Yoga- and meditation-based lifestyle intervention increases neuroplasticity and reduces severity of major depressive disorder: A randomized controlled trial
Abstract
Background: Current interventions for major depressive disorder (MDD) are suboptimal, and only one third respond to them on initial treatment. Neuroplasticity theories are the basis for several emerging treatments. Evidence on the impact of yoga, a well-known mind-body intervention, on neuroplasticity in MDD is limited. Objectives: To determine the effects of 12-week yoga- and meditation-based lifestyle intervention (YMLI) on depression severity and systemic biomarkers of neuroplasticity in adult MDD patients on routine drug treatment. Methods: A total of 58 MDD patients were randomized into yoga or control group. The severity of depression was assessed with Beck Depression Inventory-II scale (BDI-II). Blood samples were collected before and after intervention for the measurement of the biomarkers that characterize neuroplasticity, including mind-body communicative and cellular health biomarkers. Results: There was a significant decrease [difference between means, (95% CI)] in BDI-II score [–5.83 (–7.27, –4.39), p < 0.001] and significant increase in BDNF (ng/ml) [5.48 (3.50, 7.46), p < 0.001] after YMLI compared to control group. YMLI significantly increased DHEAS, sirtuin 1, and telomerase activity levels, and decreased cortisol, and IL-6 levels, in addition to decreasing DNA damage and balancing oxidative stress. Multiple regression analyses were used to associate neuroplasticity biomarkers with depression severity. A ‘post-intervention change in BDNF’ x ‘group’ interaction indicated that yoga group had more BDNF in association with less BDI-II scores relative to controls. Increased sirtuin 1 and telomerase activity and decreased cortisol significantly predicted this association (all p < 0.05). Conclusion: These results suggest that decrease in depression severity after YMLI in MDD is associated with improved systemic biomarkers of neuroplasticity. Thus YMLI can be considered as a therapeutic intervention in MDD management.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Comparative studies between meditators and non-meditators have revealed differences in brain connectivity, activation patterns, and both gray and white matter density.
“For example, comparative studies between meditators and non-meditators have revealed differences in brain connectivity, activation patterns, and both gray and white matter density [74].”
From Mindfulness meditation and psychedelics: potential synergies and commonalities (2023) · cites this paper as [74]
Neuroplasticity of biomarkers was associated with the degree of depression.
“The investigators also revealed that the neuroplasticity of biomarkers was associated with the degree of depression, and there was a significant increase in brain-derived neurotrophic factor (BDNF) after mindfulness yoga intervention [31].”
From The effectiveness of mindfulness yoga on patients with major depressive disorder: a systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [31]
Three included studies were from India.
“the other three from India [20, 31, 60]”
From The effectiveness of mindfulness yoga on patients with major depressive disorder: a systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [31]
There was a significant increase in brain-derived neurotrophic factor after mindfulness yoga intervention.
“The investigators also revealed that the neuroplasticity of biomarkers was associated with the degree of depression, and there was a significant increase in brain-derived neurotrophic factor (BDNF) after mindfulness yoga intervention [31].”
From The effectiveness of mindfulness yoga on patients with major depressive disorder: a systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [31]
Incomplete outcome data were rated as uncertain in one study.
“Incomplete outcome data were rated as uncertain in one study [31]”
From The effectiveness of mindfulness yoga on patients with major depressive disorder: a systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [31]
In two trials, blinding of participants and personnel was deemed ambiguous.
“whereas in two trials this was deemed ambiguous [20, 31].”
From The effectiveness of mindfulness yoga on patients with major depressive disorder: a systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [31]
Most studies provided an explanation of why participants dropped out at different times.
“Most of the studies provided an explanation of why participants dropped out at different times [31, 54, 56–58].”
From The effectiveness of mindfulness yoga on patients with major depressive disorder: a systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [31]
One included study did not state the yoga approach.
“the other [31] was not stated.”
From The effectiveness of mindfulness yoga on patients with major depressive disorder: a systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [31]
The intervention was primarily practiced in a supine posture, prone sitting position, and standing.
“The intervention were primarily practiced in a supine posture, prone sitting position, and standing [31]”
From The effectiveness of mindfulness yoga on patients with major depressive disorder: a systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [31]
Selective reporting of depression was noted in one study.
“with selective reporting of depression noted in one study [31].”
From The effectiveness of mindfulness yoga on patients with major depressive disorder: a systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [31]
The anti-depressive and anxiolytic effects of mindfulness are thought to be mediated by enhancements in decentring and cognitive flexibility.
“These anti-depressive and anxiolytic effects are thought to in turn be mediated by enhancements in decentring and cognitive flexibility, in the case of mindfulness intervention (16, 19), vs. mystical experiences and disrupted cortical connectivity in the case of psychedelic-assisted therapy (49, 50).”
From Examining the Potential Synergistic Effects Between Mindfulness Training and Psychedelic-Assisted Therapy (2021) · cites this paper as [19]
Cites
1 retracted
Shi, N., Zhu, C., & Li, L. (2016) · BioMed Research International · doi:10.1155/2016/1732163 · Cited by 27 · see citing works
RetractedMoher, D., Hopewell, S., Schulz, K. F., Montori, V., Gotzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2010) · BMJ · doi:10.1136/bmj.c869 · Cited by 8,883 · see citing works
Ferrari, A. J., Charlson, F. J., Norman, R. E., Patten, S. B., Freedman, G., Murray, C. J. L., Vos, T., & Whiteford, H. A. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001547 · Cited by 3,115 · see citing works
Walker, E. R., McGee, R. E., & Druss, B. G. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2502 · Cited by 2,976 · see citing works
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works
The integrated stress response
Pakos‐Zebrucka, K., Koryga, I., Mnich, K., Ljujic, M., Samali, A., & Gorman, A. M. (2016) · The EMBO Reports · doi:10.15252/embr.201642195 · Cited by 2,659 · see citing works
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060 · see citing works
Frank, E. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810330075011 · Cited by 1,959 · cited 1× · see citing works
“The severity of depression was assessed with BDI-II scale, which is considered a clinically useful criterion and is widely accepted in MDD trials as the primary outcome (Frank et al., 1991; Freedland et al., 2015; Reeves et al., 2012).”
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927 · see citing works
Mindfulness practice leads to increases in regional brain gray matter density
Hölzel, B. K., Carmody, J., Vangel, M., Congleton, C., Yerramsetti, S. M., Gard, T., & Lazar, S. W. (2011) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2010.08.006 · Cited by 1,914 · see citing works
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774 · see citing works
Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex
McEwen, B. S., Nasca, C., & Gray, J. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.171 · Cited by 1,574 · see citing works
Smith, M., Makino, S., Květňanský, R., & Post, R. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01768.1995 · Cited by 1,429 · see citing works
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390 · see citing works
Harnessing neuroplasticity for clinical applications
Cramer, S. C., Sur, M., Dobkin, B. H., O'Brien, C., Sanger, T. D., Trojanowski, J. Q., Rumsey, J. M., Hicks, R., Cameron, J., Chen, D., et al. (2011) · Brain · doi:10.1093/brain/awr039 · Cited by 1,259 · see citing works
Circadian Control of the NAD <sup>+</sup> Salvage Pathway by CLOCK-SIRT1
Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., & Sassone-Corsi, P. (2009) · Science · doi:10.1126/science.1170803 · Cited by 1,198 · see citing works
Mindfulness-based interventions for psychiatric disorders: A systematic review and meta-analysis
Goldberg, S. B., Tucker, R. P., Greene, P. A., Davidson, R. J., Wampold, B. E., Kearney, D. J., & Simpson, T. L. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2017.10.011 · Cited by 1,145 · see citing works
Stetler, C., & Miller, G. E. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820ad12b · Cited by 1,123 · see citing works
A novel pathway regulates memory and plasticity via SIRT1 and miR-134
Gao, J., Wang, W.-Y., Mao, Y.-W., Gräff, J., Guan, J.-S., Pan, L., Mak, G., Kim, D., Su, S. C., & Tsai, L.-H. (2010) · Nature · doi:10.1038/nature09271 · Cited by 975 · see citing works
A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor
Szuhany, K. L., Bugatti, M., & Otto, M. W. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.10.003 · Cited by 909 · see citing works
Penninx, B. W., Milaneschi, Y., Lamers, F., & Vogelzangs, N. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-129 · Cited by 839 · see citing works
Fox, K. C. R., Nijeboer, S., Dixon, M. L., Floman, J. L., Ellamil, M., Rumak, S. P., Sedlmeier, P., & Christoff, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.016 · Cited by 804 · see citing works
Major depressive disorder and hypothalamic-pituitary-adrenal axis activity
Vreeburg, S. A., Hoogendijk, W. J. G., van Pelt, J., DeRijk, R. H., Verhagen, J. C. M., van Dyck, R., Smit, J. H., Zitman, F. G., & Penninx, B. W. J. H. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.50 · Cited by 792 · see citing works
Maninger, N., Wolkowitz, O. M., Reus, V. I., Epel, E. S., & Mellon, S. H. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.11.002 · Cited by 769 · see citing works
BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
Lu, B., Nagappan, G., Guan, X.-M., Nathan, P. J., & Wren, P. B. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3505 · Cited by 747 · see citing works
Duman, R. S., & Voleti, B. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.004 · Cited by 714 · see citing works
Is depression associated with increased oxidative stress? A systematic review and meta-analysis
Black, C. N., Bot, M., Scheffer, P. G., Cuijpers, P., & Penninx, B. W. J. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.025 · Cited by 711 · see citing works
Streeter, C. C., Gerbarg, P. L., Saper, R. B., Ciraulo, D. A., & Brown, R. P. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.01.021 · Cited by 694 · see citing works
Cuijpers, P., Vogelzangs, N., Twisk, J., Kleiboer, A., Li, J., & Penninx, B. W. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13030325 · Cited by 677 · see citing works
Liew, C., Ma, J., Tang, H.-C., Zheng, R., & Dempsey, A. A. (2006) · Journal of Laboratory and Clinical Medicine · doi:10.1016/j.lab.2005.10.005 · Cited by 663 · see citing works
Neuroimmune mechanisms of depression
Hodes, G. E., Kana, V., Menard, C., Merad, M., & Russo, S. J. (2015) · Nature Neuroscience · doi:10.1038/nn.4113 · Cited by 585 · see citing works
Effects of Yoga on Mental and Physical Health: A Short Summary of Reviews
Büssing, A., Michalsen, A., Khalsa, S. B. S., Telles, S., & Sherman, K. J. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/165410 · Cited by 488 · see citing works
A Meta-analysis of oxidative stress markers in depression
Liu, T., Zhong, S., Liao, X., Chen, J., He, T., Lai, S., & Jia, Y. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138904 · Cited by 485 · see citing works
Hippocampal volume, memory, and cortisol status in major depressive disorder: Effects of treatment
Vythilingam, M., Vermetten, E., Anderson, G. M., Luckenbaugh, D., Anderson, E. R., Snow, J., Staib, L. H., Charney, D. S., & Bremner, J. D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.002 · Cited by 477 · see citing works
Stress Hormone Regulation: Biological Role and Translation into Therapy
Holsboer, F., & Ising, M. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100321 · Cited by 473 · see citing works
The hippocampus in aging and disease: From plasticity to vulnerability
Bartsch, T., & Wulff, P. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.084 · Cited by 466 · see citing works
Calorie restriction and sirtuins revisited
Guarente, L. (2013) · Genes & Development · doi:10.1101/gad.227439.113 · Cited by 464 · see citing works
Kimonides, V. G., Khatibi, N. H., Svendsen, C. N., Sofroniew, M. V., & Herbert, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1852 · Cited by 438 · cited 1× · see citing works
“DHEAS acts as a GABA(A) receptor noncompetitive antagonist and a positive allosteric modulator at the NMDA receptor (Genud et al., 2009; Kimonides et al., 1998).”
Serum and plasma BDNF levels in major depression: A replication study and meta-analyses
Bocchio-Chiavetto, L., Bagnardi, V., Zanardini, R., Molteni, R., Gabriela Nielsen, M., Placentino, A., Giovannini, C., Rillosi, L., Ventriglia, M., Riva, M. A., et al. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622971003611319 · Cited by 435 · see citing works
Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421 · see citing works
Ornish, D., Lin, J., Chan, J. M., Epel, E., Kemp, C., Weidner, G., Marlin, R., Frenda, S. J., Magbanua, M. J. M., Daubenmier, J., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70366-8 · Cited by 390 · see citing works
Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions
Klengel, T., & Binder, E. B. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.036 · Cited by 353 · see citing works
Markers of Oxidative Stress and Neuroprogression in Depression Disorder
Vaváková, M., Ďuračková, Z., & Trebatická, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/898393 · Cited by 324 · see citing works
Neurobiology of local and intercellular BDNF signaling
Sasi, M., Vignoli, B., Canossa, M., & Blum, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1964-4 · Cited by 324 · see citing works
Creswell, J. D., Taren, A. A., Lindsay, E. K., Greco, C. M., Gianaros, P. J., Fairgrieve, A., Marsland, A. L., Brown, K. W., Way, B. M., Rosen, R. K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.01.008 · Cited by 299 · see citing works
Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress
Spiers, J. G., Chen, H.-J. C., Sernia, C., & Lavidis, N. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00456 · Cited by 292 · see citing works
Strategies for Reducing or Preventing the Generation of Oxidative Stress
Poljšak, B. (2011) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2011/194586 · Cited by 287 · see citing works
Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity
Gerhard, D. M., Wohleb, E. S., & Duman, R. S. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.01.016 · Cited by 287 · see citing works
Verhoeven, J. E., Révész, D., Epel, E. S., Lin, J., Wolkowitz, O. M., & Penninx, B. W. J. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.151 · Cited by 270 · see citing works
Cognitive Behavior Therapy for Depression and Self-Care in Heart Failure Patients
Freedland, K. E., Carney, R. M., Rich, M. W., Steinmeyer, B. C., & Rubin, E. H. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.5220 · Cited by 265 · see citing works
Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders
Jęśko, H. M., Wencel, P. L., Strosznajder, R. P., & Strosznajder, J. B. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2110-y · Cited by 262 · see citing works
Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression
Schmidt, P. J., Daly, R. C., Bloch, M., SMITH, M. J., Danaceau, M. A., Clair, L. S. S., Murphy, J. H., Haq, N., & Rubinow, D. R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.154 · Cited by 252 · see citing works
Transcranial magnetic brain stimulation: Therapeutic promises and scientific gaps
Wassermann, E. M., & Zimmermann, T. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.09.003 · Cited by 243 · see citing works
Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs
Dale, E., Bang‐Andersen, B., & Sánchez, C. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.03.011 · Cited by 238 · see citing works
Taren, A. A., Gianaros, P. J., Greco, C. M., Lindsay, E. K., Fairgrieve, A., Brown, K. W., Rosen, R. K., Ferris, J. L., Julson, E., Marsland, A. L., et al. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv066 · Cited by 236 · cited 2× · see citing works
“A study by Taren et al. (Taren et al., 2015) indicates that mindfulness meditation training promotes functional neuroplastic changes, and implicate decoupling of the amygdala and subgenual anterior cingulate cortex (sgACC) as a potential neurobiological mechanism underlying mindfulness training intervention effects.”
Hypertension and physical exercise: The role of oxidative stress
Larsen, M. K., & Matchkov, V. V. (2016) · Medicina · doi:10.1016/j.medici.2016.01.005 · Cited by 223 · see citing works
Cognitive Impairment in Major Depression: Association with Salivary Cortisol
Hinkelmann, K., Moritz, S., Botzenhardt, J., Riedesel, K., Wiedemann, K., Kellner, M. B., & Otte, C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.023 · Cited by 216 · see citing works
Penn, E., & Tracy, D. K. (2012) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125312445469 · Cited by 207 · see citing works
Hippocampal volume reduction and HPA-system activity in major depression
Colla, M., Kronenberg, G., Deuschle, M., Meichel, K., Hagen, T., Bohrer, M., & Heuser, I. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.06.011 · Cited by 200 · see citing works
Duarte-Guterman, P., Yagi, S., Chow, C., & Galea, L. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.024 · Cited by 194 · see citing works
Juraska, J. M., Sisk, C. L., & DonCarlos, L. L. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.05.010 · Cited by 192 · see citing works
A systematic review of yoga for major depressive disorder
Cramer, H., Anheyer, D., Lauche, R., & Dobos, G. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.02.006 · Cited by 192 · see citing works
The meditative mind: a comprehensive meta-analysis of MRI studies.
Boccia, M., Piccardi, L., & Guariglia, P. (2015) · BioMed Research International · doi:10.1155/2015/419808 · Cited by 187 · see citing works
The role of mTOR in depression and antidepressant responses
Abelaira, H. M., Réus, G. Z., Neotti, M. V., & Quevedo, J. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.02.014 · Cited by 186 · see citing works
Burić, I., Farias, M., Jong, J., Mee, C., & Brazil, I. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00670 · Cited by 185 · see citing works
Corlett, P. R., Honey, G. D., Aitken, M. R. F., Dickinson, A., Shanks, D. R., Absalom, A. R., Lee, M., Pomarol-Clotet, E., Murray, G. K., McKenna, P. J., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.6.611 · Cited by 182 · see citing works
Frodl, T., Carballedo, A., Hughes, M. M., Saleh, K., Fagan, A., Skokauskas, N., McLoughlin, D. M., Meaney, J., O'Keane, V, & Connor, T. J. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.14 · Cited by 176 · see citing works
Tolahunase, M., Sagar, R., & Dada, R. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7928981 · Cited by 164 · see citing works
Self-citationA Systematic Review of the Effect of Expectancy on Treatment Responses to Acupuncture
Colagiuri, B., & Smith, C. A. (2011) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/857804 · Cited by 162 · see citing works
Guo, W., Qian, L., Zhang, J., Zhang, W., Morrison, A., Hayes, P. D., Wilson, S., Chen, T., & Zhao, J. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22725 · Cited by 162 · see citing works
Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation
Huang, C., McAllister, M. J., Slusher, A. L., Webb, H. E., Mock, J. T., & Acevedo, E. O. (2015) · Sports Medicine - Open · doi:10.1186/s40798-015-0031-y · Cited by 161 · see citing works
Treating major depression with yoga: A prospective, randomized, controlled pilot trial
Prathikanti, S., Rivera, R., Cochran, A., Tungol, J. G., Fayazmanesh, N., & Weinmann, E. (2017) · PLOS ONE · doi:10.1371/journal.pone.0173869 · Cited by 157 · see citing works
Neuroprotective effects of yoga practice: age-, experience-, and frequency-dependent plasticity
Villemure, C., ÄŒeko, M., Cotton, V. A., & Bushnell, M. C. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00281 · Cited by 153 · see citing works
THE ASSOCIATION BETWEEN DEPRESSION AND LEUKOCYTE TELOMERE LENGTH: A META-ANALYSIS
Schutte, N. S., & Malouff, J. M. (2015) · Depression and Anxiety · doi:10.1002/da.22351 · Cited by 144 · see citing works
Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells
Chen, H., Lombès, M., & Le Menuet, D. (2017) · Molecular Brain · doi:10.1186/s13041-017-0295-x · Cited by 138 · see citing works
Teixeira‐Lemos, E., de Oliveira, J. B. F., Pinheiro, J. P., & Reis, F. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/741545 · Cited by 136 · see citing works
Eyre, H. A., Acevedo, B. P., Yang, H., Siddarth, P., Dyk, K. V., Ercoli, L. M., Leaver, A. M., Cyr, N. S., Narr, K. L., Baune, B. T., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150653 · Cited by 135 · see citing works
Altered sirtuin deacetylase gene expression in patients with a mood disorder
Abe, N., Uchida, S., Otsuki, K., Hobara, T., Yamagata, H., Higuchi, F., Shibata, T., & Watanabe, Y. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.01.016 · Cited by 131 · see citing works
Froeliger, B., Garland, E. L., & McClernon, F. J. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/821307 · Cited by 128 · see citing works
Sibille, E. L. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/esibille · Cited by 128 · see citing works
Neuroplasticity in Depressed Individuals Compared with Healthy Controls
Player, M. J., Taylor, J. L., Weickert, C. S., Alonzo, A., Sachdev, P., Martin, D., Mitchell, P. B., & Loo, C. K. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.126 · Cited by 127 · see citing works
Nimmagadda, V. K. C., Bever, C. T., Vattikunta, N. R., Talat, S., Ahmad, V., Nagalla, N. K., Trisler, D. N., Judge, S. I. V., Royal, W., Chandrasekaran, K., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202584 · Cited by 127 · see citing works
García‐Mesa, Y., Colié, S., Corpas, R., Cristòfol, R. M., Comellas, F., Nebreda, Á. R., Giménez‐Llort, L., & Sanfeliu, C. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv005 · Cited by 124 · see citing works
Effect of Exercise on Oxidative Stress
Campbell, P. T., Gross, M. D., Potter, J. D., Schmitz, K. H., Duggan, C. R., McTiernan, A., & Ulrich, C. M. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181cfc908 · Cited by 119 · see citing works
Qu, S., Olafsrud, S. M., Meza‐Zepeda, L. A., & Saatcioglu, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061910 · Cited by 119 · see citing works
Morgan, C. J. A., Riccelli, M., Heriot-Maitland, C., & Curran, H. V. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.03.006 · Cited by 118 · see citing works
Serum cortisol and BDNF in patients with major depression—effect of yoga
Naveen, G., Varambally, S. S., Thirthalli, J., Rao, M. G., Christopher, R., & Gangadhar, B. N. (2016) · International Review of Psychiatry · doi:10.1080/09540261.2016.1175419 · Cited by 114 · see citing works
Gene—Environment Interactions in Major Depressive Disorder
Klengel, T., & Binder, E. B. (2013) · The Canadian Journal of Psychiatry · doi:10.1177/070674371305800203 · Cited by 113 · see citing works
Kerling, A., Kück, M., Tegtbur, U., Grams, L., Weber-Spickschen, S., Hanke, A., Stubbs, B., & Kahl, K. G. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.03.034 · Cited by 113 · see citing works
Szebeni, A., Szebeni, K., DiPeri, T. P., Chandley, M., Crawford, J. D., Stockmeier, C. A., & Ordway, G. A. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000698 · Cited by 112 · see citing works
Cunha-Santos, J., Duarte-Neves, J., Carmona, V., Guarente, L., Pereira de Almeida, L., & Cavadas, C. (2016) · Nature Communications · doi:10.1038/ncomms11445 · Cited by 109 · see citing works
Neuroimmune regulation of homeostatic synaptic plasticity
Pribiag, H., & Stellwagen, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.008 · Cited by 106 · cited 1× · see citing works
“The most significant dysregulation of MBCs for brain pathology in MDD includes exaggerated stress response, immune hyperactivity (Pribiag & Stellwagen, 2014), and abnormalities in adiposity, vascularity, and sexuality (Verhoeven et al., 2014).”
Fu, W., Lu, C., & Mattson, M. P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10710.2002 · Cited by 105 · see citing works
Does exercise reduce brain oxidative stress? A systematic review
Camiletti‐Moirón, D., Aparicio, V. A., Aranda, P., & Radak, Z. (2013) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12065 · Cited by 104 · see citing works
Xu, W. L., Lü, Y., Yao, J., Li, Z., Chen, Z., Wang, G., Jing, H., Zhang, X., Li, M., Peng, J., et al. (2014) · Shock · doi:10.1097/shk.0000000000000225 · Cited by 102 · see citing works
Hofer, T., Fontana, L., Anton, S. D., Weiss, E. P., Villareal, D. T., Malayappan, B., & Leeuwenburgh, C. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0712 · Cited by 89 · see citing works
Li, Z., Wang, B., Kan, Z., Zhang, B., Yang, Z. R., Chen, J., Wang, D., Wei, H., Zhang, J.-N., & Jiang, R. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.1807 · Cited by 87 · see citing works
Shin, H. K., Lee, S., & Choi, B. T. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.04.029 · Cited by 87 · see citing works
DHEA Enhances Emotion Regulation Neurocircuits and Modulates Memory for Emotional Stimuli
Sripada, R. K., Marx, C. E., King, A. P. J., Rajaram, N., Garfinkel, S. N., Abelson, J. L., & Liberzon, I. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.79 · Cited by 85 · see citing works
Shortened telomere length in patients with depression: A meta-analytic study
Lin, P., Huang, Y., & Hung, C. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.01.015 · Cited by 85 · see citing works
Na, K.-S., Won, E., Kang, J., Chang, H. S., Yoon, H.-K., Tae, W. S., Kim, Y.-K., Lee, M.-S., Joe, S.-H., Kim, H., et al. (2016) · Scientific Reports · doi:10.1038/srep21089 · Cited by 84 · see citing works
Telomerase Dysregulation in the Hippocampus of a Rat Model of Depression: Normalization by Lithium
Wei, Y. B., Backlund, L., Wegener, G., Mathé, A. A., & Lavebratt, C. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv002 · Cited by 81 · see citing works
Harkess, K. N., Ryan, J., Delfabbro, P. H., & Cohen-Woods, S. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.234 · Cited by 80 · see citing works
Oxidative Stress Modulation Through Habitual Physical Activity
Boccatonda, A., Tripaldi, R., Davı̀, G., & Santilli, F. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160413123806 · Cited by 79 · see citing works
Śliwiński, T. (2015) · Medical Science Monitor · doi:10.12659/msm.892317 · Cited by 78 · cited 1× · see citing works
“…(Abeetal.,2011;Jeskoetal.,2017),cortisol(Vree-burgetal.,2009),IL-6(Zhangetal.,2016),DHEAS (dehydroepiandrosteronesulfate)(Uhetal.,2017), andalsothemarkersofoxidativestress(Liuet al.,2015),DNAdamage(Czarnyetal.,2015),and telomeremetabolism(HenjeBlometal.,2015).”
Bayod, S., del Valle, J., Lalanza, J. F., Sanchez-Roige, S., de Luxán-Delgado, B., Coto-Montes, A., Canudas, A. M., Camins, A., Escorihuela, R. M., & Pallàs, M. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.08.004 · Cited by 77 · see citing works
Hormonal Programming Across the Lifespan
Nugent, B., Tobet, S., Lara, H., Lucion, A., Wilson, M., Recabarren, S., & Paredes, A. (2012) · Hormone and Metabolic Research · doi:10.1055/s-0032-1312593 · Cited by 71 · see citing works
Glucocorticoids depress activity-dependent expression of BDNF mRNA in hippocampal neurones
Cosi, C., Spoerri, P. E., Comelli, M. C., Guidolin, D., & Skaper, S. D. (1993) · Neuroreport · doi:10.1097/00001756-199305000-00016 · Cited by 69 · see citing works
Cho, S.-Y., So, W.-Y., & Roh, H. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14050454 · Cited by 69 · see citing works
Sarubin, N., Nothdurfter, C., Schüle, C., Lieb, M., Uhr, M., Born, C., Zimmermannc, R., Bühner, M., Konopka, K., Rupprecht, R., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.02.022 · Cited by 66 · see citing works
Vinetti, G., Mozzini, C., Desenzani, P., Boni, E., Bulla, L., Lorenzetti, I., Romano, C., Pasini, A., Cominacini, L., & Assanelli, D. (2015) · Scientific Reports · doi:10.1038/srep09238 · Cited by 65 · see citing works
Duraimani, S., Schneider, R. H., Randall, O. S., Nidich, S. I., Xu, S., Ketete, M., Rainforth, M. A., Gaylord‐King, C., Salerno, J. W., & Fagan, J. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142689 · Cited by 65 · see citing works
Fear Extinction as a Model for Synaptic Plasticity in Major Depressive Disorder
Kühn, M., Höger, N., Feige, B., Jens Blechert, A., Normann, C., & Nissen, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115280 · Cited by 64 · see citing works
Sex differences in the relationship between DHEAS and health
Goldman, N., & Glei, D. A. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.005 · Cited by 62 · see citing works
Szebeni, A., Szebeni, K., DiPeri, T. P., Johnson, L. A., Stockmeier, C. A., Crawford, J. D., Chandley, M. J., Hernandez, L. J., Burgess, K. C., Brown, R. W., et al. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw114 · Cited by 57 · see citing works
DHEA Lessens Depressive-Like Behavior via GABA-ergic Modulation of the Mesolimbic System
Genud, R., Merenlender, A., Gispan-Herman, I., Maayan, R., Weizman, A., & Yadid, G. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.46 · Cited by 55 · see citing works
Schatzberg, A. F. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.916414 · Cited by 51 · see citing works
Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder
Henje Blom, E., Han, L. K. M., Connolly, C. G., Ho, T. C., Lin, J., LeWinn, K. Z., Simmons, A. N., Sacchet, M. D., Mobayed, N., Luna, M. E., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.172 · Cited by 51 · see citing works
Pennisi, M., Lanza, G., Cantone, M., Ricceri, R., Spampinato, C., Pennisi, G., Lazzaro, V. D., & Bella, R. (2016) · Neural Plasticity · doi:10.1155/2016/8154969 · Cited by 49 · see citing works
Guida, N., Laudati, G., Anzilotti, S., Secondo, A., Montuori, P., Renzo, G. D., Canzoniero, L. M. T., & Formisano, L. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.08.010 · Cited by 48 · see citing works
Ludlow, A. T., Gratidão, L., Ludlow, L. W., Spangenburg, E. E., & Roth, S. M. (2017) · Experimental Physiology · doi:10.1113/ep086189 · Cited by 47 · see citing works
Identification of IL6 as a susceptibility gene for major depressive disorder
Zhang, C., Wu, Z., Zhao, G., Wang, F., & Fang, Y. (2016) · Scientific Reports · doi:10.1038/srep31264 · Cited by 46 · see citing works
Association of Leukocyte Telomere Length with Oxidative Stress in Yoga Practitioners
Krishna, B. H. (2015) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2015/13076.5729 · Cited by 44 · see citing works
Zheng, J., Zhang, P., Li, X., Lei, S., Li, W., He, X., Zhang, J., Wang, N., Qi, C.-Y., Chen, X., et al. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.042 · Cited by 42 · see citing works
Reeves, G. M., Rohan, K. J., LANGENBERG, P. W., Snitker, S., & Postolache, T. T. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.12.003 · Cited by 40 · see citing works
Qi, X., Luchetti, S., Verwer, R. W. H., Sluiter, A. A., Mason, M. R. J., Zhou, J., & Swaab, D. F. (2017) · Brain Pathology · doi:10.1111/bpa.12548 · Cited by 36 · see citing works
Toorie, A. M., Cyr, N. E., Steger, J. S., Beckman, R. M., Farah, G. M., & Nillni, E. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.675264 · Cited by 27 · see citing works
Wong, S. Y. S., Leung, J. C. S., Kwok, T. C. Y., Ohlsson, C., Vandenput, L., Leung, P., & Woo, J. (2011) · Asian Journal of Andrology · doi:10.1038/aja.2011.116 · Cited by 26 · see citing works
Lopizzo, N., Tosato, S., Begni, V., Tomassi, S., Cattane, N., Barcella, M., Turco, G., Ruggeri, M., Riva, M. A., Pariante, C. M., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.5 · Cited by 26 · see citing works
Bakker, J. M., Lieverse, R., Menne‐Lothmann, C., Viechtbauer, W., Pishva, E., Kenis, G., Geschwind, N., Peeters, F. P. M. L., van Os, J., & Wichers, M. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.23 · Cited by 22 · see citing works
Influence of age and physical exercise on sirtuin activity in humans.
Villanova, L., Vernucci, E., Pucci, B., Pellegrini, L., Nebbioso, M., Mauri, C., Marfè, G., Spataro, A., Fini, M., Banfi, G., et al. (2013) · PubMed · Cited by 17 · see citing works
Dong, L.-Y., Zhu, Y. H., Dong, Y. W., Yang, J., Zhao, Y., Qi, Y., Wu, P., Zhu, Y., & Zheng, P. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.154294 · Cited by 17 · see citing works
Chen, T., Tanaka, M., Wang, Y., Sha, S., Furuya, K., Chen, L., & Sokabe, M. (2017) · Glia · doi:10.1002/glia.23175 · Cited by 15 · see citing works
Uh, D., Jeong, H., Choi, K., Oh, S.-Y., Lee, S., Kim, S. H., & Joe, S.-H. (2017) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2017.15.2.163 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The sirtuin family in health and disease
Wu, Q., Zhang, T., Chen, H., Yu, X., Lv, J.-L., Liu, Y., Liu, Y., Zheng, G., Zhao, J.-Q., Wei, Y., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01257-8 · Cited by 891 · see citing works
Dauwan, M., Begemann, M. J. H., Slot, M. I. E., Lee, E. H. M., Scheltens, P., & Sommer, I. E. C. (2021) · Journal of Neurology · doi:10.1007/s00415-019-09493-9 · Cited by 239 · see citing works
Adverse Childhood Experiences, Outcomes, and Interventions
Gilgoff, R., Singh, L. B., Koita, K., Gentile, B., & Marques, S. S. (2020) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2019.12.001 · Cited by 168 · see citing works
Neurobiological Changes Induced by Mindfulness and Meditation: A Systematic Review
Calderone, A., Latella, D., Impellizzeri, F., Pasquale, P. D., Famà, F., Quartarone, A., & Calabrò, R. S. (2024) · Biomedicines · doi:10.3390/biomedicines12112613 · Cited by 158 · see citing works
Stress and immunosenescence: The role of telomerase
de Punder, K., Heim, C. C., Wadhwa, P. D., & Entringer, S. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.10.019 · Cited by 90 · see citing works
Gautam, S., Tolahunase, M., Kumar, U., & Dada, R. (2019) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-180875 · Cited by 87 · see citing works
Self-citationGautam, S., Kumar, M., Kumar, U., & Dada, R. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.02259 · Cited by 74 · see citing works
Self-citationVollbehr, N. K., Bartels-Velthuis, A. A., Nauta, M. H., Castelein, S., Steenhuis, L. A., Hoenders, H. J. R., & Ostafin, B. D. (2018) · PLOS ONE · doi:10.1371/journal.pone.0204925 · Cited by 69 · see citing works
Dunn, T. J., & Dimolareva, M. (2022) · Clinical Psychology Review · doi:10.1016/j.cpr.2022.102124 · Cited by 69 · see citing works
A unified model of ketamine’s dissociative and psychedelic properties
Marguilho, M., Figueiredo, I., & Castro-Rodrigues, P. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221140011 · Cited by 65 · see citing works
Martínez-Calderón, J., Casuso-Holgado, M. J., Muñoz-Fernández, M. J., García‐Muñoz, C., & Heredia‐Rizo, A. M. (2023) · British Journal of Sports Medicine · doi:10.1136/bjsports-2022-106497 · Cited by 65 · see citing works
Riveros, M. E., Ávila, A., Schruers, K. R. J., & Ezquer, F. E. (2022) · Antioxidants · doi:10.3390/antiox11030540 · Cited by 59 · see citing works
Stress and serum cortisol levels in major depressive disorder: a cross-sectional study
G Bertollo, A., 1 Laboratory of Physiology Pharmacology and Psychopathology, G. P. I. B. S., E Grolli, R., E Plissari, M., A Gasparin, V., Quevedo, J., Z Réus, G., D Bagatini, M., M Ignácio, Z., 2 Santa Catarina State University, W. H. E. C., et al. (2020) · AIMS Neuroscience · doi:10.3934/neuroscience.2020028 · Cited by 56 · see citing works
Meditation and telomere length: a meta-analysis
Schutte, N. S., Malouff, J. M., & Keng, S. (2020) · Psychology and Health · doi:10.1080/08870446.2019.1707827 · Cited by 56 · see citing works
Effectiveness of yoga for major depressive disorder: A systematic review and meta-analysis
Wu, Y., Yan, D., & Yang, J. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1138205 · Cited by 54 · see citing works
Paramasivam, P., Poongothai, S., Shanthirani, C. S., Anjana, R. M., Mohan, V., & Balasubramanyam, M. (2020) · Acta Diabetologica · doi:10.1007/s00592-020-01486-9 · Cited by 52 · see citing works
Gomutbutra, P., Yingchankul, N., Chattipakorn, N., Chattipakorn, S. C., & Srisurapanont, M. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.02209 · Cited by 52 · see citing works
Maddock, A., Blair, C., Ean, N., & Best, P. (2021) · International Journal of Mental Health Systems · doi:10.1186/s13033-021-00482-y · Cited by 57 · see citing works
Watt, T. T., Ceballos, N. A., Kim, S., Pan, X., & Sharma, S. (2019) · Journal of Child & Adolescent Trauma · doi:10.1007/s40653-019-00270-4 · Cited by 53 · see citing works
Gautam, S., Kumar, U., Kumar, M., Rana, D., & Dada, R. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.03.004 · Cited by 53 · see citing works
Self-citationIob, E., Pingault, J., Munafo, M. R., Stubbs, B., Gilthorpe, M. S., Maihofer, A. X., & Danese, A. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02133-9 · Cited by 48 · see citing works
Dada, T., Bhai, N., Midha, N., Shakrawal, J., Kumar, M., Chaurasia, P., Gupta, S., Angmo, D., Yadav, R., Dada, R., et al. (2020) · American journal of ophthalmology-glaucoma · doi:10.1016/j.ajo.2020.10.012 · Cited by 43 · see citing works
Self-citationMindfulness meditation and psychedelics: potential synergies and commonalities
Holas, P., & Kamińska, J. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00551-8 · Cited by 43 · see citing works
“For example, comparative studies between meditators and non-meditators have revealed differences in brain connectivity, activation patterns, and both gray and white matter density [74].”
BackgroundNovel treatments for anorexia nervosa: Insights from neuroplasticity research
Keeler, J. L., Kan, C., Treasure, J. L., & Himmerich, H. (2023) · European Eating Disorders Review · doi:10.1002/erv.3039 · Cited by 41 · see citing works
Sadhasivam, S., Alankar, S., Maturi, R. K., Vishnubhotla, R. V., Mudigonda, M., Pawale, D., Narayanan, S., Hariri, S., Ram, C., Chang, T. F. H., et al. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/8438272 · Cited by 41 · see citing works
Eleftheriou, M. E., & Thomas, E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.707057 · Cited by 39 · see citing works
“These anti-depressive and anxiolytic effects are thought to in turn be mediated by enhancements in decentring and cognitive flexibility, in the case of mindfulness intervention (16, 19), vs.”
BackgroundYoga and psychiatric disorders: a review of biomarker evidence
Bhargav, H., George, S., Varambally, S. S., & Gangadhar, B. N. (2020) · International Review of Psychiatry · doi:10.1080/09540261.2020.1761087 · Cited by 40 · see citing works
Bisht, S., Banu, S., Srivastava, S., Pathak, R. U., Kumar, R., Dada, R., & Mishra, R. K. (2020) · Andrologia · doi:10.1111/and.13551 · Cited by 37 · see citing works
Self-citationTherapeutic role of yoga in neuropsychological disorders
Nourollahimoghadam, E., Gorji, S., Gorji, A., & Ghadiri, M. K. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i10.754 · Cited by 44 · see citing works
Pal, R., Adhikari, D., Heyat, M. B. B., Guragai, B., Lipari, V., Ballester, J. B., Díez, I. D. L. T., Abbas, Z., & Lai, D. (2022) · Bioengineering · doi:10.3390/bioengineering9120793 · Cited by 35 · see citing works
Potential Role of Yoga Intervention in the Management of Chronic Non-malignant Pain
Gupta, S., Gautam, S., Kumar, U., Arora, T., & Dada, R. (2022) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2022/5448671 · Cited by 34 · see citing works
Self-citationAdverse childhood experiences and neuroinflammatory biomarkers—The role of sex
Kim, S., Watt, T. T., Ceballos, N. A., & Sharma, S. (2019) · Stress and Health · doi:10.1002/smi.2871 · Cited by 32 · see citing works
Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature
Muneer, A., & Minhas, F. A. (2019) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2019.17.3.343 · Cited by 31 · see citing works
Yoga, Meditation and Mindfulness in pediatric oncology − A review of literature
Stritter, W., Everding, J., Luchte, J., Eggert, A., & Seifert, G. (2021) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2021.102791 · Cited by 30 · see citing works
Yoga for Preventive Health: A Holistic Approach
Madan, S., Sembhi, J., Khurana, N., Makkar, K., & Byati, P. (2022) · American Journal of Lifestyle Medicine · doi:10.1177/15598276211059758 · Cited by 30 · see citing works
Chen, Q. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112550 · Cited by 30 · see citing works
Vollbehr, N. K., Hoenders, H. J. R., Bartels-Velthuis, A. A., Nauta, M. H., Castelein, S., Schroevers, M. J., Stant, A. D., Albers, C. J., de Jong, P. J., & Ostafin, B. D. (2022) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000777 · Cited by 26 · see citing works
You, T., & Ogawa, E. F. (2020) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2020.03.001 · Cited by 27 · see citing works
Lee, J., Kim, J., & Ory, M. G. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1471269 · Cited by 29 · see citing works
A Mechanistic Model for Yoga as a Preventive and Therapeutic Modality
Basu‐Ray, I. (2021) · International Journal of Yoga · doi:10.4103/ijoy.ijoy_136_20 · Cited by 27 · see citing works
Thakur, M. K., Patil, Y., Philip, S. T., Hamdule, T., Thimmapuram, J., Vyas, N., & Thakur, K. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1158760 · Cited by 27 · see citing works
Sun, W. J., Lu, E. Y., Wang, C., & Tsang, H. W. H. (2023) · Mental health and physical activity · doi:10.1016/j.mhpa.2023.100538 · Cited by 29 · see citing works
Inflammation and Cognition in Depression: A Narrative Review
Wachowska, K., & Gałecki, P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245859 · Cited by 26 · see citing works
Li, W., Weng, L., Xiang, Q., & Fan, T. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2021.794836 · Cited by 27 · see citing works
Dada, R., Tolahunase, M., & Sagar, R. (2018) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_398_17 · Cited by 25 · see citing works
Self-citationSystematic Review for the Medical Applications of Meditation in Randomized Controlled Trials
Kim, D.-Y., Hong, S.-H., Jang, S.-H., Park, S., Noh, J.-H., Seok, J.-M., Jo, H.-J., Son, C., & Lee, E. J. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031244 · Cited by 24 · see citing works
Miao, C., Gao, Y., Li, X., Zhou, Y., Chung, J. W.-Y., & Smith, G. D. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04141-2 · Cited by 22 · see citing works
“Incomplete outcome data were rated as uncertain in one study [31] and as high risk in two others [57, 60], with selective reporting of depression noted in one study [31].”
BackgroundResultInfluentialWu, J., Song, J., He, Y., Li, Z., Deng, H., Huang, Z.-M., Xie, X., Wong, N. M. L., Tao, J., Lee, T. M. C., et al. (2023) · Sports Medicine - Open · doi:10.1186/s40798-023-00637-w · Cited by 25 · see citing works
Jin, Y., Zhou, X., Deng, L., Xiong, X., Li, Y., Wei, Q., Dong, B., & Qiu, S. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1038573 · Cited by 22 · see citing works
Bisht, S., Chawla, B. V., Tolahunase, M., Mishra, R., & Dada, R. (2019) · Annals of Neurosciences · doi:10.5214/ans.0972.7531.260206 · Cited by 22 · see citing works
Self-citationKoyuncu, S. B., & Bülbül, M. (2021) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2021.101438 · Cited by 21 · see citing works
Yoga in major depressive disorder: molecular mechanisms and clinical utility
Tolahunase, M., Gautam, S., Sagar, R., Kumar, M., & Dada, R. (2021) · Frontiers in Bioscience-Scholar · doi:10.52586/s553 · Cited by 22 · see citing works
Self-citationWatt, T. T., Hartfield, K., Kim, S., & Ceballos, N. A. (2021) · Journal of American College Health · doi:10.1080/07448481.2021.1947838 · Cited by 17 · see citing works
Wu, X., Zhang, Y., Wang, J., Qin, L., Li, Y., He, Q., Zhang, T., Wang, Y., Song, L., Ji, L., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156120 · Cited by 17 · see citing works
Pragya, S. U., Mehta, N. D., Abomoelak, B., Uddin, P., Veeramachaneni, P., Mehta, N., Moore, S., Jean‐Francois, M. N., Garcia, S. J., Pragya, S. C., et al. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.607573 · Cited by 18 · see citing works
Yoga and mental health: what every psychiatrist needs to know
Bhargav, H., George, S., & Varambally, S. S. (2022) · BJPsych Advances · doi:10.1192/bja.2022.22 · Cited by 17 · see citing works
Bhandari, R. B. (2022) · Annals of Neurosciences · doi:10.1177/09727531221117623 · Cited by 16 · see citing works
Brierley, M.-E. E., Thompson, E. M., Albertella, L., & Fontenelle, L. F. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000988 · Cited by 14 · see citing works
Küçükosmanoğlu, H. S., Cramer, H., Tavakoly, R., Moosburner, A., & Bîlc, M. I. (2024) · Current Psychiatry Reports · doi:10.1007/s11920-024-01548-7 · Cited by 15 · see citing works
Yoga—Impact on Mitochondrial Health: Clinical Consequences
Gautam, S., Saxena, R., Dada, T., & Dada, R. (2021) · Annals of Neurosciences · doi:10.1177/09727531211009431 · Cited by 15 · see citing works
Self-citationBossert, L., Arzberger, K., Dorok, F., Kern, J., Stickler, C., Wunderlich, M., & Tran, U. S. (2023) · Mindfulness · doi:10.1007/s12671-023-02075-x · Cited by 15 · see citing works
Campisi, M., Cannella, L., Celik, D., Gabelli, C., Gollin, D., Simoni, M., Ruaro, C., Fantinato, E., & Pavanello, S. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1354025 · Cited by 14 · see citing works
Kaushik, M., Yadav, A., Upadhyay, A., Gupta, A., Tiwari, P., Tripathi, M., & Dada, R. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1449485 · Cited by 14 · see citing works
Self-citationImpact of mindfulness based stress reduction on sperm DNA damage
Gautam, S., Chawla, B. V., Bisht, S., Tolahunase, M., & Dada, R. (2018) · Journal of Anatomical Society of India · doi:10.1016/j.jasi.2018.07.003 · Cited by 14 · see citing works
Self-citationGautam, S., Kumar, U., Mishra, R., & Dada, R. (2022) · International Journal of Microbiology Research · doi:10.4103/ijmr.ijmr_3196_20 · Cited by 12 · see citing works
Self-citationA long-term perspective on cardiovascular job stress research
Theorell, T. (2019) · Journal of Occupational Health · doi:10.1002/1348-9585.12032 · Cited by 12 · see citing works
Silva, R. C., Meattini, M., Perusi, G., Carletto, S., Bortolomasi, M., Gennarelli, M., Baune, B. T., & Minelli, A. (2025) · Psychological Medicine · doi:10.1017/s0033291725100743 · Cited by 16 · see citing works
The Influence of Meditative Interventions on Immune Functioning: A Meta-Analysis
Oyler, D. L., Hulett, J. M., Pratscher, S. D., Price‐Blackshear, M. A., Murphy, E. A., & Bettencourt, B. A. (2023) · Mindfulness · doi:10.1007/s12671-023-02157-w · Cited by 11 · see citing works
Peng, Y.-Y., Tang, C. L., Wang, H., Ding, Y., Yang, H., Ma, X., Gao, J., Li, S., Long, Z.-Y., Lu, X., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123175 · Cited by 11 · see citing works
Dhawan, V., Malhotra, N., Singh, N., Dadhwal, V., & Dada, R. (2024) · Scientific Reports · doi:10.1038/s41598-024-62380-w · Cited by 11 · see citing works
Self-citationSchröder, J. D., de Araújo, J. B., de Oliveira, T., de Moura, A. B., Fries, G. R., Quevedo, J., Réus, G. Z., & Ignácio, Z. M. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2021-0070 · Cited by 11 · see citing works
Neuroinflammation to neurodegeneration: Boulevard of broken nerves
Attiq, A., Afzal, S., Raman, H., & Ahmad, W. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115015 · Cited by 11 · see citing works
Connecting Mind-Body Therapy-Mediated Effects to Pathological Features of Alzheimer’s Disease
Hüttenrauch, M., López‐Noguerola, J. S., & Castro‐Obregón, S. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200743 · Cited by 10 · see citing works
Simkin, D. R., & Arnold, L. E. (2020) · OBM Integrative and Complementary Medicine · doi:10.21926/obm.icm.2004040 · Cited by 9 · see citing works
Lai, Y., Lin, C., Hsieh, C. C., Yang, J.-C., Tsou, H., Lin, C., Li, S., Chan, H., & Liu, W. (2022) · Applied Sciences · doi:10.3390/app12020922 · Cited by 9 · see citing works
Telles, S., Kala, N., Gupta, R. K., Verma, S., Vishwakarma, B., Agnihotri, S., Gandharva, K., & Balkrishna, A. (2019) · Work · doi:10.3233/wor-192925 · Cited by 9 · see citing works
Mental effects of physical activity in patients with fibromyalgia: A narrative review
Talotta, R., Porcello, M., Restuccia, R., & Magaudda, L. (2024) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2024.10.067 · Cited by 7 · see citing works
Noortgate, M. V. D., Eede, F. V. D., Coppens, V., Giltay, E. J., Picker, L. D., & Morrens, M. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.100965 · Cited by 9 · see citing works
Kumari, D., Kumar, M., Upadhyay, A. D., Malhotra, N., Mahey, R., Dadhwal, V., Sehgal, T., Mishra, R., & Dada, R. (2025) · International Journal of Yoga · doi:10.4103/ijoy.ijoy_212_24 · Cited by 7 · see citing works
Self-citationPhysical Activity and Depression in Breast Cancer Patients: Mechanisms and Therapeutic Potential
Li, A., Zheng, X., Liu, D., Huang, R., Ge, H., Cheng, L. J., Zhang, M., & Cheng, H. (2025) · Current Oncology · doi:10.3390/curroncol32020077 · Cited by 7 · see citing works
Rajkumar, R. P. (2024) · Brain Sciences · doi:10.3390/brainsci14060543 · Cited by 7 · see citing works
Yoga—A complementary and traditional medicine for human health
Pandey, S., Pandey, A. C., & Kotecha, V. R. (2025) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2025.01.002 · Cited by 7 · see citing works
Huang, X., Lv, J., Zhu, D., Peng, H., & Yu, T. (2025) · Biogerontology · doi:10.1007/s10522-025-10287-y · Cited by 6 · see citing works
Neuroyoga: uma abordagem multiprofissional para a yoga como terapia através do método Kaiut Yoga
Kaiut, R. K. T., & Rodrigues, F. D. A. A. (2023) · Contribuciones a las Ciencias Sociales · doi:10.55905/revconv.16n.8-068 · Cited by 6 · see citing works
Jayanna, K. (2023) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2023.100796 · Cited by 6 · see citing works
Yoga: Impact on sperm genome and epigenome - clinical consequences
Bisht, S., & Dada, R. (2019) · Annals of Neurosciences · doi:10.5214/ans.0972.7531.260202 · Cited by 6 · see citing works
Self-citationSystematic Review of High-Dimensional Omics in Mind-Body Medicine
Schoenberg, P. L. A., & Gonzalez, K. M. (2022) · OBM Integrative and Complementary Medicine · doi:10.21926/obm.icm.2204052 · Cited by 6 · see citing works
Thurin, J., Étain, B., Bellivier, F., & Cynthia Marie-claire, A. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.04.013 · Cited by 5 · see citing works
Talukdar, P. M., Reddy, P. V., Bhargav, P. H., Subbanna, M., Karmani, S. J., Arasappa, R., Subramanian, G. V., Kesavan, M., & Debnath, M. (2023) · International Journal of Yoga · doi:10.4103/ijoy.ijoy_174_23 · Cited by 5 · see citing works
Dalal, M., Holcomb, J. M., Sundaresan, D., Dutta, A., Riobueno‐Naylor, A., Peloquin, G., Benheim, T. S., Jellinek, M. S., & Murphy, J. M. (2022) · Clinical Child Psychology and Psychiatry · doi:10.1177/13591045221105198 · Cited by 5 · see citing works
Saxena, K., Kurian, S. R., Kumar, R. R., Arnold, L. E., & Simkin, D. R. (2023) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2022.08.012 · Cited by 6 · see citing works
Symptom Science: Omics and Response to Non-Pharmacological Interventions
Wagner, M. A., Wesmiller, S. W., Maydick, M., Gawron, L. M., Peterson-Burch, F., & Conley, Y. P. (2020) · Biological Research For Nursing · doi:10.1177/1099800420975205 · Cited by 5 · see citing works
Zhao, F.-Y., Xu, P., Zheng, Z., Conduit, R., Xu, Y., Yue, L.-P., Wang, H., Wang, Y., Li, Y., Li, C., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1288346 · Cited by 5 · see citing works
Sonawane, M., Lee, A. K., Gaikwad, S., Almeida, G. J., Darby, N., Calderón, T., Ramírez, A. G., Hughes, D. C., & Patel, D. I. (2025) · Integrative Cancer Therapies · doi:10.1177/15347354251385573 · Cited by 4 · see citing works
Mechanistic Model for Yoga as a Therapeutic Modality in Cardiovascular Disease
Basu‐Ray, I. (2022) · Springer eBooks · doi:10.1007/978-981-16-6913-2_5 · Cited by 4 · see citing works
Perinatal Depression and the Role of Synaptic Plasticity in Its Pathogenesis and Treatment
Shenoy, S., & Ibrahim, S. (2023) · Behavioral Sciences · doi:10.3390/bs13110942 · Cited by 4 · see citing works
Thakur, M. K., Philip, S. T., Desai, K. R., & Thakur, K. (2025) · Stress and Health · doi:10.1002/smi.70034 · Cited by 4 · see citing works
Yoga, Meditation, and Acupuncture for Male Reproductive Health
Dhawan, V., & Dada, R. (2020) · Springer eBooks · doi:10.1007/978-3-030-32300-4_48 · Cited by 4 · see citing works
Self-citationSakurai, H., Norton, R. J., Fisher, L. B., Nagaswami, M. V., Streeter, C. C., Meyer, A. K., Dean, T., D, M. F. M., Mischoulon, D., & Nyer, M. B. (2021) · Journal of Psychiatric Practice · doi:10.1097/pra.0000000000000587 · Cited by 4 · see citing works
Role of Yoga in Stroke Management: Current Evidence and Future Directions
Jasti, N., Reddy, A. V., Ramakrishna, K. K., Bhargav, H., & Kulkarni, G. B. (2022) · Springer eBooks · doi:10.1007/978-981-16-6913-2_20 · Cited by 4 · see citing works
- Authors
- Tolahunase, M. R., Sagar, R., Faiq, M., & Dada, R.
- Affiliations
- All India Institute of Medical Sciences (IN)
- Corresponding author
- Dada, Rima
- Venue
- Restorative Neurology and Neuroscience
- Publisher
- SAGE Publications
- Published
- 2018-03-25
- Volume
- 36
- Issue
- 3
- Pages
- 423-442
- ISSN
- 0922-6028 (ISSN-L)
- 1878-3627
- OpenAlex
- W2794914738
- Cited by
- 167
- References
- 134
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 27 · 2023: 23 · 2022: 25 · 2021: 20 · 2020: 22 · 2019: 10 · 2018: 5
- FWCI
- 16.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Restorative Neurology and Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, yoga, meditation, lifestyle intervention, neuroplasticity, brain-derived neurotrophic factor, dehydroepiandrosterone sulfate, SIRT1, telomerase activity, cortisol, interleukin-6, oxidative stress, DNA damage, mind-body interventions, depression severity
- MeSH terms
- Adult, Depression, Major Depressive Disorder, Female, Humans, Life Style, Male, Middle Aged, Neuronal Plasticity, Psychiatric Status Rating Scales, Yoga, Meditation, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
