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A specific and sensitive method for detection of hypochlorous acid for the imaging of microbe-induced HOCl production
Abstract
A specific and sensitive fluorescence-based method was developed for the imaging of microbe-induced HOCl production. Furthermore, we demonstrate dual oxidase (DUOX)-mediated HOCl generation in the mucosa of live animals providing a novel insight into mucosal innate immunity.
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“HOCl has superior bactericidal characteristics to superoxide [177].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [177]
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Metadata
- Authors
- Chen, X., Lee, K.-A., Ha, E.-M., Lee, K. M., Seo, Y. Y., Choi, H. K., Kim, H. N., Kim, M. J., Cho, C.-S., Lee, S. Y., Lee, W.-J., & Yoon, J.
- Affiliations
- Ewha Womans University (KR)
- Daegu Catholic University (KR)
- Seoul National University (KR)
- Corresponding author
- Lee, Won-Jae
- Yoon, Juyoung
- ORCID
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 47
- Issue
- 15
- Pages
- 4373
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2048840387
- Cited by
- 246
- References
- 42
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 11 · 2021: 11 · 2020: 9 · 2019: 14 · 2018: 22 · 2017: 22 · 2016: 34 · 2015: 26 · 2014: 24 · 2013: 36 · 2012: 18
- FWCI
- 12.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Keywords
- hypochlorous acid, fluorescence detection, microbial infection, dual oxidase, mucosal innate immunity, live animal imaging, reactive oxygen species
- MeSH terms
- Animals, Cell Survival, Drosophila melanogaster, Fungi, Humans, Hypochlorous Acid, Immunity, Innate, Intestinal Mucosa, Neutrophils, Phagosomes, Rhodamines, Bacterial Physiological Phenomena, NADPH Oxidases, Molecular Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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