Influence of Mindfulness-Based Stress Reduction (MBSR) on Telomerase Activity in Women with Breast Cancer (BC)
Open accessAbstract
Mindfulness-based stress reduction (MBSR) reduces symptoms of depression, anxiety, and fear of recurrence among breast cancer (BC) survivors. However, the effects of MBSR (BC) on telomere length (TL) and telomerase activity (TA), known markers of cellular aging, psychological stress, and disease risk, are not known. This randomized, wait-listed, controlled study, nested within a larger trial, investigated the effects of MBSR (BC) on TL and TA. BC patients (142) with Stages 0-III cancer who had completed adjuvant treatment with radiation and/or chemotherapy at least 2 weeks prior to enrollment and within 2 years of completion of treatment with lumpectomy and/or mastectomy were randomly assigned to either a 6-week MBSR for BC program or a usual care. Assessments of TA and TL were obtained along with psychological measurements at baseline, 6 weeks, and 12 weeks after completing the MBSR(BC) program. The mean age of 142 participants was 55.3 years; 72% were non-Hispanic White; 78% had Stage I or II cancer; and 36% received both chemotherapy and radiation. In analyses adjusted for baseline TA and psychological status, TA increased steadily over 12 weeks in the MBSR(BC) group (approximately 17%) compared to essentially no increase in the control group (approximately 3%, p < .01). In contrast, no between-group difference was observed for TL (p = .92). These results provide preliminary evidence that MBSR(BC) increases TA in peripheral blood mononuclear cells from BC patients and have implications for understanding how MBSR(BC) may extend cell longevity at the cellular level.
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A shortened telomere length is linked to increased cancer incidence and mortality, and populations under chronic stress exhibit accelerated telomere shortening.
“A shortened telomere length is linked to increased cancer incidence and mortality, and populations under chronic stress exhibit accelerated telomere shortening.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [75]
Telomeres are highly sensitive to chronic stress.
“Telomeres, the protective caps at the ends of chromosomes, are highly sensitive to chronic stress.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [75]
BSRPs have shown promise in mitigating accelerated telomere shortening.
“BSRPs have shown promise in mitigating this effect.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [75]
In one study, BSRPs were significantly associated with increased telomere length in CD14(+) monocytes, with similar trends observed in CD14(-) T lymphocytes.
“In one study, BSRPs were significantly associated with increased telomere length in CD14(+) monocytes, with similar trends observed in CD14(-) T lymphocytes.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [75]
In women with breast cancer, telomerase activity increased by approximately 17% over 12 weeks in the BSRP group, compared to negligible changes in the control group.
“Furthermore, in women with breast cancer, telomerase activity—a key enzyme in maintaining telomere length—increased by approximately 17% over 12 weeks in the BSRP group, compared to negligible changes in the control group [75,76].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [75]
Longitudinal increases in the naive T-cell population were noted in BSRP studies, suggesting a rejuvenating effect on immune cells.
“Longitudinal increases in the naive T-cell population were also noted, suggesting a rejuvenating effect on immune cells.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [75]
Lengacher et al. (2014) showed, in a sample of breast cancer patients, that mindfulness-based stress reduction for six weeks significantly increased PBMC basal TA compared to a waitlist control group.
“Lengacher et al. (2014) showed, in a sample of breast cancer patients, that mindfulness-based stress reduction for six weeks significantly increased PBMC basal TA compared to a waitlist control group.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Lengacher et al., 2014
In Lengacher et al. (2014), baseline PBMC basal TA was controlled for, but the active group was heterogeneous in terms of treatment received and time since treatment completion.
“In this study, baseline PBMC basal TA was controlled for, but potential limitations were that the active group was heterogeneous in terms of treatment received and time since treatment completion.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Lengacher et al., 2014
In Lengacher et al. (2014), the treatment program was relatively short and thus only allowed for short-term assessment of PBMC basal TA.
“Moreover, the treatment program was relatively short and thus only allowed for short-term assessment of PBMC basal TA.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Lengacher et al., 2014
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- Authors
- Lengacher, C. A., Reich, R. R., Kip, K. E., Barta, M., Ramesar, S., Paterson, C. L., Moscoso, M. S., Carranza, I., Budhrani, P. H., Kim, S. J., Park, H. Y., Jacobsen, P. B., Schell, M. J., Jim, H. S. L., Post-White, J., Farias, J. R., & Park, J. Y.
- Affiliations
- University of South Florida (US)
- Moffitt Cancer Center (US)
- Dana-Farber Cancer Institute and Harvard Medical Center, Boston, MA, USA
- Catholic University of Korea (KR)
- College of Nursing, University of South Florida, Tampa, FL, USA
- Corresponding author
- Lengacher, Cecile A.
- ORCID
- Venue
- Biological Research For Nursing
- Publisher
- SAGE Publications
- Published
- 2014-01-30
- Volume
- 16
- Issue
- 4
- Pages
- 438-447
- ISSN
- 1099-8004 (ISSN-L)
- 1552-4175
- PMC
- PMC4559344
- OpenAlex
- W1972454857
- Cited by
- 169
- References
- 55
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 61 · 2019: 15 · 2018: 18 · 2017: 6 · 2016: 10 · 2015: 10 · 2014: 4
- FWCI
- 11.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Research For Nursing (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01ca131080-05)
- National Cancer Institute (R01-CA131080, P30CA076292)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- mindfulness-based stress reduction, breast cancer, telomerase activity, telomere length, cellular aging, peripheral blood mononuclear cells, psychological stress, breast cancer survivors, adjuvant therapy, cell longevity
- MeSH terms
- Aged, Base Sequence, Breast Neoplasms, Combined Modality Therapy, Female, Humans, Middle Aged, Pregnancy, Stress, Psychological, Polymerase Chain Reaction, DNA Primers, Telomerase, Mindfulness
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