The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
PFOS or PreFOS? Are perfluorooctane sulfonate precursors (PreFOS) important determinants of human and environmental perfluorooctane sulfonate (PFOS) exposure?
Abstract
The extent to which perfluorooctanesulfonate precursors (PreFOS) play a role in human or environmental exposure to perfluorooctanesulfonate (PFOS) is not well characterized. The diversity of manufactured PreFOS and its degradation products (e.g. C(8)F(17)SO(2)R and C(8)F(17)SO(2)NR'R'', where R is H or F, and R' and R'' are various) has made it difficult to track their fate. Temporal trends of PFOS in both humans and wildlife are discrepant, thus it is difficult to predict future exposure, and hypotheses about the role of PreFOS have been raised. Although abiotic degradation of commercially important PreFOS materials requires further research, current data suggest that the yield of PFOS is negligible or minor. On the other hand, in vivo biotransformation of PreFOS yields PFOS as the major metabolite, and >32% yields have been observed. In Canadians, exposure to PreFOS was equivalent or greater than direct PFOS exposure prior to 2002. In most ocean water, PFOS is dominant to PreFOS, but in the oceans east of Greenland there may be more PreFOS than PFOS, consistent with the fact that whales and humans in this region also show evidence of substantial PreFOS exposure. Quantitative assessments of PFOS body-burdens coming from PreFOS are complicated by the fact that PreFOS partitions to the cellular fraction of blood, thus biomonitoring in serum under predicts PreFOS relative to PFOS. Many unknowns exist that prevent accurate modelling, thus analytical methods that can distinguish directly manufactured PFOS, from PFOS that has been biotransformed from PreFOS, should be applied in future human and environmental monitoring. Two new source tracking principles are presented and applied to human serum.
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“PFSAs and their precursors have been manufactured almost exclusively by ECF which produced a mixture of linear (70%) and many branched (total 30%) isomers [32].”
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Items 301–311 of 311
Mehdi, Q., Blackman, L. E., Lydersen, C., Kovacs, K. M., Fisk, A. T., & Bowden, J. A. (2026) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2026.181603
Occurrence of per- and polyfluoroalkyl substances in tap drinking water in British Columbia, Canada
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“MeFOSAA is a degradation product of MeFOSE, a key PFOS precursor used in the textile and carpet industries (Dassuncao et al. 2018; Martin et al. 2010).”
PFAS in Mallard Breast Tissue and Surface Water in Green Bay, Wisconsin, USA
Eifert, R.-A., Gorski, P. R., Magee, M. R., & Strom, S. M. (2026) · Environments · doi:10.3390/environments13050271
“It is also important to note that N-EtFOSAA is a precursor for PFOS, which means it may contribute to the higher concentration of PFOS found in the mallard duck breast tissue [41].”
McDonough, C. A. (2026) · The Conversation · doi:10.64628/aai.pksyev7jh
Tracking early-life PFAS exposure in the Ebro Delta flamingo colony: temporal trends and sources
Dulsat‐Masvidal, M., Oró-Nolla, B., Bertolero, A., & Lacorte, S. (2026) · Environmental Research · doi:10.1016/j.envres.2026.125035
Smith, A. R., Lin, P. D., Rifas‐Shiman, S. L., Gold, D. R., Hivert, M., Oken, E., & Cárdenas, A. (2026) · Environmental Health · doi:10.1186/s12940-026-01322-7
“While limited toxicological data exist specifically for MeFOSAA and EtFOSAA, available evidence suggests these precursors may have distinct biological activities beyond their role as PFOS sources [55].”
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Mukhopadhyay, R., Pures, R., Sanchez, D. V. P., & McDonough, C. A. (2026) · ACS ES&T Engineering · doi:10.1021/acsestengg.6c00294
Shin, H., Park, N.-Y., Lee, Y. A., Jun, J. K., Choi, K., Cho, S. W., & Kho, Y. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.6c08434
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Faxneld, S., Sköld, M., Plassmann, M. M., Benskin, J. P., Elmeros, M., & Roos, A. M. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.129418
Self-citation
Metadata
- Authors
- Martin, J. W., Asher, B. J., Beesoon, S., Benskin, J. P., & Ross, M. S.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Martin, Jonathan W.
- Venue
- Journal of Environmental Monitoring
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 12
- Issue
- 11
- Pages
- 1979
- ISSN
- 1464-0325 (ISSN-L)
- 1464-0333
- OpenAlex
- W2088093177
- Cited by
- 311
- References
- 169
- Citations by year
- 2026: 21 · 2025: 21 · 2024: 18 · 2023: 22 · 2022: 24 · 2021: 19 · 2020: 21 · 2019: 9 · 2018: 22 · 2017: 17 · 2016: 10 · 2015: 19 · 2014: 23 · 2013: 19 · 2012: 27
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Environmental Monitoring (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Chemistry › Organic Chemistry › Fluorine in Organic Chemistry
- Keywords
- PFOS, human exposure, environmental exposure, serum biomonitoring, body burden, source tracking, whales, abiotic degradation, temporal trends
- MeSH terms
- Animals, Biotransformation, Environmental Exposure, Environmental Monitoring, Environmental Pollutants, Fluorocarbons, Food Analysis, Humans, Alkanesulfonic Acids
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