002/cncr.29063 · Cited by 194 · see citing works
ATRX represses alternative lengthening of telomeres
Napier, C. E., Huschtscha, L. I., Harvey, A., Bower, K., Noble, J. R., Hendrickson, E. A., & Reddel, R. R. (2015) · Oncotarget · doi:10.18632/oncotarget.3846 · Cited by 182 · see citing works
Body mass index and leukocyte telomere length in adults: a systematic review and meta‐analysis
Müezzinler, A., Zaineddin, A. K., & Brenner, H. (2013) · Obesity Reviews · doi:10.1111/obr.12126 · Cited by 179 · see citing works
Zalli, A., de Carvalho, L. A., Lin, J., Hamer, M., Erusalimsky, J. D., Blackburn, E. H., & Steptoe, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322145111 · Cited by 177 · see citing works
Self-citationDoes Quick to Blame Mean Quick to Anger? The Role of Agreeableness in Dissociating Blame and Anger
Meier, B. P., & Robinson, M. D. (2004) · Personality and Social Psychology Bulletin · doi:10.1177/0146167204264764 · Cited by 170 · see citing works
Lengacher, C. A., Reich, R. R., Kip, K. E., Barta, M., Ramesar, S., Paterson, C. L., Moscoso, M. S., Carranza, I., Budhrani, P. H., Kim, S. J., et al. (2014) · Biological Research For Nursing · doi:10.1177/1099800413519495 · Cited by 169 · see citing works
Tolahunase, M., Sagar, R., & Dada, R. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7928981 · Cited by 164 · see citing works
Five-factor model personality traits and inflammatory markers: New data and a meta-analysis
Luchetti, M., Barkley, J. M., Stephan, Y., Terracciano, A., & Sutin, A. R. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.08.014 · Cited by 162 · see citing works
Daubenmier, J., Lin, J., Blackburn, E., Hecht, F. M., Kristeller, J., Maninger, N., Kuwata, M., Bacchetti, P., Havel, P. J., & Epel, E. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.10.008 · Cited by 157 · see citing works
Self-citationProteostatic Control of Telomerase Function through TRiC-Mediated Folding of TCAB1
Freund, A., Zhong, F. L., Venteicher, A. S., Meng, Z., Veenstra, T. D., Frydman, J., & Artandi, S. E. (2014) · Cell · doi:10.1016/j.cell.2014.10.059 · Cited by 151 · see citing works
ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres
Tong, A. S., Stern, J. L., Sfeir, A. J., Kartawinata, M., de Lange, T., Zhu, X., & Bryan, T. M. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.041 · Cited by 136 · see citing works
A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation
Ford, L. P., Wright, W. E., & Shay, J. W. (2002) · Oncogene · doi:10.1038/sj.onc.1205086 · Cited by 136 · see citing works
The Role of Double-Strand Break Repair Pathways at Functional and Dysfunctional TelomeresPreprint
Doksani, Y., & de Lange, T. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016576 · Cited by 134 · see citing works
The telomere lengthening conundrum—artifact or biology?
Steenstrup, T., Hjelmborg, J., Kark, J. D., Christensen, K., & Aviv, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt370 · Cited by 122 · see citing works
Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes
Lin, J., Cheon, J., Brown, R. R., Coccia, M., Puterman, E. M., Aschbacher, K., Sinclair, E., Epel, E. S., & Blackburn, E. H. (2016) · Journal of Immunology Research · doi:10.1155/2016/5371050 · Cited by 118 · see citing works
Self-citationLoving-kindness meditation practice associated with longer telomeres in women
Hoge, E. A., Chen, M. M., Orr, E., Metcalf, C. A., Fischer, L. E., Pollack, M. H., DeVivo, I., & Simon, N. M. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.04.005 · Cited by 116 · see citing works
Puterman, E., & Epel, E. (2012) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2012.00465.x · Cited by 106 · see citing works
Self-citationHuman UPF1 interacts with TPP1 and telomerase and sustains telomere leading‐strand replication
Chawla, R., Redon, S., Raftopoulou, C., Wischnewski, H., Gagos, S., & Azzalin, C. M. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.280 · Cited by 105 · see citing works
Meditation and vacation effects have an impact on disease-associated molecular phenotypes
Epel, E. S., Puterman, E., Lin, J., Blackburn, E. H., Lum, P. Y., Beckmann, N. D., Zhu, J., Lee, E., Gilbert, A., Rissman, R. A., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.164 · Cited by 105 · see citing works
Self-citationHow “reversible” is telomeric aging?
Epel, E. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0370 · Cited by 103 · see citing works
Telomeres in a Life-Span Perspective
Epel, E. S. (2009) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2009.01596.x · Cited by 96 · see citing works
Self-citationCTC1-mediated C-strand fill-in is an essential step in telomere length maintenance
Feng, X., Hsu, S.-J., Kasbek, C., Fedor‐Chaiken, M., & Price, C. M. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx125 · Cited by 93 · see citing works
Zen meditation, Length of Telomeres, and the Role of Experiential Avoidance and Compassion
Alda, M., Puebla‐Guedea, M., Rodero, B., Demarzo, M., Montero‐Marín, J., Roca, M., & García‐Campayo, J. (2016) · Mindfulness · doi:10.1007/s12671-016-0500-5 · Cited by 90 · see citing works
Hoen, P. W., Rosmalen, J. G. M., Schoevers, R. A., Huzen, J., van der Harst, P., & de Jonge, P. (2013) · Psychological Medicine · doi:10.1017/s0033291712001766 · Cited by 88 · see citing works
Exploring the Causal Pathway From Telomere Length to Coronary Heart Disease
Zhan, Y., Karlsson, I., Karlsson, R., Tillander, A., Reynolds, C. A., Pedersen, N. L., & Hägg, S. (2017) · Circulation Research · doi:10.1161/circresaha.116.310517 · Cited by 84 · see citing works
Personality and physical health
Murray, A. L., & Booth, T. (2015) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2015.03.011 · Cited by 80 · see citing works
Telomere Length Regulation and Telomeric Chromatin Require the Nonsense-Mediated mRNA Decay Pathway
Lew-Smith, J., Enomoto, S., & Berman, J. G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.6121 · Cited by 80 · see citing works
Rosenberger, P. H., Ickovics, J. R., Epel, E. S., Nadler, E., Jokl, P., Fulkerson, J. P., Tillie, J. M., & Dhabhar, F. S. (2009) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.h.00989 · Cited by 76 · see citing works
Self-citationSeyedAlinaghi, S., Jam, S., Foroughi, M., Imani, A., Mohraz, M., Djavid, G. E., & Black, D. S. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31825abfaa · Cited by 76 · see citing works
Duraimani, S., Schneider, R. H., Randall, O. S., Nidich, S. I., Xu, S., Ketete, M., Rainforth, M. A., Gaylord‐King, C., Salerno, J. W., & Fagan, J. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142689 · Cited by 65 · see citing works
Baseline biopsychosocial determinants of telomere length and 6-year attrition rate
Révész, D., Milaneschi, Y., Terpstra, E. M., & Penninx, B. W. J. H. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.02.007 · Cited by 63 · see citing works
The relationship between positive psychological characteristics and longer telomeres
Schutte, N. S., Palanisamy, S. K. A., & McFarlane, J. R. (2016) · Psychology and Health · doi:10.1080/08870446.2016.1226308 · Cited by 49 · see citing works
Telomere-Regulating Genes and the Telomere Interactome in Familial Cancers
Robles‐Espinoza, C. D., Velasco‐Herrera, M. D. C., Hayward, N. K., & Adams, D. J. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0305 · Cited by 40 · see citing works
Turan, B., Foltz, C., Cavanagh, J. F., Wallace, B. A., Cullen, M., Rosenberg, E. L., Jennings, P. A., Ekman, P., & Kemeny, M. E. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.11.014 · Cited by 39 · see citing works
The Experience of Insight: A Simple and Direct Guide to Buddhist Meditation
Goldstein, J. (1983) · Medical Entomology and Zoology · Cited by 36 · see citing works
Personality, blood type, and the five-factor model
Cramer, K. M., & Imaike, E. (2002) · Personality and Individual Differences · doi:10.1016/s0191-8869(01)00064-2 · Cited by 34 · see citing works
Kalfalah, F. M., Seggewiß, S., Walter, R., Tigges, J., Moreno‐Villanueva, M., Bürkle, A., Ohse, S., Busch, H. S., Boerries, M., Hildebrandt, B., et al. (2015) · Aging · doi:10.18632/aging.100723 · Cited by 33 · see citing works
Platt, L. M., Whitburn, A. I., Platt-Koch, A. G., & Koch, R. L. (2016) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20160725-07 · Cited by 33 · cited 1× · see citing works
“…interventions incorporating Buddhistderived meditation practices in both retreat and non-retreat contexts may reduce anxiety (Goyal et al., 2014; Platt et al., 2016; Sahdra et al., 2011) and depression (Epel et al., 2016) and influence psychological and physiological processes implicated in…”
Backgroundvan Ockenburg, S. L., de Jonge, P., van der Harst, P., Ormel, J., & Rosmalen, J. G. M. (2013) · Psychological Medicine · doi:10.1017/s0033291713001657 · Cited by 27 · see citing works
Telomerase enzymatic component hTERT shortens long telomeres in human cells
Zheng, Y., Zhang, F., Sun, B., Du, J., Sun, C., Yuan, J., Wang, Y., Tao, L., Kota, K. K., Liu, X., et al. (2014) · Cell Cycle · doi:10.4161/cc.28705 · Cited by 27 · see citing works
Defective Artemis causes mild telomere dysfunction
Yasaei, H., & Slijepčević, P. (2010) · Genome Integrity · doi:10.1186/2041-9414-1-3 · Cited by 22 · see citing works
Effects of stress on immune function: Implications for immunoprotection and immunopathology.
Dhabhar, F. S. (2011) · Cited by 21 · see citing works
Principles and neurobiological correlates of concentrative, diffuse, and insight meditation.
Mehrmann, C., & Karmacharya, R. (2013) · PubMed · doi:10.1097/hrp.0b013e31828e8ef4 · Cited by 19 · see citing works
Savolainen, K., Eriksson, J. G., Kajantie, E., Pesonen, A., & Räikkönen, K. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.04.011 · Cited by 14 · see citing works
Edmonds, G. W., Côté, H. C. F., & Hampson, S. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134077 · Cited by 13 · see citing works
Rao, K. S., Chakraharti, S. K., Dongare, V. S., Chetana, K., Ramirez, C. M., Koka, P. S., & Deb, K. D. (2015) · PubMed · Cited by 11 · see citing works
The health promoting lifestyle profile : development and psychometric charactristics
Walker, S. N. (1978) · Nurse Researcher · Cited by 3 · see citing works
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Meditation, stress processes, and telomere biology
Conklin, Q. A., Crosswell, A. D., Saron, C. D., & Epel, E. S. (2019) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.11.009 · Cited by 69 · see citing works
Self-citationBiological mechanism study of meditation and its application in mental disorders
Shen, H., Chen, M., & Cui, D. (2020) · General Psychiatry · doi:10.1136/gpsych-2020-100214 · Cited by 44 · see citing works
- Authors
- Conklin, Q. A., King, B. G., Zanesco, A. P., Lin, J., Hamidi, A. B., Pokorny, J. J., Álvarez-López, M. J., Cosín-Tomás, M., Huang, C., Kaliman, P., Epel, E. S., & Saron, C. D.
- Affiliations
- University of California, Davis (US)
- University of California, San Francisco (US)
- Institut de Biomedicina de la Universitat de Barcelona (ES)
- University of California Davis Medical Center (US)
- Corresponding author
- Conklin, Quinn A.
- ORCID
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 70
- Pages
- 233-245
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2792824670
- Cited by
- 66
- References
- 101
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 11 · 2022: 7 · 2021: 4 · 2020: 17 · 2019: 10 · 2018: 3
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Update notices
- erratum (2018-10-01)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- MindRxiv (OSF Preprints) (submittedVersion)
- Funders
- Fetzer Institute (2191)
- John Templeton Foundation (39970)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Social Sciences › Health › Religion, Spirituality, and Psychology
- Keywords
- insight meditation, telomere length, telomerase activity, personality traits, neuroticism, agreeableness, GAR1, hnRNP A1, meditation experience, psychological stress, telomere maintenance
- MeSH terms
- Neuroticism, Adult, Female, Humans, Male, Personality, Stress, Psychological, Telomere, Telomerase, Meditation, Telomere Homeostasis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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