Cited by 1053D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis ApplicationsCancer Cells and Metastasis

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A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids

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Ruppen, Janine, Cortes-Dericks, Lourdes, Marconi, Emanuele, Karoubi, Golnaz, Schmid, Ralph A., Peng, Renwang, Marti, Thomas M., Guenat, Olivier T.·2014·Lab Chip

DOI 10.1039/c3lc51093j

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Abstract

This study reports on a microfluidic platform on which single multicellular spheroids from malignant pleural mesothelioma (MPM), an aggressive tumor with poor prognosis, can be loaded, trapped and tested for chemotherapeutic drug response.

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Authors: Ruppen, J., Cortes-Dericks, L., Marconi, E., Karoubi, G., Schmid, R. A., Peng, R., Marti, T. M., & Guenat, O. T.
Affiliations: University of Bern (CH)
Division of General Thoracic Surgery
Corresponding author: Guenat, Olivier T.
ORCID: Karoubi, Golnaz
Schmid, Ralph A.
Marti, Thomas M.
Guenat, Olivier T.
Venue: Lab Chip
Publisher: Royal Society of Chemistry (RSC)
Published: 2014
Volume: 14
Issue: 6
Pages: 1198-1205
ISSN: 1473-0189 (ISSN-L)
1473-0197
DOI: 10.1039/c3lc51093j
OpenAlex: W2079761432
Cited by: 105
References: 36
Citations by year: 2025: 5 · 2024: 10 · 2023: 4 · 2022: 7 · 2021: 18 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 7 · 2015: 14 · 2014: 3
FWCI: 6.06
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Lab on a Chip (publishedVersion, cc-by)
PubMed (publishedVersion)
Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
Open Access CRIS of the University of Bern
Funders: Novartis Foundation
École Polytechnique Fédérale de Lausanne
Novartis Stiftung für Medizinisch-Biologische Forschung
Bernische Krebsliga
Topics: Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: malignant pleural mesothelioma, tumor spheroids, chemoresistance, cisplatin, microfluidic perfusion, caspase activity, spheroid viability, drug susceptibility testing, personalized medicine, continuous perfusion
MeSH terms: Drug Screening Assays, Antitumor, Humans, Mesothelioma, Pleural Neoplasms, Spheroids, Cellular, Cell Line, Tumor, Microfluidic Analytical Techniques

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A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids

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