The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Triggering cryptic natural product biosynthesis in microorganisms
Abstract
Natural products from microorganisms are a crucial source for novel therapeutics. Even so, it seems that many valuable compounds are overlooked when culturing microbes under standardized laboratory conditions. Many biosynthesis genes remain silent and such "cryptic" or "orphan" pathways are only activated under specific conditions. This report gives an overview on the strategies to trigger biosynthetic pathways to yield "cryptic natural products" through external cues, co-cultivation and genomic approaches such as genome-mining, epigenetic remodeling, and engineered pathway activation.
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Cites
Natural products as sources of new drugs over the last 25 years
Newman, D. J., & Cragg, G. M. (2007) · Journal of Natural Products · doi:10.1021/np068054v · Cited by 5,517
Bioactive Microbial Metabolites: A Personal View
Bérdy, J. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.1 · Cited by 3,170
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
Nierman, W. C., Pain, A., Anderson, M. J., Wortman, J. R., Kim, H. S., Arroyo, J., Berriman, M., Abe, K., Archer, D. B., Bermejo, C., et al. (2005) · Nature · doi:10.1038/nature04332 · Cited by 1,391
Transcriptional Regulation of Chemical Diversity in Aspergillus fumigatus by LaeA
Perrin, R. M., Fedorova, N. D., Bok, J. W., Cramer, R. A., Wortman, J. R., Kim, H. S., Nierman, W. C., & Keller, N. P. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030050 · Cited by 352
Cited by
Nützmann, H.-W., Reyes-Dominguez, Y., Scherlach, K., Schroeckh, V., Horn, F., Gacek, A., Schümann, J., Hertweck, C., Strauss, J., & Brakhage, A. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103523108 · Cited by 337
Self-citationMarine biotechnology advances towards applications in new functional foods
Freitas, A. C., Rodrigues, D., Rocha-Santos, T. A. P., Gomes, A. M. P., & Duarte, A. C. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.03.006 · Cited by 145
The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs
Boto, A., Pérez de la Lastra, J., & González, C. (2018) · Molecules · doi:10.3390/molecules23020311 · Cited by 136
Omics for Bioprospecting and Drug Discovery from Bacteria and Microalgae
Maghembe, R., Damian, D., Makaranga, A., Nyandoro, S. S., Lyantagaye, S. L., Kusari, S., & Hatti-Kaul, R. (2020) · Antibiotics · doi:10.3390/antibiotics9050229 · Cited by 66
Nucleophilic 1,4-Additions for Natural Product Discovery
Cox, C. L., Tietz, J. I., Sokolowski, K., Melby, J. O., Doroghazi, J. R., & Mitchell, D. A. (2014) · ACS Chemical Biology · doi:10.1021/cb500324n · Cited by 63
Metadata
- Authors
- Scherlach, K., & Hertweck, C.
- Venue
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 7
- Issue
- 9
- Pages
- 1753
- ISSN
- 1477-0520 (ISSN-L)
- 1477-0539
- OpenAlex
- W2144217762
- Cited by
- 574
- References
- 4
- FWCI
- 23.27
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
