The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Branched and linear poly(ethylene imine)-based conjugates: synthetic modification, characterization, and application
Abstract
Poly(ethylene imine)s (PEIs) are widely used in different applications, but most extensively investigated as non-viral vector systems. The high ability of cationic PEIs to complex and condense negatively charged DNA and RNA combined with their inherent proton sponge behavior accounts for the excellent efficiency in gene delivery. Further chemical modifications of the polymer expand the application potential, primarily aiming at increased transfection efficiency, cell selectivity and reduced cytotoxicity. Improvements in the synthesis of tailor-made PEIs in combination with new in-depth analytical techniques offer the possibility to produce highly purified polymers with defined structures. The contemporary strategies towards linear and branched poly(ethylene imine)s with modified surface characteristics, PEI-based copolymers as well as conjugates with bioactive molecules will be discussed. In this regard, the versatile branched PEIs have been successfully modified in a statistical manner, whereas the linear counterparts open avenues to design and synthesize well-defined architectures, in order to exploit their high potential in gene delivery.
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Cites
Effect of pegylation on pharmaceuticals
Harris, J. M., & Chess, R. B. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1033 · Cited by 3,431
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Nonviral vectors for gene delivery
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Polymers for Drug Delivery Systems
Liechty, W. B., Kryscio, D. R., Slaughter, B. V., & Peppas, N. A. (2010) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-073009-100847 · Cited by 1,608
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Priyadarsini, S., Mohanty, S., Mukherjee, S., Basu, S., & Mishra, M. (2018) · Journal of Nanostructure in Chemistry · doi:10.1007/s40097-018-0265-6 · Cited by 570
The chemistry of tissue adhesive materials
Bouten, P. J. M., Zonjee, M., Bender, J., Yauw, S. T. K., van Goor, H., van Hest, J. C. M., & Hoogenboom, R. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2014.02.001 · Cited by 448
The great escape: how cationic polyplexes overcome the endosomal barrier
Bus, T., Traeger, A., & Schubert, U. S. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00967h · Cited by 409
Self-citationRecent progress in biomedical applications of pluronic (PF127): Pharmaceutical perspectives
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Metadata
- Authors
- Jäger, M., Schubert, S., Ochrimenko, S., Fischer, D., & Schubert, U. S.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 41
- Issue
- 13
- Pages
- 4755
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2069717129
- Cited by
- 341
- References
- 5
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jäger, M., Schubert, S., Ochrimenko, S., Fischer, D., & Schubert, U. S. (2012). Branched and linear poly(ethylene imine)-based conjugates: synthetic modification, characterization, and application. Chemical Society Reviews. https://doi.org/10.1039/c2cs35146c
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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