Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women
Open accessAbstract
Yoga is associated with reduced stress and increased well-being, although the molecular basis for these benefits is not clear. Mounting evidence implicates the immune response, with current studies focused on protein immune markers (such as cytokines) in clinical populations. To explore the molecular impact, this pilot study uses a subsample (n=28) from a randomised waitlist control trial investigating the impact of an 8-week yoga intervention in a community population of women reporting psychological distress (N=116). We measured interleukin-6 (IL-6), tumour necrosis factor (TNF) and C-reactive protein (CRP) protein levels, and the DNA methylation of these genes and the global indicator, LINE-1. Correlations between these and psychological variables were explored, identifying moderate correlations with CRP protein levels, and methylation of IL-6, CRP and LINE-1. Many cytokine samples were below detection, however a Mann-Whitney U demonstrated a trend of moderate between-group effect for elevated IL-6 in the yoga group. Methylation analyses applied cross-sectional and non-controlled longitudinal analyses. Waist-to-height ratio and age were covaried. We demonstrated reduced methylation of the TNF region in the yoga group relative to the waitlist control group. No other genes demonstrated a significant difference. Longitudinal analysis further supported these results. This study is one of the first to explore yoga and immunological markers in a non-clinical population, and is the first study to explore DNA methylation. These findings indicate that further research into molecular impact of yoga on markers of immune function is warranted, with larger studies required.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An 8-week yoga intervention in distressed women showed reduced tumor necrosis factor gene (TNF) methylation in the yoga group as compared to the control group, indicating a potential immuno-regulatory effect.
“Another study investigating the impact of an 8-week yoga intervention in distressed women discerned a potential immuno-regulatory effect of meditation, with reduced tumor necrosis factor gene (TNF) methylation in the yoga group as compared to the control group (Harkess, Ryan, Delfabbro, & Cohen-Woods, 2016).”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Harkess, Ryan, Delfabbro, & Cohen-Woods, 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807 · see citing works
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
What's wrong with Bonferroni adjustments
Perneger, T. V. (1998) · BMJ · doi:10.1136/bmj.316.7139.1236 · Cited by 5,900 · see citing works
McEwen, B. S. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.18.2093 · Cited by 4,365 · see citing works
Psychological stress and the human immune system: a meta-analytic study of 30 Years of inquiry
Segerstrom, S. C., & Miller, G. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.4.601 · Cited by 3,334 · see citing works
The pro- and anti-inflammatory properties of the cytokine interleukin-6
Scheller, J., Chalaris, A., Schmidt-Arras, D., & Rose-John, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.034 · Cited by 3,212 · see citing works
Psychological Stress and Disease
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007) · JAMA · doi:10.1001/jama.298.14.1685 · Cited by 3,168 · see citing works
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
Colotta, F., Allavena, P., Sica, A., Garlanda, C., & Mantovani, A. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp127 · Cited by 2,882 · see citing works
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works
Allostatic load biomarkers of chronic stress and impact on health and cognition
Juster, R.-P., McEwen, B. S., & Lupien, S. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.10.002 · Cited by 2,565 · see citing works
Understanding Power and Rules of Thumb for Determining Sample Sizes
VanVoorhis, C. R. W., & Morgan, B. L. (2007) · Tutorials in Quantitative Methods for Psychology · doi:10.20982/tqmp.03.2.p043 · Cited by 1,946 · see citing works
The impact of retrotransposons on human genome evolution
Cordaux, R., & Batzer, M. (2009) · Nature reviews genetics · doi:10.1038/nrg2640 · Cited by 1,691 · see citing works
The impact of daily stress on health and mood: Psychological and social resources as mediators.
DeLongis, A., Folkman, S., & Lazarus, R. S. (1988) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.54.3.486 · Cited by 1,621 · see citing works
The impact of daily stress on health and mood: psychological and social resources as mediators
DeLongis, A., Folkman, S., & Lazarus, R. S. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.3.486 · Cited by 1,621 · see citing works
Epigenetic regulation in psychiatric disorders
Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400 · see citing works
Iliopoulos, D., Hirsch, H. A., & Struhl, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.014 · Cited by 1,374 · see citing works
Protective and damaging effects of stress mediators: central role of the brain
McEwen, B. S. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/bmcewen · Cited by 1,220 · see citing works
Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology.
Kiecolt-Glaser, J. K., McGuire, L., Robles, T. F., & Glaser, R. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135217 · Cited by 1,176 · see citing works
Trends in the Use of Complementary Health Approaches Among Adults in the United States
Jackson, C. (2015) · Holistic Nursing Practice · doi:10.1097/hnp.0000000000000088 · Cited by 1,174 · see citing works
Inflammation and cancer: An ancient link with novel potentials
Hussain, S. P., & Harris, C. C. (2007) · International Journal of Cancer · doi:10.1002/ijc.23173 · Cited by 1,096 · see citing works
(2015) · PubMed · Cited by 926 · see citing works
Leonard, B., & Maes, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.005 · Cited by 805 · see citing works
Carlson, L. E., Speca, M., Patel, K. D., & Goodey, E. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000074003.35911.41 · Cited by 773 · see citing works
Measurement and Mismeasurement of Mood: Recurrent and Emergent issues
Watson, D., & Clark, L. A. (1997) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6802_4 · Cited by 720 · see citing works
Cramer, H., Lauche, R., Langhorst, J., & Dobos, G. (2013) · Depression and Anxiety · doi:10.1002/da.22166 · Cited by 708 · see citing works
Gimeno, D., Kivimäki, M., Brunner, E. J., Elovainio, M., De Vogli, R., Steptoe, A., Kumari, M., Lowe, G. D. O., Rumley, A., Marmot, M. G., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291708003723 · Cited by 561 · see citing works
Penninx, B. W. J. H., Kritchevsky, S. B., Yaffe, K. S., Newman, A. B., Simonsick, E. M., Rubin, S. M., Ferrucci, L., Harris, T. B., & Pahor, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01811-5 · Cited by 530 · see citing works
Anxiety disorders and inflammation in a large adult cohort
Vogelzangs, N., Beekman, A. T. F., de Jonge, P., & Penninx, B. W. J. H. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.27 · Cited by 458 · see citing works
Psychological and metabolic stress: A recipe for accelerated cellular aging?
Epel, E. S. (2009) · HORMONES · doi:10.14310/horm.2002.1217 · Cited by 422 · see citing works
Chalitchagorn, K., Shuangshoti, S., Hourpai, N., Kongruttanachok, N., Tangkijvanich, P., Thong‐Ngam, D., Voravud, N., Sriuranpong, V., & Mutirangura, A. (2004) · Oncogene · doi:10.1038/sj.onc.1208137 · Cited by 419 · see citing works
Zhang, F. F., Cardarelli, R., Carroll, J. F., Fulda, K. G., Kaur, M., González, K., Vishwanatha, J. K., Santella, R. M., & Morabia, A. (2011) · Epigenetics · doi:10.4161/epi.6.5.15335 · Cited by 399 · see citing works
Kiecolt‐Glaser, J. K., Bennett, J. M., Andridge, R., Peng, J., Shapiro, C. L., Malarkey, W. B., Emery, C. F., Layman, R. M., Mrózek, E., & Glaser, R. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.51.8860 · Cited by 392 · see citing works
Nile, C. J., Read, R. C., Akil, M., Duff, G. W., & Wilson, A. G. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23758 · Cited by 338 · see citing works
Characteristics of Yoga Users: Results of a National Survey
Birdee, G. S., Legedza, A. T., Saper, R. B., Bertisch, S. M., Eisenberg, D. M., & Phillips, R. S. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0735-5 · Cited by 335 · see citing works
Stress, Inflammation, and Yoga Practice
Kiecolt-Glaser, J. K., Christian, L., Preston, H., Houts, C. R., Malarkey, W. B., Emery, C. F., & Glaser, R. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181cb9377 · Cited by 327 · see citing works
DNA methylation in white blood cells
Terry, M. B., Delgado‐Cruzata, L., Vin‐Raviv, N., Wu, H. C., & Santella, R. M. (2011) · Epigenetics · doi:10.4161/epi.6.7.16500 · Cited by 318 · see citing works
Flotho, C., Claus, R., Batz, C., Schneider, M., Sandrock, I., Ihde, S., Plass, C., Niemeyer, C. M., & Lübbert, M. (2009) · Leukemia · doi:10.1038/leu.2008.397 · Cited by 316 · see citing works
Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators
Kaliman, P., Álvarez-López, M. J., Cosín-Tomás, M., Rosenkranz, M. A., Lutz, A., & Davidson, R. J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.004 · Cited by 300 · see citing works
Lavretsky, H., Epel, E. S., Siddarth, P., Nazarian, N., Cyr, N. S., Khalsa, D. S., Lin, J., Blackburn, E., & Irwin, M. R. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3790 · Cited by 298 · see citing works
Global DNA Methylation Level in Whole Blood as a Biomarker in Head and Neck Squamous Cell Carcinoma
Hsiung, D. T., Marsit, C. J., Houseman, E. A., Eddy, K., Furniss, C. S., McClean, M. D., & Kelsey, K. T. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0636 · Cited by 293 · see citing works
Epigenetic Mechanisms in Inflammation
Bayarsaihan, D. (2010) · Journal of Dental Research · doi:10.1177/0022034510378683 · Cited by 290 · see citing works
Bower, J. E., Greendale, G., Crosswell, A. D., Garet, D., Sternlieb, B., Ganz, P. A., Irwin, M. R., Olmstead, R., Arevalo, J., & Cole, S. W. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.019 · Cited by 283 · see citing works
El‐Maarri, O., Becker, T., Junen, J., Manzoor, S. S., Diaz-Lacava, A. N., Schwaab, R., Wienker, T. F., & Oldenburg, J. (2007) · Human Genetics · doi:10.1007/s00439-007-0430-3 · Cited by 271 · see citing works
(2012) · PubMed · Cited by 266 · see citing works
Unternaehrer, E., Luers, P., Mill, J., Dempster, E., Meyer, A. H., Staehli, S., Lieb, R., Hellhammer, D. H., & Meinlschmidt, G. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.77 · Cited by 250 · see citing works
Black, D. S., Cole, S. W., Irwin, M. R., Breen, E., St. Cyr, N. M., Nazarian, N., Khalsa, D. S., & Lavretsky, H. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.06.011 · Cited by 249 · see citing works
Oncogenic Ras Diverts a Host TNF Tumor Suppressor Activity into Tumor Promoter
Cordero, J. B., Macagno, J. P., Stefanatos, R. K. A., Strathdee, K. E., Cagan, R. L., & Vidal, M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.014 · Cited by 239 · see citing works
Banerjee, B., Vadiraj, H. S., Ram, A., Rao, R., Jayapal, M., Gopinath, K. S., Ramesh, B. S., Rao, N. H. R., Kumar, A., Nagarathna, R., et al. (2007) · Integrative Cancer Therapies · doi:10.1177/1534735407306214 · Cited by 225 · see citing works
Patel, N. K., Newstead, A. H., & Ferrer, R. L. (2012) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2011.0473 · Cited by 223 · see citing works
Toyokawa, S., Uddin, M., Koenen, K. C., & Galea, S. (2011) · Social Science & Medicine · doi:10.1016/j.socscimed.2011.09.036 · Cited by 219 · see citing works
Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis
Zhu, Z.-Z., Hou, L., Bollati, V., Tarantini, L., Marinelli, B., Cantone, L., Yang, A. S., Vokonas, P., Lissowska, J., Fustinoni, S., et al. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyq154 · Cited by 218 · see citing works
Kim, K.-Y., Kim, D.-S., Lee, S.-K., Lee, I.-K., Kang, J.-H., Chang, Y.-S., Jacobs, D. R., Steffes, M., & Lee, D.-H. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901131 · Cited by 216 · see citing works
DNA methylation as a universal biomarker
Levenson, V. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.17 · Cited by 172 · see citing works
Implications of LINE1 Methylation for Bladder Cancer Risk in Women
Wilhelm-Benartzi, C. S., Kelsey, K. T., Butler, R. A., Plaza, S., Gagne, L. A., Zens, M. S., Andrew, A. S., Morris, S., Nelson, H. H., Schned, A. R., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2983 · Cited by 169 · see citing works
Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective
Eyre, H. A., Papps, E., & Baune, B. T. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00003 · Cited by 144 · see citing works
Yoga in Australia: Results of a national survey
Penman, S., Cohen, M. M., Stevens, P. J., & Jackson, S. (2012) · International Journal of Yoga · doi:10.4103/0973-6131.98217 · Cited by 134 · see citing works
Rusiecki, J. A., Chen, L., Srikantan, V., Zhang, L., Yan, L., Polin, M., & Baccarelli, A. (2012) · Epigenomics · doi:10.2217/epi.11.116 · Cited by 132 · see citing works
Exercise and inflammation-related epigenetic modifications: focus on DNA methylation.
Horsburgh, S., Robson-Ansley, P. J., Adams, R. C. M., & Smith, C. (2015) · PubMed · Cited by 130 · see citing works
TNF‐α Promoter Methylation as a Predictive Biomarker for Weight‐loss Response
Campión, J., Milagro, F. I., Goyenechea, E., & Martínez, J. A. (2009) · Obesity · doi:10.1038/oby.2008.679 · Cited by 126 · see citing works
Loftis, J. M., Huckans, M. S., Ruimy, S., Hinrichs, D. J., & Hauser, P. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.11.001 · Cited by 117 · see citing works
The epigenetic bottleneck of neurodegenerative and psychiatric diseases
Sananbenesi, F., & Fischer, A. (2009) · Biological Chemistry · doi:10.1515/bc.2009.131 · Cited by 106 · see citing works
Genetic and epigenetic predictors of responsiveness to treatment in RA
Plant, D., Wilson, A. G., & Barton, A. C. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.16 · Cited by 93 · see citing works
Recreational and household physical activity at different time points and DNA global methylation
White, A. J., Sandler, D. P., Bolick, S. C. E., Xu, Z., Taylor, J. A., & DeRoo, L. A. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.02.013 · Cited by 91 · see citing works
Zhang, F. F., Santella, R. M., Wolff, M. S., Deyssenroth, M. A., Markowitz, S. B., & Morabia, A. (2012) · Epigenetics · doi:10.4161/epi.20236 · Cited by 91 · see citing works
El‐Maarri, O., Walier, M., Behne, F., van Üüm, J., Singer, H., Diaz-Lacava, A. N., Nüsgen, N., Niemann, B., Watzka, M., REINSBERG, J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016252 · Cited by 87 · see citing works
Age-related loss of CpG methylation in the tumour necrosis factor promoter
Gowers, I., Walters, K., Kiss‐Toth, E., Read, R. C., Duff, G. W., & Wilson, A. G. (2011) · Cytokine · doi:10.1016/j.cyto.2011.09.009 · Cited by 84 · see citing works
Forge, R. L. (2005) · ACSMʼs Health & Fitness Journal · doi:10.1097/00135124-200509000-00006 · Cited by 83 · see citing works
Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass
Kirchner, H., Nylén, C., Laber, S., Barrès, R., Yan, J., Krook, A., Zierath, J. R., & Näslund, E. B. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2013.12.019 · Cited by 72 · see citing works
Expression, polymorphism and methylation pattern of interleukin-6 in periodontal tissues
Stefani, F. A., Viana, M. B., Souza, A. C. D., Brito, J. A. R., Gomez, R. S., Costa, J. E., & Moreira, P. R. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.12.001 · Cited by 65 · see citing works
Kessler Psychological Distress Scale
Kessler, R. C., Andrews, G., Colpe, L. J., Hiripi, E., Mroczek, D. K., Normand, S. T., Walters, E. E., & Zaslavsky, A. M. (2002) · PsycTESTS Dataset · doi:10.1037/t08324-000 · Cited by 64 · see citing works
Regulation of gene expression by yoga, meditation and related practices: A review of recent studies
Saatcioglu, F. (2012) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2012.10.002 · Cited by 60 · see citing works
Are cytokines associated with neuropsychiatric syndromes in humans?
Hickie, I. B., & Lloyd, A. R. (1995) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(95)00054-6 · Cited by 59 · see citing works
Epigenetic Changes in Response to Tai Chi Practice: A Pilot Investigation of DNA Methylation Marks
Ren, H., Collins, V., Clarke, S., Han, J.-S., Lam, P., Clay, F. J., Williamson, L. M., & Choo, K. H. A. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/841810 · Cited by 53 · see citing works
Morabia, A., Zhang, F. F., Deyssenroth, M. A., Flory, J. D., Mirer, F., Santella, R. M., Wolff, M. S., & Markowitz, S. B. (2012) · Preventive Medicine · doi:10.1016/j.ypmed.2012.01.019 · Cited by 24 · see citing works
Functional genomics in the study of mind-body therapies.
Niles, H. F., Mehta, D. H., Corrigan, A. A., Bhasin, M., & Denninger, J. W. (2014) · PubMed Central · Cited by 23 · see citing works
Epigenetic mechanisms as mediators of environmental risks for psychiatric disorders
Docherty, S. J., & Mill, J. S. (2008) · Psychiatry · doi:10.1016/j.mppsy.2008.10.006 · Cited by 15 · see citing works
Brief Report on the Psychophysiological Effects of a Yoga Intervention for Chronic Stress
Harkess, K. N., Delfabbro, P., Blake-Mortimer, J. S., Hannaford, Z., & Cohen‐Woods, S. (2016) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000169 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Ramos-López, O., Milagro, F. I., Riezu‐Boj, J. I., & Martínez, J. A. (2020) · Inflammation Research · doi:10.1007/s00011-020-01425-y · Cited by 185 · see citing works
Tolahunase, M. R., Sagar, R., Faiq, M., & Dada, R. (2018) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-170810 · Cited by 167 · see citing works
Yoga and immune system functioning: a systematic review of randomized controlled trials
Falkenberg, R., Eising, C., & Peters, M. (2018) · Journal of behavioral medicine · doi:10.1007/s10865-018-9914-y · Cited by 114 · see citing works
Schiele, M. A., Gottschalk, M. G., & Domschke, K. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101830 · Cited by 156 · see citing works
The role of yoga in inflammatory markers
Estevao, C. (2022) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2022.100421 · Cited by 94 · see citing works
Impact of Yoga on Inflammatory Biomarkers: A Systematic Review
Djalilova, D., Schulz, P., Berger, A., Case, A., Kupzyk, K., & Ross, A. (2018) · Biological Research for Nursing · doi:10.1177/1099800418820162 · Cited by 77 · see citing works
Molecules of Silence: Effects of Meditation on Gene Expression and Epigenetics
Venditti, S., Verdone, L., Reale, A., Vetriani, V., Caserta, M., & Zampieri, M. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.01767 · Cited by 76 · see citing works
Kaushik, D., Shah, P., Mukherjee, N. Z., Ji, N., Dursun, F., Kumar, A. P., Thompson, I. M., Mansour, A. M., Jha, R., Yang, X., et al. (2021) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-021-00470-w · Cited by 68 · see citing works
Benefits of Yoga on IL-6: Findings from a Randomized Controlled Trial of Yoga for Depression
Nugent, N. R., Brick, L. A. D., Armey, M. F., Tyrka, A. R., Ridout, K. K., & Uebelacker, L. A. (2019) · Behavioral Medicine · doi:10.1080/08964289.2019.1604489 · Cited by 49 · see citing works
Epigenetic Changes Associated with Different Types of Stressors and Suicide
Dee, G., Ryznar, R. J., & Dee, C. (2023) · Cells · doi:10.3390/cells12091258 · Cited by 48 · see citing works
Investigating the epigenetic profile of the inflammatory gene IL-6 in late-life depression
Ryan, J., Pilkington, L., Neuhaus, K., Ritchie, K., Ancelin, M., & Saffery, R. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1515-8 · Cited by 39 · see citing works
Self-citationNoroozi, R., Rudnicka, J., Pisarek, A., Wysocka, B., Masny, A., Boroń, M., Migacz-Gruszka, K., Pruszkowska‐Przybylska, P., Kobus, M., Lisman, D., et al. (2023) · GeroScience · doi:10.1007/s11357-023-01029-4 · Cited by 41 · see citing works
Bisht, S., Banu, S., Srivastava, S., Pathak, R. U., Kumar, R., Dada, R., & Mishra, R. K. (2020) · Andrologia · doi:10.1111/and.13551 · Cited by 37 · see citing works
Huang, T., Trudel‐Fitzgerald, C., Poole, E. M., Sawyer, S., Kubzansky, L. D., Hankinson, S. E., Okereke, O. I., & Tworoger, S. S. (2019) · Cancer Causes & Control · doi:10.1007/s10552-019-01176-0 · Cited by 36 · see citing works
Choudhary, A., Pathak, A., Ponnaiah, M., Purohit, M. R., Rajasekhar, T. D., Dhoble, P., Sharma, A., Suliya, J., Apsingekar, D., Patil, V., et al. (2019) · Geriatrics · doi:10.3390/geriatrics4040064 · Cited by 35 · see citing works
Yoga as a complementary therapy for metabolic syndrome: A narrative review
Khoshnaw, D. M., & Ghadge, A. A. (2020) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2020.09.002 · Cited by 34 · see citing works
Yoga for Preventive Health: A Holistic Approach
Madan, S., Sembhi, J., Khurana, N., Makkar, K., & Byati, P. (2022) · American Journal of Lifestyle Medicine · doi:10.1177/15598276211059758 · Cited by 30 · see citing works
Yang, H., Koh, E., & Kang, Y. (2021) · Biomolecules · doi:10.3390/biom11050708 · Cited by 31 · see citing works
Changes Induced by Mind–Body Intervention Including Epigenetic Marks and Its Effects on Diabetes
Yang, H., Koh, E., Sung, M.-K., & Kang, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031317 · Cited by 28 · see citing works
Saud, A., Abbasi, M., Merris, H., Parth, P., Jones, X. M., Aggarwal, R., & Gupta, L. (2022) · Clinical Rheumatology · doi:10.1007/s10067-022-06280-2 · Cited by 28 · see citing works
Effects of yoga on immune function: A systematic review of randomized controlled trials
Yeun, Y.-R., & Kim, S.-D. (2021) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2021.101446 · Cited by 24 · see citing works
Porter, N. S., & Jason, L. A. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s379653 · Cited by 23 · see citing works
Mishra, B., Agarwal, A., George, J. A., Upadhyay, A. D., Nilima, N., Mishra, R., Kuthiala, N., Basheer, A., Vishnu, V. Y., & Srivastava, V. P. (2024) · Cureus · doi:10.7759/cureus.57541 · Cited by 22 · see citing works
The potential positive epigenetic effects of various mind-body therapies (MBTs): a narrative review
Kripalani, S., Pradhan, B., & Gilrain, K. (2021) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2021-0039 · Cited by 20 · see citing works
Shah, K. H., Adhikari, C., Sharma, S., Saha, S., & Saxena, D. B. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/3523432 · Cited by 18 · see citing works
Holistic frailty prevention: The promise of movement‐based mind–body therapies
Loewenthal, J. V., Berning, M., Wayne, P. M., Eckstrom, E., & Orkaby, A. (2023) · Aging Cell · doi:10.1111/acel.13986 · Cited by 17 · see citing works
Osteopathic Manipulative Treatment for Allostatic Load Lowering
Nuño, V., Siu, A., Deol, N., & Juster, R. (2019) · Journal of Osteopathic Medicine · doi:10.7556/jaoa.2019.112 · Cited by 17 · see citing works
Tulloch, H. E., & Greenman, P. S. (2018) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000553 · Cited by 16 · see citing works
Takakura, S., Oka, T., & Sudo, N. (2019) · BioPsychoSocial Medicine · doi:10.1186/s13030-019-0171-2 · Cited by 16 · see citing works
Muñoz‐Vergara, D., Grabowska, W. A., Yeh, G. Y., Khalsa, S. B. S., Schreiber, K. L., Huang, C. A., Zavacki, A. M., & Wayne, P. M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269300 · Cited by 15 · see citing works
Epigenetic Biomarkers of Metabolic Responses to Lifestyle Interventions
Ramos-López, O. (2023) · Nutrients · doi:10.3390/nu15194251 · Cited by 13 · see citing works
Forseth, B. M., Polfuss, M. L., Brondino, M. J., Hunter, S. D., Lawlor, M. W., Beatka, M. J., Prom, M. J., Eells, J. T., & Lyons, J. (2022) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2022.01.004 · Cited by 13 · see citing works
Yoga and Lifestyle Changes: A Path to Improved Fertility – A Narrative Review
Yadav, A., Tiwari, P., & Dada, R. (2024) · International Journal of Yoga · doi:10.4103/ijoy.ijoy_211_23 · Cited by 12 · see citing works
On the road to resilience: Epigenetic effects of meditation
Verdone, L., Caserta, M., Ben‐Soussan, T. D., & Venditti, S. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2022.12.009 · Cited by 12 · see citing works
Zaccari, B., Kelly, U. A., Lovejoy, T. I., Hubbard, K., Newman, A. G., & Loftis, J. M. (2023) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2023.100031 · Cited by 12 · see citing works
Brown, K., Hui, Q., Huang, Y., Taylor, J. Y., Prescott, L., Barcelona, V., Crusto, C. A., & Sun, Y. V. (2019) · Chronic Stress · doi:10.1177/2470547019879088 · Cited by 14 · see citing works
Forseth, B. M., Boyer, W. R., Miller, A. L., & Fitzhugh, E. C. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.04.006 · Cited by 11 · see citing works
Giridharan, S. (2023) · International Journal of Yoga · doi:10.4103/ijoy.ijoy_141_23 · Cited by 10 · see citing works
Association between yoga, physiologic and psychologic health: A cross sectional study
Forseth, B. M., Polfuss, M. L., Brondino, M. J., Lawlor, M. W., Beatka, M. J., Prom, M. J., Eells, J. T., & Lyons, J. (2021) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2021.101350 · Cited by 10 · see citing works
Adhikari, B., Starkweather, A. R., Xu, W., Acabchuk, R. L., Ramesh, D., Eze, B., Yang, Y., Yang, G. S., Walker, J. M., Laubenbacher, R., et al. (2022) · Pilot and Feasibility Studies · doi:10.1186/s40814-022-01103-2 · Cited by 10 · see citing works
Yoga and Cardiovascular Diseases – A Mechanistic Review
Murugesan, P. (2024) · International Journal of Yoga · doi:10.4103/ijoy.ijoy_55_24 · Cited by 12 · see citing works
Khokhar, M., Tomo, S., Gadwal, A., & Purohit, P. (2022) · International Journal of Yoga · doi:10.4103/ijoy.ijoy_146_21 · Cited by 10 · see citing works
Taylor, J. Y., Jones‐Patten, A., Prescott, L., Potts‐Thompson, S., Joyce, C., Tayo, B. O., & Saban, K. L. (2024) · PLoS ONE · doi:10.1371/journal.pone.0295293 · Cited by 8 · see citing works
Azizi, B., Soltani, D., Arero, A. G., Karimi, A. S., Ramezani, A., Vasheghani‐Farahani, A., Ashraf, H., Akhondzadeh, S., Khosravi, H., Nateghi, S., et al. (2024) · Current Cardiology Reports · doi:10.1007/s11886-024-02082-x · Cited by 9 · see citing works
Yoga, immunity and COVID-19: A scoping review
Shah, K., Adhikari, C., Saha, S., & Saxena, D. (2022) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_2182_21 · Cited by 7 · see citing works
Yoga: Impact on sperm genome and epigenome - clinical consequences
Bisht, S., & Dada, R. (2019) · Annals of Neurosciences · doi:10.5214/ans.0972.7531.260202 · Cited by 6 · see citing works
Primer for Mainstreaming Mind-Body Techniques for Extreme Climates-Insights and Future Directions
Anand, A., Kaur, G., Bammidi, S., Mathur, D., Battu, P., Sharma, K., Tyagi, R., Pannu, V. S., Bhanushali, D., & Limaye, N. (2020) · Medicines · doi:10.3390/medicines7030012 · Cited by 6 · see citing works
Shields, A. E., Zhang, Y., Argentieri, M. A., Warner, E. T., Cozier, Y. C., Liu, C., Dye, C. K., Kent, B. V., Baccarelli, A., & Palmer, J. R. (2021) · Epigenomics · doi:10.2217/epi-2021-0275 · Cited by 8 · see citing works
Systematic Review of High-Dimensional Omics in Mind-Body Medicine
Schoenberg, P. L. A., & Gonzalez, K. M. (2022) · OBM Integrative and Complementary Medicine · doi:10.21926/obm.icm.2204052 · Cited by 6 · see citing works
Effects of stress and mindfulness on epigenetics
Househam, A. M. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2022.11.003 · Cited by 6 · see citing works
Saban, K. L., Janusek, L. W., de la Peña, P., Lee, S., Tell, D., Mathews, H. L., Nowak, A. L., Nyembwe, A., & Taylor, J. Y. (2025) · Biological Research For Nursing · doi:10.1177/10998004251346179 · Cited by 5 · see citing works
Marson, F., Zampieri, M., Verdone, L., Bacalini, M. G., Ravaioli, F., Morandi, L., Chiarella, S. G., Vetriani, V., Venditti, S., Caserta, M., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0293199 · Cited by 5 · see citing works
Symptom Science: Omics and Response to Non-Pharmacological Interventions
Wagner, M. A., Wesmiller, S. W., Maydick, M., Gawron, L. M., Peterson-Burch, F., & Conley, Y. P. (2020) · Biological Research For Nursing · doi:10.1177/1099800420975205 · Cited by 5 · see citing works
Epigenomic Impacts of Meditative Practices
Zahir, F. (2022) · Epigenomics · doi:10.2217/epi-2022-0306 · Cited by 4 · see citing works
Remodeling the Epigenome Through Meditation: Effects on Brain, Body, and Well-being
Venditti, S. (2025) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-75980-2_7 · Cited by 5 · see citing works
Gaignard, M., Stanić, J., Bodmer, A., Zaman, K., Sarivalasis, A., Labidi‐Galy, S. I., Jermann, F., Marco, M. D., Ljuslin, M., Ryser, S., et al. (2023) · Journal of Psychosocial Oncology Research and Practice · doi:10.1097/or9.0000000000000096 · Cited by 3 · see citing works
Guyon, A., Ravenet, J., & Midol, N. (2021) · Staps · doi:10.3917/sta.132.0083 · Cited by 3 · see citing works
Kusuma, R. M., Amelia, V. L., Phiri, D., & Chung, M. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120953 · Cited by 2 · see citing works
The Effects of Yoga on the Mental Health of Individuals With Autoimmune Disorders: A Scoping Review
Nagy, S. S., Tague, K., Ossorio, A., Patel, N., Callahan, R., Jose, E., Tran, M., Mejia, A. S., McPhail, M. N., Junco, J., et al. (2025) · Cureus · doi:10.7759/cureus.77669 · Cited by 2 · see citing works
A review of yoga on inflammation and its related diseases
Mooventhan, A., Nivethitha, L., & Gowthami, R. (2023) · Annals of Rheumatology and Autoimmunity · doi:10.4103/ara.ara_16_22 · Cited by 1 · see citing works
Yoga in the Management of Arterial Hypertension
Roche, L. T., Menon, P., & Tiwari, S. (2022) · Springer eBooks · doi:10.1007/978-981-16-6913-2_23 · Cited by 1 · see citing works
Mishra, N., & Mishra, S. (2023) · Current Traditional Medicine · doi:10.2174/2215083809666230125141650 · Cited by 1 · see citing works
Neuro-molecular Effects of Yoga and Endurance Exercises: Similarities and Dissimilarities
Sharma, K., Arya, K., Kumar, S., & Sharma, S. (2024) · Springer eBooks · doi:10.1007/978-981-97-2851-0_9 · Cited by 1 · see citing works
Effects of Yoga on Gene Expression: A Systematic Review of Randomised Controlled Trials
Giridharan, S., Soumian, S., Kumar, N. V., & Ansari, J. (2025) · Cureus · doi:10.7759/cureus.82690 · Cited by 1 · see citing works
Mody, J. (2018) · Journal of Clinical Epigenetics · doi:10.21767/2472-1158.100095 · Cited by 1 · see citing works
Arya, J., Verma, P., Mathur, D., Tyagi, R., Pannu, V. S., & Anand, A. (2022) · Springer eBooks · doi:10.1007/978-981-16-6913-2_18 · Cited by 1 · see citing works
Epigenetic landscape of infertility
Bisht, S., Chaurasia, P., Goswami, A., Khan, S., & Dada, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814259-2.00013-3
Proposed effect of epigenetic alterations on stress-related disorders
Yılmaz, O. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823039-8.00010-1
Protocol for the pilot study of group video yogic breathing app in breast cancer survivorsPreprint
Balasubramanian, S., Harper, J. L., Sterba, K. R., Viswanathan, R., & Eldredge-Hindy, H. (2022) · medRxiv · doi:10.1101/2022.04.08.22273610
The Effect of Yoga on Basic Cognitive Functions in Children with ADHD: A Three-Month Follow-up Study
Khorashad, R. S. (2024) · Physical activity in children. · doi:10.61186/pach.416260.1006
Dasanayaka, N. N., Sirisena, N. D., & Samaranayake, N. (2024) · Research Square · doi:10.21203/rs.3.rs-4456071/v1
The Beneficial Effects of Yoga on Stress: A Positive Psychology Perspective
Park, C. L., & Skoggard, C. S. (2025) · Springer eBooks · doi:10.1007/978-3-031-89095-6_18
The science behind serenity: biochemical effects of yogic and naturopathic interventions
Balu, P. B., Harshitha, M., Rao, V., & Devarajan, A. (2025) · CCRYN Indian Journal of Yoga & Naturopathy · doi:10.4103/ijyn.ijyn_9_25
Adhikari, B., Starkweather, A. R., Xu, W., Acabchuk, R. L., Ramesh, D., Eze, B., Yang, Y., Yang, G. S., Walker, J., Laubenbacher, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20252833
Adhikari, B., Starkweather, A. R., Xu, W., Acabchuk, R. L., Ramesh, D., Eze, B., Yang, Y., Yang, G. S., Walker, J., Laubenbacher, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20252830
Adolescent disordered eating and epigenetic age acceleration
Curtis, M., Balfour, D., Melton, P. E., Lin, A. P., Kleinig, Z., & Cohen‐Woods, S. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03595-3
Self-citationCognitive Dysfunction and Suicide
Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_19
Gianeselli, I., Brighi, A., & Basso, D. (2026) · Body Movement and Dance in Psychotherapy · doi:10.1080/17432979.2026.2693529
Sharma, D. (2026) · Journal of the Indian Academy of Geriatrics · doi:10.4103/jiag.jiag_73_26
Asteria, C., Scichilone, G., Cardani, R., Lazarevic, D., Milani, V., Ambrogi, F., Renna, L. V., Morelli, M., Giannese, F., Tascini, A. S., et al. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1858629
- Authors
- Harkess, K. N., Ryan, J., Delfabbro, P. H., & Cohen-Woods, S.
- Affiliations
- The University of Adelaide (AU)
- The University of Melbourne (AU)
- Venue
- Translational Psychiatry
- Published
- 2016-11-29
- Volume
- 6
- Issue
- 11
- Pages
- e965-e965
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC5290356
- OpenAlex
- W2558895165
- Cited by
- 80
- References
- 76
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 8 · 2023: 12 · 2022: 18 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 5 · 2017: 1
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Translational Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by)
- Flinders Academic Commons (Flinders University) (submittedVersion)
- Flinders Academic Commons (Flinders University) (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- Flinders University
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- yoga intervention, chronic stress, women, psychological distress, inflammation, DNA methylation, interleukin-6, TNF-α, C-reactive protein, LINE-1 methylation, cytokines, immune function, epigenetics
- MeSH terms
- Adult, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Middle Aged, Pilot Projects, Stress, Psychological, Tumor Necrosis Factor-alpha, Yoga, Interleukin-6, Inflammation Mediators, DNA Methylation, Long Interspersed Nucleotide Elements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
