Cited by 346Phytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stressBioactive natural compounds

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Chemopreventive effects of natural dietary compounds on cancer development

Pan, Min-Hsiung, Ho, Chi-Tang·2008·Chemical Society Reviews

DOI 10.1039/b801558a

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Abstract

Chemoprevention, a relatively new and promising strategy to prevent cancer, is defined as the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse, or retard the process of carcinogenesis. The chemopreventive effects elicited by these natural dietary compounds are believed to include antioxidative, anti-inflammatory activity, induction of phase II enzymes, apoptosis, and cell cycle arrest. Many mechanisms have been shown to account for the anticarcinogenic actions of natural dietary compounds; attention has recently been focused on intracellular-signaling cascades as common molecular targets for various chemopreventive natural dietary compounds. In this critical review, we will summarize current knowledge on natural dietary compounds that act through the signaling pathways and modulate gene expression to induce detoxifying enzymes, programmed cell death, anti-inflammatory, and anti-proliferative effects, thus providing evidence for these substances in cancer chemopreventive action (128 references).

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Self-citation

Authors: Pan, M.-H., & Ho, C.-T.
Affiliations: National Kaohsiung Marine University (TW)
Rutgers, The State University of New Jersey (US)
Corresponding author: Ho, Chi-Tang
ORCID: Pan, Min-Hsiung
Ho, Chi-Tang
Venue: Chemical Society Reviews
Publisher: Royal Society of Chemistry (RSC)
Published: 2008
Volume: 37
Issue: 11
Pages: 2558
ISSN: 0306-0012 (ISSN-L)
1460-4744
DOI: 10.1039/b801558a
OpenAlex: W2046704995
Cited by: 346
References: 121
Citations by year: 2026: 4 · 2025: 5 · 2024: 11 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 19 · 2019: 18 · 2018: 17 · 2017: 25 · 2016: 19 · 2015: 31 · 2014: 35 · 2013: 38 · 2012: 27
FWCI: 1.74
Type: journal article
Language: en
Open access: closed
Locations: Chemical Society Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
Keywords: chemoprevention, carcinogenesis, phase II enzymes, apoptosis, cell cycle arrest, anti-inflammatory activity, antioxidant activity, intracellular signaling, gene expression modulation, antiproliferative activity
MeSH terms: Animals, Antioxidants, Carotenoids, Cell Cycle, Diet, Enzyme Induction, Flavonoids, Humans, Neoplasms, Terpenes, Fatty Acids, Omega-3, Anticarcinogenic Agents, Apoptosis, Isothiocyanates, Proanthocyanidins, Flavonolignans

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Chemopreventive effects of natural dietary compounds on cancer development

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